Abstracts Archive - Page 2427 of 2607 - ACR Meeting Abstracts

Abstract Number: L12 • 2013 ACR/ARHP Annual Meeting
Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Demonstrates Efficacy and Significantly Reduces Proinflammatory Cytokines in Patients with Active Longstanding Rheumatoid Arthritis with High Gonadotropin Levels: A Proof-of-Concept, Double-Blind, Randomized Trial
Anita Kåss^1,2, Ivana Hollan³, Peter Torjesen⁴, Hans Christian Gulseth⁵ and Øystein T. Førre⁶, ¹Faculty of Medicine, University of Oslo, Oslo, Norway, ²Dept. of Rheumatology, Betanien Hospital, Skien, Norway, ³Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁴Department of Endocrinology, Oslo University Hospital, Oslo, Norway, ⁵Rheumatology, Betanien Hospital, Skien, Norway, ⁶Oslo University Hospital, Oslo, Norway
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and treatment options can be improved. Gonadotropin-releasing hormone (GnRH) stimulates immune responses (1). Inhibiting GnRH, by…
Abstract Number: L8 • 2013 ACR/ARHP Annual Meeting
Overexpression of Set1 at the Promoter Contributes to cAMP Response Element Modulator Alpha Overexpression in Systemic Lupus Erythematosus
Qing Zhang¹, Huilin Zhang², Hai Long¹, Jieyue Liao³, Ming Zhao¹, Xiangning Qiu¹ and Qianjin Lu¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Nursing Department, Second Xiangya Hospital, Central South University, Changsha, China, ³Department of Dermatology, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: In recent years, accumulating evidence has demonstrated that increased cAMP response element modulator α (CREMα) which contributes to IL-2 reduction and IL-17A overproduction in…
Abstract Number: L19 • 2013 ACR/ARHP Annual Meeting
Kellgren-Lawrence Grade (KL) 0 Vs. KL 1 Knees Differ in Their MRI Predictors of Subsequent Radiographic Osteoarthritis
C.Kent Kwoh¹, Ali Guermazi², Tomoko Fujii³, Robert M. Boudreau³, Michael Hannon⁴, Jason Grago⁴, David Hunter⁵, Felix Eckstein⁶ and Frank Roemer⁷, ¹Department of Medicine, The University of Arizona Arthritis Center, Tucson, AZ, ²Radiology, Boston University School of Medicine, Boston, MA, ³Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA, ⁵University of Sydney, Sydney, Australia, ⁶Paracelsus Medical University, Salzburg, Austria, ⁷Klinikum Augsburg, Augsburg, Germany
Background/Purpose: Kellgren-Lawrence grade (KL) 1, defined by a questionable osteophyte and/or doubtful joint space narrowing, is thought to be an intermediate stage from non-OA (i.e.,…
Abstract Number: L20 • 2013 ACR/ARHP Annual Meeting
Association Between Germinal Center Formation in Labial Salivary Gland Biopsies and Predictors of Lymphoma Among Participants of the Sjӧgren’s International Collaborative Clinical Alliance (SICCA)
Annie Chou¹, Kimberly E. Taylor², Richard C.K. Jordan³, John S. Greenspan⁴, Troy E. Daniels⁴, Caroline H. Shiboski¹ and Lindsey A. Criswell^5,6, ¹Orofacial Sciences, University of California San Francisco, San Francisco, CA, ²Department of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Orofacial Sciences, Pathology, & Radiation Oncology, University of California San Francisco, San Francisco, CA, ⁴Orofacial Sciences & Pathology, University of California San Francisco, San Francisco, CA, ⁵University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ⁶University of California, San Francisco, Department of Medicine, San Francisco, CA
Background/Purpose: Sjӧgren’s Syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the lacrimal and salivary glands causing dry eyes and dry mouth. …
Abstract Number: L9 • 2013 ACR/ARHP Annual Meeting
Tofacitinib Monotherapy Versus Methotrexate in Methotrexate-Naïve Patients with Rheumatoid Arthritis: Radiographic, Clinical and Functional Comparison
Roy Fleischmann¹, E. B. Lee², S Hall³, B. E. Wilkinson⁴, John D. Bradley⁵, D. Gruben⁴, T. Koncz⁶, S. Krishnaswami⁷, G. Wallenstein⁶, S. H. Zwillich⁴ and R.F. van Vollenhoven⁸, ¹Metroplex Clinical Research Center, Dallas, TX, ²Seoul National University, Seoul, South Korea, ³Cabrini Health and Monash University, Melbourne, Australia, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc., Groton, CT, ⁶Pfizer Inc, New York, NY, ⁷Clinical Pharmacology, Pfizer Inc, Groton, CT, ⁸The Karolinska Institute, Stockholm, Sweden
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of RA. This Phase 3, 24-mo study (ORAL Start; NCT01039688) compared efficacy, including inhibition…
Abstract Number: L17 • 2013 ACR/ARHP Annual Meeting
Safety and Immunogenicity of Inactivated Varicella-Zoster Virus Vaccine in Adults with Autoimmune Disease
Lawrence McAdam¹, Michael Eberhardson², William Grainger³, Kim Papp⁴, Stephen Hall⁵, Tina Sterling⁶, Jon Stek⁶, Lei Pang⁶, Yanli Zhao⁶, Ivan Chan⁶, Richard Haupt⁶, Janie Parrino⁶ and Jeffrey Silber⁶, ¹Advanced Rheumatology, Infusion and Clinical Research Center, Thousand Oaks, CA, ²Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Neurological Physicians of Arizona, Gilbert, AZ, ⁴K. Papp Clinical Research,, Waterloo, ON, Canada, ⁵Emeritus Research, Malvern, Australia, ⁶Merck & Co., Inc., Whitehouse Station, NJ
Background/Purpose: Patients with autoimmune diseases are often immunocompromised, resulting in higher incidence of HZ than in immunocompetent individuals with significant morbidity and occasional mortality from…
Abstract Number: L16 • 2013 ACR/ARHP Annual Meeting
Kidney Resident B Cells and Plasmacytoid Dendritic Cells in Urine of Systemic Lupus Erythematosus patients
Eric Scott¹, Mary Anne Dooley² and Steve Clarke¹, ¹Microbiology/Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC
Title: Kidney resident B Cells and plasmacytoid dendritic cells (pDCs) in the urine of systemic lupus erythematosus (SLE) patients. Background/Purpose: Renal involvement remains the principal…
Abstract Number: L7 • 2013 ACR/ARHP Annual Meeting
Improvement in Psoriasis Symptoms and Physical Functioning with Secukinumab Compared with Placebo and Etanercept in Subjects with Moderate-to-Severe Plaque Psoriasis and Psoriatic Arthritis: Results of a Subanalysis from the Phase 3 Fixture Study
Alice Gottlieb¹, Richard Langley², Sandra Philipp³, Ruvie Martin⁴, Charis Papavassilis⁵ and Shephard Mpfofu⁵, ¹Tufts Medical Center, Boston, MA, ²Dalhousie University, Halifax, NS, Canada, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Novartis Pharma AG, East Hanover, NJ, ⁵Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab (SEC; AIN457), a fully human anti–IL-17A monoclonal antibody, has demonstrated efficacy in phase 3 trials for treatment of plaque psoriasis and preliminary results…
Abstract Number: L18 • 2013 ACR/ARHP Annual Meeting
Long-Term Evaluation of Bone Mineral Density Change in Women Receiving Depot Leuprolide Acetate during Cyclophosphamide Therapy for Severe Lupus Nephritis
Nathan Meier¹ and Mary Anne Dooley², ¹Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Cohort studies demonstrate that 11-83% of female patients receiving cyclophosphamide (CYC) for treatment of severe manifestations of SLE develop premature ovarian failure (POF), dependent…
Abstract Number: L10 • 2013 ACR/ARHP Annual Meeting
Efficacy and Safety of Ustekinumab in Patients with Active Psoriatic Arthritis: 2-Year Results from a Phase 3, Multicenter, Double-Blind, Placebo-Controlled Study
Arthur Kavanaugh¹, Luis Puig², Alice B. Gottlieb³, Christopher T. Ritchlin⁴, Shu Li⁵, Yuhua Wang⁵, Alan Mendelsohn⁶, Michael Song⁵, Proton Rahman⁷ and Iain B. McInnes⁸, ¹UCSD School of Medicine, La Jolla, CA, ²Universitat Autònoma de Barcelona, Barcelona, Spain, ³Tufts Medical Center, Boston, MA, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵Janssen Research & Development, LLC., Spring House, PA, ⁶Immunology, Janssen Research & Development, LLC, Spring House, PA, ⁷Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁸University of Glasgow, Glasgow, United Kingdom
Background/Purpose: To evaluate long-term clinical/radiographic efficacy of subcutaneous UST 45/90 mg in patients with active psoriatic arthritis (PsA) through wk108 of the PSUMMIT 1 trial.…
Abstract Number: L14 • 2013 ACR/ARHP Annual Meeting
For Remission Induction with Glucocorticoid Bridging, Methotrexate Monotherapy Is As Effective As a Combination with Other Dmards, with Fewer Reported Side Effects: 4 Month Primary Outcome of Carera, a Randomized Induction Strategy and Treat to Target Trial in Early RA
Diederik De Cock¹, Sabrina Meyfroidt¹, Johan Joly², Kristien Van der Elst^2,3, Rene Westhovens^4,5 and Patrick Verschueren^2,6, ¹Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, ²University Hospitals Leuven on behalf of the CareRA Study Group, Leuven, Belgium, ³Skeletal Biology and Engineering Research Center, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium, ⁴University of Leuven, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration; Rheumatology, University Hospital Leuven, Leuven, Belgium, ⁵Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, KU Leuven, Leuven, Belgium, ⁶1Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
Background/Purpose: Intensive combination therapy with glucocorticoids (GCs) is the most favorable treatment to benefit from the window of opportunity in early Rheumatoid Arthritis (eRA) but…
Abstract Number: L13 • 2013 ACR/ARHP Annual Meeting
Serum 14-3-3η Marks RA Development in Arthralgia and Radiographic Progression in Early RA Patients
D. van Schaardenburg¹, Marian van Beers-Tas², Karin Britsemmer², Mairead Murphy³, Walter P. Maksymowych⁴, Maarten Boers⁵ and Anthony Marotta⁶, ¹Jan van Breemen Research Institute, Amsterdam, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, ⁶Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: The focus of RA management is increasingly towards early detection and treatment. While newly-diagnosed patients will benefit from treatment decisions based on more robust…
• 2013 ACR/ARHP Annual Meeting
2012 Lee C. Howley, Sr. Prize for Arthritis Research Introductory Talk
George C. Tsokos, Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Abstract Number: 2687 • 2012 ACR/ARHP Annual Meeting
Modular Microarray Analysis Fails to Reveal a Significant Biological Effect of Vitamin D3 Treatment in Patients Participating in a Double-Blind Randomized Placebo-Controlled Trial of the Effect of Vitamin D3 On the Interferon Signature in Patients with Systemic Lupus Erythematosus
Michaela Oswald¹, Cynthia Aranow², Diane L. Kamen³, Meggan C. Mackay⁴, Ellen A. Goldmuntz⁵, Betty Diamond⁶, Peter K. Gregersen⁷ and ALE02 Study Team⁸, ¹Laboratory of Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, NY, ²Feinstein Institute for Medical Research, Manhasset, NY, ³Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ⁴Autoimmune & Musculoskeletal Disease, The Feinstein Institute, Manhasset, NY, ⁵DAIT, NIAID/NIH, Bethesda, MD, ⁶Autoimmune & Musculoskeletal, Feinstein Institute Med Rsch, Manhasset, NY, ⁷Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁸NIAID/NIH Rm 6807, Bethesda, MD
Background/Purpose: Vitamin D modulates the immune response. Exposing normal PBMCs to activating SLE sera induces an interferon signature which can be inhibited by preexposure of…
Abstract Number: 2689 • 2012 ACR/ARHP Annual Meeting
Quality of Sleep, Physical Activity and Fatigue in Patients with Rheumatoid Arthritis. A Cross-Sectional Study
Katrine Loeppenthin¹, Bente Appel Esbensen¹, Poul Jennum², Mikkel Østergaard³, Tanja Thomsen¹ and Julie Midtgaard⁴, ¹Nursing and Health Science Research Unit, DK-2600 Glostrup, Denmark, ²Danish Centre for Sleep Medicine, Department of Clinical Neurophysiology, DK-2600 Glostrup, Denmark, ³Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁴Health Care Research Centre, Copenhagen, Denmark
Background/Purpose: Sleep disturbances and fatigue are frequently experienced (40-70 %) in patients with rheumatoid arthritis (RA) and contribute to decreased quality of life and adverse…

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