Abstracts Archive - Page 2424 of 2425 - ACR Meeting Abstracts

Abstract Number: 2683 • 2012 ACR/ARHP Annual Meeting
Interferon-Associated Cytokine and Chemokine Expression in Patients with Serologically Active Clinically Quiescent (SACQ) Systemic Lupus Erythematosus (SLE)
Amanda J. Steiman¹, Murray B. Urowitz², Dominique Ibanez², Carolina Landolt-Marticorena³, Dafna D. Gladman⁴ and Joan E. Wither⁵, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Interferon-α (IFN-α) plays a prominent pro-inflammatory role in SLE. Studies suggest clinical/serologic discordance may illuminate SLE pathophysiology: peripheral IFN-α production is blunted in autoantibody-producing,…
Abstract Number: 2684 • 2012 ACR/ARHP Annual Meeting
Cerebrospinal Fluid IL-6 and Anti-NMDA Receptor NR2 Antibodies As Surrogate Markers for CNS Disease Severity in SLE
Shunsei Hirohata, Yoshiyuki Arinuma and Eisuke Ogawa, Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Neuropsychiatric manifestations occur in approximately one-half of patients with SLE and may cause substantial impairment of quality of life as well as disability. Among…
Abstract Number: 2685 • 2012 ACR/ARHP Annual Meeting
Overall and Cause Specific Mortality in Patients with Systemic Lupus Erythematosus. A Meta-Analysis of Observational Studies
Marko Yurkovich¹, Kateryna Vostretsova² and J. Antonio Avina-Zubieta³, ¹Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Rheumatology, Arthritis Research Centre of Canada/University of British Columbia, Richmond, BC, Canada
Background/Purpose: Systemic lupus erythematosus (SLE), is a chronic autoimmune condition. It has the potential to affect any organ system and can be associated with severe…
Abstract Number: 2646 • 2012 ACR/ARHP Annual Meeting
Cost-Effectiveness of Tai Chi Mind-Body Exercise for the Treatment of Fibromyalgia
John B. Wong¹ and Chenchen Wang², ¹Medicine/Clinical Decision Making, Tufts Medical Center, Boston, MA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Although fibromyalgia is associated with substantial annual direct medical and indirect productivity costs, the cost-effectiveness of treatments for fibromyalgia remains understudied. A randomized…
Abstract Number: 2647 • 2012 ACR/ARHP Annual Meeting
Effects of Pain Expectations On Neuromuscular Control of the Spine in Patients with Chronic Low Back Pain and Healthy Participants
Yves Henchoz, Charles Tétreau, Jacques Abboud, Mathieu Piché and Martin Descarreaux, Département de chiropratique, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada
Background/Purpose: The mechanisms underlying the transition from acute to chronic low back pain (cLBP) are poorly understood. Physiological and psychological factors are implicated. Although significant…
Abstract Number: 2648 • 2012 ACR/ARHP Annual Meeting
Randomized Placebo-Controlled Trial of Local Steroid Injection for Moderately Severe Carpal Tunnel Syndrome
Isam Atroshi¹, Magnus Flondell² and Manfred Hofer³, ¹Department of Orthopedics Hässleholm-Kristianstad, Lund University, Hässleholm, Sweden, ²Department of Hand Surgery, Lund University, Malmö, Sweden, ³Physiotherapy, Kristianstad Hospital, Kristianstad, Sweden
Background/Purpose: Patients with idiopathic carpal tunnel syndrome (CTS) are commonly treated with local steroid injection but there is currently no evidence from placebo-controlled trials supporting efficacy…
Abstract Number: 2649 • 2012 ACR/ARHP Annual Meeting
Trends in US Arthroplasty Rates 1991-2005: Patients with Inflammatory Arthritis Continue to Require Joint Replacement
Christina Mertelsmann-Voss¹, Ting Jung Pan², Stephen L. Lyman³, Mark P. Figgie⁴ and Lisa A. Mandl⁵, ¹Pediatric Rheumatology, Hospital for Special Surgery, Cornell University, New York, NY, ²Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ³Research, Hospital Special Surgery, New York, NY, ⁴Orthopedics, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Overall rates of total joint replacement surgeries (TJR) have increased dramatically over the past decades. By contrast, TJR rates among patients with rheumatoid arthritis…
Abstract Number: 2650 • 2012 ACR/ARHP Annual Meeting
The Meteor Trial: Preliminary Results of an RCT of Arthroscopic Partial Meniscectomy Vs. Physical Therapy in Patients greater Than 45
Jeffrey N. Katz¹, Christine E. Chaisson², Brian Cole³, Laurel Donnell-Fink¹, Morgan Jones⁴, Bruce Levy⁵, Lisa A. Mandl⁶, Scott Martin¹, Robert Marx⁷, Anthony Miniaci⁸, Joseph Palmisano⁹, Emily Reinke¹⁰, Clare Safran-Norton¹, Debra J. Skoniecki¹¹, Daniel Solomon¹², Kurt P. Spindler¹⁰, John Wright¹³, Rick Wright¹⁴ and Elena Losina¹⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Rush University, Chicago, IL, ⁴Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, ⁵Orthopedics, Mayo Clinic, Rochester, MN, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Orthopedic Surgery, Hospital for Special Surgery, New York, NY, ⁸Orthopedics, Cleveland Clinic, Cleveland, OH, ⁹Boston University School of Public Health, ¹⁰Vanderbilt University, Nashville, TN, ¹¹Brigham & Womens Hospital, Boston, MA, ¹²Division of Rheumatology, Brigham & Womens Hospital, Boston, MA, ¹³Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, ¹⁴Orthopedics, Washington University, Saint Louis, MO, ¹⁵Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Patients who present with a symptomatic knee that has both osteoarthritis and a meniscal tear present a difficult treatment challenge. They may be treated…
Abstract Number: 2651 • 2012 ACR/ARHP Annual Meeting
Associations Between Body Mass Index and Physical Activity Following Total Knee Replacement
Carol A. Oatis¹, Wenjun Li², Milagros Rosal³, David Ayers² and Patricia D. Franklin², ¹Physical Therapy, Arcadia University, Glenside, PA, ²Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ³Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: In 2009 over 620,000 total knee replacement (TKR) surgeries were performed. That number is expected to increase to 3.5 million annually by 2030. On…
Abstract Number: 2652 • 2012 ACR/ARHP Annual Meeting
Benefits of Aerobic Training in Patients with Ankylosing Spondylitis Are Not Coupled by Effects On Cytokines: A Randomized Controlled Trial
Fabio Jennings¹, Hilda A. Oliveira², Marcelo C. Sousa¹, Vaneska G. Cruz¹, Fabio S. Lira³ and Jamil Natour¹, ¹Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Psicobiology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Ankylosing Spondylitis (AS) is a systemic inflammatory disease that causes deterioration of physical capacity. Although exercises remain essential in the treatment, the literature lacks…
Abstract Number: 2653 • 2012 ACR/ARHP Annual Meeting
A Subset of up-Regulated IFN Regulated Genes in Candle Patients Decrease with Treatment with a JAK Inhibitor
Adriana Almeida de Jesus¹, Yin Liu², Gina A. Montealegre³, Adam L. Reinhardt⁴, Diane Brown⁵, Antonio Torrelo⁶, Angel V. Casano⁷, Lena Das⁸, Yongqing Chen⁹, Yan Huang⁹, Deborah Stone¹⁰, Dawn C. Chapelle², Nicole Plass², Steven H. Zuckerman¹¹, William Macias¹² and Raphaela T. Goldbach-Mansky², ¹Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ²Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ³NIAMS, Bethesda, MD, ⁴Rheumatology, Children's Hosp of Omaha/UNMC, Omaha, NE, ⁵Division Of Rheumatology MS #60, Children's Hospital Los Angeles, Los Angeles, CA, ⁶Departments of Pediatric Dermatology, Hospital Niño Jesús, Madrid, Spain, Madrid, Spain, ⁷Meditex Spain, Malaga, Spain, ⁸Pediatric Rheumatology, KK Women's and Children's Hospital, Singapore, Singapore, ⁹Translational Autoinflammatory Disease Section, Office of the Clinical Director NIAMS, Bethesda, MD, ¹⁰National Institute of Arthritis & Muscoloskeletal, National Institutes of Health, Bethesda, MD, ¹¹Immunology, Lilly Research Labs, Indianapolis, IN, ¹²Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described early-onset autoinflammatory disease caused by autosomal recessive mutations in…
Abstract Number: 2654 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Methotrexate Response Identifies Novel Genes in a Large Cohort of European Juvenile Idiopathic Arthritis Cases
Joanna Cobb¹, Erika Cule², Halima Moncrieffe³, Edward Flynn⁴, Anne Hinks¹, Fiona Patrick³, Laura Kassoumeri³, Simona Ursu⁵, Maja Bulatovic⁶, Marek Bohm⁷, Bertrand D. van Zelst⁸, Pavla Dolezalova⁹, Robert De Jonge⁸, Nico M. Wulffraat⁶, Stanton Newman¹⁰, Maria de Iorio¹¹, Lucy R. Wedderburn³ and Wendy Thomson¹, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom, ³Institute of Child Health, University College London, London, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁵Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁶Paediatric Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁷First Faculty of Medicine and General Faculty Hospital, Prague, Czech Republic, ⁸Clinical Chemistry, Erasmus Medical Center, Rotterdam, Netherlands, ⁹Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁰School of Community & Health Sciences, City University London, London, United Kingdom, ¹¹Department of Statistical Sciences, University College London, London, United Kingdom
Background/Purpose: The drug methotrexate (MTX) is the first line treatment for many children with Juvenile Idiopathic Arthritis (JIA). Only 45% of children treated with MTX…
Abstract Number: 2655 • 2012 ACR/ARHP Annual Meeting
Rapid and Effective Response to Immunosuppression in Treating Macrophage Activation Syndrome Associated with a Heterozygous Dominant Negative Mutation in RAB27a Leading to Decreased Cytolytic Activity
Randy Q. Cron¹, Mingce Zhang², Christina J. Bemrich-Stolz² and Timothy Beukelman¹, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pediatrics, Univ of Alabama-Birmingham, Birmingham, AL
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is an often fatal disorder of infancy resulting from homozygous mutations in proteins involved in cytolysis (e.g. MUNC13-4, RAB27a, Perforin 1,…
Abstract Number: 2656 • 2012 ACR/ARHP Annual Meeting
Elevated Serum Follistatin-Like Protein 1 Suggests an Interleukin-1 Independent Pathway for Inflammation in Patients with Cryopyrin Associated Periodic Syndromes
Mark Gorelik¹, Daniel Bushnell², Raphaela T. Goldbach-Mansky³, Hal M. Hoffman⁴ and Raphael Hirsch⁵, ¹Pediatric Rheumatology/Floor 3, Univ of Pittsburgh Med Ctr Children's Hospital, Pittsburgh, PA, ²Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁴Division of Allergy, Immunology and Rheumatology, University of California at San Diego, La Jolla, CA, ⁵Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Cryopyrin associated periodic syndromes (CAPS) are a group of IL-1β mediated autoinflammatory diseases characterized by fever, urticaria and conjunctivitis, and in severe cases, CNS…
Abstract Number: 2657 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Meta-Analysis of Eight Independent Systemic Juvenile Idiopathic Arthritis Collections Reveals Regional Association Spanning the Major Histocompatibility Complex Class II and III Gene Cluster
Michael J. Ombrello¹, Elaine Remmers², Alexei A. Grom³, Wendy Thomson⁴, Alberto Martini⁵, Marco Gattorno⁶, Seza Ozen⁷, Sampath Prahalad⁸, John F. Bohnsack⁹, Andrew Zeft¹⁰, Norman T. Ilowite¹¹, Elizabeth D. Mellins¹², Ricardo A. G. Russo¹³, Claudio Len¹⁴, Sheila K. Oliveira¹⁵, Rae SM Yeung¹⁶, Lucy R. Wedderburn¹⁷, Jordi Anton Lopez¹⁸, Colleen Satorius¹⁹, Ioanna Tachmazidou²⁰, Carl D. Langefeld²¹, Eleftheria Zeggini²⁰, Susan D. Thompson²², Patricia Woo²³ and Daniel L. Kastner², ¹Translational Genetics and Genomics Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³PRCSG, Cincinnati, OH, ⁴Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, Manchester, United Kingdom, ⁵Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, ⁶Second Division of Paediatrics, Istituto Giannina Gaslini, Genova, Italy, ⁷Hacettepe University, Ankara, Turkey, ⁸Pediatrics, Emory Children's Center, Atlanta, GA, ⁹Dept of Pediatriacs, University of Utah, Salt Lake City, UT, ¹⁰Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, ¹¹Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ¹²Dept of Pediatrics CCSR, Stanford University Medical Center, Stanford, CA, ¹³Immunology & Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina, ¹⁴Pediatrics, Universidade Federal de São Paulo / UNIFESP, Sao Paulo, Brazil, ¹⁵Pediatric Rheumatology, Instituto de Pediatria e Puericultura Martagão Gesteira (IPPMG) da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil, ¹⁶Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹⁷Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, ¹⁸pediatric Rheumatology, University Childrenxs Hospital, Barcelona, Spain, ¹⁹Inflammatory Disease Section, National Human Genome Research Institute, Nationsl Institutes of Health, Bethesda, MD, ²⁰The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, ²¹Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²²Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²³Division of Infection and Immunity, University College London, London, United Kingdom
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a rare inflammatory disease that is inherited as a complex genetic trait. While the pathophysiology of sJIA is…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].