Abstract Number: 42 • 2013 ACR/ARHP Annual Meeting
Inhibition Of B Cell Differentiation To The Plasmablast and Plasma Cell Lineage By CC-220, a Potent Modulator Of The Cereblon E3 Ubiquitin Ligase Complex
Background/Purpose: CC-220 is an immunomodulatory compound which binds to the CUL4 family E3 ubiquitin ligase complex protein cereblon (CRBN) with high affinity and modulates the…Abstract Number: 43 • 2013 ACR/ARHP Annual Meeting
Overexpression Of Lamin A In Mesenchymal STEM CELLS Compromises Chondrogenesis and Enhances Adipogenesis
Background/Purpose: Previous work by our group and others indicated that an accumulation of lamin A (LMNA) is associated with the osteoarthritis (OA) chondrocyte phenotype. Mutations…Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis
Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…Abstract Number: 46 • 2013 ACR/ARHP Annual Meeting
Alarmins S100A8/A9 Regulate Osteophyte Formation In Experimental Osteoarthritis With High Synovial Activation
Background/Purpose: Osteophytes are cartilage capped, bony outgrowths that limit joint movement and originate from the periosteum or from ligaments during osteoarthritis (OA). There is increasing…Abstract Number: 47 • 2013 ACR/ARHP Annual Meeting
Exogenous Hydrogen Sulfide Donors Show Anti-Catabolic and Anti-Inflammatory Properties But Limited Anti-Oxidant Capability On Human Articular Osteoarthritic Chondrocytes
Background/Purpose: Osteoarthritis (OA) is characterized by an imbalance between catabolism and anabolism, higher than normal levels of matrix metalloproteinases (MMPs), an increase in inflammatory markers…Abstract Number: 48 • 2013 ACR/ARHP Annual Meeting
The In Vivo Role Of Bone Specific EphB4 Receptor Overexpression In Osteoarthritic Synovial Membrane
Background/Purpose: Osteoarthritis (OA) is characterized by progressive destruction of all joint tissues including inflammation of the synovial membrane. The histological changes that occur in OA…Abstract Number: 49 • 2013 ACR/ARHP Annual Meeting
Chondrocyte-Specific Bone Morphogenetic Protein-2 Overexpression Results In Severe Aggravation Of Osteophyte Formation In Experimental Osteoarthritis Without Altering Cartilage Damage In Young Mice
Background/Purpose: In murine osteoarthritis (OA) models chondrocytes surrounding lesions express elevated levels of Bone Morphogenetic Protein-2 (BMP2). This growth factor is well known for its…Abstract Number: 50 • 2013 ACR/ARHP Annual Meeting
Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice
Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…Abstract Number: 51 • 2013 ACR/ARHP Annual Meeting
Collagen-Based Microspheres Delivering TGF-β3 For Mesenchymal STEM CELL Differentiation: An Innovative Strategy For Cartilage Engineering
Background/Purpose: Because of a poor self-healing ability, joint cartilage undergoes progressive degradation in the course of aging or following traumatic injuries. One promising therapeutic approach…Abstract Number: 52 • 2013 ACR/ARHP Annual Meeting
Altered Lipid Metabolism In Osteoarthritis With Subsequent Proinflammatory Properties Of Apolipoprotein A-I
Background/Purpose: Osteoarthritis (OA) is associated with a local inflammatory process. It is now considered as a metabolic syndrome rather than due to aging or mechanical…Abstract Number: 54 • 2013 ACR/ARHP Annual Meeting
ANTI-Fibrotic and ANTI-Hypertrophic Effect Of Adipose Mesenchymal Stromal CELLS On Osteoarthritic Chondrocytes
Background/Purpose: Mesenchymal stem cells (MSC) isolated from bone marrow (MSC) or adipose (ASC) tissues secrete a large amount of trophic factors. The possibility that these…Abstract Number: 55 • 2013 ACR/ARHP Annual Meeting
Glucocorticoid Receptor Modulator Compound A Does Not Induce Leptin In Human Osteoarthritic Synovial Fibroblasts and In Dedifferentiated Chondrocytes
Background/Purpose: Leptin is generally considered detrimental in osteoarthritis (OA) as it can induce IL-8 in synovial fibroblasts (SF) and matrix metalloproteinases in chondrocytes. We recently…Abstract Number: 56 • 2013 ACR/ARHP Annual Meeting
Age-Related Loss Of The Transforming Growth Factor Beta Receptor ALK5 Precedes Osteoarthritis Development In Cartilage
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and (old) age is its main risk factor. One of OA's main hallmarks is degradation of…Abstract Number: 57 • 2013 ACR/ARHP Annual Meeting
Role Of Procatabolic Cytokines In Dysregulation Of O-Linked N-Acetylglucosamine Modified Proteins In Human Osteoarthritic Chondrocytes
Background/Purpose: Nuclear and cytoplasmic protein glycosylation by the addition of O-linked N-Acetylglucosamine (O-GlcNAc) to serine and threonine residues is a widespread post-translational modification that has…Abstract Number: 23 • 2013 ACR/ARHP Annual Meeting
Seizures In Systemic Lupus Erythematosus Are Not An Inflammatory Manifestation Of Lupus Anticoagulant
Background/Purpose: About 50% of SLE patients make an antiphospholipid antibody and 10% develop classic antiphospholipid syndrome. Seizures are one of the components of the SLICC…
ACR Meeting Abstracts