Abstracts Archive - Page 2422 of 2425 - ACR Meeting Abstracts

Abstract Number: L8 • 2012 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Parallel-Group Study of the Safety and Efficacy of Tocilizumab Subcutaneous Versus Placebo in Combination with Traditional Dmards in Patients with Moderate to Severe Rheumatoid Arthritis (BREVACTA)
Alan J. Kivitz¹, Ewa Olech², Michael A. Borofsky³, Beatriz M. Zazueta⁴, Federico Navarro-Sarabia⁵, Lucy Rowell⁶, Clare Nasmyth-Miller⁶ and Janet E. Pope⁷, ¹Altoona Center for Clinical Research, Duncansville, PA, ²Internal Medicine, University of Nevada School of Medicine, Las Vegas, NV, ³Clinical Research Center of Reading, Reading, PA, ⁴Reumatologia, Centro de Investigacion en Enfermedades Reumaticas, Mexicali, Mexico, ⁵Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain, ⁶Roche, Welwyn Garden City, United Kingdom, ⁷Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada
Background/Purpose: The intravenous formulation of tocilizumab (TCZ) has demonstrated efficacy with a manageable safety profile in patients (pts) with rheumatoid arthritis (RA) in multiple clinical…
Abstract Number: 1 • 2012 ACR/ARHP Annual Meeting
Evaluation of Synovial Inflammation Assessed by Macroscopic and Histological Criteria in Patients with Knee Osteoarthritis
Montserrat Romera-Baures Sr.¹, Ramon Valls-Garcia Sr.², Antonio Rozadilla Sr.³, Marta Terricabras Sr.⁴ and Joan Miquel Nolla Sr.⁵, ¹Rheumatology, Hospital Universitari Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital de Palamos, Girona, Palamos (Girona), Spain, ³Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ⁴Departament of Pathology, Hospital Universitari de Bellvitge., Barcelona, Spain, ⁵Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: Although osteoarthritis (OA) is commonly described as a non-inflammatory joint disease, synovial inflammation is increasingly recognized as contributing to the symptoms and progression of…
Abstract Number: 2 • 2012 ACR/ARHP Annual Meeting
Microrna-558 Regulates the Expression of Cyclooxygenase-2 and IL-1beta Responses in Human Articular Chondrocytes
Su Jin Park¹, Eun-Jeong Cheon² and Hyun Ah Kim², ¹Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ²Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea
Background/Purpose: Osteoarthritis (OA) is a chronic degenerative joint disease in which multiple factors contribute to cartilage degradation. It is widely accepted that excess production of…
Abstract Number: 3 • 2012 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Differentiate Into Osteoblasts in Response to Inflammation
Koshiro Sonomoto¹, Kunihiro Yamaoka¹, Koichi Oshita¹, Shunsuke Fukuyo¹, Xiangmei Zhang², Kazuhisa Nakano³, Yosuke Okada¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Bone destruction due to enhanced osteoclast differentiation is a common observation in rheumatoid arthritis. It is well known that inflammatory cytokines cause osteoclatogenesis, however,…
Abstract Number: 4 • 2012 ACR/ARHP Annual Meeting
Pro-Inflammatory Effect of Extracellular RNA On Synovial Fibroblasts From Patients with Rheumatoid Arthritis
Birgit Zimmermann¹, Silvia Fischer², Markus Rickert³, Stefan Rehart⁴, Angela Lehr⁵, Ulf Müller-Ladner⁶, Klaus T. Preissner² and Elena Neumann⁷, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Dept of Biochemistry, Justus-Liebig-University of Giessen, Medical School, Giessen, Germany, ³Dept of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, ⁴Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁵Dept Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁶Dept of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁷Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Extracellular RNA (exRNA) is present in the serum of patients suffering of different kinds of cancer. exRNA influences physiological processes like blood coagulation and…
Abstract Number: 5 • 2012 ACR/ARHP Annual Meeting
Adalimumab Inhibits TNF-Enhanced Human Osteoclast Development More Effectively Than Other Biologic Agents Under in Vitro Conditions of Chronic TNF Exposure
Bohdan P. Harvey¹ and Zehra Kaymakcalan², ¹Biologics, Abbott Laboratories, Worcester, MA, ²Biologics, Abbott, Worcester, MA
Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast development. …
Abstract Number: 2686 • 2012 ACR/ARHP Annual Meeting
Difference in Clinical Features and Mortality Between Pediatric-Onset and Adult-Onset Systemic Lupus Erythematosus
So-Yeon Park¹, Jeeseon Shim², Dam Kim³, Ji-Young Choi³, So-Young Bang⁴, Chan-Bum Choi⁵ and Sang-Cheol Bae⁶, ¹Department of rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ³Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ⁵Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁶Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: The aim of this study was to investigate differences in clinical features and outcomes including mortality between pediatric-onset systematic lupus erythematosus (pSLE) and adult-onset…
Abstract Number: 2688 • 2012 ACR/ARHP Annual Meeting
The Health Improvement and Prevention Program in Systemic Lupus Erythematosus Demonstrates Improvement in Mental Health and Framingham Risk Score At One Year
Paul R. Fortin¹, Ellie Aghdassi², Anne Cymet³, Stacey Morrison⁴, Willy Wynant⁵, Janet E. Pope⁶, Sara Hewitt⁷, Christian A. Pineau⁸, Carolyn Neville⁹, Paula Harvey¹⁰, Jean-Claude Tardif¹¹, Michal Abrahamowicz¹² and Deborah DaCosta¹³, ¹Medicine, Centre de Recherche du Chu de Québec et Université Laval, Quebec City, QC, Canada, ²University Health Network Research Institute - Western Division, Toronto, ON, Canada, ³Nursing, University Health Network - Western Division, Toronto, ON, Canada, ⁴Div Rheumatology Rm MP-10-304, The Toronto Western Hospital, Toronto, ON, Canada, ⁵Division of Clinical Epidemiology, McGill University Health Centre and McGill University, Montreal, QC, Canada, ⁶Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁷Rheumatology, St. Joseph's Health Care, University of Western Ontario, London, ON, Canada, ⁸Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁹Epidemiology, Royal Victoria Hospital, Montreal, QC, Canada, ¹⁰Cardiology, Women's College Hospital, Toronto, ON, Canada, ¹¹Montreal Heart Institute, Universite de Montreal endowed research chair in atherosclerosis, Quebec, QC, Canada, ¹²Clinical Epidemiology, McGill University, Montreal, QC, Canada, ¹³Montreal General Hospital, Montreal, Canada
Background/Purpose: The Health Improvement and Prevention Program (HIPP) is a behavioral intervention aimed at improving health status and coping of persons with lupus while reducing…
Abstract Number: 2695 • 2012 ACR/ARHP Annual Meeting
Benefits of the Chronic Disease Self-Management Program in Low-Income African American Women with Systemic Lupus Erythematosus: Results of a Pilot Test
Cristina Drenkard¹, Charmayne M. Dunlop-Thomas², Kirk Easley³, Gaobin Bao⁴, S. Sam Lim⁵ and Teresa J. Brady⁶, ¹Medicine, Div Rheumatology, Emory University, Atlanta, GA, ²Medicine Rheumatology, Emory University, Atlanta, GA, ³Emory University, Atlanta, GA, ⁴Medicine, Emory University, Atlanta, GA, ⁵Emory University School of Medicine, Division of Rheumatology, Atlanta, GA, ⁶Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Minorities with systemic lupus erythematosus (SLE) are at high risk of poor disease outcomes and may face challenges in effectively self-managing multiple health problems.…
Abstract Number: 2696 • 2012 ACR/ARHP Annual Meeting
The Mary Kirkland Center for Lupus Care General Health Assessment Initiative for Systemic Lupus Erythematosus Patients
Monica C. Richey¹, Doruk Erkan¹ and Kyriakos A. Kirou², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY
Background/Purpose: Aiming to broaden the care of lupus patients beyond the standard lupus management, we launched a pilot general health assessment (GHA) initiative under the…
Abstract Number: 2697 • 2012 ACR/ARHP Annual Meeting
The Short Term Effect of Individualized Nutrition Counseling On Nutrients and Select Cardiovascular Risk Factors in Patients with Systemic Lupus Erythematosus
Sotiria Everett¹, Virginia Haiduc², Monica C. Richey² and Doruk Erkan², ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at a high risk for developing cardiovascular disease (CVD) due to increased prevalence of traditional and nontraditional…
Abstract Number: 2698 • 2012 ACR/ARHP Annual Meeting
FMS and SLE Patients Have Higher Treatment Expectations Than RA Patients
Robert S. Katz¹, Hannah Bond², Jessica L. Polyak², Lauren Kwan² and Susan Shott¹, ¹Rush University Medical Center, Chicago, IL, ²Rheumatology Associates, Chicago, IL
Background/Purpose: It is anticipated that patients with high expectations for improvement of their medical condition may get frustrated when a significant degree of benefit does…
Abstract Number: 2699 • 2012 ACR/ARHP Annual Meeting
Psychosocial Stress and Complement Activation Product C4d On Reticulocytes in Patients with Systemic Lupus Erythematosus
Xiaotian Chen¹, Yu Cheng², Chau Ching Liu³, Amy H. Kao⁴, Susan Manzi⁵, Joseph M. Ahearn⁶ and Carol M. Greco⁷, ¹Biostatistics, University of Pittsburgh, Pittsburgh, PA, ²Biostatistics and Psychiatry, University of Pittsburgh, Pittsburgh, PA, ³Allegheny Singer Research Institute, Pittsburgh, PA, ⁴Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, ⁵Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Lupus Center of Excellence, West Penn Allegheny Health System, Pittsburgh, PA, ⁷Center for Integrative Med, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Although patients with SLE may report that psychosocial stress is linked with disease flares, research results on stress-disease activity associations are mixed. The lack…
Abstract Number: 2700 • 2012 ACR/ARHP Annual Meeting
A Multi-Center Study of the Appropriateness of Anti-Neutrophilic Cytoplasmic Antibody Testing
Tarun S. Sharma¹, Vikash Sinha², Vino Unson², Saurav Acharya³, Sahar Mohammadi² and Amer Syed², ¹Rheumatology, Geisinger Medical Center, Danville, PA, ²Internal Medicine, Mount.Sinai School of Medicine-Jersey City Medical Center, Jersey City, NJ, ³Internal Medicine, Jersey City Medical Center-Barnabas Health, Jersey City, NJ
A Multi-Center Study of the Appropriateness of Anti-Neutrophilic Cytoplasmic Antibody TestingBackground/Purpose: Anti Neutrophil Cytoplasmic Antibody (ANCA) test is an Indirect Immunoflorescence test used as an…
Abstract Number: 2666 • 2012 ACR/ARHP Annual Meeting
A Link Between B Cells and Bone Erosion in RA: RANKL Production by Memory B Cells
Nida Meednu¹, Teresa Owen², Hengwei Zhang³, Christopher A. Cistrone¹, Lianping Xing⁴ and Jennifer H. Anolik⁵, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Allergy, Immununolgy and Rheumatology,, University of Rochester, Rochester, NY, ³Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disorder that often leads to joint damage. Several lines of evidence suggests the role of B cells…

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