Abstract Number: 60 • 2012 ACR/ARHP Annual Meeting
The Burden of Early Arthritis in Latin America: Utility Analysis Using Patient-Level Data From the Argentinian Consortium for Early Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is estimated to be one of the leading causes of non-fatal burden in the world. However, data from developing countries including…Abstract Number: 61 • 2012 ACR/ARHP Annual Meeting
Role of Health Literacy in Population Estimates of Musculoskeletal Disorders
Background/Purpose: Disease diagnosis carries with it implications for self care and for healthful action. Public health campaigns, for example, are regularly launched to raise awareness…Abstract Number: 62 • 2012 ACR/ARHP Annual Meeting
Clinical Implication of Rheumatoid Factor Formation According to Various Hepatitis B Virus Infection Status and Vaccination
Background/Purpose: Rheumatoid factor (RF) is produced as a result of polyclonal B cell activation, but the reasons for its production are still unknown. RF positivity…Abstract Number: 63 • 2012 ACR/ARHP Annual Meeting
The Association Between Silica and the Risk of Anti-Citrullinated Protein Antibody Positive RA in the Malaysian and Swedish Epidemiological Investigation of Rheumatoid Arthritis Studies
Background/Purpose: Silica exposure has been associated with an increased risk of developing ACPA+ (anti-citrullinated protein antibody) RA, especially among smokers (1). These findings were based…Abstract Number: 64 • 2012 ACR/ARHP Annual Meeting
Use of Moist Snuff and the Risk of Developing Rheumatoid Arthritis; Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Background/Purpose: Smoking is the major known environmental risk factor for RA, and notably this risk factor is exclusively seen in ACPA-positive RA. Whether this increased…Abstract Number: 65 • 2012 ACR/ARHP Annual Meeting
Serum Inflammatory Biomarkers Correlated Stronger with a Panel of Serum Steroid and Pituitary Hormones in a Cohort of Pre-Rheumatoid Arthritis (pre-RA) Than in Non-RA Control (CN) Subjects
Background/Purpose: Inflammatory cytokines influence steroid hormone production in tissue culture and affect serum levels and synovial fluid of active RA patients. Inflammatory biomarker and hormonal…Abstract Number: 26 • 2012 ACR/ARHP Annual Meeting
Quantitative Analysis of Bone Damage Morphological Changes in the Citrullinated Collagen Induced Arthritis Mouse Model Using Micro CT
Background/Purpose: Patients with rheumatic diseases given immunosuppressive therapy are susceptible to various types of infections, especially pulmonary infections that affect their vital prognosis. The aim…Abstract Number: 27 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies As an Indicator of Bone Damage in the Citrullinated Collagen Induced Arthritis Model
Background/Purpose: Although the pathogenesis and cause of rheumatoid arthritis (RA) remains uncertain, various disease-driving auto-antigens and auto-antibodies with different specificities have been used as diagnostic…Abstract Number: 28 • 2012 ACR/ARHP Annual Meeting
Role of Microrna 455 Networks in Mesenchymal Cell Differentiation and Osteoarthritis
Background/Purpose: The objectives of this study were to identify cartilage specific microRNAs (miRNAs, miR-) that are regulated by SOX9 and are increased in chondrogenesis, to…Abstract Number: 29 • 2012 ACR/ARHP Annual Meeting
Level of IL-1â-Induced Epigenetic Modifications Differ in Chondrocytes From Different Histological Zones of Human Cartilage
Background/Purpose: Osteoarthritis (OA) reduces mobility and function of the affected joint and is a leading cause of disability among the elderly. Recent evidence points to…Abstract Number: 30 • 2012 ACR/ARHP Annual Meeting
A Mouse Myeloid Precursor with Osteoclastogenic Function in Vivo
Background/Purpose: Osteoporosis and peri-articular erosions in patients with inflammatory arthritis are characterized by increased osteoclast resorptive activity. Although a great deal is known about how…Abstract Number: 31 • 2012 ACR/ARHP Annual Meeting
Anti Citrullinated Protein Antibodies From Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis
Background/Purpose: Presence of anti CCP2 antibodies identifies a subgroup of RA patients that are more prone to develop bone erosions. We hypothesized that anti CCP2…Abstract Number: 32 • 2012 ACR/ARHP Annual Meeting
Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software
Background/Purpose: To facilitate an understanding of the biological factors involved in inflammation- mediated bone loss, in vitro systems and murine models of bone loss, such…Abstract Number: 33 • 2012 ACR/ARHP Annual Meeting
Novel Targets for Blocking Osteoclast-Mediated Resorption in Inflammatory Disorders
Background/Purpose: Osteoclasts are specialized myeloid lineage cells that mediate both pathologic and physiologic bone remodeling Fully differentiated and functional osteoclasts are found exclusively associated with…Abstract Number: 34 • 2012 ACR/ARHP Annual Meeting
Rebamipide Attenuates Pain Severity and Cartilage Degeneration in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes
Background/Purpose: The development and progression of osteoarthritis (OA) are now believed to involve inflammation, even in the early stage of disease. Proinflammatory cytokines and chemokines are…
ACR Meeting Abstracts