Abstract Number: 50 • 2012 ACR/ARHP Annual Meeting
Human Chondrocyte Dedifferentiation Is Accompagnied by CD105 Endoglin Expression, ALK-1/Smad1/5 Phosphorylation and Leptin Production – Stimulation by Prednisolone and Aldosterone Through the Glucocorticoid Receptor
Background/Purpose: Leptin, mainly produced by the adipose tissue including fat neighboring the joint, is considered as pro-inflammatory in osteoarthritis (OA). Normal cartilage does not…Abstract Number: 51 • 2012 ACR/ARHP Annual Meeting
Phosphodiesterase 4 Expression in Rheumatoid Arthritis Synovium and Anti-Inflammatory Effects of Apremilast On Synovial Fibroblasts
Background/Purpose: Apremilast (APR), a small molecule specific inhibitor of phosphodiesterase 4 (PDE4), works intracellularly to modulate pro- and anti-inflammatory mediator production in both immune and…Abstract Number: 52 • 2012 ACR/ARHP Annual Meeting
The Validity of the Diagnosis Inflammatory Arthritis in Primary Care
Background/Purpose: Large population-based databases, such as electronic medical records (EMRs) from patients in primary care, are useful data sources to investigate morbidity and health care…Abstract Number: 53 • 2012 ACR/ARHP Annual Meeting
Comparison of Decision Rules for Identifying Patients with Rheumatoid Arthritis (RA) in Administrative Healthcare Databases
Background/Purpose: Identification of RA cases in administrative healthcare databases is used to estimate disease frequency, healthcare utilization and cost for RA. However, the optimal methodology…Abstract Number: 54 • 2012 ACR/ARHP Annual Meeting
Use of Health Plan Data to Assess Feasibility of Large Pragmatic Clinical Trials in Rheumatoid Arthritis
Background/Purpose: Large pragmatic clinical trials (PCTs) are increasingly used to conduct comparative effectiveness research (CER). PCTs typically have simple inclusion/exclusion criteria and hard outcomes (e.g.…Abstract Number: 55 • 2012 ACR/ARHP Annual Meeting
Accuracy of Canadian Health Administrative Databases in Identifying Patients with Rheumatoid Arthritis Seen by Rheumatologists
Background/Purpose: In a predominantly universal single-payer health system, Canadian health administrative data are a valuable tool and increasingly used for research. Few studies have rigorously…Abstract Number: 56 • 2012 ACR/ARHP Annual Meeting
A Validated Mathematical Model Using Electronic Health Records to Identify Rheumatoid Arthritis Patients for Observational Studies
Background/Purpose: To develop and validate a search algorithm with a high specificity and sensitivity to identify rheumatoid arthritis (RA) patients in a large health care…Abstract Number: 57 • 2012 ACR/ARHP Annual Meeting
A British Survey of Time to Presentation and Treatment of Rheumatoid Arthritis in Subjects of Black and Minority Ethnic Origin
Background/Purpose: National guidelines mandate urgent referral of rheumatoid arthritis (RA) for specialist treatment if more than three months from symptom onset; initial combination therapy with…Abstract Number: 58 • 2012 ACR/ARHP Annual Meeting
5 Million Patients and Not 0.34% Is Worrisome: Burden of Rheumatoid Arthritis in India Based On a Bone and Joint Decade India Community Oriented Program for Control of Rheumatic Disease
Background/Purpose : The 1 % prevalence of RA Worldwide is a deep rooted ancient dogma. None of the recent WHO ILAR COPCORD (Community Oriented Program…Abstract Number: 59 • 2012 ACR/ARHP Annual Meeting
A Staggering Burden of Pain and Rheumatic Disorders in India: A National Bone & Joint Decade India Community Oriented Program for Control of Rheumatic Disease Survey 2006-2011
Background/Purpose : The maiden COPCORD (Community Oriented Program for Control of Rheumatic Diseases) population survey in village Bhigwan (Pune) findings proposed a high burden of…Abstract Number: 60 • 2012 ACR/ARHP Annual Meeting
The Burden of Early Arthritis in Latin America: Utility Analysis Using Patient-Level Data From the Argentinian Consortium for Early Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is estimated to be one of the leading causes of non-fatal burden in the world. However, data from developing countries including…Abstract Number: 61 • 2012 ACR/ARHP Annual Meeting
Role of Health Literacy in Population Estimates of Musculoskeletal Disorders
Background/Purpose: Disease diagnosis carries with it implications for self care and for healthful action. Public health campaigns, for example, are regularly launched to raise awareness…Abstract Number: 62 • 2012 ACR/ARHP Annual Meeting
Clinical Implication of Rheumatoid Factor Formation According to Various Hepatitis B Virus Infection Status and Vaccination
Background/Purpose: Rheumatoid factor (RF) is produced as a result of polyclonal B cell activation, but the reasons for its production are still unknown. RF positivity…Abstract Number: 63 • 2012 ACR/ARHP Annual Meeting
The Association Between Silica and the Risk of Anti-Citrullinated Protein Antibody Positive RA in the Malaysian and Swedish Epidemiological Investigation of Rheumatoid Arthritis Studies
Background/Purpose: Silica exposure has been associated with an increased risk of developing ACPA+ (anti-citrullinated protein antibody) RA, especially among smokers (1). These findings were based…Abstract Number: 64 • 2012 ACR/ARHP Annual Meeting
Use of Moist Snuff and the Risk of Developing Rheumatoid Arthritis; Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Background/Purpose: Smoking is the major known environmental risk factor for RA, and notably this risk factor is exclusively seen in ACPA-positive RA. Whether this increased…