Abstracts Archive - Page 2407 of 2425 - ACR Meeting Abstracts

Abstract Number: 216 • 2012 ACR/ARHP Annual Meeting
Clinical and Serological Associations of Malignancy in Adult Patients with Polymyositis and Dermatomyositis
Yuji Hosono¹, Ran Nakashima¹, Yoshitaka Imura², Naoichiro Yukawa³, Hajime Yoshifuji¹, Motomu Hashimoto⁴, Koichiro Ohmura⁵, Takao Fujii⁶ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁵Rheumatology & Clin Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁶Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) are systemic connective tissue disorders, which are often associated with internal malignancy. Several studies have reported the association between…
Abstract Number: 217 • 2012 ACR/ARHP Annual Meeting
Myositis-Associated Usual Interstitial Pneumonia Has Better Survival Than Idiopathic Pulmonary Fibrosis
Christine McBurney¹, Rohit Aggarwal², Kevin Gibson³, Kathleen Lindell⁴, Carl Fuhrman⁵, Diane Koontz⁶, Frank Schneider⁷, Naftali Kaminski⁴ and Chester V. Oddis⁸, ¹Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, University of Pittsburgh, Pittsburgh, PA, ³Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴University of Pittsburgh Dorothy P. & Richard P. Simmons Center for Lung Disease, Pittsburgh, PA, ⁵Radiology, Division of Thoracic Imaging, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Anatomic Pathology Department, Pittsburgh, PA, ⁸Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Usual interstitial pneumonia associated with idiopathic pulmonary fibrosis (IPF-UIP) has a poor prognosis with a median survival of 3 years. It is unknown whether…
Abstract Number: 218 • 2012 ACR/ARHP Annual Meeting
Proteomics Study of a Phase 1b Trial with an Anti-IFN-α Monoclonal Antibody Indicates Association of Soluble Interleukin 2 Receptor with Type I Interferon Activity in Patients with Dermatomyositis or Polymyositis
Xiang Guo¹, Brandon W. Higgs¹, Wei Zhu², Yihong Yao¹ and Wendy White³, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Translational Science, MedImmune, LLC, Gaithersburg, MD, ³Translational Sciences, MedImmune, Gaithersburg, MD
Background/Purpose: To evaluate downstream effects of an anti-IFN-α monoclonal antibody (mAb) in adult dermatomyositis (DM) and polymyositis (PM) patients using serum proteomics and gene expression…
Abstract Number: 219 • 2012 ACR/ARHP Annual Meeting
Significant Functional Improvement Using Aggressive Immunomodulatory Therapy in Patients with Inflammatory Myopathy and Interstitial Lung Disease
Ramona Mihu¹, Roger D. Rossen², Jovan Popovich³ and Sandra L. Sessoms¹, ¹Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, ³Medicine/Rheumatology, The Methodist Hospital, Houston, TX
Background/Purpose: Pulmonary disease in patients with idiopathic inflammatory myopathies, polymyositis (PM), dermatomyositis (DM), and clinically amyopathic dermatomyositis (CADM) is a major cause of morbidity. Approximately…
Abstract Number: 220 • 2012 ACR/ARHP Annual Meeting
Efficacy of Rituximab for the Treatment of Refractory Inflammatory Myopathies Associated with Anti-Histidyl-tRNA Synthetase Antibodies (the FORCE Jo1 Study)
Yves Allenbach¹, Aude Rigolet², Marguerite Guiguet³, Isabelle Marie⁴, Eric Hachulla⁵, Dominique Farge⁶, Kuberaka Mariampillai⁷, Serge Jacquot⁸, Fabienne Jouen⁹, Olivier Boyer¹⁰, Lucile Musset¹¹, Serge Herson⁷ and Olivier Benveniste¹², ¹Internal Medicine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ²Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ³Biostatistique, Pitie-Salpetriere Hospital, Paris, France, ⁴Service de médecine interne, CHU de Rouen, Rouen, France., Rouen, France, ⁵Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, ⁶Medicine, EBMT, Paris, France, ⁷Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁸INSERM U905, University of Rouen, Rouen, France, ⁹Immunology, Rouen University Hospital, Rouen Cedex, France, ¹⁰Immunology, INSERM U905, University of Rouen, Rouen, France, ¹¹Laboratoire d'Immunochimie, CHU Pitié-Salpêtrière, Paris, France, ¹²Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France
Background/Purpose: anti-histidyl-tRNA synthetase (anti-Jo1) antibodies are found in approximately 25–30% of patients with idiopathic inflammatory myopathies, frequently in the frame of an anti-synthetase syndrome characterized…
Abstract Number: 221 • 2012 ACR/ARHP Annual Meeting
Expanding the Clinical and Serological Spectrum of MDA5-Associated Dermatomyositis
John C. Hall¹, Livia Casciola Rosen¹, Sonye K. Danoff², Lesly-Anne Samedy³ and Lisa Christopher-Stine⁴, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine/Pulmonary, Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Medicine and Neurology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Dermatomyositis (DM) is a heterogeneous systemic disease with specific autoantibodies (Abs) which correlate with unique clinical phenotypes. Melanoma differentiation-associated gene 5 (MDA5) Abs have…
Abstract Number: 222 • 2012 ACR/ARHP Annual Meeting
Lung Nodules in Patients with Idiopathic Inflammatory Myopathies
Laura C. Cappelli¹, Andrew L. Mammen², Sonye K. Danoff³, Grant H. Louie⁴, Thomas E. Lloyd⁵ and Lisa Christopher-Stine⁶, ¹Ste 4500, Johns Hopkins University, Baltimore, MD, ²NIAMS, NIH, Bethesda, MD, ³Medicine/Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵Neurology, Johns Hopkins, Baltimore, MD, ⁶Medicine and Neurology, Johns Hopkins University, Baltimore, MD
Background/Purpose: The idiopathic inflammatory myopathies are associated with an increased incidence of malignancy, and interstitial lung disease (ILD) has been reported in as many as…
Abstract Number: 223 • 2012 ACR/ARHP Annual Meeting
High Prevalence and Clustering Over Time of Anti-PL-7 Autoantibody-Positive Idiopathic Inflammatory Myopathies
Yoshioki Yamasaki¹, Minoru Satoh², Hidehiro Yamada¹, Machiko Mizushima¹, Takahiro Okazaki¹, Hiroko Nagafuchi¹, Seido Ooka³, Tomohiko Shibata¹, Hiromasa Nakano⁴, Hitoshi Ogawa¹, Kohei Azuma¹, Akihiko Maeda¹, Hirofumi Mitomi¹, Tomofumi Kiyokawa¹, Kosei Tsuchida¹, Hidenori Mikage¹, Jason Y.F. Chan² and Shoichi Ozaki¹, ¹Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²Medicine, University of Florida, Gainesville, FL, ³St. Marianna University School of Medicine, Kawasaki, Japan, ⁴Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Unusually high prevalence of autoantibodies to threonyl tRNA (PL-7) [17% in polymyositis/dermatomyositis (PM/DM) associated with lower levels of serum creatine kinase (CK) and milder…
Abstract Number: 224 • 2012 ACR/ARHP Annual Meeting
Standardized Incidence Ratios and Predictors of Malignancies in 215 Southern Chinese Patients with Inflammatory Myopathies
Chi Chiu Mok¹, Chi Hung To¹, ML Yip² and King Yee Ying³, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Division of Rheumatology, Department of Medicine, Kwong Wah Hospital, Kowloon, Hong Kong, ³Department of Medicine, Princess Margaret Hospital, Hong Kong, Hong Kong
Background/Purpose: To examine the standardized incidence ratios (SIRs) and predictive factors for malignancy in a cohort of southern Chinese patients with inflammatory myopathies (IM). Methods:…
Abstract Number: 225 • 2012 ACR/ARHP Annual Meeting
Polymyositis in HIV+ Patients Is Associated to Uncontrolled Viral Load
Yves Allenbach¹, Odile Dubourg², Thierry Maisonobe², Anthony Behin³, Charles Duyckaerts², Guillaume Breton⁴, Olivier Fain⁵, Marie-Caroline Meyhoas⁶, Catherine Leport⁷, Marc-Antoine Valentin⁸, Daniel Vittecoq⁹, Jean-François Bergmann¹⁰, Thomas Anslik¹¹, Marie-Paule Chauveheid¹², Zahir Amoura¹³, Thomas de Broucker¹⁴, Pierre Bourgeois¹⁵, Bruno Eymard³, Serge Herson¹⁶ and Olivier Benveniste¹⁷, ¹Internal Medicine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ²Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ³Institute of Myology, Pitie-Salpetriere Hospital, Paris, France, ⁴Internal Medecine, Pitie-Salpetriere Hospital, Paris, France, ⁵Internal Medicine, Jean Verdier Hospital, Bondy, France, ⁶Department of Infectious Diseases, Saint Antoine Hospital, Paris, France, ⁷Epidemic and biological risk coordination unit, AP-HP, Paris, France, ⁸Department of Infectious Diseases, Pitié-Salpetriere Hospital, Paris, France, ⁹Department of Infectious Diseases, K Bicetre Hospital, Kremlin-Bicetre, France, ¹⁰Internal Medicine, Lariboisiere Hospital, Paris, France, ¹¹Internal Medicine, Ambroise Pare Hospital, Boulogne Billancourt, France, ¹²Internal Medicine,, University Paris-7, APHP, Bichat Hospital, Paris, France, ¹³Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ¹⁴Department of Neurology, Delafontaine Hospital, Saint Denis, France, ¹⁵Rheumatology, APHP,Pitie-Salpetriere Hospital, Paris 6, Paris, France, ¹⁶Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ¹⁷Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France
Background/Purpose: Different myopathies can be observed in HIV-infected patients, such as idiopathic inflammatory myopathies (inclusion-body myositis or polymyositis) or toxic mitochondrial myopathies secondary to antiretroviral…
Abstract Number: 226 • 2012 ACR/ARHP Annual Meeting
Autoantibodies to Small Ubiquitin-Like Modifier Activating Enzymes in Japanese Patients with Dermatomyositis
Manabu Fujimoto¹, Takashi Matsushita², Yasuhito Hamaguchi³, Kenzo Kaji³, Minoru Hasegawa¹ and Kazuhiko Takehara⁴, ¹Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ²Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ³Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ⁴Dermatology, Kanazawa University, Kanazawa, Japan
Background/Purpose: Myositis-specific autoantibodies (MSAs) are closely associated with distinct clinical subsets within idiopathic inflammatory myopaties, and thus serve as useful diagnostic tools. Recently, anti-small ubiquitin-like modifier…
Abstract Number: 187 • 2012 ACR/ARHP Annual Meeting
Effect of Colchicine On Cholesterol Levels in Patients with Familial Mediterranean Fever and Behçet’s Syndrome
SerdaL Ugurlu¹, Emire Seyahi², Idil Hanci³, Huri Ozdogan⁴, Seval Masatlioglu-Pehlivan⁵ and Hasan Yazici⁶, ¹Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ²Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ³Department of Neurology, Krankrenhaus Nordwest, Frankfurt am Main, Frankfurt, Germany, ⁴Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ⁵Haydarpasa Numune Research and Education Hospital, MD,Rheumatology, Istanbul, Turkey, ⁶Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey
Background/Purpose: We and others have previously shown that patients with Familial Mediterranean Fever (FMF) had low cholesterol levels when compared to healthy controls (1-2). The…
Abstract Number: 188 • 2012 ACR/ARHP Annual Meeting
Etiology of Uveitis: A Hospital-Based Study in a Referral Centre
Claudia Ferrari¹, Rosaria Talarico¹, Michele Figus², Chiara Stagnaro³, Anna d'Ascanio⁴ and Stefano Bombardieri⁵, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Neurosciences Department, Ophthalmology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Defined as an intraocular inflammation, uveitis may be associated to a systemic disease or represent an isolated entity. It affects people from all parts…
Abstract Number: 189 • 2012 ACR/ARHP Annual Meeting
Pedal Swelling As a Characteristic Phenotype of the New Category of Autoinflammatory Disease Associated with NOD2 Gene Mutations
Qingping Yao, Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high titer autoantibodies or antigen specific T cells, and derive from genetic variants…
Abstract Number: 190 • 2012 ACR/ARHP Annual Meeting
NLRP3 Gene Analysis for Patients with Schnitzler’s Syndrome
Cong-Qiu Chu¹, Carrie R. Austin², Trudy M. Doyle², Kelley A. Goodwin², Noha El Torgomen², Regina Treudler³ and Tammy M. Martin⁴, ¹Rheumatology, Oregon Health & Science Univ and Portland VA Medical Center, Portland, OR, ²Casey Eye Institute, Oregon Health & Science University, Portland, OR, ³Department of Dermatology, Venereology and Allergology, Universitätsklinikum Leipzig AöR, Leipzig, Germany, ⁴Ophthalmology/L467AD, Oregon Health & Science Univ, Portland, OR
Background/Purpose: Schnitzler's syndrome is characterized by chronic urticaria, intermittent fever, arthralgia, bone pain, gammopathy and marked systemic inflammation. The striking response to IL-1 blockade suggests…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].