Abstract Number: 251 • 2012 ACR/ARHP Annual Meeting
Smaller Baseline and Follow-up Quadriceps Muscle Cross-Sectional Area Increases the Odds of Knee Replacement in Knee Osteoarthritis
Background/Purpose: Knee osteoarthritis (OA) is one of the major causes of disability among elderly. Knee replacement (KR) is the final effective treatment of OA after…Abstract Number: 252 • 2012 ACR/ARHP Annual Meeting
Presence of Severe Medial Mensical Pathology Increases the Odds for Knee Replacement: Data From the Osteoarthritis Initiative
Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcome. However, at present there is no clear consensus on indications for KR.…Abstract Number: 253 • 2012 ACR/ARHP Annual Meeting
Incidence of Osteoarthritis-Related Knee and Hip Joint Surgery in Southern Sweden
Background/Purpose: To estimate the incidence and age and sex patterns of subjects having had osteoarthritis (OA)-related surgical treatment. Methods: The Skåne Health Care Register (SHCR)…Abstract Number: 254 • 2012 ACR/ARHP Annual Meeting
Effects of Strontium Ranelate On Knee Osteoarthritis Pain: A Responder Analysis
Background/Purpose: In a large, randomised, placebo-controlled, double-blind phase-III 3-year study (SEKOIA), strontium ranelate 2g/day (SrRan) has demonstrated structure-modifying activity associated with statistically significant symptomatic improvement…Abstract Number: 255 • 2012 ACR/ARHP Annual Meeting
Clinically Meaningful Effect of Strontium Ranelate On Knee Osteoarthritis Symptoms
Background/Purpose: In the SEKOIA study, strontium ranelate 2g/day has been demonstrated to reduce total WOMAC score, pain subscore and global knee pain assessed using a…Abstract Number: 256 • 2012 ACR/ARHP Annual Meeting
Strontium Ranelate Decreases the Level of Urinary CTX-II in Patients with Knee Osteoarthritis
Background/Purpose: Knee osteoarthritis is a chronic disease affecting the global joint and characterized by cartilage degradation as well as subchondral bone remodelling. Effects of strontium…Abstract Number: 257 • 2012 ACR/ARHP Annual Meeting
Meta-Analysis of Four 12-Week Phase III Clinical Trials Investigating the Effect of TDT 064, a Transdermal Gel, in Osteoarthritis of the Knee
Background/Purpose: A transfersome is an ultradeformable lipid vesicle originally developed to deliver high concentrations of drug (eg NSAIDs) transdermally. Large interventional trials in osteoarthritis (OA)…Abstract Number: 258 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of the Chinese Herbal Compound Hou-Lou-Xiao-Ling Dan in Patients with Osteoarthritis of the Knee: Results of a Phase II International Study
Background/Purpose: Traditional Chinese Medicine (TCM), which includes the use of herbal medicines, is widely used to treat osteoarthritis (OA) of the knee in Asian societies;…Abstract Number: 259 • 2012 ACR/ARHP Annual Meeting
Long-Term Tanezumab Treatment for Osteoarthritis: Efficacy and Safety Results
Background/Purpose: Nerve growth factor (NGF) levels are associated with increased pain perception and are elevated in joints of arthritis patients. Tanezumab, a humanized monoclonal antibody,…Abstract Number: 260 • 2012 ACR/ARHP Annual Meeting
Adjudication of Reported Serious Adverse Joint Events in the Tanezumab Clinical Development Program
Background/Purpose: Tanezumab (TNZ) has been shown to be efficacious for pain and function in patients with hip and knee osteoarthritis (OA). Unexpected reports of adverse…Abstract Number: 261 • 2012 ACR/ARHP Annual Meeting
Effect of Advancing Age On the Gastrointestinal Safety of Celecoxib Versus Nonselective Nonsteroidal Anti-Inflammatory Drugs: A Post Hoc Analysis of GI-Reasons
Background/Purpose: Celecoxib use was associated with a lower risk of clinically relevant upper and lower GI events than nonselective (ns)NSAIDs in patients (≥ 55 years)…Abstract Number: 262 • 2012 ACR/ARHP Annual Meeting
Flexible Footwear Reduces Dynamic Joint Loads in Knee Osteoarthritis: Results of a 6 Month Randomized Controlled Trial
Background/Purpose: Dynamic joint loads are important in the pathophysiology of knee OA and biomechanical interventions aim to reduce these loads in hopes of improving symptoms…Abstract Number: 263 • 2012 ACR/ARHP Annual Meeting
Efficacy of Ketoprofen Vs Ibuprofen and Diclofenac: A Systematic Review of the Literature and Meta-Analysis
Background/Purpose : The management of mild-to-moderate pain has traditionally been based on the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the synthetic non-opioid analgesic paracetamol…Abstract Number: 264 • 2012 ACR/ARHP Annual Meeting
Specialized Footwear Decreases Medial Tibial Bone Mineral Density Over 48 Weeks in Knee Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is characterized by increased subchondral bone mineral density at affected joints. In the knee, proximal tibial bone mineral density (BMD) is…Abstract Number: 265 • 2012 ACR/ARHP Annual Meeting
Reducing Loads in the Contralateral Side in Medial Knee Osteoarthritis; A 3-Year Follow-up Study
Background/Purpose: No strategies have been shown to prevent Medial knee osteoarthritis (MKOA). For those with symptomatic unilateral MKOA, the contralateral knee may be at risk…