Abstracts Archive - Page 2400 of 2425 - ACR Meeting Abstracts

Abstract Number: 314 • 2012 ACR/ARHP Annual Meeting
Transcriptome and Surface Phenotype Analyses Suggest an Alternatively Activated (M2) Function for Hemophagocytes
Scott W. Canna¹, Ana Patrícia Costa Reis², William E. Bernal³, Kathleen E. Sullivan⁴, Michele E. Paessler⁵ and Edward M. Behrens⁶, ¹Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, ⁶Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Hemophagocytes (HPCs) are activated macrophages identified in situ by having engulfed other hematopoietic cells. HPCs are rarely seen in normal bone marrow, but are…
Abstract Number: 315 • 2012 ACR/ARHP Annual Meeting
Pediatric Lupus Nephritis: Micrornas – Macro Inflammation
Patrícia Costa Reis¹, Pierre Russo² and Kathleen E. Sullivan³, ¹Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: New biomarkers to guide clinical management of lupus nephritis (LN) patients are highly desirable, since the histopathologic classification currently in use is an unreliable…
Abstract Number: 316 • 2012 ACR/ARHP Annual Meeting
The Interleukin-10 (IL-10) Producing Regulatory B Cell (“B10 cell”) Compartment Expands with Disease Activity in Juvenile Dermatomyositis (JDM) and Pediatric-Onset Systemic Lupus Erythematosus (pSLE)
Ioannis Kalampokis¹, Jeffrey A. Dvergsten² and Thomas Tedder³, ¹Immunology and Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ²Pediatrics Division of Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ³Department of Immunology, Duke University Medical Center, Durham, NC
Background/Purpose: pSLE and JDM are multisystem inflammatory diseases, whereas juvenile idiopathic arthritis (JIA) is typically an organ-limited disease. “B10 cells”, a rare subset of human…
Abstract Number: 317 • 2012 ACR/ARHP Annual Meeting
Fatty Acid Profiling: Potential New Biomarkers in Juvenile Idiopathic Arthritis (pilot study)
Weng Tarng Cham¹, Enzo Ranieri², Janice Fletcher² and Christina A. Boros³, ¹Paediatric Rheumatology, Women's and Children's Hospital, North Adelaide, SA 5006, Australia, ²Chemical Pathology and Molecular Genetics, SA Pathology, North Adelaide, SA 5006, Australia, ³Paediatrics, University of Adelaide/Women's and Children's Hospital, Adelaide, Australia
Background/Purpose: The prostanoids are a family of biologically active lipids derived from the 20-carbon essential fatty acids (LCPUFA) all of which are involved in the…
Abstract Number: 318 • 2012 ACR/ARHP Annual Meeting
Replication Analysis of Non-HLA Gene Variants with Prior Evidence of Association with Juvenile Idiopathic Arthritis
Justine Ellis¹, Raul Chavez², Anne-Louise Ponsonby², Angela Pezic², Roger Allen³, Jonathan Akikusa⁴ and Jane Munro⁵, ¹Murdoch Childrens Research Institute, Parkville, Australia, ²Environmental & Genetic Epidemiology Research, Murdoch Childrens Research Institute, Parkville, Australia, ³PRINTO, Genoa, Italy, ⁴Rheumatology, Royal Childrens Hospital, Parkville, Australia, ⁵Rheumatology, Royal Children's Hospital, Melbourne, Australia
Background/Purpose: Over the last few years, there have been numerous reports of associations of single nucleotide polymorphisms (SNPs) at various genetic loci with juvenile idiopathic…
Abstract Number: 319 • 2012 ACR/ARHP Annual Meeting
Gamma Interferon-Induced Protein-10 (IP-10) As a Potential Biomarker for Disease Activity in Pediatric Localized Scleroderma
Katherine Kurzinski¹, Carol A. Feghali-Bostwick², Christina Kelsey¹, Kelsey Magee³ and Kathryn S. Torok⁴, ¹Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, ²Medicine, University of Pittsburgh, Pittsburgh, PA, ³Pediatric Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Pediatric Rheumatology, Scleroderma Center of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Background/Purpose: Pediatric localized scleroderma (LS) is an autoimmune disease affecting the skin and underlying tissue. Cutaneous findings assist in categorizing the patients into active or…
Abstract Number: 320 • 2012 ACR/ARHP Annual Meeting
Evaluation of Anti-Citrullinated Type II Collagen and Anti-Citrullinated Vimentin Antibodies in Patients with Juvenile Idiopathic Arthritis
Brooke Gilliam¹, Anil K. Chauhan² and Terry L. Moore³, ¹IM-Rheumatology, Saint Louis University, St. Louis, MO, ²Rheumatology, Saint Louis University, St. Louis, MO, ³Rheumatology/Immunology, Saint Louis University, St. Louis, MO
Background/Purpose: Several studies have identified anti-cyclic citrullinated peptide (CCP) antibodies as an important indicator for destructive disease in patients with juvenile idiopathic arthritis (JIA). This…
Abstract Number: 321 • 2012 ACR/ARHP Annual Meeting
Glycosylation of Vitamin D Binding Protein Reduced in Juvenile Idiopathic Arthritis Patients At Risk of Disease Extension
David S. Gibson¹, Sorcha Finnegan², Gwen Manning³, Mark Duncan⁴, Stephen R. Pennington⁵, Terry L. Moore⁶ and Madeleine Rooney⁷, ¹Centre for Infection and immunity, Arthritis Research Group, Queens University Belfast, Belfast, United Kingdom, ²Centre for Infection and Immunity, Queen's University, Belfast, Belfast, United Kingdom, ³Proteome Research Centre, University College Dublin, Dublin, Ireland, ⁴Division of Endocrinology, University of Colorado, Denver, ⁵UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland, ⁶Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO, ⁷Medicine, Queens University Belfast, Belfast, United Kingdom
Background/Purpose: Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic, childhood onset, autoimmune diseases with variable clinical outcomes.We investigated whether profiling of the…
Abstract Number: 322 • 2012 ACR/ARHP Annual Meeting
Immune Response to Porphyromonas Gingivalis Citrullinated α-Enolase Cross-Reacts with Human α-Enolase in Polyarticular JIA Patients
Peggy Lee¹, Rebecca Howsmon², Claire Murphy², Sarah Ringold³ and Anne M. Stevens⁴, ¹School of Dentistry, University of Washington, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Pediatrics, Seattle Children's Hospital, Seattle, WA, ⁴Pediatrics, University of Washington, Seattle, WA
Background/Purpose: Antibodies recognizing cyclic citrullinated peptides (CCP) are highly specific for rheumatoid arthritis (RA) and polyarticular juvenile idiopathic arthritis (poly JIA), and may both predict…
Abstract Number: 323 • 2012 ACR/ARHP Annual Meeting
Immunoprecipitation and Advanced Proteomics for the Discovery of Novel Antigenic Targets in Juvenile Idiopathic Arthritis
Ginger L. Janow¹, Cristina Clement², Norman T. Ilowite³, Laura Santambrogio² and Steven A. Porcelli⁴, ¹Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, ²Pathology Department, Albert Einstein College of Medicine, Bronx, NY, ³Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ⁴Microbiology& Immunology, Albert Eistein College of Medicine, Bronx, NY
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic condition seen by pediatric rheumatologists. The pathogenesis of disease is poorly understood, but is believed to…
Abstract Number: 324 • 2012 ACR/ARHP Annual Meeting
Measurement and Evaluation of Isotypes of Anti-Citrullinated Fibrinogen and Anti-Citrullinated Alpha-Enolase Antibodies in Juvenile Idiopathic Arthritis Patients
Brooke Gilliam¹, Sandra Crespo-Pagnussat², Anil K. Chauhan² and Terry L. Moore³, ¹IM-Rheumatology, Saint Louis University, St. Louis, MO, ²Rheumatology, Saint Louis University, St. Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: Anti-cyclic citrullinated peptide (CCP) antibodies in juvenile idiopathic arthritis (JIA) have been identified as an important indicator for destructive disease, as is the case…
Abstract Number: 325 • 2012 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibody Isotyping and Identification of Citrullinated Proteins in the Synovial Fluid of Juvenile Idiopathic Arthritis Patients
Brooke Gilliam¹, Sandra Crespo-Pagnussat², Anil K. Chauhan², Reema H. Syed² and Terry L. Moore³, ¹IM-Rheumatology, Saint Louis University, St. Louis, MO, ²Rheumatology, Saint Louis University, St. Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: Several citrullinated proteins have been detected in the serum and synovial fluid (SF) of rheumatoid arthritis (RA) patients. However, few studies have evaluated citrullination…
Abstract Number: 326 • 2012 ACR/ARHP Annual Meeting
Silencing Intraarticular Snail Expression Ameliorates Rat Collagen-Induced Arthritis Through Induction of Mesenchymal-Epithelial Transition in Synovial Fibroblasts
Chrong-Reen Wang¹, Shih-Yao Chen², Ai-Li Shiau³, Yuan-Tsung Li⁴, Ming-Fei Liu⁵ and Chao-Liang Wu², ¹Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ²Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁵Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Morphological characteristics of rheumatoid arthritis (RA) synovial fibroblasts (SF) are similar to transformed cells. We hypothesized that epithelial-mesenchymal transition (EMT) of SF regulated by…
Abstract Number: 327 • 2012 ACR/ARHP Annual Meeting
Tolerogenic Dendritic Cells Ameliorates the Disease Severity of Murine Collagen-Induced Arthritis
Bin Ning¹, Shang-You Yang², Jianlu Wei¹, Weiming Gong¹ and Paul H. Wooley², ¹Orthopaedic Surgery, Shandong University Jinan Central Hospital, Jinan, China, ²Orthopaedic Research Institute, Via Christi Wichita Hospitals, Wichita, KS
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by synovial inflammation, cartilage breakdown and bone destruction with the involvement of various types of…
Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Nathan D. Chamberlain¹, Seung-jae Kim², Michael Volin³, Anjali Mehta², Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…

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