Abstract Number: 369 • 2012 ACR/ARHP Annual Meeting
Differences in Short-Term Radiographic Progression Following Early Response to Adalimumab Plus Methotrexate Vs. Methotrexate Alone
Background/Purpose: To prevent disease progression, treat-to-target recommendations for rheumatoid arthritis (RA) include the evaluation and adjustment of drug therapy at least every 3 months until…Abstract Number: 330 • 2012 ACR/ARHP Annual Meeting
Fut1 Plays A Unique Role in K/BxN Serum Transfer Arthritis by Regulating Angiogenesis and Adhesion Molecule Expression
Background/Purpose: Angiogenesis is important in rheumatoid arthritis (RA) synovial tissue proliferation and leukocyte ingress into the inflamed joints. Fucosyltransferases (Futs) are involved in the synthesis…Abstract Number: 331 • 2012 ACR/ARHP Annual Meeting
PDL241, a Novel Humanized Monoclonal Antibody, Reveals CD319 As a Therapeutic Target for Rheumatoid Arthritis
Background/Purpose: Current therapies have shown tremendous progress in the treatment of rheumatoïd arthritis (RA). However, a substantial group of RA patients are still refractory to…Abstract Number: 332 • 2012 ACR/ARHP Annual Meeting
Blockade of CTGF Restores Aberrant Ostoclastgenesis in Collagen Induced Arthritis (CIA) Mice Through Inhibition of Th-17 Differentiation
Background/Purpose: Our previous study demonstrated changes in the profiles of serum protein biomarkers in infliximab-treated rheumatoid arthritis (RA) patients using a novel approach to proteomic…Abstract Number: 333 • 2012 ACR/ARHP Annual Meeting
Pressure and Blood Flow Measurements in Efferent Lymphatics As Biomarkers of Arthritic Flare
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease with episodic flares in affected joints. These flares are associated with decreased lymphatic drainage. In TNF-Tg mice,…Abstract Number: 334 • 2012 ACR/ARHP Annual Meeting
Selective iNOS Inhibition Increases the Lymphatic Pulse and Drainage From Arthritic Joints in TNF-Tg Mice
Background/Purpose: Sufficient lymphatic drainage, which is partially controlled by an intrinsic lymphatic pulse, is an important mechanism to limit joint inflammation and destruction from arthritis.…Abstract Number: 335 • 2012 ACR/ARHP Annual Meeting
Treatment with Bgp-15, a Novel Insulin Sensitizer Attenuates Collagen-Induced Arthritis in DBA/1 Mice
Background/Purpose: BGP-15, a small synthetic hydroxylamine derivative is a member of a new class of insulin-sensitizing medications also known as chaperone-inducers. Beside its beneficial effects…Abstract Number: 336 • 2012 ACR/ARHP Annual Meeting
Preclinical Development of ALX-0061, an Anti-IL-6R Nanobody® For Therapeutic Use in Rheumatoid Arthritis with a High in Vitro Affinity and Potency and a Competitive in Vivo Pharmacological Profile
Background/Purpose: Interleukin-6 (IL-6) is a pleiotropic cytokine inducing a wide range of biological activities via its receptor IL-6R. IL-6 plays an important role in the…Abstract Number: 337 • 2012 ACR/ARHP Annual Meeting
In Vivo Quantification of Joint Inflammation in a Murine Arthritis Model by Anato-Molecular Imaging
Background/Purpose: Positron Emission Tomography (PET) using the radiotracer 18F-fluorodeoxyglucose (FDG) with X-ray Computed Tomography (CT) has the ability of producing an in vivo, three-dimensional quantitative…Abstract Number: 338 • 2012 ACR/ARHP Annual Meeting
The Potent Phosphoinositide-3-Kinase-(δ,γ) Inhibitor IPI-145 Is Active in Preclinical Models of Arthritis and Well Tolerated in Healthy Adult Subjects
Background/Purpose: Phosphoinositide-3-kinases (PI3K) play pivotal roles in cell signaling and regulate a variety of cellular functions. PI3K-δ and PI3K-γ isoforms are necessary for adaptive and…Abstract Number: 339 • 2012 ACR/ARHP Annual Meeting
Differences Between Juvenile and Adult Rodents with Collagen Induced Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is among the most common chronic diseases of childhood. Arthritis is a potentially disabling disease that can result in ongoing…Abstract Number: 340 • 2012 ACR/ARHP Annual Meeting
Myeloid Deletion of SIRT1 Aggravates Inflammatory Arthritis Via Nuclear Factor-Kappab Activation in Animal Model of Rheumatoid Arthritis
Background/Purpose: The nuclear factor-kappaB (NF-kB) activation plays a pivotal role and macrophages are of central importance in the pathogenesis of rheumatoid arthritis (RA). The SirT1,…Abstract Number: 341 • 2012 ACR/ARHP Annual Meeting
Oral Administration of a Novel Small Molecule BET Bromodomain Inhibitor, RVX-297, Reduces Disease Severity in a Rat Collagen-Induced Arthritis Model
Background/Purpose: BET (Bromodomain and Extra-Terminal) proteins have recently emerged as a key epigenetic regulator of genes at the transcriptional level and inhibition of their binding…Abstract Number: 342 • 2012 ACR/ARHP Annual Meeting
Novel Combination Therapy of Existing Repurposed Therapies, Designed by Predictive Software Modeling, Shows Profound Impact On Disease Progression in a Murine Collagen-Induced Arthritis Model
Background/Purpose: Rheumatoid Arthritis (RA) involves a complex interaction of multiple cell systems, cytokines and mediators. We recently developed a predictive software-based mathematical model that emulates…Abstract Number: 343 • 2012 ACR/ARHP Annual Meeting
Functional Impairment in an Animal Model for Rheumatoid Arthritis Assessed As Changes in Gait Is Due to Joint Destruction but Not Synovial Inflammation Per Se
Background/Purpose: To investigate the individual impact of synovial inflammation, subchondral bone erosion or cartilage damage on functional impairment in an animal model of Rheumatoid Arthritis…