Abstracts Archive - Page 2394 of 2425 - ACR Meeting Abstracts

Abstract Number: 424 • 2012 ACR/ARHP Annual Meeting
Influence of Pregnancy On Disease Activity-Associated Genes in Rheumatoid Arthritis
Erik J. Peterson¹, Shreyasee Amin², Hatice Bilgic³, Emily Baechler Gillespie³, Jane E. Salmon⁴, Ann M. Reed⁵, Weihua Guan⁶ and Daniel L. Mueller¹, ¹Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³University of Minnesota Medical School, Minneapolis, MN, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶University of Minnesota School of Public Health, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) disease activity can often quiesce during pregnancy. Nevertheless, most women will experience a disease flare postpartum (PP). We hypothesized that changes…
Abstract Number: 425 • 2012 ACR/ARHP Annual Meeting
Slug Is Induced by Benzo(a)Pyrene and EGF Through PI3K/Akt/mTOR Pathway and Is Closely Involved in the Regulation of the Invasive Properties of FLS in Rheumatoid Arthritis
Jaejoon Lee¹, Jiwon Hwang¹, Chan Hong Jeon², Joong Kyong Ahn³, Hoon-Suk Cha¹ and Eun-Mi Koh⁴, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ³Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea
Background/Purpose: Slug, a Snail family of zinc finger transcription factor, plays a critical role in tumor proliferation, invasion and metastasis. We have previously shown that…
Abstract Number: 426 • 2012 ACR/ARHP Annual Meeting
Dickkopf-1 Stimulates Fibroblast-Like Synoviocyte Migration Through Janus Kinase Activation
Yubin Luo¹, Bryan Dieffenbach², Jung-Soo Song³, Jinseok Kim⁴, David L. Boyle⁵, Michael Karin⁶, Gary S. Firestein⁷ and Maripat Corr⁸, ¹Medicine, UCSD School of Medicine, La Jolla, CA, ²Medicine, UCSD School of Medicine, la Jolla, CA, ³Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Internal Medicine, Jeju National University Hospital, Jeju, Korea, South Korea, ⁵Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁶Departments of Pharmacology, UCSD School of Medicine, La Jolla, CA, ⁷Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁸Medicine, Univ of California-San Diego, La Jolla, CA
Background/Purpose: Wnt (wingless) pathway signaling has been implicated in patterning in embryogenesis and in adult wound healing and homeostasis. A canonical Wnt antagonist, Dickkopf-1 (DKK-1),…
Abstract Number: 427 • 2012 ACR/ARHP Annual Meeting
Epigenetic Features As Predictive Markers of Responsiveness to Epitope-Specific Therapy in Rheumatoid Arthritis
Roberto Spreafico¹, Maura Rossetti¹, Theodorus Van Der Broek¹, Olivia Morrow¹ and Salvatore Albani², ¹Translational Immunology, Sanford-Burnham Medical Research Institute, La Jolla, CA, ²Translational Research Program, Infectious and Inflammatory Diseases, Sanford-Burnham Medical Research Institute, La Jolla, CA
Background/Purpose: The focus of current research for new therapeutic approaches in Rheumatoid arthritis (RA) is shifting from mere suppression to induction and maintenance of tolerance.…
Abstract Number: 428 • 2012 ACR/ARHP Annual Meeting
TNFα Modulates the Expression of Circadian Clock Gene, Per2, Via D-Box Motif in the Promoter Region in Rheumatoid Synovial Cells
Kohsuke Yoshida¹, Akira Hashiramoto², Takaichi Okano³, Nao Shibanuma⁴ and Shunichi Shiozawa⁵, ¹Hyogo Prefectural Rehabilitation Center at Nishi-harima, Tatsuno, Japan, ²Department of Internal Medicine, Kobe University Graduate School of Medicine / The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan, ³The Center for Rheumatic Diseases,, Kobe University Hospital, Kobe, Japan, ⁴The Center for Rheumatic Diseases, Kobe University Hospital / Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
Abstract Number: 429 • 2012 ACR/ARHP Annual Meeting
The Significance of the Apoptosis Level and the Apoptosis Related Signal Proteins of CD4⁺t�ACD4⁺Foxp3⁺t Cell in Patients with Rheumatoid Arthritis
Ning Li¹, Tianrui Ma², Jie Han¹, Jieru Zhou¹ and Songguo Zheng³, ¹Rheumatology, Shanghai East Hospital, Shanghai, China, ²Rheumatology, Ningbo Pediatric Hospital, Ningbo, China, ³Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA
Background/Purpose: To investigate the apoptosis of CD4+T cell and Tregs in the pathogenesis and disease activity of rheumatoid arthritis patients. Methods: Isolated lymphocytes from human…
Abstract Number: 390 • 2012 ACR/ARHP Annual Meeting
Performance of Criteria for Remission in a Long-Term Observational Study of Patients with Early Rheumatoid Arthritis
Bjorn Svensson¹, Maria LE Andersson², Sidona-Valentina Bala³, Kristina Forslind⁴ and Ingiäld Hafström⁵, ¹Section of Rheumatology, Institution of Clinical Science, Lund University, Lund, Sweden, ²R&D Center, Spenshult Hospital, Oskarström, Sweden, ³Department of Health Sciences,, Lund University, Lund, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden, ⁵Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Remission is widely accepted as the goal of treatment in RA and has to be sustained to keep joint damage at a minimum (Smolen…
Abstract Number: 391 • 2012 ACR/ARHP Annual Meeting
DAS28 Is Not a Sufficient Disease Activity Measure for Obese Rheumatoid Arthritis Patients – Don’t Leave the Feet Behind
Vikram Garg¹, Paul Maranian², Mihaela B. Taylor³, Harold E. Paulus⁴, David Elashoff⁵ and Veena K. Ranganath⁶, ¹Division of Rheumatology, UCLA David Geffen School of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, ²Division of Rheumatology, UCLA Medical School, Los Angeles, CA, ³Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁴Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁵Departments of Biostatistics and Medicine, University of California, Los Angeles, Los Angeles, CA, ⁶Medicine/Rheumatology, University of California, Los Angeles, Western Consortium of Practicing Rheumatologists, Los Angeles, CA
Background/Purpose: Current literature suggests that obesity impacts disease activity in rheumatoid arthritis (RA) and the incidence of obesity is on the rise. The objective of…
Abstract Number: 392 • 2012 ACR/ARHP Annual Meeting
Analysis of Factors Impact On Patient Global Assessment in Daily Practice Based On Observational Cohort IORRA (Institute of Rheumatology, Rheumatoid Arthritis)
Yasushi Inoue¹, Eiichi Tanaka², Ayako Nakajima³, Eisuke Inoue⁴, Akiko Kobayashi⁴, Daisuke Hoshi¹, Naoki Sugimoto⁴, Kumi Shidara⁴, Yohei Seto⁴, Atsuo Taniguchi⁴, Shigeki Momohara¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Tokyo Women's Medical University, Tokyo, Japan, ³Rheumatology, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Patient global assessment (PtGA) is an element of the new ACR/EULAR remission criteria for rheumatoid arthritis (RA). This definition has been reported to better…
Abstract Number: 393 • 2012 ACR/ARHP Annual Meeting
Defining Criteria for Rheumatoid Arthritis Patient-Derived Disease Activity Score That Corrresponds to Disease Activity Score 28 and Clnical Disease Activity Index Based Statuses and Response Criteria
Alexander MH Leung¹, Daniel Farewell², Chak S. Lau³ and Ernest Choy⁴, ¹Department of Rheumatology, Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, ²Institute of Primary Care and Public Health, Cardiff, ENGLAND, United Kingdom, ³Univ Dept of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ⁴Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Patient-based disease activity score (PDAS1 [with ESR] & PDAS2 [without ESR]) in rheumatoid arthritis (RA) are validated patient reported outcome measures of disease activity.…
Abstract Number: 394 • 2012 ACR/ARHP Annual Meeting
Remission After One Year in ACPA Positive and ACPA Negative Patients with Early Arthritis
K.V.C. Wevers-de Boer¹, L. Heimans¹, K. Visser¹, A.A. Schouffoer², T.H.E. Molenaar³, J.B. Harbers⁴, C. Bijkerk⁵, I. Speyer⁶, M. de Buck⁷, P.B. de Sonnaville⁸, B.A. Grillet⁹, Tom Huizinga¹ and C.F. Allaart¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Haga Hospital, The Hague, Netherlands, ³Dept of Rheumatology, Groene Hart Hospital, Gouda, Netherlands, ⁴Franciscus Hospital, Roosendaal, ⁵Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, ⁶Rheumatology, Bronovo Hospital, Den Haag, Netherlands, ⁷MCH, The Hague, ⁸Department of Rheumatology, Admiraal de Ruyter hospital, Goes, Netherlands, ⁹Department of Rheumatology, Zorgsaam Hospital, Terneuzen, Netherlands
Background/Purpose: To evaluate possible differences in clinical response after one year of remission steered treatment in Anti Citrullinated Protein Antibody (ACPA) positive and negative RA…
Abstract Number: 395 • 2012 ACR/ARHP Annual Meeting
Trends in Disease Activity, Response and Remission Rates in Rheumatoid Arthritis During the Last Decade: Results From the NOR-DMARD Register
Anna-Birgitte Aga¹, Elisabeth Lie², Karen M. Fagerli², Till Uhlig², Tore K. Kvien² and Espen A. Haavardsholm³, ¹Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: During the past decade there has been an increasing focus on early, aggressive treatment of patients with rheumatoid arthritis (RA), and combined with the…
Abstract Number: 396 • 2012 ACR/ARHP Annual Meeting
Prevalence, Concordance and Predictors of Early and Sustained Remission Assessed by Various Indices in the French Early Arthritis Espoir Cohort
Cédric Lukas¹, Ihsane Hmamouchi², Xavier Le Loet³, Bruno Fautrel⁴ and Bernard Combe⁵, ¹Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, ²El Ayachi Hospital, Rabat, Morocco, ³Rheumatology Department, CHU de ROUEN, Rouen, France, ⁴Rheumatology / GRC08-EEMOIS, APHP-Pitie Salpetriere Hospital / UPMC, Paris, France, ⁵Rheumatology, Hopital Lapeyronie, Montpellier, France
Background/Purpose: Clinical remission is the best achievable state in patients with rheumatoid arthritis (RA). The definition of remission, however, is still under debate. The aim…
Abstract Number: 397 • 2012 ACR/ARHP Annual Meeting
Assessment of Global Disease Activity in Rheumatoid Arthritis Patients Monitored in the Measurement of Efficacy of Treatment in the Era of Rheumatology Database: The patient’s Versus the rheumatologist’s Opinion
E. Gvozdenovic¹, R. Koevoets¹, R. Wolterbeek², Désirée van der Heijde³, T.W.J. Huizinga¹, C.F. Allaart¹ and Robert B. M. Landewé⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Biostatistics, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands
Background/Purpose: Disagreement on disease activity between rheumatoid arthritis (RA) patients and rheumatologists may influence treatment decisions and compliance. The aim is to compare the physician's…
Abstract Number: 398 • 2012 ACR/ARHP Annual Meeting
Basal Metabolic Rate As an Indicator of Rheumatoid Arthritis Disease Activity and Predictor of Remission
Heather Jones¹, Annette Szumski² and Andrew S. Koenig³, ¹Pfizer Inc., Collegeville, PA, ²Specialty Care, Pfizer Inc., Collegeville, PA, ³Specialty Care Business Unit, Pfizer Inc., Collegeville, PA
Background/Purpose: The role of body mass index (BMI) in rheumatoid arthritis (RA) disease activity and response to treatment has been difficult to determine.1 As a…

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