Abstracts Archive - Page 2388 of 2607 - ACR Meeting Abstracts

Abstract Number: 654 • 2013 ACR/ARHP Annual Meeting
Effects Of Macitentan and Its Active Metabolite In Modulating Extracellular Matrix Synthesis In Cultured Human Systemic Sclerosis and Normal Skin Fibroblasts
Maurizio Cutolo¹, Paola Montagna², Renata Brizzolara², Elisa Alessandri³, Pietro Paolo Tavilla⁴, Aurora Parodi⁴, Alberto Sulli⁵ and Stefano Soldano⁶, ¹University of Genova, Genova, Italy, ²Department of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁴Department of Endocrinologial and Medical Science, Unit of Dermatology, University of Genova, Genova, Italy, ⁵Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁶Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
Background/Purpose: Endothelin-1 (ET-1) has been shown to activate myofibroblasts and to enhance the synthesis of extracellular matrix proteins (ECM), such as collagen type I (COL-1)…
Abstract Number: 655 • 2013 ACR/ARHP Annual Meeting
DNA Methylation and Systemic Sclerosis
Gloria Salazar¹, Khurshida Begum², Xinjian Guo³, Minghua Wu¹, Shervin Assassi¹, Maureen D. Mayes¹, John D. Reveille¹ and Xiaodong Zhou¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Baylor College of Medicine, Houston, TX, ³Rheumatology, The University of Texas Medical School at Houston, Houston, TX
DNA Methylation and Systemic SclerosisBackground/Purpose: Epigenetic modiﬁcations are stable and heritable alterations in gene expression and cellular function that do not involve changes to the…
Abstract Number: 656 • 2013 ACR/ARHP Annual Meeting
Gene Expression Variation and The Role Of Interferon In Patients With Morphea From The Morphea In Adults and Children Cohort
Daniel Grabell¹, Andrew Kim², Virginia Pascual³, Shervin Assassi⁴ and Heidi Jacobe¹, ¹Dermatology, UT Southwestern Medical Center at Dallas, Dallas, TX, ²Lenox Hill Hospital, New York, NY, ³Baylor University, Dallas, TX, ⁴Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: Localized scleroderma (morphea) is characterized by inflammation and sclerosis of the dermis and underlying tissue and may be associated with significant morbidity. Overproduction of…
Abstract Number: 657 • 2013 ACR/ARHP Annual Meeting
Lipoic Acid Plays a Crucial Role In Scleroderma Dermal Fibroblasts
Pei-Suen Tsou¹, Beatrix Balogh², Adam J. Pinney², George Zakhem², Ann Kendzicky², Elena Schiopu³, Dinesh Khanna⁴, David A. Fox⁵ and Alisa E. Koch^5,6, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁶VA Medical Service, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by vasculopathy and fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived…
Abstract Number: 658 • 2013 ACR/ARHP Annual Meeting
Elevated 8-Isoprostane In Scleroderma: Implications Of Its Role In Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis
Pei-Suen Tsou¹, George Zakhem², Beatrix Balogh², M. Asif Amin³, Phillip Campbell⁴, Gautam Edhayan¹, Ray Ohara², Elena Schiopu⁵, Dinesh Khanna⁶, Alisa E. Koch^3,7 and David A. Fox¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁴Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁶Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁷Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive disposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…
Abstract Number: 659 • 2013 ACR/ARHP Annual Meeting
Circulating Cell-free microRNAs in Systemic Sclerosis
Samantha Steen¹, Anting L. Carlsen², Line V. Iversen¹, Christoffer T. Nielsen³, Christian Lood⁴, Anders A. Bengtsson⁴ and Niels H. H. Heegaard¹, ¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ²Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ³Infectious Diseases and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden
Background/Purpose: microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression through target mRNAs and are involved in important physiological and pathological…
Abstract Number: 660 • 2013 ACR/ARHP Annual Meeting
Bleomycin Delivery By Mini-Osmotic Pump: A Novel Multi-Organ Murine Model For Fibrosis
Rebecca Lee¹, Elena Tourkina², Richard P. Visconti³ and Stanley Hoffman⁴, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Rheumatology, Medical University of SC, Charleston, SC, ³Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁴Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic sclerosis (SSc, Scleroderma) is a rare but severe systemic connective tissue disorder involving the skin and multiple internal organs, in particular lung, kidney,…
Abstract Number: 661 • 2013 ACR/ARHP Annual Meeting
Topoisomerase-1 Specific T Cells Exhibit a Proinflammatory Th17 Phenotype and Are Associated With Interstitial Lung Disease In Scleroderma
Andrea Fava¹, Raffaello Cimbro¹, Antony Rosen², Qing-Rong Liu³, Fredrick M. Wigley² and Francesco Boin², ¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³NIH/NIDA, Baltimore, MD
Background/Purpose: Anti-topoisomerase-1 (Topo-1 or Scl70) autoantibodies are present in 30-45% of scleroderma (SSc) patients and identify a more aggressive disease phenotype with worse clinical outcome…
Abstract Number: 662 • 2013 ACR/ARHP Annual Meeting
Oxidative Stress-Dependent Activation Of Collagen Synthesis Is Induced In Human Pulmonary Vascular Smooth Muscle Cells By Scleroderma Sera and Predicts Pulmonary Vascular Disease
Francesco Boin¹, Anna Maria Posadino², Annalisa Cossu², Roberta Giordo², Ami A. Shah¹, Gaia Spinetti³, Gian Luca Erre⁴, Costanza Emanueli⁵, Giuseppe Passiu⁴, Fredrick M. Wigley¹ and Gianfranco Pintus², ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Biomedical Sciences, University of Sassari, Sassari, Italy, ³Istitituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Multi Medica, Milan, Italy, ⁴Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Sassari, Sassari, Italy, ⁵Laboratories of Vascular Pathology and Regeneration, University of Bristol, Bristol, United Kingdom
Background/Purpose: Vascular disease is a dominant component of Systemic Sclerosis (SSc) pathogenesis. Hypoxia and oxidative stress have been linked to endothelial injury, intimal hyperplasia and…
Abstract Number: 625 • 2013 ACR/ARHP Annual Meeting
Smoking and Secondhand Smoke Exposure Among Patients With Systemic Lupus Erythematosus and Controls: Associations With Disease and Disease Damage
Samantha J. Minkin, Stephanie N. Slan, Gary S. Gilkeson and Diane L. Kamen, Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Previous reports suggest smoking may be a risk factor for developing systemic lupus erythematosus (SLE), however the significance of this relationship varies among studies.…
Abstract Number: 642 • 2013 ACR/ARHP Annual Meeting
Serum Concentrations Of Type I Interferon-Regulated Chemokines Are Associated With Disease Activity In Systemic Lupus Erythematosus
Eric F. Morand, Kathryn Connelly and Alberta Y. Hoi, Centre for Inflammatory Diseases, Monash University, Melbourne, Australia
Background/Purpose: Expression array studies suggest the activity of Type I interferon (IFN), as reflected in IFN-induced genes, is associated with phenotypic subsets in SLE. Three…
Abstract Number: 622 • 2013 ACR/ARHP Annual Meeting
Serum Anti-Apolipoprotein 1 Antibodies Are Present In a Quarter Of Patients With Systemic Lupus Erythematosus At The Time Of Diagnosis and Are Associated With Earlier Mortality
Sara Croca¹, Maria Davari², D.A. Isenberg² and Anisur Rahman³, ¹Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ²Centre for Rheumatology Research, University College London, London, United Kingdom, ³Centre for Rheumatology Research,Rayne Institute, 4th Floor, University College London, London, United Kingdom
Background/Purpose: A large number of different autoantibodies have been reported in patients with systemic lupus erythematosus but not all have been related to clinical outcomes.…
Abstract Number: 623 • 2013 ACR/ARHP Annual Meeting
Lupus Patients Have a High Prevalence Of Abnormalities On Resting Electrocardiogram That Are Associated With Increased Risk For Cardiovascular Events
Zahi Touma¹, Paula Harvey², Dafna D. Gladman³, Arthy Sabapathy⁴ and Murray B. Urowitz³, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Cardiology, Women's College Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Patients with lupus are at increased risk for cardiovascular disease (CVD). Abnormalities detected on resting electrocardiography (ECG) that may be associated with an increased…
Abstract Number: 624 • 2013 ACR/ARHP Annual Meeting
Extremely High Coronary Artery Calcium Scores Among Patients With Systemic Lupus Erythematosus
Susan Due Kay¹, Anne Voss², Axel Cosmus Pyndt Diederichsen³ and Mikael Kjær Poulsen⁴, ¹Department of Rheumatology, Odense University hospital, University of Southern Denmark, Odense - 5000, Denmark, ²Dept of Rheumatology, Odense University Hospital, Odense C, Denmark, ³Departmen of Cardiology,, Odense University Hospital, Odens-5000, Denmark, ⁴Department of Cardiology, Odense University Hospital, Odense - 5000, Denmark
Background/Purpose: Investigations of major lupus-cohorts have demonstrated cardiovascular disease to have major impact on morbidity and mortality (Am J Epidemiol 1997;145:408-15). The aim of this…
Abstract Number: 626 • 2013 ACR/ARHP Annual Meeting
Ultrasound Assessment Of Both Carotid and Femoral Arteries In Patients With Systemic Lupus Erythematosus Increases Sensitivity For Detecting Asymptomatic Atherosclerosis
Sara Croca¹, D.a. Isenberg² and Anisur Rahman³, ¹Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ²Centre for Rheumatology Research, University College London, London, United Kingdom, ³Centre for Rheumatology Research,Rayne Institute, 4th Floor, University College London, London, United Kingdom
Background/Purpose: SLE is an independent risk factor for cardiovascular disease (CVD). Traditional risk assessment tools underestimate the actual CVD risk of these patients limiting the…

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