Abstracts Archive - Page 2387 of 2607 - ACR Meeting Abstracts

Abstract Number: 683 • 2013 ACR/ARHP Annual Meeting
HRCT Predictors Of Decline In FVC% predicted—Implications For Cohort Enrichment For Scleroderma Lung Disease (SLD) Trials
Dinesh Khanna¹, Chi-hong Tseng², Robert D. Suh³, Fereidoun Abtin⁴, Athol U. Wells⁵, Donald Tashkin⁶ and Jonathan Goldin⁷, ¹University of Michigan, Ann Arbor, MI, ²Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³UCLA Department of Radiological Sciences, Ronald Reagan UCLA Medical Center, Los Angeles, CA, ⁴Radiology, University of California Los Angeles Medical Center, Santa Monica, CA, ⁵Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom, ⁶Medicine, University of California at Los Angeles, Los Angeles, CA, ⁷Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Moderate-to-severe HRCT-defined lung involvement (total lung involvement or fibrosis) is a predictor of decline in FVC% predicted and mortality in SLD. Various staging systems…
Abstract Number: 684 • 2013 ACR/ARHP Annual Meeting
Clinical Characteristics Of Scleroderma Patients With Calcinosis In a Single-Center Cohort
Danielle Velez¹ and Vivien M. Hsu², ¹RWJMS, South Plainfield, NJ, ²Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ
Clinical characteristics of scleroderma patients with calcinosis in a single-center cohort Background/Purpose: Calcinosis is soft tissue deposition of calcium hydroxyapatite crystals in scleroderma spectrum disorder…
Abstract Number: 685 • 2013 ACR/ARHP Annual Meeting
Lung Function and Survival In Systemic Sclerosis Associated Interstitial Lung Disease
Samar M. Shadly¹, Sindhu R. Johnson², Cathy Chau³ and Theodore K. Marras⁴, ¹Medicine, University Health Network Interstitial Lung Diseases Program, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada, ²Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ³Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁴Medicine, University Health Network Interstitial Lung Diseases Program, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: We sought to assess for an association between baseline forced vital capacity (FVC) and diffusion capacity (DLCO) with mortality, and to identify threshold values…
Abstract Number: 686 • 2013 ACR/ARHP Annual Meeting
Blood Flow In The Hands Of a Predefined Homogeneous Systemic Sclerosis Population: The Presence Of Digital Ulcers and The Improvement With Bosentan
Jessica Meijs¹, Annemie J.M. Schuerwegh¹, Alexandre E. Voskuyl², Joanne P.J. Bloemsaat-Minekus³ and Madelon C. Vonk⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Actelion, Woerden, Netherlands, ⁴Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Digital ulcers (DU) are complications of systemic sclerosis (SSc) and arise as a result of ischaemia due to vasculopathy of the digital arteries (1).…
Abstract Number: 643 • 2013 ACR/ARHP Annual Meeting
Potential Immunopathological Roles Of The Novel Anti-Inflammatory Cytokine Interleukin-35 In Patients With Systemic Lupus Erythematous
Zhe Cai¹, Chun-Kwok Wong² and Lai Shan Tam³, ¹The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: IL-35, a dimeric protein with two subunits, IL-12A (p35) and Epstein-Barr virus induced 3, is a novel IL-12 cytokine family regulatory T-cells (Treg)-specific immunosuppressive/anti-inflammatory…
Abstract Number: 644 • 2013 ACR/ARHP Annual Meeting
Expansion Of CD4⁺CXCR3⁺ T Cells In Patients With Systemic Lupus Erythematosus (SLE) Correlates With Subclinical Atherosclerosis
Karim Sacre¹, Brigitte Escoubet², Nicolas Charles³, Antoine Dossier⁴, Marie-Paule Chauveheid⁵ and Thomas Papo¹, ¹Internal Medicine, University Paris-7, INSERM U699, APHP, Bichat Hospital, Paris, France, ²Cardiology, University Paris-7, INSERM U872, APHP, Bichat Hospital, Paris, France, ³INSERM U699, Paris, France, ⁴Internal Medicine, University Paris-7, APHP, Bichat Hospital, Paris, France, ⁵Internal Medicine,, University Paris-7, APHP, Bichat Hospital, Paris, France
Background/Purpose: The mechanisms for accelerated atherosclerosis in SLE remain unclear. As atherosclerosis is itself immune-mediated, features of SLE-associated immunity might explain accelerated cardiovascular disease beside traditional…
Abstract Number: 645 • 2013 ACR/ARHP Annual Meeting
Transcript Profiling Of Blood and Kidney Biopsies From Chinese Patients With Lupus Nephritis Reveals Concordant Activation Of Type I IFN Signaling In The Blood and Kidney, Reduced B Cell Presence In The Blood, and Increased Macrophages In The Kidney
Zheng Liu¹, Chris, A. Morehouse¹, Xinfang Huang², Philip Brohawn¹, Nan Shen², Yihong Yao¹ and Brandon W. Higgs¹, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Dept of Rheumatology, Shanghai Ren Ji Hospital, Shanghai, China
Background/Purpose: Up-regulated expression of type I interferon-regulated genes has consistently been observed within the peripheral blood in a large proportion of patients with active systemic…
Abstract Number: 646 • 2013 ACR/ARHP Annual Meeting
Expression Of Interferon-Inducible Gene (Lymphocyte Antigen 6 Complex Locus E) In Systemic Lupus Erythematosus Patients and Its Association With Disease Activity
Eman Omran¹, Tayseer M Khidre², Eman Alkady³, Eman Mosaad⁴ and Mona Hussein Abd Elsamea³, ¹Rheumatology and Clincal Immunology, Assiut University- Faulty of Medicne, Assiut, Egypt, ²Assiut University, Faculty of Medicine, Assiut, Egypt, ³Assiut University- Faculty of Medicine, Assiut, Egypt, ⁴AssiutUniversity- Faculty of Medicine, Assiut, Egypt
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear and other autoantibodies, generation of…
Abstract Number: 647 • 2013 ACR/ARHP Annual Meeting
Enhanced Expression of CCR Receptors in Healthy AA and SSc ILD Monocytes
Rebecca Lee¹, Charles Reese², Beth Perry³, Jonathan Heywood², Michael Bonner¹, Richard P. Visconti⁴, Richard M. Silver⁵, Stanley Hoffman³ and Elena Tourkina², ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Rheumatology, Medical University of SC, Charleston, SC, ³Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁵Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC
Background/Purpose: Scleroderma-associated Interstitial Lung Disease (SSc ILD) is more prevalent and more severe in African Americans (AA) than in Caucasian (C) patients, but little is…
Abstract Number: 648 • 2013 ACR/ARHP Annual Meeting
A Possible Contribution of Inducible Costimulator to the Development of Skin Sclerosis and Interstitial Lung Disease in Systemic Sclerosis
Koichi Yanaba¹, Yoshihide Asano² and Shinichi Sato², ¹Dermatology, The University of Tokyo, Tokyo, Japan, ²Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous disorder characterized by excessive fibrosis and microvascular damage of the skin and various internal organs. Cutaneous mononuclear cell…
Abstract Number: 649 • 2013 ACR/ARHP Annual Meeting
Altered BMP Signalling In a TGFβ Dependent Murine Model Of Scleroderma May Contribute To Development Of Pulmonary Arterial Hypertension
Adrian J Gilbane¹, Emma C. Derrett-Smith², Sarah Trinder³, Andrew Pearce⁴, Christopher P. Denton¹ and Alan M. Holmes⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Disease, UCL Medical School, London, United Kingdom, ⁴Respiratory Disease Area, Novartis, London, United Kingdom, ⁵Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose: Pulmonary arterial hypertension associated is an important complication of scleroderma (PAH-SSc) and has a poor prognosis compared to idiopathic (iPAH) or heritable (hPAH) forms…
Abstract Number: 650 • 2013 ACR/ARHP Annual Meeting
Parental Influence On Systemic Sclerosis
Tracy M. Frech¹, Richard Pimentel², Allen D. Sawitzke³, Gopi Penmetsa⁴ and Jathine Wong², ¹Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, ²University of Utah, Salt Lake, UT, ³Rheumatology, University of Utah Medical Ctr, Salt Lake City, UT, ⁴Rheumatology Division, University Of Utah Hospital, Salt lake City, UT
Background/Purpose: A genealogic resource, the Utah Population Database (UPDB) has successfully identified systemic sclerosis (SSc) pedigrees and hereditable risk for this disease (1). We hypothesized…
Abstract Number: 651 • 2013 ACR/ARHP Annual Meeting
Growth Differentation Factor-15, a Marker Of lung disease In Systemic Sclerosis, Is Involved In Fibrosis Development But Does Not Impair Fibrosis Development
Stijn Lambrecht¹, Vanessa Smith², Katelijne De wilde³, Julie Coudenys⁴, Filip De Keyser² and Dirk Elewaut⁵, ¹Dept of Rheumatology, Laboratory for Molecular Immunology and Inflammation, Ghent University, Ghent, Belgium, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³Deptartment of Rheumatology, Ghent University, Ghent, Belgium, ⁴Dept of Rheumatology, Ghent University, Ghent, Belgium, ⁵Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose: It is generally known that members of the TGF-β superfamily are involved in the regulation of connective tissue biology in systemic sclerosis (SSc). Growth…
Abstract Number: 652 • 2013 ACR/ARHP Annual Meeting
Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis
Yuko Ota¹, Yasushi Kawaguchi¹, Kae Takagi¹, Hisae Ichida¹, Yasuhiro Katsumata¹, Takahisa Gono¹, Yuko Okamoto¹, Tomoaki Higuchi², Hidenaga Kawasumi¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute Of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Pirfenidone (5-methyle-1-phenyl-2- [1H]-pyridone) and BIBF1120 (Nintedanib) are currently evaluated in clinical trials as a potential idiopathic pulmonary fibrosis (IPF). Pirfenidone was approved as the…
Abstract Number: 653 • 2013 ACR/ARHP Annual Meeting
Norepinephrine-Induced IL-6 Regulates Fibrosis In Systemic Sclerosis
Sei-ichiro Motegi, Akihito Uehara, Kazuya Yamada, Akihiko Uchiyama, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi and Osamu Ishikawa, Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan
Background/Purpose: Raynaud phenomenon is freaquently observed in patients of systemic sclerosis (SSc) and characterized by episodic vasospasm and ischemia of extremities in response to cold or…

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