Abstracts Archive - Page 2386 of 2607 - ACR Meeting Abstracts

Abstract Number: 664 • 2013 ACR/ARHP Annual Meeting
Formate, Acetate and Acetone : News Biomarkers in Systemic Sclerosis identified by Metabolomics
Emmanuel Chatelus¹, Francois Marie Moussallieh², Christelle Sordet¹, Arnaud Theulin¹, Alain Meyer¹, Karim El Bayed³, Jean Francois Kleinmann¹, Jean Sibilia¹, Jacques-Eric Gottenberg⁴ and Izzie Jacques Namer², ¹Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Nuclear Medicine, Strasbourg University Hospital, Strasbourg, France, ³UMR 7177 CNRS/Strasbourg University, Strasbourg, France, ⁴Strasbourg University Hospital, Strasbourg, France
Background/Purpose: High throughput study of metabolic pathways might help identify new biomarkers and therapeutic targets in autoimmune diseases. Systemic sclerosis (SSc) currently lacks prognostic biomarkers…
Abstract Number: 665 • 2013 ACR/ARHP Annual Meeting
DNA hypermethylation of Forkhead box protein 3 (FOXP3) locus leads to quantitative defects of regulatory T cells in systemic sclerosis
Yaoyao Wang¹, Ye Shu², Qing Wang¹, Ming Zhao¹, Gongping Liang¹, Qianjin Lu¹ and Rong Xiao¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Hunan Children's Hospital, Changsha, China

Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of which the etiology and pathogenesis remains complex and poorly understood. Attention has recently been directed…
Abstract Number: 666 • 2013 ACR/ARHP Annual Meeting
Involvement Of TCR Vdelta1⁺ NKT Cells In Systemic Sclerosis: Association With Interstitial Pneumonia
Seiji Segawa¹, Daisuke Goto², Masanobu Horikoshi², Yuya Kondo³, Naoto Umeda², Shinya Hagiwara², Masahiro Yokosawa⁴, Tomoya Hirota³, Haruka Miki¹, Hiroto Tsuboi³, Hiroshi Ogishima², Takeshi Suzuki⁴, Isao Matsumoto⁵ and Takayuki Sumida³, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, ²Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁴Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, ⁵Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Interstitial pneumonia (IP) is one of the critical complications in patients with several autoimmune diseases. However, the exact mechanism of IP remains elusive. Recently,…
Abstract Number: 667 • 2013 ACR/ARHP Annual Meeting
IL6 and CCL2 Co-Regulate Fibroblast Dependent Trans-Endothelial Migration Of Mononuclear Cells and Fibrotic Response In Scleroderma
Rebecca Alade¹, Korsa Khan², Xu Shiwen³, Christopher P. Denton⁴ and Voon Ong⁵, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL medical School, London, United Kingdom, ³Rheumatology, Royal Free Hospital, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁵Department of Rheumatology, UCL Medical School, London, England
Background/Purpose: IL6 is a key mediator recently implicated in activation of extracellular matrix (ECM) proteins in scleroderma (SSc) fibroblasts. CCL2 is a proinflammatory chemokine that…
Abstract Number: 668 • 2013 ACR/ARHP Annual Meeting
Enhanced Expression Of The Cold-Sensing Receptor-TRPM8 In Scleroderma Endothelial Cells and Skin and Endothelial Dysfunction Following TRPM8 Activation
Yongqing Wang¹, David R. Giovannucci² and Bashar Kahaleh³, ¹Medicine, University of Toledo, Toledo, OH, ²Neurosciences, University of Toledo, Toledo, OH, ³Medicine/Rheumatology, University of Toledo, Toledo, OH
Background/Purpose: Cold exposure induces vasospasm and incites reperfusion injury in SSc. The mechanisms responsible for enhanced cold sensitivity in SSc are poorly understood. Transient receptor…
Abstract Number: 669 • 2013 ACR/ARHP Annual Meeting
Up-Regulated Expression Of CXCL5 In Circulating Platelets From Patients With Systemic Sclerosis: A Role In Fibrosis
Hidekata Yasuoka¹, Ken Stern², Yuka Okazaki³, Tetsuya Nishimoto⁴, Tsutomu Takeuchi¹ and Masataka Kuwana¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Keio University School of Medicine, Tokyo, Japan, ³Rheumatology, Keio University School of Medicine, Tokyo, Japan, ⁴Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic sclerosis (SSc) is a systemic fibroproliferative disease characterized by concomitant occurrence of microvascular injury and autoantibody production. It has long been suggested that…
Abstract Number: 671 • 2013 ACR/ARHP Annual Meeting
Autoantibody Diversity In Scleroderma Patients With Antinucleolar Antibodies and Negative For Three Major Disease-Specific Markers
Sarada Nandiwada¹, Troy Jaskowski², Maureen D. Mayes³, Minoru Satoh⁴ and Anne E. Tebo¹, ¹Pathology, University of Utah, Salt Lake City, UT, ²ARUP Laboratories, Salt Lake City, UT, ³University of Texas Health Science Center at Houston, Houston, TX, ⁴Medicine, University of Florida, Gainesville, FL
Background/Purpose: Antinuclear antibodies (ANA) in a nucleolar pattern (antinucleolar antibodies, ANoA) by indirect immunofluorescence technique correlate with several autoantibody specificities and clinical manifestations in scleroderma…
Abstract Number: 672 • 2013 ACR/ARHP Annual Meeting
Anti-Th/To Antibodies In Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 ELISA
Ann D. Chauffe¹, Eric S. Sobel², Michael R. Bubb¹, Westley H. Reeves³, Michael Mahler⁴, Cristina Gascon⁵, Jason Y.F. Chan¹, S. John Calise⁶, Edward K.L. Chan⁶ and Minoru Satoh¹, ¹Medicine, University of Florida, Gainesville, FL, ²Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, ³Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁴Research, INOVA Diagnostics, San Diego, CA, ⁵Research, INOVA Diagnostics, Inc., San Diego, CA, ⁶Oral Biology, University of Florida, Gainesville, FL
Background/Purpose: Anti-Th/To antibodies (anti-Th) are one of the specificities that show nucleolar staining in indirect immunofluorescence antinuclear antibody test. Anti-Th is associated with systemic sclerosis…
Abstract Number: 674 • 2013 ACR/ARHP Annual Meeting
Systemic Sclerosis Disease Subset Is a Better Predictor Of Long Term Outcome Than Autoantibody Profile
Svetlana I. Nihtyanova¹, Voon H. Ong² and Christopher P. Denton³, ¹Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom, ³Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom
Background/Purpose: Disease subset has been shown to strongly correlate with survival and risk of organ complications in patients with systemic sclerosis (SSc). Nevertheless evidence in…
Abstract Number: 675 • 2013 ACR/ARHP Annual Meeting
Impact Of Male Sex On Survival In Systemic Sclerosis
Haseena Hussein¹, Peter Lee², Cathy Chau³ and Sindhu R. Johnson⁴, ¹Medicine, Toronto Scleroderma Research Program, Mount Sinai Hospital, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Lebovic Bldg, Mt. Sinai Hospital, Toronto, ON, Canada, ³Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁴Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic sclerosis (SSc) has a female predominance with a female-to-male ratio of 3:1. Sex differences have been seen in many autoimmune diseases; however, little…
Abstract Number: 676 • 2013 ACR/ARHP Annual Meeting
Early Systemic Sclerosis: Marker Autoantibody Positive Patients Have A Faster Pace Of The Disease
Gabriele Valentini¹, Antonella Marcoccia², Michele Iudici³, Serena Vettori¹ and Giovanna Cuomo³, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Angiology Unit, Sandro Pertini Hospital, Rome, Italy, ³Department of Internal and Experimental Medicine, Second University of Naples, Naples, Italy
Background/Purpose: To investigate whether patients affected with any of the 3 subsets of early systemic sclerosis (SSc) i.e. Raynaud’s Phenomenon (RP) with SSc marker autoantibody…
Abstract Number: 678 • 2013 ACR/ARHP Annual Meeting
Quantifying Change In Pulmonary Function As a Prognostic Marker In Systemic Sclerosis-Related Interstitial Lung Disease
Owen Moore^1,2, Susanna Proudman³, Nicole Goh⁴, Tamera Corte⁵, Hannah Rouse⁶, Oliver Hennessy⁶, Vivek Thakkar⁷, Joanne Sahhar⁸, Janet E. Roddy⁹, Peter Youssef¹⁰, Eli Gabbay¹¹, Peter Nash¹², Jane Zochling¹³, Wendy Stevens¹⁴ and Mandana Nikpour¹⁵, ¹Rheumatology, St. Vincent’s Hospital, Melbourne, Australia, ²Rheumatology, Derriford Hospital, Plymouth, United Kingdom, ³Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁴Department of Respiratory Medicine, Alfred Hospital, Melbourne, Australia, ⁵Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia, ⁶Department of Radiology, St. Vincent’s Hospital, Melbourne, Australia, ⁷St Vincent's Hospital, Melbourne, Australia, ⁸Rheumatology Unit, Monash Medical Centre, Clayton, Australia, ⁹Royal Perth Hospital, Perth, Australia, ¹⁰Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, Australia, ¹¹Advanced Lung Disease Unit, Royal Perth Hospital, Perth, Australia, ¹²Rheumatology Research Unit, Nambour Hospital, Sunshine Coast, Australia, ¹³Menzies Research Institute Tasmania, Hobart, Australia, ¹⁴Rheumatology, St Vincent's Hospital, Melbourne, Australia, ¹⁵Department of Medicine (St Vincent's Hospital), University of Melbourne, Fitzroy, Australia
Background/Purpose: Interstitial lung disease (ILD) is a leading cause of mortality in systemic sclerosis (SSc) but it is not severe or progressive in all patients.…
Abstract Number: 679 • 2013 ACR/ARHP Annual Meeting
Validation Of a Novel Radiographic Scoring System For Calcinosis Affecting The Hands Of Patients With Systemic Sclerosis
Lorinda Chung¹, Antonia Maria Valenzuela Vergara², David Fiorentino³, Kate Stevens², Shufeng Li⁴, Jonathan Harris⁵, Charles E. Hutchinson⁶, Shervin Assassi⁷, Lorenzo Beretta⁸, Santhanam Lakshminarayanan⁹, Tatiana Rodriguez Reyna¹⁰, Christopher P. Denton¹¹, Rebecca G. Taillefer¹², Solene Tatibouet¹³, Ariane Herrick¹⁴ and Murray Baron¹⁵, ¹Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA, ³Dermatology, Stanford University School of Medicine, Redwood City, CA, ⁴Dermatology, Stanford University School of Medicine, Palo Alto, CA, ⁵Salford Royal Hospital, Manchester, United Kingdom, ⁶Warwick Medical School, University of Warwick, Coventry, United Kingdom, ⁷Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁸Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁹Dept of Med/Div Rheum Diseases, University of Connecticut School of Medicine, Farmington, CT, ¹⁰Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico, ¹¹Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ¹²University of Montreal, Montreal, QC, Canada, ¹³Jewish General Hospital, McGill University, Montreal, QC, Canada, ¹⁴Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, ¹⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Calcinosis affects approximately 25% of patients with systemic sclerosis (SSc) and is associated with substantial morbidity. There are currently no validated outcome measures…
Abstract Number: 680 • 2013 ACR/ARHP Annual Meeting
Diastolic Dysfunction Amongst Autoantibody Subgroups Of Patients With Diffuse Scleroderma
Cory Perugino¹, John Stephens², Colin O'Rourke³ and Soumya Chatterjee⁴, ¹Internal Medicine, Cleveland Clinic, Cleveland, OH, ²Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, ³Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ⁴Rheumatic and Immunologic Ds, Cleveland Clinic, Cleveland, OH
Background/Purpose: Scleroderma or systemic sclerosis (SSc) is an autoimmune disease characterized by microangiopathy, tissue hypoxia, and fibrosis. At least seven different autoantibodies have been identified…
Abstract Number: 682 • 2013 ACR/ARHP Annual Meeting
Effects Of Extracoporeal Shock Wave Therapy To The Digital Ulcers Of Scleroderma:a Pilot Study
Shinichiro Saito¹, Yukiko Kamogawa², Kyohei Nakamura³, Ryu Watanabe³, Tsuyoshi Shirai², Yoko Fujita⁴, Hiroshi Fujii³, Yuko Shirota⁵, Tomonori Ishii³, Hideo Harigae³, Katsuko Kikuchi⁶ and Yasushi Kawaguchi⁷, ¹Department of hematology and rheumatology, Tohoku University, Sendai, Japan, ²Tohoku University, Sendai, Japan, ³Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ⁴Department of Hematolgy and rheumatolgy, Tohoku University, Sendai, Japan, ⁵Department of Hematology and Rheumatolgy, Tohoku University, Sendai, Japan, ⁶Department of Dermatology, Tohoku University, Sendai, Japan, ⁷Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Vasculopathy, immunological abnormalities and excessive tissue fibrosis are key elements in the pathogenesis of Scleroderma (SSc). In winter, patients often display Raynaud syndrome, which…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].