Abstracts Archive - Page 2384 of 2607 - ACR Meeting Abstracts

Abstract Number: 718 • 2013 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells and Skin Fibroblasts Both Suppress Early Steps In T Cell Activation In a Nitric-Oxide Dependent Manner
Runsheng Wang¹, Francoise Meylan², Jizhong Zou³, Mahendra Rao³ and Richard M. Siegel⁴, ¹NIH/NIAMS, Rheumatology fellowship and training branch, Bethesda, MD, ²NIH/NIAMS, autoimmunity branch, Bethesda, MD, ³NIH/NIAMS, center for regenerative medicine, Bethesda, MD, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Mesenchymal stem cells (MSCs) are multipotent cells with capacity to differentiate into osteoblasts, chondrocytes, and adipocytes. A phase II study in Europe has shown…
Abstract Number: 719 • 2013 ACR/ARHP Annual Meeting
Mammalian Target Of Rapamycin (mTOR) Skews T Cell Lineage Development In Systemic Lupus Erythematosus (SLE)
Hiroshi Kato¹ and Andras Perl², ¹Internal Medicine, Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ²Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: mTOR activity is increased in SLE T cells and its blockade has therapeutic efficacy in SLE. Murine studies showed essential roles of mTORC1 in…
Abstract Number: 720 • 2013 ACR/ARHP Annual Meeting
Abatacept Efficacy Is Overruled By IL-7 In TSLP-Primed Myeloid Dendritic cell driven T Cell Activation From Rheumatoid Arthritis Patients
F.M. Moret¹, T.R.D.J. Radstake², J.W.J. Bijlsma¹, F.P.J.G. Lafeber³ and J.a.G. van Roon⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Abatacept is an effective treatment for a subset of rheumatoid arthritis (RA) patients, interfering in the interaction between antigen-presenting cells and T cells preventing…
Abstract Number: 721 • 2013 ACR/ARHP Annual Meeting
T Cell Activation Induces Increased mRNA Expression Of The Splicing Factor SF2/ASF But Simultaneous Protein Downregulation Via Proteasome Mediated Degradation
Vaishali R. Moulton¹, Andrew R. Gillooly¹ and George C. Tsokos², ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) are poor producers of the vital cytokine interleukin (IL)-2. We recently showed that SLE…
Abstract Number: 722 • 2013 ACR/ARHP Annual Meeting
BAFF Promotes T Follicular Helper Cell Development and Germinal Center Generation In Mice
Song Guo Zheng¹, Maogeng Chen¹, Qiang Li² and William Stohl³, ¹Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, ²University of Southern California Keck School of Medicine, Los Angeles, CA, ³Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: BAFF (B cell activating factor belonging to the TNF family) promotes B cells maturation in germinal center. The generation of germinal center depends on…
Abstract Number: 723 • 2013 ACR/ARHP Annual Meeting
Abatacept Is Highly Effective At Inhibiting T Cell Priming and Induces a Unique Transcriptional Profile In CD4⁺t Cells
Agapitos Patakas¹, Rui-Ru Ji², William Weir³, Sean Connolly², Steven G. Nadler², James M. Brewer⁴, Iain B. McInnes⁴ and Paul Garside⁴, ¹Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Department of Immunology and Inflammation, Bristol Myers Squibb Co. Research and Development, Princeton, NJ, ³Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Absence of co-stimulation in the presence of TCR-stimulation has been proposed to induce tolerance via deletion or anergy. Abatacept is a CTLA-4-Ig molecule that…
Abstract Number: 724 • 2013 ACR/ARHP Annual Meeting
Dose-Dependent Suppression Of Cytokine Production From T Cells By a Novel Phosphoinositide 3-Kinase Delta Inhibitor
Emily E. Way¹, Kong Chen², Kamal D. Puri³ and Jay K. Kolls², ¹Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³Gilead Sciences, Inc., Seattle, WA
Background/Purpose: The use of specific cytokine inhibitors to treat inflammatory autoimmune conditions is common but typically utilizes monoclonal antibodies, fusion proteins, and other molecules whose…
Abstract Number: 725 • 2013 ACR/ARHP Annual Meeting
Localization At The Immunological Synapse Of Adaptor Protein Grb2 and PLC Gamma-1 In Non-Stimulated Peripheral Blood T Lymphocytes From Patients With Systemic Lupus Erythematosus Suggests An In Vivo dysregulated Activation State
Nursamaa Abdoel¹, Mireyma Sanchez², Hector Rojas³, Martin Rodriguez⁴ and Ana M. Blasini¹, ¹Sección de Investigación en Inmunoreumatologia, Hospital Universitario de Caracas, Caracas, Venezuela, ²Rheumatology, Hospital Universitario de Caracas, Caracas, Venezuela, ³Instituto de Inmunologia, Escuela de Medicina, Universidad Central de Venezuela, Caracas, Venezuela, ⁴Centro Nacional de Enfermedades Reumáticas, Hospital Universitario de Caracas, Caracas, Venezuela
Background/Purpose: We previously showed an increased metabolic rate of transmembrane adaptor protein LAT in TCR/CD3 stimulated lupus T cells, associated with delocalization of this adaptor…
Abstract Number: 726 • 2013 ACR/ARHP Annual Meeting
Tofacitinib Does Not Inhibit Dendritic Cell Maturation and T Cell Proliferation In Vitro
Emmanuelle Le Bras^1,2, Dagmar Halbritter³ and Martin Fleck^2,4, ¹Internal Medicine I, University Medical Center of Regensburg, Regensburg 93053, Germany, ²Rheumatology & Clinical Immunology, Asklepios Clinic Bad Abbach, Bad Abbach, Germany, ³Internal Medicine I, University Medical Center of Regensburg, 93042 Regensburg, Germany, ⁴Internal Medicine I, University Medical Center of Regensburg, Regensburg, Germany
Background/Purpose: Tofacitinib is the first approved Janus Kinase (JAK) Inhibitor for the treatment of rheumatoid arthritis (RA). The JAK/STAT pathway-inhibition leads to dysfunction of several…
Abstract Number: 687 • 2013 ACR/ARHP Annual Meeting
Role Of Class II Human Leukocyte Antigens In The Progression From Early To Definite Systemic Sclerosis
Barbara Vigone¹, Alessandro Santaniello², Maurizio Marchini¹, Gaia Montanelli¹, Monica Caronni¹, Adriana Severino¹, Stefania Celeste¹ and Lorenzo Beretta³, ¹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ²Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ³Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy
Background/Purpose: Criteria for the diagnosis of Early Systemic Sclerosis (EaSSc) have been formalized by LeRoy and Medsger in 2001 and later validated by Koenig et…
Abstract Number: 688 • 2013 ACR/ARHP Annual Meeting
Minimal Clinically Important Investigations In Systemic Sclerosis
Jessica Meijs¹, Anne A. Schouffoer¹, Nina Ajmone Marsan², Maarten K. Ninaber³ and Tom W.J. Huizinga¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Cardiology, Leiden University Medical Center, Leiden, Netherlands, ³Pulmonology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The optimal management of Systemic Sclerosis (SSc) is a challenge due to the complexity of early diagnosis and identification of patients who are at…
Abstract Number: 689 • 2013 ACR/ARHP Annual Meeting
Subclinical Biventricular Systolic Function Is Impaired In Patients With Systemic Sclerosis: A Speckle Tracking-Based Echocardiographic Study
Sukru Taylan Sahin¹, Selen Yurdakul², Neslihan Yilmaz³, Yonca Cagatay³, Saide Aytekin¹ and Sule Yavuz⁴, ¹Cardiology, Istanbul Florence Nightingale Hospital, Cardiology, Istanbul, Turkey, ²Cardiology, Bilim University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey, ³Department of Rheumatology, Bilim University Faculty of Medicine, Istanbul, Turkey, ⁴Rheumatology, Bilim University, Faculty of Medicine, Rheumatology Department, Istanbul, Turkey
Subclinical biventricular systolic function is impaired in patients with systemic sclerosis: A speckle tracking-based echocardiographic studyBackground/Purpose : Myocardial involvement is associated with poor prognosis in…
Abstract Number: 690 • 2013 ACR/ARHP Annual Meeting
Assessment Of The New American and European Classification Criteria For Systemic Sclerosis In The Norwegian Systemic Connective Tissue Disease and Vasculitis Registry
Anna-Maria Hoffmann-Vold¹, Torhild Garen², Oyvind Midtvedt¹ and Øyvind Molberg³, ¹Rheumatology, Oslo University Hospital, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ³Oslo University Hospital, Oslo, Norway
Background/Purpose: To assess the newly established ACR/EULAR classification criteria for systemic sclerosis 1 (SSc) in a large Norwegian SSc registry cohort. Methods: The Norwegian systemic…
Abstract Number: 691 • 2013 ACR/ARHP Annual Meeting
Descriptive Review Of Morphea Subjects From a Single Cohort Center
Lesley Portugal¹, Muneera Naeem², Lakshmi N. Moorthy³ and Vivien M. Hsu⁴, ¹Medicine, Robert Wood Johnson Medical School, New Brunswick, NJ, ²Medicine, Mountainside Hospital, Montclair, NJ, ³Pediatric Rheumatology, Robert Wood Johnson Medical School-Rutgers University, New Brunswick, NJ, ⁴Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ
Descriptive review of Morphea subjects from a single cohort center Background/Purpose: Morphea, or localized scleroderma, is an idiopathic, rare fibrotic skin disorder that may result…
Abstract Number: 692 • 2013 ACR/ARHP Annual Meeting
Characterization Of Lower Limb Cutaneous Ulcers In Systemic Sclerosis: The Analysis of 424 Lesions
Jelena Blagojevic^1,2, Guya Piemonte¹, Laura Benelli¹, Francesca Braschi¹, Ginevra Fiori¹, Felice Galluccio¹, Francesca Bartoli¹, Lorenza Busco³, Alberto Pignone³, Giulia Carnesecchi¹, Gemma Lepri⁴, Serena Guiducci¹ and Marco Matucci Cerinic¹, ¹Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy, ²Doctorate in Genetics, Oncology and Clinical Medicine, University of Siena, Siena, Italy, ³Department of Internal Medicine, University of Florence, Florence, Italy, ⁴Department of Internal Medicine, Section of Rheumatology, Transition Clinic, University of Florence, Florence, Italy
Background/Purpose: Cutaneous ulcers reppresent one of the most frequent complications in course of systemic sclerosis (SSc). They are often disabling and difficult to treat. The…

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