Abstracts Archive - Page 2383 of 2425 - ACR Meeting Abstracts

Abstract Number: 580 • 2012 ACR/ARHP Annual Meeting
Changes in Sclerostin, Dickkopf-1 and Serum Markers of Inflammation, Cartilage and Bone Turnover in Patients with Axial Spondyloarthritis Treated with Adalimumab
Susanne Juhl Pedersen¹, Inge Juul Sørensen², Julia S. Johansen³, Patrick Garnero⁴, Anne Gitte Loft⁵, Jens Skoedt⁶, Gorm Thamsborg⁷, Karsten Asmussen⁸, Elka Kluger⁹, Jesper Nørregaard¹⁰, Torben Grube Christensen¹¹ and Mikkel Østergaard¹², ¹Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Department of Rheumatology, Hvidovre Hospital, Copenhagen, Denmark, ³Department of Internal Medicine and Oncology, Herlev Hospital, Herlev, Denmark, ⁴INSERM, UMR 1033, Lyon and Cisbio Bioassays, Bagnols/Cèze, France, ⁵Department of Rheumatology, Sygehus Lillebaelt, Vejle, Denmark, ⁶Department of Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁷Dep. of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ⁸Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ⁹King Christian 10th Rheumatism Hospital at Gråsten, Graasten, Denmark, ¹⁰Dep of Rheumatology, Hørsholm Hospital, Hørsholm, Denmark, ¹¹Department of Rheumatology, Slagelse Hospital, Slagelse, Denmark, ¹²Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: Few studies have investigated changes in plasma sclerostin and Dickkopf1 (DKK-1) in relation to other biomarkers of inflammation, cartilage and bone turnover during treatment…
Abstract Number: 581 • 2012 ACR/ARHP Annual Meeting
Examining a Role for Th17 Regulation and Toll-Like Receptor Signaling in Psoriatic Arthritis
Fatima Abji¹, Remy Pollock², Fawnda Pellett³, Vinod Chandran⁴ and Dafna D. Gladman², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a seronegative inflammatory arthritis that develops in 30% of patients with cutaneous psoriasis (PsC). Joint inflammation in PsA is mediated…
Abstract Number: 582 • 2012 ACR/ARHP Annual Meeting
Proteomic Analysis of Synovial Tissue: A Unique Tool to Predict Response to Anti-TNF Alpha Therapy in Patients with Inflammatory Arthritis
Opeyemi S. Ademowo¹, Emily S. Collins¹, Cathy Rooney¹, A. W van Kuijk², Danielle M. Gerlag³, Paul P. Tak², Oliver FitzGerald⁴ and Stephen R. Pennington¹, ¹UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland, ²Clinical Immunology / Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Inflammatory arthritis, which includes rheumatoid arthritis (RA) and psoriatic arthritis (PsA), is a leading cause of joint deformity, disability and reduced quality of life…
Abstract Number: 583 • 2012 ACR/ARHP Annual Meeting
Familial Aggregation and Heritability of Ankylosing Spondylitis in Taiwan: A Nationwide Population Study
Chang-Fu Kuo¹, Matthew J. Grainge², Lai-Chu See³, Kuang-Hui Yu⁴, Shue-Fen Luo⁴, Ana M. Valdes⁵, I-Jun Chou⁶, Weiya Zhang¹ and Michael Doherty⁷, ¹Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ²Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, ³Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Division of Rheumatology, Immunology and Allergy, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁵Dept of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London, London, United Kingdom, ⁶Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁷Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
Background/Purpose: To estimate the risk of ankylosing spondylitis (AS) among individuals with affected first-degree relatives and to assess the magnitude of genetic contribution to the…
Abstract Number: 584 • 2012 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and â1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seung Cheol Shim¹, Donghyuk Sheen², Mi Kyoung Lim¹ and Hyo Park¹, ¹Medicine, Eulji University Hospital, Daejeon, South Korea, ²Rheumatology, Eulji University Hospital, Daejeon, South Korea
Background/Purpose: Genetic factors provide over 90% of the susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The etiology…
Abstract Number: 585 • 2012 ACR/ARHP Annual Meeting
Relative Overexpression of Membrane-Bound Versus Soluble TNF in Human and Experimental Spondyloarthritis
Carmen Ambarus¹, Leonie M. van Duivenvoorde¹, Huriatul Masdar¹, Melissa N. van Tok², Paul P. Tak¹, Nataliya Yeremenko³ and Dominique L. Baeten³, ¹Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Macrophages and their pro-inflammatory cytokines, including TNF, are pivotal mediators of chronic synovitis in rheumatoid arthritis (RA) as well as spondyloarthritis (SpA). Despite similar…
Abstract Number: 586 • 2012 ACR/ARHP Annual Meeting
High Prevalence of Anti-CD-74 Antibodies with Specificity for the Class II-Associated Invariant Chain Peptide in Patients with Axial Spondyloarthritis but Not in Controls
Xenofon Baraliakos¹, Niklas T. Baerlecken², Frank Heldmann³, Torsten Witte⁴ and Jürgen Braun³, ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Clinical Immunology and Rheumatology, Medical University Hannover, Hannover, Germany, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany
Background/Purpose: The pathogenesis of axial spondyloarthritis (axSpA) is still unclear. Based on the strong association with HLA-B27 and ERAP-1, T cells are believed to play…
Abstract Number: 587 • 2012 ACR/ARHP Annual Meeting
Brain MRI and Psychophysics Analysis Demonstrate Neuropathic Pain to Be a Component of Back Pain in Ankylosing Spondylitis
Q. Wu¹, Robert D. Inman² and Karen Davis³, ¹Research, Toronto Western Research Institute, Toronto, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ³Department of Surgery, Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: The mechanisms underlying pain in ankylosing spondylitis (AS) are unclear. The aim of this study was to investigate whether there is a neuropathic component…
Abstract Number: 588 • 2012 ACR/ARHP Annual Meeting
Discovery of Two Public T Cell Receptor Clonotypes in B27+ Ankylosing Spondylitis by Deep Repertoire Sequence Analysis
Malek Faham¹, Victoria Carlton² and Robert D. Inman³, ¹Research, Sequenta, Inc., South San Francisco, CA, ²Sequenta, Inc., South San Francisco, CA, ³Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: The strong association of AS with HLA-B27 implicates a T cell response restricted by this Class I MHC molecule, predicting that specific T Cell…
Abstract Number: 589 • 2012 ACR/ARHP Annual Meeting
NGF and Trka: A Novel Therapeutic Target in Chronic Inflammation
Siba P. Raychaudhuri¹, Ananya Datta Mitra² and Smriti K. Raychaudhuri², ¹Rheumatology, VA Sacramento Medical Center/UC Davis School of Medicine, Mather, CA, ²Rheumatology, VA Sacramento Medical Center, Mather, CA
Background/Purpose: Outside the nervous system, several studies have established the regulatory role of nerve growth factor (NGF) and its high affinity receptor, TrkA. A clinical…
Abstract Number: 590 • 2012 ACR/ARHP Annual Meeting
The Association Between KIR3DL1 Alleles and Psoriatic Arthritis
Remy Pollock¹, Jeffrey Berinstein², Arane Thavaneswaran², Fawnda Pellett³, Dafna D. Gladman⁴ and Vinod Chandran⁵, ¹Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁵Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Killer-cell immunoglobulin-like receptors (KIRs) are activating and inhibitory receptors that regulate NK and NK-T cells, which have been found in psoriatic plaques and synovial…
Abstract Number: 551 • 2012 ACR/ARHP Annual Meeting
Prevalence of Enthesitis in Psoriatic Patients: Agreement Between Clinical and Power Doppler Ultrasonography Exploration and Its Implications for the Classification of Psoriatic Arthritis
Jose Luis Fernandez-Sueiro¹, JA Pinto¹, S. Pertega-Diaz² and Carlos Fernandez-Lopez³, ¹Rheumatology Division, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, ²Epidemiology and Statistics, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, ³INIBIC- Complejo Hospitalario Universitario La Coruña(CHUAC). Rheumatology Division., La Coruña, Spain
Background/Purpose: Enthesitis constitutes one of the CASPAR stem criteria for the classification of psoriasis arthritis, however as enthesitis may be clinically silent many psoriatic patients…
Abstract Number: 552 • 2012 ACR/ARHP Annual Meeting
Simple Questions in the Dermatology Office May Reasonably Exclude, but Do Not Reliably Identify Psoriatic Arthritis Patients: Results From the Center of Excellence for Psoriasis and Psoriatic Arthritis
Neha Garg¹, Atul A. Deodhar², Benjamin Ehst³, Andrew Blauvelt⁴, Jennifer Ku⁵ and Brian Truong⁴, ¹Internal Medicine, Division of arthritis and rheumatic diseases, Oregon Health and Sciences University, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Dermatology, Oregon Health and Sciences University, Portland, OR, ⁴Oregon Health and Sciences University, Portland, OR, ⁵Arthritis and Rheumatic Diseases, Oregon Health and Science University, Portland, OR
Background/Purpose: Psoriatic arthritis (PsA) affects between 10-30% of patients with psoriasis (PsO), but is often missed when assessed in a dermatology clinic. The Center of…
Abstract Number: 553 • 2012 ACR/ARHP Annual Meeting
Identification of Axial Spondyloarthritis Among Patients with Chronic Back Pain in Primary Care – How Does Determination of HLA B27 Influence the Performance of Clinical Assessments of Inflammatory Back Pain?
Annalina Braun¹, Holger Gnann², Ertan Saracbasi¹, Joachim Grifka³, Uta Kiltz¹, Jürgen Braun⁴, Katrin Letschert⁵ and Jürgen Braun⁴, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Abteilung Biostatistik, GKM Gesellschaft für Therapieforschung mbH, München, Germany, ³Orthopedic Surgery, University of Regensburg, Bad Abbach, Germany, ⁴Institut für angewandte Statistik Dr. Jörg Schnitker GmbH, Bielefeld, Germany, ⁵Abbott Inc., Wiesbaden, Germany
Background/Purpose: The value of a combination of items defining inflammatory back pain (IBP) to screen for axial spondyloarthritis (axSpA) in primary care has recently been…
Abstract Number: 554 • 2012 ACR/ARHP Annual Meeting
A Reduction in Ultrasound Synovitis Score Discriminates Between Clinical Responders and Non-Responders and Is Predictive for a Favourable Clinical Outcome in Early Psoriartic Arthritis
Axel P. Nigg¹, Anna M. Malchus¹, Joerg C. Prinz², Mathias Gruenke³ and Hendrik Schulze-Koops⁴, ¹Division of Rheumatology, Medizinische Klinik IV, University of Munich, Munich, Germany, ²Psoriasis Center, Department of Dermatology, University of Munich, Munich, Germany, ³Division of Rheumatoloy, Medizinische Klinik IV, University of Munich, Munich, Germany, ⁴Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Accurate monitoring of disease activity in early PsA is limited by the potential underestimation of inflammation by clinical examination, the absence of disease-specific biochemical…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].