Abstracts Archive - Page 2382 of 2425 - ACR Meeting Abstracts

Abstract Number: 605 • 2012 ACR/ARHP Annual Meeting
Increased Incidence of Herpes Zoster Among Patients with Systemic Lupus Erythematosus
Eliza F. Chakarvarty¹, Kaleb Michaud², Robert S. Katz³ and Frederick Wolfe⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, ²Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE, ³Rush University Medical Center, Chicago, IL, ⁴National Data Bank for Rheumatic Diseases, Wichita, KS
Background/Purpose: Herpes zoster (HZ) is the painful reactivation of latent varicella zoster virus infection. The incidence of HZ may be increased in some autoimmune…
Abstract Number: 606 • 2012 ACR/ARHP Annual Meeting
Risk Factors Associated with Cervical Human Papillomavirus Infection in Women with Systemic Lupus Erythematosus: The Role of Rituximab
Mario Garcia-Carrasco¹, Claudia Mendoza Pinto¹, Alejandro Taboada-Cole¹, Verónica Vallejo-Ruiz², Julio Reyes-Leyva² and Aurelio Lopez-Colombo³, ¹Systemic Autoimmune Disease, HGR 36 CMN Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico, ²Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Hospital General de Zona No. 5, Puebla, Mexico, ³Research Departament, Delegación Estatal, Instituto Mexicano del Seguro Social, Puebla, Mexico
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, autoimmune, multisystemic disease that affects women of reproductive age. Women with SLE have an increased risk of…
Abstract Number: 607 • 2012 ACR/ARHP Annual Meeting
Activity Index After Renal Failure in a Cohort of 32 Patients with Lupus Nephritis
Cristina Gonzalez-Pulido¹, Sara Croca² and D.A. Isenberg³, ¹Internal Medicine, University Hospital Virgen del Rocio, Seville, Spain, ²Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ³Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose: Most published studies that have measured activity in patients with lupus nephritis suggest the disease is relatively quiescent after renal failure. Purpose: To analyze…
Abstract Number: 608 • 2012 ACR/ARHP Annual Meeting
Association of Discoid Lupus with Other Clinical Manifestations Among Patients with Systemic Lupus Erythematosus
Joseph F. Merola¹, Christina Iversen², Jose A. Gomez-Puerta², Tabatha Norton², Hsun Tsao², Peter H. Schur², Elena M. Massarotti², Bonnie L. Bermas³ and Karen H. Costenbader², ¹Rheumatology, Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Prior studies suggest that cutaneous discoid lupus (DLE) is a marker for less severe disease with a low frequency of nephritis and end-stage renal…
Abstract Number: 609 • 2012 ACR/ARHP Annual Meeting
Peripheral Neuropathy in Systemic Lupus Erythematosus
Amin Oomatia¹, Hong Fang², Michelle Petri² and Julius Birnbaum³, ¹School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Whilst Neurological disorders are a common manifestation of systemic lupus erythematosus (SLE), peripheral neuropathies have received little attention. The literature consists mostly of small…
Abstract Number: 610 • 2012 ACR/ARHP Annual Meeting
B Lymphocyte Stimulator Levels Are Higher in Caucasian SLE Patients Earlier in Disease Course and Predict Damage Accumulation
Eoghan M. McCarthy¹, Ruth Lee¹, Joan Ni Gabhann², Siobhan Smith², Michele Doran³, Gaye Cunnane³, Donough G. Howard¹, Paul G. O'Connell⁴, Grainne M. Kearns⁵ and Caroline Jefferies², ¹Rheumatology, Beaumont Hospital, Dublin 9, Ireland, ²Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ³Dept of Rheumatology, St. James Hospital, Dublin, Ireland, ⁴Department of Rheumatology, Beaumont Hospital, Dublin 9, Ireland, ⁵Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: B Lymphocyte Stimulator(BLyS) plays an important role in the pathogenesis of Systemic Lupus Erythematosus(SLE). Whilst trials of anti BLyS-targeted therapy have shown promise, the optimal…
Abstract Number: 571 • 2012 ACR/ARHP Annual Meeting
Description of Distribution of Active Inflammatory Lesions On Magnetic Resonance Imaging of the Sacroiliac Joints and the Spine in Patients with Early Axial Spondyloarthritis – Analysis of the Esther Trial Baseline Data
In-Ho Song¹, Christian Althoff², Hildrun Haibel¹, Joachim Listing³, Anja Weiß⁴, Bruce Freundlich⁵, Martin Rudwaleit⁶ and Joachim Sieper⁷, ¹Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ²Radiology, Charite Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ³German Rheumatism Research Center, Berlin, Germany, ⁴German Rheumatism Research Centre, Berlin, Germany, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Endokrinologikum Berlin, Berlin, Germany, ⁷Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: To address the question whether active inflammation starts at specific sites of the sacroiliac joints (SI-joints) and/ or the spine. Methods: Wb-MRIs of…
Abstract Number: 572 • 2012 ACR/ARHP Annual Meeting
Radiographic Damage in Ankylosing Spondylitis Over 12 Years of Follow-up: A Longitudinal Analysis
Sofia Ramiro¹, Carmen Stolwijk², A.M. Van Tubergen³, Désirée van der Heijde⁴ and Robert Landewé⁵, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam and Atrium Medical Center, Heerlen, Netherlands
Background/Purpose: Radiographic damage is one of the core outcomes recommended by the Assessment in Spondyloarthritis international Society (ASAS) for follow-up of patients with axial SpA.…
Abstract Number: 573 • 2012 ACR/ARHP Annual Meeting
Differential Association Between Human Leukocyte Antigen (HLA) Alleles and Joint Subluxation and Ankylosis in Patients with Psoriatic Arthritis
Vinod Chandran¹, Arane Thavaneswaran², Amir Haddad², Fawnda Pellett³ and Dafna D. Gladman⁴, ¹Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously reported the association between HLA and KIR gene variants with the development of Arthritis Mutilans (AM) in psoriatic arthritis (PsA). However,…
Abstract Number: 574 • 2012 ACR/ARHP Annual Meeting
Long Term Inhibition of Interleukin (IL)-17A with Secukinumab Improves Clinical Symptoms and Reduces Spinal Inflammation As Assessed by Magnetic Resonance Imaging in Patients with Ankylosing Spondylitis
Xenofon Baraliakos¹, Jürgen Braun², D. D. Laurent³, Dominique L. Baeten⁴, D. van der Heijde⁵, Joachim Sieper⁶, Paul Emery⁷, Iain B. McInnes⁸, Jacob M. van Laar⁹, R. Landewe¹⁰, Paul Wordsworth¹¹, Jurgen Wollenhaupt¹², Herbert Kellner¹³, Andrew Wright³, Francois Vandenhende¹⁴, Kath Radford¹⁵, Babul Borah¹⁵ and Hueber Wolfgang¹⁵, ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Novartis Pharma AG, Basel, Switzerland, ⁴Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Charitè Berlin, Campus Benjamin Franklin, Berlin, Germany, ⁷Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁸Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁹Newcastle University, Newcastle upon Tyne, United Kingdom, ¹⁰Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ¹¹Nuffield Orthopaedic Centre, Oxford, United Kingdom, ¹²Division of Reheumatology, Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ¹³Centre for Inflammatory Joint Diseases, Munich, Germany, Munich, Germany, ¹⁴Clinbay, Genappe, Belgium, Genappe, Belgium, ¹⁵Novartis Institutes for BioMedical Research, Basel, Switzerland
Background/Purpose: In a recent proof-of-concept (PoC) trial it was shown that secukinumab, a fully human IgG1k anti-IL17A monoclonal antibody, significantly improved clinical signs and symptoms…
Abstract Number: 575 • 2012 ACR/ARHP Annual Meeting
Profiling of Response to Anti-TNFα Therapy by Serum Markers of Tissue Degradation End Products in Ankylosing Spondylitis Patients
Anne Sofie Siebuhr¹, Anne C. Bay-Jensen², Morten Asser Karsdal³, Efstathios Vassiliadis⁴, Stephanie Wichuk⁵, Claus Christiansen⁶ and Walter P. Maksymowych⁷, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience A/S, Herlev, Denmark, ⁴Nordic Bioscience, Herlev, Denmark, ⁵Medicine, University of Alberta, Edmonton, AB, Canada, ⁶CCBR, Ballerup, Denmark, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Chronic inflammatory diseases such as Ankylosing Spondylitis (AS) are diverse and therefore hard to clearly diagnose and treat. Conventional biomarkers for AS, as CRP…
Abstract Number: 576 • 2012 ACR/ARHP Annual Meeting
Reference Intervals of Spinal Mobility Measures in Normal Individuals – the Mobility Study
Sofia Ramiro¹, Carmen Stolwijk², A.M. Van Tubergen³, Patrick Royston⁴, Désirée van der Heijde⁵ and Robert Landewé⁶, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴MRC Clinical Trials Unit, University College of London, London, United Kingdom, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam and Atrium Medical Center, Heerlen, Netherlands
Background/Purpose: Spinal mobility is frequently assessed in the follow-up of patients with axial SpA, which is also in accordance with the recommendations by the Assessment…
Abstract Number: 577 • 2012 ACR/ARHP Annual Meeting
MRI of the Spine for Detection of Bone Spurs and Ankylosis in Patients with Ankylosing Spondylitis: Does MRI Offer Any Advantages Over Radiography?
Susanne Juhl Pedersen¹, Mikkel Østergaard², Robert GW Lambert³ and Walter P. Maksymowych⁴, ¹Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ²Department of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The current gold standard for detection of disease progression in ankylosing spondylitis (AS) is conventional radiography. The most reliable method mSASSS includes the anterior…
Abstract Number: 578 • 2012 ACR/ARHP Annual Meeting
Assessment of the Link Between Inflammation and Fat Metaplasia in Patients with Spondyloarthritis On Non-Biological Therapy: A Long Term Magnetic Resonance Imaging Study
Zheng Zhao¹, Susanne Juhl Pedersen², Robert GW Lambert³, Stephanie Wichuk⁴, Mikkel Ostergaard⁵ and Walter P. Maksymowych⁶, ¹Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ²Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, ⁶Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: There is growing awareness of the importance of fat metaplasia in the pathogenesis of SpA and its potential link with inflammation and new bone…
Abstract Number: 579 • 2012 ACR/ARHP Annual Meeting
Prevalence of Psoriatic Arthritis in Psoriasis Patients According to Newer Classification Criteria
Hernan Maldonado-Ficco¹, Gustavo Citera¹, Ana Alba Porrini² and Jose A. Maldonado-Cocco¹, ¹Rheumatology, Instituto de Rehabilitacion Psicofisica - Fundacion Reumatologica Argentina Dr. Osvaldo Garcia-Morteo, Buenos Aires, Argentina, ²Rheumatology, Hospital Argerich, Buenos Aires, Argentina
Background/Purpose: To determine the prevalence of Psoriatic Arthritis (PsA) in a cohort of psoriasis patients according to CASPAR criteria, and compare it with that resulting from…

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