Abstract Number: 585 • 2012 ACR/ARHP Annual Meeting
Relative Overexpression of Membrane-Bound Versus Soluble TNF in Human and Experimental Spondyloarthritis
Background/Purpose: Macrophages and their pro-inflammatory cytokines, including TNF, are pivotal mediators of chronic synovitis in rheumatoid arthritis (RA) as well as spondyloarthritis (SpA). Despite similar…Abstract Number: 586 • 2012 ACR/ARHP Annual Meeting
High Prevalence of Anti-CD-74 Antibodies with Specificity for the Class II-Associated Invariant Chain Peptide in Patients with Axial Spondyloarthritis but Not in Controls
Background/Purpose: The pathogenesis of axial spondyloarthritis (axSpA) is still unclear. Based on the strong association with HLA-B27 and ERAP-1, T cells are believed to play…Abstract Number: 587 • 2012 ACR/ARHP Annual Meeting
Brain MRI and Psychophysics Analysis Demonstrate Neuropathic Pain to Be a Component of Back Pain in Ankylosing Spondylitis
Background/Purpose: The mechanisms underlying pain in ankylosing spondylitis (AS) are unclear. The aim of this study was to investigate whether there is a neuropathic component…Abstract Number: 588 • 2012 ACR/ARHP Annual Meeting
Discovery of Two Public T Cell Receptor Clonotypes in B27+ Ankylosing Spondylitis by Deep Repertoire Sequence Analysis
Background/Purpose: The strong association of AS with HLA-B27 implicates a T cell response restricted by this Class I MHC molecule, predicting that specific T Cell…Abstract Number: 589 • 2012 ACR/ARHP Annual Meeting
NGF and Trka: A Novel Therapeutic Target in Chronic Inflammation
Background/Purpose: Outside the nervous system, several studies have established the regulatory role of nerve growth factor (NGF) and its high affinity receptor, TrkA. A clinical…Abstract Number: 590 • 2012 ACR/ARHP Annual Meeting
The Association Between KIR3DL1 Alleles and Psoriatic Arthritis
Background/Purpose: Killer-cell immunoglobulin-like receptors (KIRs) are activating and inhibitory receptors that regulate NK and NK-T cells, which have been found in psoriatic plaques and synovial…Abstract Number: 551 • 2012 ACR/ARHP Annual Meeting
Prevalence of Enthesitis in Psoriatic Patients: Agreement Between Clinical and Power Doppler Ultrasonography Exploration and Its Implications for the Classification of Psoriatic Arthritis
Background/Purpose: Enthesitis constitutes one of the CASPAR stem criteria for the classification of psoriasis arthritis, however as enthesitis may be clinically silent many psoriatic patients…Abstract Number: 552 • 2012 ACR/ARHP Annual Meeting
Simple Questions in the Dermatology Office May Reasonably Exclude, but Do Not Reliably Identify Psoriatic Arthritis Patients: Results From the Center of Excellence for Psoriasis and Psoriatic Arthritis
Background/Purpose: Psoriatic arthritis (PsA) affects between 10-30% of patients with psoriasis (PsO), but is often missed when assessed in a dermatology clinic. The Center of…Abstract Number: 553 • 2012 ACR/ARHP Annual Meeting
Identification of Axial Spondyloarthritis Among Patients with Chronic Back Pain in Primary Care – How Does Determination of HLA B27 Influence the Performance of Clinical Assessments of Inflammatory Back Pain?
Background/Purpose: The value of a combination of items defining inflammatory back pain (IBP) to screen for axial spondyloarthritis (axSpA) in primary care has recently been…Abstract Number: 554 • 2012 ACR/ARHP Annual Meeting
A Reduction in Ultrasound Synovitis Score Discriminates Between Clinical Responders and Non-Responders and Is Predictive for a Favourable Clinical Outcome in Early Psoriartic Arthritis
Background/Purpose: Accurate monitoring of disease activity in early PsA is limited by the potential underestimation of inflammation by clinical examination, the absence of disease-specific biochemical…Abstract Number: 555 • 2012 ACR/ARHP Annual Meeting
Performances of the ASAS Axial Spondyloarthritis Criteria for Diagnosis and Classification Purposes in Patients Visiting a Rheumatologist Because of Chronic Back Pain: The Declic Study
Background/Purpose: To evaluate the performances at diagnosis (sensitivity [Se], specificity [Spe], positive and negative predictive values) and study visit (classification purpose) of the ASAS criteria…Abstract Number: 556 • 2012 ACR/ARHP Annual Meeting
Eos Imaging Could Replace Conventional Computed Radiography for Ankylosis Assessment in Axial Spondyloarthritis
Background/Purpose: EOS® is a new osteoarticular imaging modality with significantly lower radiation than conventional computed radiography (CR). However, the diagnostic performance of this 2D biplanar…Abstract Number: 557 • 2012 ACR/ARHP Annual Meeting
Effect of Certolizumab Pegol On the Multiple Facets of Psoriatic Arthritis As Reported by Patients: 24 Week Patient Reported Outcome Results of a Phase 3 Double Blind Randomized Placebo-Controlled Study
Background/Purpose: RAPID-PsA (NCT01087788) reports efficacy and safety of certolizumab pegol (CZP), a PEGylated Fc-free anti-TNF, in psoriatic arthritis (PsA).1 The effect of different imputation methodologies…Abstract Number: 558 • 2012 ACR/ARHP Annual Meeting
Rapid Improvements in Patient Reported Outcomes with Certolizumab Pegol in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis: 24 Week Results of a Phase 3 Double Blind Randomized Placebo-Controlled Study
Background/Purpose: Axial spondyloarthritis (axSpA) is a form of spondyloarthritis (SpA) that includes both ankylosing spondylitis (AS) and non-radiographic axial SpA (nr-axSpA), as defined by the…Abstract Number: 559 • 2012 ACR/ARHP Annual Meeting
Utility of Dual-Energy X-Ray absorptiometry Scanning and Risk of Osteoporosis in Ankylosing Spondylitis; A Prospective Study
Background/Purpose: Conventional DXA imaging of spine and hip to measure bone mineral density (BMD) has limitations in patients with ankylosying spondylitis (AS) as their spinal…