Abstracts Archive - Page 2381 of 2425 - ACR Meeting Abstracts

Abstract Number: 630 • 2012 ACR/ARHP Annual Meeting
Risk Factors Associated with Early Central Nervous System Damage Detected Through Diffusion Tensor Imaging (DTI) in Patients with Systemic Lupus Erythematosus
Paola Tomietto¹, Federica Casagrande², Maja Ukmar³, Luca Weis⁴, Pia Morassi⁵, Rita Moretti⁶, Gianni Biolo⁶, Carlo Giansante⁷ and Maria Assunta Cova⁸, ¹Internal Medicine Department, AOU Ospedali Riuniti, Trieste, Italy, ²Radiology department, University of Trieste, Trieste, Italy, ³Radiology Department, University of Trieste, Trieste, ⁴Radiology Department, University of Trieste, Trieste, Italy, ⁵Internal Medicine Department, AOU Ospedali Riuniti di Trieste, Trieste, Italy, ⁶Internal Medicine Department, University of Trieste, Trieste, Italy, ⁷Internal Medicine epartment, University of Trieste, Trieste, Italy, ⁸Department of Radiology, University of Trieste, Trieste, Italy
Background/Purpose: Antiphosholipid antibodies, SLICC-DI and some cardiovascular risk factors have been identified as risk factors for neuropsychiatric lupus (NPSLE). Diffusion tensor imaging (DTI) is an…
Abstract Number: 591 • 2012 ACR/ARHP Annual Meeting
Structural Progression of Ankylosing Spondylitis Associated with Elevation in Two NOVEL, Inflammatory Biomarkers; Matrix Metalloproteinase and Cathepsin-Derived
Anne C. Bay-Jensen¹, Morten Asser Karsdal², Stephanie Wichuk³, Zheng Zhao⁴, Robert GW Lambert⁵, Per Qvist⁶ and Walter P. Maksymowych⁷, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience A/S, Herlev, Denmark, ³Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ⁵Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Current inflammatory biomarkers, such as CRP, have insufficient sensitivity and specificity to be broadly accepted for diagnosis and prognosis of AS. We hypothesized, that…
Abstract Number: 592 • 2012 ACR/ARHP Annual Meeting
Two Novel Diagnostic Biomarkers of Cartilage Degradation and Connective Tissue Inflammation Are Predictive of Disease Progression in Ankylosing Spondylitis
Anne C. Bay-Jensen¹, Stephanie Wichuk², Inger Byrjalsen³, Zheng Zhao⁴, Robert GW Lambert⁵, Morten Asser Karsdal⁶ and Walter P. Maksymowych⁷, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³Research & Development, Nordic Bioscience, Herlev, Denmark, ⁴Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ⁵Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Nordic Bioscience A/S, Herlev, Denmark, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Cartilage degradation and inflammation of synovial and connective tissue are key events in inflammatory arthropathies such as SpA. Presently there are no prognostic tools…
Abstract Number: 593 • 2012 ACR/ARHP Annual Meeting
DKK1 Serum Level Is Increased in Recent Spondyloarthritis and Is Associated with Higher Prevalence of Syndesmophytes. Sclerostin Is Highly Correlated with Age. Data From the DESIR Cohort
Gaetane Nocturne¹, Stephan Pavy², Désirée van der Heijde³, Philipe M. Goupille⁴, Maxime Dougados⁵, Christian Roux⁶, Xavier Mariette⁷ and Corinne Miceli-Richard², ¹INSERM U1012, Université Paris Sud, Le Kremlin Bicêtre, France, ²Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Hopital Trousseau, Tours, France, ⁵Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, ⁶Paris Descartes University, Paris, France, ⁷Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France
Background/Purpose: Dickkopf-1 (DKK-1) and sclerostin (SOST) are 2 inhibitory proteins of the Wnt signalling pathway that could rationally be involved either in AS osteoporosis or…
Abstract Number: 594 • 2012 ACR/ARHP Annual Meeting
Evidence of Human Leucozyte Antigen-B27 in Healthy Individuals and Patients with Uveitis Is a Risk Factor for Alterations in Bone Metabolism
Sarah Schmidt¹, Stephanie Finzel¹, Jürgen Rech², Matthias Englbrecht¹, Silke Winkler¹, Isabel Schmidt¹, Roula Said-Nahal³, Maxime A. Breban³ and Georg A. Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medizinische Klinik 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: To test whether positivity for HLA-B27 per se is associated with changes of biomarkers of the Wnt pathway. HLA-B27 is strongly associated with the…
Abstract Number: 595 • 2012 ACR/ARHP Annual Meeting
A Genomewide Association Study of Anterior Uveiti
Dorith Claushuis¹, Adrian Cortes², Linda A. Bradbury¹, Tammy M. Martin³, James T. Rosenbaum⁴, John D. Reveille⁵, Paul Wordsworth⁶, Jennifer Pointon⁶, Australo-Anglo-American Spondyloarthritis Consortium⁷, David Evans⁸, Paul Leo², Pamela Mukhopadhyay² and Matthew A. Brown², ¹Human Genetics Group, The University of Queensland Diamantina Institute, Brisbane, Australia, ²Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ³Ophthalmology/L467AD, Oregon Health & Science Univ, Portland, OR, ⁴Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁶Ndorms, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁷Houston, TX, ⁸School of Social and Community Medicine, Bristol University, Bristol, United Kingdom
Background/Purpose: Anterior uveitis (AU) is the most common extra-articular manifestation of ankylosing spondylitis (AS), occurring in up to 30-40% of AS cases. The aim of…
Abstract Number: 596 • 2012 ACR/ARHP Annual Meeting
Evolution of Atherosclerosis in Psoriatic Arthritis: Is the Former an Independent Inflammatory Process?
Roberta Ramonda¹, Massimo Puato², Valentina Modesti³, Mariagrazia Lorenzin⁴, Paola Frallonardo⁴, Augusta Ortolan⁴, Carla Campana³, Alessandro Lo Nigro³ and Leonardo Punzi⁵, ¹Rheumatology Unit, University of Padova, Padova, Italy, ²Department of Internal Medicine, University of Padova, Padova, Italy, ³Unit of Rheumatology, University of Padova, Padova, Italy, ⁴Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁵Clinical and Experimental Medicine, Rheumatology Unit - University of Padova, Padova, Italy
Background/Purpose: A non-invasive study focusing on the structural and functional properties of the carotid arteries was carried out in psoriatic arthritis (PsA) patients. Increased cardiovascular…
Abstract Number: 597 • 2012 ACR/ARHP Annual Meeting
Investigating the Genetic Association Between ERAP1 and Spondyloarthritis
Amir Kadi¹, Brigitte Izac², Roula Said-Nahal³, Ariane Leboime⁴, Kurt L. de Vlam⁵, Dirk Elewaut⁶, Gilles Chiocchia² and Maxime A. Breban³, ¹Institut Cochin - Université Paris Descartes - INSERM U1016 - CNRS (UMR 8104), Paris, France, ²Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ³Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁴Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁵Rheumatology, University Hospitals Leuven, Leuven, Belgium, ⁶Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose: A robust association was recently identified between polymorphisms in the non-major histocompatibility complex gene ERAP1 and ankylosing spondylitis (AS) in several populations. The aim…
Abstract Number: 598 • 2012 ACR/ARHP Annual Meeting
The Non-Synonymous Polymorphism IL23R Arg381Gln Is Associated with Ankylosis in Spondyloarthritis
Amir Kadi¹, Félicie Costantino², Brigitte Izac³, Ariane Leboime⁴, Roula Said-Nahal⁵, Gilles Chiocchia³ and Maxime A. Breban⁵, ¹Institut Cochin - Université Paris Descartes - INSERM U1016 - CNRS (UMR 8104), Paris, France, ²INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ³Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁴Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁵Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: Spondyloarthritis (SpA) is a group of articular disorders sharing genetic background. Single-nucleotide polymorphisms (SNP) of the interleukin 23 receptor (IL23R) gene have been reproducibly…
Abstract Number: 599 • 2012 ACR/ARHP Annual Meeting
LIGHT (TNFSF14), Cathepsin K, DKK-1 and Sclerostin in Ankylosing Spondylitis: Osteoclast/OSTEOBLAST Imbalance Unrelated to Disease Activity and Effect of ANTI-TNFα Treatment On the WNT/β Catenin Pathway
Alberto Cauli¹, Grazia Dessole¹, Giovanni Porru¹, Matteo Piga¹, Alessandra Vacca², Valentina Ibba¹, Pietro Garau¹ and Alessandro Mathieu¹, ¹Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, ²Rheumatology Unit - Medical Sciences, University of Cagliari, Cagliari, Italy
Background/Purpose: Ankylosing Spondylitis (AS) is an inflammatory arthritis characterized by erosions and new bone formation. These processes appear to be related by the fine balance…
Abstract Number: 600 • 2012 ACR/ARHP Annual Meeting
Regulatory T Cells in Spondyloarthritis (SpA) Animal Model and Modulatory Role of Inducible Costimulator (ICOS)
Luiza Krause¹, Ingrid Fert¹, Karine Labroquère², Muriel Andrieu², Gilles Chiocchia³ and Maxime A. Breban⁴, ¹Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104)-Université Paris Descartes (UMR-S 1016), Paris, France, ²Cochin Immunobiology Facility, Paris, France, ³Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France, ⁴Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: HLA-B27/human β2m transgenic rats (B27-rats), a model of SpA develop spontaneous colitis and arthritis. It was recently shown in this model that IL-17 producing…
Abstract Number: 601 • 2012 ACR/ARHP Annual Meeting
Bath Ankylosing Spondylitis Functional Index (BASFI) Is a Better Indicator of Poor Quality of Life Than Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in Ankylosing Spondylitis: Results From SIRAS – the Scotland and Ireland Registry for Ankylosing Spondylitis
Gareth T. Jones¹, Linda E. Morton¹, Gary J. Macfarlane¹ and Scotland and Ireland Registry for Ankylosing Spondylitis², ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²Aberdeen
Background/Purpose: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Functional Index (BASFI) are validated instruments used to determine disease activity and function amongst ankylosing spondylitis…
Abstract Number: 602 • 2012 ACR/ARHP Annual Meeting
Sexual and Reproductive Health Counseling Among Adolescents with Systemic Lupus Erythematosus
Xue Tian¹, Murray H. Passo², Janice D. Key³, Thomas C. Hulsey⁴ and Natasha M. Ruth¹, ¹Pediatric Rheumatology, The Medical University of South Carolina, Charleston, SC, ²Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ³Adolescent Medicine, The Medical University of South Carolina, Charleston, SC, ⁴Pediatrics, The Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that is known to target young adults, especially women of child-bearing age. Although it is well-accepted…
Abstract Number: 603 • 2012 ACR/ARHP Annual Meeting
Cell Bound Complement Activation Products Are Associated with Disease Activity in Systemic Lupus Erythematosus
Kenneth C. Kalunian¹, W. Winn Chatham², Elena M. Massarotti³, Joyce Reyes-Thomas⁴, Richard Furie⁵, Jill P. Buyon⁶, Emily C. Somers⁷, Chaim Putterman⁸, Rachel L. Gross⁹, Kyriakos A. Kirou¹⁰, Rosalind Ramsey-Goldman¹¹, Christine Hsieh¹², Thierry Dervieux¹³ and A. Weinstein¹⁴, ¹UCSD School of Medicine, La Jolla, CA, ²University of Alabama at Birmingham, Birmingham, AL, ³Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Rheum/Forchheimer Rm 701, Albert Einstein College of Med, Bronx, NY, ⁵North Shore-LIJ Health System, Lake Success, NY, ⁶Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁷IntMed, Environmental Health, and OB/GYN, University of Michigan, Ann Arbor, MI, ⁸Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁹Rheumatology, Albert Einstein College of Medicine, New York, NY, ¹⁰Hospital for Special Surgery, New York, NY, ¹¹Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹²Rheumatology, University of Chicago, Chicago, IL, ¹³Research and Development, Exagen Diagnostics, Albuquerque, NM, ¹⁴Washington Hospital Center, Washington, DC
Background/Purpose: Elevated cell-bound complement activation products (CBCAPs) and decreased erythrocyte complement receptor 1 (ECR1) expression may correlate with disease activity in systemic lupus erythematosus (SLE).…
Abstract Number: 604 • 2012 ACR/ARHP Annual Meeting
Comparing the ACR and the SLICC Criteria for the Classification of SLE Patients Using Data from an Existing Multi-Ethnic Cohort
Graciela S. Alarcon¹, Gerald McGwin Jr.², Larry Madger³ and Michelle Petri⁴, ¹Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Maryland, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The SLICC group has proposed a modification of the revised/updated SLE ACR classification criteria; it has comparable metric properties but is felt to be…

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