Abstracts Archive - Page 2381 of 2607 - ACR Meeting Abstracts

Abstract Number: 753 • 2013 ACR/ARHP Annual Meeting
Validation Of The New Histopathological Classification Of ANCA Glomerulonephritis and Its Association With Renal Outcomes In a Paediatric Population
Marinka Twilt¹, Damien Noone², Wesley Hayes², Paul Thorner³, Susanne M. Benseler⁴, Ronald M. Laxer⁴, Rulan Parekh² and Diane Hebert², ¹Pediatric Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Nephrology, The Hospital for Sick Children, Toronto, ON, Canada, ³Pathology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Anti-Neutrophil Cytoplasmic Antibody (ANCA) associated glomerulonephritides (ANCA GN) include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and Churg-Strauss. A novel histopathologic classification for GPA…
Abstract Number: 754 • 2013 ACR/ARHP Annual Meeting
Outcome Of Kidney Transplantation In Paediatric Patients With ANCA Associated Glomerulonephritis: A Single-Center Experience
Marinka Twilt¹, Damien Noone², Wesley Hayes², Paul Thorner³, Susanne M. Benseler⁴, Ronald M. Laxer⁴, Rulan Parekh² and Diane Hebert², ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Nephrology, The Hospital for Sick Children, Toronto, ON, Canada, ³Pathology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Kidney transplant outcomes for paediatric patients with end stage kidney disease (ESKD) secondary to ANCA GN, particularly granulomatosis with polyangiitis (GPA) and microscopic polyangiitis…
Abstract Number: 755 • 2013 ACR/ARHP Annual Meeting
Survival Of Patients With ANCA-Associated Vasculitides In Chronic Dialysis In France From 2002 To 2011: Data From The National Rein Registry
Manon Romeu¹, Cécile Couchoud Sr.², Jean-Christophe Delarozière³, Laurent Chiche Sr.⁴, Jean-Robert Harle⁵, Bertrand Gondoin⁶, Stéphane Burtey⁶, Philippe Brunet⁶, Yvon Berland⁶ and Noémie Jourde-Chiche Sr.⁷, ¹Nephrology, Aix-Marseille Universite, APHM, Marseille, France, ²registre REIN, agence de la biomédecine, paris, France, ³public health, APHM, Marseille, France, ⁴Internal Medicine, CHU Marseille, Marseille, France, ⁵Internal Medicine, APHM, Marseille, France, ⁶Nephrology, APHM, Marseille, France, ⁷Nephrology, Aix-Marseille Université - APHM, Marseille, France
Background/Purpose: Despite dramatic outcome improvement in ANCA-associated vasculitides (AAV), renal involvement is still leading to end-stage renal disease (ESRD) in 20-30% of patients. This study…
Abstract Number: 756 • 2013 ACR/ARHP Annual Meeting
Clinical Value Of Commonly-Measured Laboratory Tests In Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)
Peter C. Grayson¹, Paul A. Monach², David Cuthbertson³, Simon Carette⁴, Gary S. Hoffman⁵, Nader A. Khalidi⁶, C. L. Koening⁷, Carol A. Langford⁸, Kathleen Maksimowicz-McKinnon⁹, Christian Pagnoux¹⁰, Philip Seo¹¹, Ulrich Specks¹², Steven R. Ytterberg¹³ and Peter A. Merkel¹⁴, ¹NIAMS, National Institutes of Health, Bethesda, MD, ²Rheumatology, Boston University, Boston, MA, ³Department of Biostatistics, University of South Florida, Tampa, FL, ⁴Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁶Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁷Internal Medicine, Salt Lake City Veterans Administration, Salt Lake City, UT, ⁸Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁹Rheumatology, Henry Ford Hospital, Detroit, MI, ¹⁰Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, ¹¹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹²Mayo Clinic, Rochester, MN, ¹³Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁴Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Serial measurement of absolute eosinophil count (Eos), serum immunoglobulin E (IgE), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) is common practice in the…
Abstract Number: 757 • 2013 ACR/ARHP Annual Meeting
Impact Of Cardiac Magnetic Resonance Imaging On Eosinophilic Granulomatosis With Polyangiitis Outcomes: A Long-Term Retrospective Study On 42 Patients
Bertrand Dunogué¹, Pascal Cohen², Benjamin Terrier³, Julien Marmursztejn⁴, Denis Duboc⁴, Olivier Vignaux⁵ and Loic Guillevin³, ¹Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ³Internal Medicine, Cochin University Hospital, Paris, France, ⁴Cardiology, Cochin University Hospital, Paris, France, ⁵Radiology, Cochin University Hospital, Paris, France
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) cardiomyopathy carries a poor prognosis, and is the main cause of 1st-year and long-term mortality. Morbidity due to chronic…
Abstract Number: 758 • 2013 ACR/ARHP Annual Meeting
Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome) – Re-Analysis Of The French Vasculitis Study Group Cohort Using Different Disease Definitions and Cluster Analysis
Christian Pagnoux¹, Pascal N. Tyrrell², Chiara Baldini³, Simon Carette¹, Jean-Francois Cordier⁴, Loic Guillevin⁵ and French Vasculitis Study Group FVSG⁶, ¹Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ²Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, ³University of Pisa, Rheumatology Unit, Pisa, Italy, ⁴Division of Pneumology, Hôpital Louis-Pradel, Hospices Civils de Lyon, Lyon 1, Lyon, France, ⁵Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ⁶Internal Medicine, Service de médecine interne, Centre de Références des Vascularites, Université Paris Descartes, APHP, Hôpital Cochin, 75005 Paris, France., Paris, France
Background/Purpose: Because only 25–40% of the patients are ANCA+ and biopsy is not always taken or helpful, EGPA diagnosis can be challenging. Previous cohort analyses…
Abstract Number: 759 • 2013 ACR/ARHP Annual Meeting
Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss Syndrome): Comparison Of The Independent French Vasculitis Study Group and Italian–Pisa Patient Cohorts and Cross-Validation Of Cluster Analysis
Chiara Baldini¹, Pascal N. Tyrrell², Manuela Latorre³, Simon Carette⁴, Nader A. Khalidi⁵, Veronica Seccia⁶, Loic Guillevin⁷ and Christian Pagnoux⁴, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, ³University of Pisa, Pneumology Unit, Pisa, Italy, ⁴Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Unit of Otorhinolaryngology, Department of Neuroscience, University of Pisa, Pisa, Italy, Pisa, Italy, ⁷Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Previous analyses of the FVSG- and Pisa-cohort EGPA patients identified several covariates associated with poor outcomes and suggested differences between ANCA+ and ANCA– EGPA-patient…
Abstract Number: 760 • 2013 ACR/ARHP Annual Meeting
Cluster Analysis To Explore Clinical Subclassification Of Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss)
Thomas Neumann¹, Frank Moosig², Augusto Vaglio³, Jochen Zwerina⁴, Renato Alberto Sinico⁵, Wojciech Szczeklik⁶, Paolo Bottero⁷, Phillip Bremer⁸, Andrea Gioffredi⁹, Barbara Sokolowska⁶, Luca Di Toma⁵, Federica Maritati⁹, Julian Großkreutz¹⁰, Claus Kroegel¹¹, Matthieu Resche-Rigon¹² and Alfred Mahr¹³, ¹Jena University Hospital, Internal Medicine III, Jena, Germany, ²Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt, Germany, ³Unit of Nephrology, University Hospital of Parma, Parma, Italy, ⁴Ludwig Bolzmann institut of osteology at the 4th medical departmen, Hanusch Hospital, Vienna, Austria, ⁵Clinical Immunology Unit and Renal Unit, Department of Medicine, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milan, Italy, ⁶Department of Medicine, Jagiellonian University Medical College, Krakow, Poland, ⁷llergy and Clinical Immunology Unit, Magenta Hospital, Magenta, Italy, ⁸University Hospital Schleswig Holstein and Klinikum Bad Bramstedt, Bad Bramstedt, Germany, ⁹Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy, ¹⁰Department of Neurology, Jena University-Hospital, Jena, Germany, ¹¹Jena University Hospital, Internal Medicine I, Jena, Germany, ¹²Biostatistics, Hopital Saint-Louis, Paris, France, ¹³Department of Internal Medicine, Hospital Saint-Louis, Paris, France
Background/Purpose: Results from descriptive studies of eosinophilic granulomatosis with polyangiitis (EGPA) suggest distinct clinical subclasses that may be determined by anti-neutrophil cytoplasmic antibody (ANCA) status.…
Abstract Number: 761 • 2013 ACR/ARHP Annual Meeting
Apremilast For The Treatment Of Behçet’s Syndrome: A Phase II Randomized, Placebo-Controlled, Double-Blind Study
Gulen Hatemi¹, Melike Melikoglu², Recep Tunc³, Cengiz Korkmaz⁴, Banu Turgut Ozturk⁵, Cem Mat⁶, Peter A. Merkel⁷, Kenneth Calamia⁸, Ziqi Liu⁹, Lilia Pineda⁹, Randall M. Stevens⁹, Hasan Yazici² and Yusuf Yazici¹⁰, ¹Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ²Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ³Necmettin Erbakan University, Meram Medical Faculty,Division of Rheumatology, Konya, Turkey, ⁴Eskisehir Osmangazi University, Eskisehir, Turkey, ⁵Selçuk University, Konya, Turkey, ⁶Istanbul University, Cerrahpasa Medical Faculty, Dermatology, Istanbul, Turkey, ⁷Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, ⁸Mayo Clinic, Jacksonville, FL, ⁹Celgene Corporation, Warren, NJ, ¹⁰Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Apremilast for the Treatment of Behçet's Syndrome: A Phase II Randomized, Placebo-Controlled, Double-Blind StudyBackground/Purpose: Mucocutaneous manifestations of Behçet's syndrome (BS) can be resistant to conventional…
Abstract Number: 762 • 2013 ACR/ARHP Annual Meeting
Inhibition Of TGF-Beta Signaling In Articular Chondrocytes Leads To OA-Like Pathological Defects and Pain-Related Behavior Change In Mice
Jia Li¹, Jie Shen², Shan Li¹, John Dickerson¹, Jeffrey Kroin¹, Hee-Jeong Im¹ and Di Chen¹, ¹Rush University, Chicago, IL, ²University of Rochester, Rochester, NY
Background/Purpose: TGF-β signaling plays an important role in chondrocyte differentiation and osteoarthritis (OA) pathogenesis. However TGF-β downstream target genes and signaling mechanism in OA development…
Abstract Number: 763 • 2013 ACR/ARHP Annual Meeting
The Risk Of Myocardial Infarction In Systemic Sclerosis: A Population-Based Cohort Study
Iman Hemmati¹, Hyon K. Choi^2,3, Kamran Shojania^3,4, Eric C. Sayre³ and J. Antonio Avina-Zubieta^3,5, ¹Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: An increased risk of premature atherosclerosis has been well described in patients with rheumatoid arthritis and systemic lupus erythematosus. However, there is limited data…
Abstract Number: 764 • 2013 ACR/ARHP Annual Meeting
Inflammatory Disease Due To Dysregulated Nuclear Factor-κB Activation and Impaired Type I Interferon Response Resulting From a De Novo Human NEMO Hypomorphic Mutation
Alex Wessel¹, Amy Hsu², Jevgenia Zilberman-Rudenko¹, Raphaela Goldbach-Mansky³, Richard M. Siegel¹ and Eric Hanson¹, ¹Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Laboratory of Clinical Infectious Diseases, NIAID, Bethesda, MD, ³Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: The NF-kB family of transcription factors regulate innate and adaptive immunity, in addition to driving pro-inflammatory-disease states. The type I interferon response acts in…
Abstract Number: 765 • 2013 ACR/ARHP Annual Meeting
Angiogenic Factor Dysregulation and Risk Of Adverse Pregnancy Outcome In Lupus Pregnancies
Jane E. Salmon¹, Mimi Kim², Marta M. Guerra³, Michael D. Lockshin⁴, Ware D. Branch⁵, Michelle Petri⁶, Carl A. Laskin⁷, Joan T. Merrill⁸, Lisa R. Sammaritano¹, Jill P. Buyon⁹ and S. Ananth Karumanchi¹⁰, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, ³Rheumatology 3rd Fl Rsrch, Hospital for Special Surgery, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁵Obsterics and Gynecology, Univ of Utah, Salt Lake City, UT, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada, ⁸Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ¹⁰Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Pregnant women with lupus and APL are at increased risk for adverse outcomes, particularly preeclampsia (PE), yet identification of those destined for complications remains…
Abstract Number: 766 • 2013 ACR/ARHP Annual Meeting
Cholesterol Accumulation By Synovial Lining Macrophages Results In Ectopic Bone Formation During Experimental Osteoarthritis
Wouter de Munter¹, Arjen B. Blom¹, Monique M. Helsen¹, Birgitte Walgreen¹, Peter M. van Der Kraan¹, Leo A. Joosten², Wim B. van den Berg³ and Peter L. van Lent⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial macrophages have previously shown to play a significant role in the etiopathology of experimental collagenase-induced osteoarthritis (OA). In addition to production of pro-inflammatory…
Abstract Number: 727 • 2013 ACR/ARHP Annual Meeting
Adiponectin Promotes The Differentiation Of naïve T Cell To Th17 Cell and Aggravates Collagen-Induced Arthritis
Miaojia Zhang¹, Xiaoxuan Sun², Wenfeng Tan³, Xiaoke Feng⁴ and Ke Gan⁵, ¹Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ²Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA, Nanjing, China, ³Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁴Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ⁵Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Background/Purpose: To investigate a role of Adiponectin (AD) on the differentiation of naïve T cell to Th17 cell and bone erosion in collagen-induced arthritis (CIA)…

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