Abstracts Archive - Page 2380 of 2605 - ACR Meeting Abstracts

Abstract Number: 762 • 2013 ACR/ARHP Annual Meeting
Inhibition Of TGF-Beta Signaling In Articular Chondrocytes Leads To OA-Like Pathological Defects and Pain-Related Behavior Change In Mice
Jia Li¹, Jie Shen², Shan Li¹, John Dickerson¹, Jeffrey Kroin¹, Hee-Jeong Im¹ and Di Chen¹, ¹Rush University, Chicago, IL, ²University of Rochester, Rochester, NY
Background/Purpose: TGF-β signaling plays an important role in chondrocyte differentiation and osteoarthritis (OA) pathogenesis. However TGF-β downstream target genes and signaling mechanism in OA development…
Abstract Number: 763 • 2013 ACR/ARHP Annual Meeting
The Risk Of Myocardial Infarction In Systemic Sclerosis: A Population-Based Cohort Study
Iman Hemmati¹, Hyon K. Choi^2,3, Kamran Shojania^3,4, Eric C. Sayre³ and J. Antonio Avina-Zubieta^3,5, ¹Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: An increased risk of premature atherosclerosis has been well described in patients with rheumatoid arthritis and systemic lupus erythematosus. However, there is limited data…
Abstract Number: 764 • 2013 ACR/ARHP Annual Meeting
Inflammatory Disease Due To Dysregulated Nuclear Factor-κB Activation and Impaired Type I Interferon Response Resulting From a De Novo Human NEMO Hypomorphic Mutation
Alex Wessel¹, Amy Hsu², Jevgenia Zilberman-Rudenko¹, Raphaela Goldbach-Mansky³, Richard M. Siegel¹ and Eric Hanson¹, ¹Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Laboratory of Clinical Infectious Diseases, NIAID, Bethesda, MD, ³Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: The NF-kB family of transcription factors regulate innate and adaptive immunity, in addition to driving pro-inflammatory-disease states. The type I interferon response acts in…
Abstract Number: 765 • 2013 ACR/ARHP Annual Meeting
Angiogenic Factor Dysregulation and Risk Of Adverse Pregnancy Outcome In Lupus Pregnancies
Jane E. Salmon¹, Mimi Kim², Marta M. Guerra³, Michael D. Lockshin⁴, Ware D. Branch⁵, Michelle Petri⁶, Carl A. Laskin⁷, Joan T. Merrill⁸, Lisa R. Sammaritano¹, Jill P. Buyon⁹ and S. Ananth Karumanchi¹⁰, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, ³Rheumatology 3rd Fl Rsrch, Hospital for Special Surgery, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁵Obsterics and Gynecology, Univ of Utah, Salt Lake City, UT, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada, ⁸Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ¹⁰Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Pregnant women with lupus and APL are at increased risk for adverse outcomes, particularly preeclampsia (PE), yet identification of those destined for complications remains…
Abstract Number: 766 • 2013 ACR/ARHP Annual Meeting
Cholesterol Accumulation By Synovial Lining Macrophages Results In Ectopic Bone Formation During Experimental Osteoarthritis
Wouter de Munter¹, Arjen B. Blom¹, Monique M. Helsen¹, Birgitte Walgreen¹, Peter M. van Der Kraan¹, Leo A. Joosten², Wim B. van den Berg³ and Peter L. van Lent⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial macrophages have previously shown to play a significant role in the etiopathology of experimental collagenase-induced osteoarthritis (OA). In addition to production of pro-inflammatory…
Abstract Number: 727 • 2013 ACR/ARHP Annual Meeting
Adiponectin Promotes The Differentiation Of naïve T Cell To Th17 Cell and Aggravates Collagen-Induced Arthritis
Miaojia Zhang¹, Xiaoxuan Sun², Wenfeng Tan³, Xiaoke Feng⁴ and Ke Gan⁵, ¹Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ²Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA, Nanjing, China, ³Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁴Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ⁵Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Background/Purpose: To investigate a role of Adiponectin (AD) on the differentiation of naïve T cell to Th17 cell and bone erosion in collagen-induced arthritis (CIA)…
Abstract Number: 728 • 2013 ACR/ARHP Annual Meeting
Unraveling The Identity Of FoxP3⁺ Regulatory T-Cells In Gpa-Patients
WH Abdulahad¹, Coen A. Stegeman², MG Huitema¹, Pieter C. Limburg³, Abraham Rutgers¹, Peter Heeringa⁴ and Cees G.M. Kallenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Nephrology, University Medical Center Groningen, Groningen, Netherlands, ³Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, ⁴Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Human FoxP3+ Th-cells are heterogeneous in function and include not only suppressive cells (TRegs) but also non-suppressive cells that abundantly secrete proinflammatory cytokines. We…
Abstract Number: 729 • 2013 ACR/ARHP Annual Meeting
Role Of Innate Immunity In The Pathogenesis Of ANCA-Associated Vasculitis
Angelica Gattamelata¹, Giovanna Peruzzi², Rossana Scrivo³, Roberta Priori³, Stefania Morrone⁴, Angela Santoni² and Guido Valesini³, ¹Sapienza University of Rome, Rome, Italy, ²Department of Molecular Medicine, Sapienza University, Rome, Italy, ³Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ⁴Department of Experimental Medicine, Sapienza University, Rome, Italy
Background/Purpose: Natural killer cells (NK) represent one of the main effectors of the innate immune response through the defense against viral infections and the production…
Abstract Number: 730 • 2013 ACR/ARHP Annual Meeting
Cell-Mediated Immune Responses To Influenza and Herpesvirus Antigen Stimulation Are Conserved But Adversely Impacted By Immunosuppressive Therapy and Active Infection In Patients With Granulomatosis With Polyangiitis
John McKinnon¹, Robbie Mailliard², Dawn McClemens-McBride³, Donald Jones³, Charles Rinaldo Jr.⁴ and Kathleen Maksimowicz-McKinnon⁵, ¹Infectious Disease, Henry Ford Hospital, Detroit, MI, ²Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, ³Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Infectious Diseases and Microbiology, Pathology, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology, Henry Ford Hospital, Detroit, MI
Background/Purpose: Reactivation of chronic herpesvirus infections is not uncommon in immunosuppressed patients, including those with granulomatosis with polyangiitis (GPA). The effects of GPA disease and…
Abstract Number: 731 • 2013 ACR/ARHP Annual Meeting
C3 Activation Is Associated With The Disease Activity Of Microscopic Polyangiitis
Dan Liu^1,2,3, Jin-song Zhou⁴, Qing-ping Chen⁴, Chao-yang Duan¹, Li Wang⁴, Yuan Jia³ and Ke Li¹, ¹Core Research Laboratory, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China, ²Department of Rheumatology and Immunology, The Fifth Hospital of Xi'an, Xi'an, China, ³Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ⁴Department of Rheumatology and Immunology, The Fifth Hospital of Xi'an, Xi’an, China
Background/Purpose: Microscopic polyangiitis (MPA) is the most common anti-neutrophil cytoplasmic antibodies(ANCA) associated small-vessel vasculitis with specificity of the ANCA to myeloperoxidase(MPO) of neutrophils. MPA mainly…
Abstract Number: 732 • 2013 ACR/ARHP Annual Meeting
Expansion Of IgA-Plasma Cells As a Sign For Ear-Nose-Throat-Involvment In Granulomatosis With Polyangiitis?
Bimba F. Hoyer^1,2, Adriano Taddeo³, Qingyu Cheng², Laleh Khodadadi², Gerd Burmester² and Falk Hiepe², ¹Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, ²Charité University Medicine, Department of Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Centre Berlin (DRFZ), Germany, Berlin, Germany, ³Deutsches Rheumaforschungszentrum, Berlin, Germany
Background/Purpose: B cells are playing a major role in granulomatosis with polyangiitis (GPA, formarly known as Wegener’s disease). This is reflected by the presence of…
Abstract Number: 733 • 2013 ACR/ARHP Annual Meeting
Plasma Levels Of Fibrin/Fibrinogen Degradation Products Might Be a Useful Indicator Of Disease Activity, Classification and Nephritis Complications In Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Kuninobu Wakabayashi, Nao Oguro, Yoko Miura, Sho Ishii, Shinya Seki, Masayu Umemura, Takahiro Tokunaga, Hiroyuki Tsukamoto, Sakiko Isojima, Hidekazu Furuya, Ryo Yanai, Kumiko Otsuka, Ryo Takahashi, Takeo Isozaki, Nobuyuki Yajima, Yusuke Miwa and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: It is important to determine the biomarkers for assessing disease activity of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Plasma levels of fibrin/fibrinogen…
Abstract Number: 734 • 2013 ACR/ARHP Annual Meeting
The Significance Of Anti-Myeloperoxidase and Anti-Proteinase 3 Antibodies In The Absence Of Anti-Neutrophil Cytoplasmic Antibody Immunofluorescence Positivity
Deepak A. Rao¹, Joseph F. Merola¹, William R. O'Brien¹, Kevin Wei¹, Samuel U. Takvorian², Paul F. Dellaripa³ and Peter H. Schur¹, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Identification of serum anti-neutrophil cytoplasmic antibodies (ANCA) for the detection of ANCA-associated vasculitis (AAV) is often performed by screening with indirect immunofluorescence (IF), followed…
Abstract Number: 735 • 2013 ACR/ARHP Annual Meeting
Clinical Research Of Microscopic Polyangiitis Combined With Autoimmune Hemolytic Anemia
Dan Liu^1,2,3, Qing-ping Chen⁴, Hai-hong Yao⁵, Ru Li¹, Yin Su¹, Jie Zhang⁴, Yu Chen⁴, Ke Li³ and Yuan Jia¹, ¹Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, The Fifth Hospital of Xi'an, Xi'an, China, ³Core Research Laboratory, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China, ⁴Department of Rheumatology and Immunology, The Fifth Hospital of Xi'an, Xi’an, China, ⁵Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
Background/Purpose: Autoimmune hemolytic anemia (AIHA) and Microscopic polyangiitis (MPA) are both rare autoimmune conditions. AIHA is caused by autoantibody-induced hemolysis (the premature destruction of circulating…
Abstract Number: 736 • 2013 ACR/ARHP Annual Meeting
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Associated With Systemic Sclerosis In Japan: A Review Of The Literature
Natsumi Nagao¹, Yuri Sadanaga¹, Satoko Tashiro¹, Rie Suematsu¹, Syuichi Koarada¹, Akihide Ohta² and Yoshifumi Tada¹, ¹Rheumatology, Saga University, Saga, Japan, ²Nursing, Saga University, Saga, Japan
Background/Purpose: Cases of Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during the course of systemic sclerosis (SSc) have recently been reported. Japanese cases of AAV associated…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].