Abstract Number: 690 • 2012 ACR/ARHP Annual Meeting
Molecular Analysis of 9G4+ Antibodies in Systemic Lupus Erythematosus
Background/Purpose: Elevated titers of serum autoantibodies expressing the 9G4 idiotype are highly specific for SLE and correlate with disease activity and clinical manifestations. 9G4+ antibodies…Abstract Number: 651 • 2012 ACR/ARHP Annual Meeting
Suicidal Ideation in Patients with Systemic Lupus Erythematosus: Incidence and Relationship with Anxiety/Depression Score Disease Activity and Organ Damage
Background/Purpose: To study the incidence of suicidal ideation in patients with SLE and its relationship with anxiety/depression score, disease activity and organ damage Methods: Consecutive…Abstract Number: 652 • 2012 ACR/ARHP Annual Meeting
Serum Rituximab Levels and Efficiency of B-Cell Depletion: Differences Between Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Background/Purpose: Variability in rituximab-induced B-cell depletion (BCD) occurs in a significant number of patients with Systemic Lupus Erythematosus (SLE) and to a lesser extent in…Abstract Number: 653 • 2012 ACR/ARHP Annual Meeting
Longitudinal Analysis of Plasma Factors and Disease Activity Identifies Von Willebrand Factor As A Biomarker of Lupus Flare
Background/Purpose: Lupus, a chronic autoimmune disease, is characterized by a variable clinical course, with periods of active disease termed flares. The severity of flares can…Abstract Number: 654 • 2012 ACR/ARHP Annual Meeting
Incidence Studies of Systemic Lupus Erythematosus in Southern Sweden. Have the Tides Turned
Background/Purpose: The main objective was to study the incidence of Systemic Lupus Erythematosus (SLE) within a defined area in Southern Sweden over a period of…Abstract Number: 655 • 2012 ACR/ARHP Annual Meeting
Non-White Race, Younger Age, and Use of Primary and Gynecologic Care Are Associated with Higher Rates of Cervical Cancer Screening in Systemic Lupus Erythematosus Patients At a Public Hospital
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) are at increased risk of cervical dysplasia and persistent Human Papilloma Virus (HPV) infection. There are few prior…Abstract Number: 656 • 2012 ACR/ARHP Annual Meeting
Effects of Nelfinavir On Anti-dsDna Antibody Binding and Pro-Inflammatory Cytokine Gene Expression
Background/Purpose: The hallmark of SLE is pathogenic autoantibody (aab) production that is closely associated with organ damage. Anti-dsDNA aab are specific to SLE; their deleterious…Abstract Number: 657 • 2012 ACR/ARHP Annual Meeting
Serial Screening Shows That 28% of Systemic Lupus Erythematosus Adult Patients Carry an Underlying Primary Immunodeficiency
Background/Purpose: Systemic Lupus Erythematosus (SLE) is known to be associated with deficiency of C1q, C4, and C2. There is high frequency of discoid lesions (2.7%)…Abstract Number: 658 • 2012 ACR/ARHP Annual Meeting
Up-Regulation of A Disintegrin and Metalloprotease with Thrombospondin Type I Repeats-13 Correlates with Ischemic Cerebrovascular Disease in Systemic Lupus Erythematosus Patients
Background/Purpose: ADAMTS13 (A Disintegrin-like And Metalloprotease with ThromboSpondin type 1 motif) belongs to a recently described group of metalloproteinase enzymes which possess proteoglycanase and anti-angiogenic…Abstract Number: 659 • 2012 ACR/ARHP Annual Meeting
The Small Molecule Activator to ACE2 Prevents the Inhibition of ACE2 Activity by Autoantibodies
Background/Purpose: Angiotensin-converting enzyme 2 (ACE2) is a member of renin-angiotensin system that plays a critical role in regulating blood pressure and cardiovascular function. It is…Abstract Number: 660 • 2012 ACR/ARHP Annual Meeting
Abnormal Neutrophil Development in Human Systemic Lupus Erythematosus
Background/Purpose: Recent research has increased the appreciation of the contributions of neutrophils to systemic lupus erythematosus (SLE). An abnormal circulating pool of granulocytes has been…Abstract Number: 661 • 2012 ACR/ARHP Annual Meeting
Co-Localization of C-Reactive Protein, Immunoglobulin G and Complement in Renal Subendothelial Immune Deposits of Proliferative Lupus Nephritis Detected Using Immunogold Electron Microscopy
Background/Purpose: The pattern recognition molecules C-reactive protein (CRP) and complement protein 1q (C1q) are pivotal parts of the innate immune system and display relevant biological…Abstract Number: 662 • 2012 ACR/ARHP Annual Meeting
Increased C1q, C4 and C3 Deposition On Platelets in Patients with Systemic Lupus Erythematosus – A Possible Link to Venous Thrombosis?
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing vascular diseases (VD) such as myocardial infarction, stroke and venous thrombosis, which…Abstract Number: 663 • 2012 ACR/ARHP Annual Meeting
The Clinical Significance and Expression of P2X7 Purinergic Receptor in Peripheral Blood from Patients with New-Oneset Systemic Lupus Erythematosus
Background/Purpose: P2X7 purinergic receptor (P2X7R) is encoded by a gene within the human SLE locus SLEB4. Extracellular adenosine triphosphate (ATP) regulates inflammatory cells by activation…Abstract Number: 664 • 2012 ACR/ARHP Annual Meeting
Estrogen Upregulates Interleukin-21 Production of Clusters of Differentiation 4 Positive T Lymphocytes in Patients with Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease in which various organs and tissues are damaged through abnormal immune responses mediated by tissue-binding autoantibodies…
ACR Meeting Abstracts