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  • Abstract Number: 838 • 2013 ACR/ARHP Annual Meeting

    Recommendations for the Classification and Diagnosis of Fibromyalgia Syndrome Provided By Independently Developed Evidence-Based Interdisciplinary Guidelines Spanning Three Continents

    Mary-Ann Fitzcharles1, Yoram Shir2, Jacob N. Ablin3, Dan Buskila4, Howard Amital5, Peter Henningsen6 and Winfried Häuser7, 1Rheumatology & Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, 2Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, 3Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 4Ben-Gurion University, Beer-Sheva, Israel, 5Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, 6Department Internal Medicine I, Klinikum Saarbrücken, Saarbrücken, Germany, 7Klinikum Saarbrücken, Saarbrücken, Germany

    Background/Purpose: Fibromyalgia (FM), often disputed and challenged, has emerged as a clear cluster of symptoms and co-morbidities, characterized by subjective complaints without physical or biomarker…
  • Abstract Number: 839 • 2013 ACR/ARHP Annual Meeting

    A Paradigm Change for Treatment Strategies for Fibromyalgia Syndrome Reflected By Recommendations of Recent Evidence-Based Interdisciplinary Guidelines Developed Independently in Three Countries

    Jacob N. Ablin1, Dan Buskila2, Howard Amital3, Mary-Ann Fitzcharles4, Yoram Shir5, Peter Henningsen6 and Winfried Häuser7, 1Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Ben-Gurion University, Beer-Sheva, Israel, 3Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, 4Rheumatology & Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, 5Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, 6Department Internal Medicine I, Klinikum Saarbrücken, Saarbrücken, Germany, 7Klinikum Saarbrücken, Saarbrücken, Germany

    Background/Purpose: Although the ideal treatment for fibromyalgia (FM) remains elusive, the medical community requires direction in the care of these patients.  The literature however abounds…
  • Abstract Number: 840 • 2013 ACR/ARHP Annual Meeting

    Fibromyalgia, Somatic Symptoms, and Mental Illness In View Of The 2013 Diagnostic and Statistical Manual Of Mental Disorders

    Frederick Wolfe1, Brian T. Walitt2, Robert S. Katz3 and Winfried Häuser4, 1National Data Bank for Rheumatic Diseases, Wichita, KS, 2Rheumatology, Washington Hospital Center, Washington, DC, 3Rush Medical College, Chicago, IL, 4Klinikum Saarbrücken, Saarbrücken, Germany

    Background/Purpose: Pain research conceptualizes fibromyalgia (FM) as a Physical or Somatic Symptom Disorder (PSD or SSD). However, the 2013 Diagnostic and Statistical Manual of Mental…
  • Abstract Number: 841 • 2013 ACR/ARHP Annual Meeting

    The Prevalence Of Fibromyalgia In The General Population – a Comparison Of The ACR 1990, 2010 and Modified 2010 Classification Criteria

    Gareth T. Jones1, Marcus Beasley1, Fabiola Atzeni2, Elisa Flüß1, Piercarlo Sarzi-Puttini2 and Gary Macfarlane1, 1Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, 2Rheumatology Unit, L. Sacco University Hospital, Milan, Italy

    Background/Purpose: In 1990 the ACR published criteria for the classification of fibromyalgia (FM), based on widespread pain and tenderness.  In 2010 new criteria were published…
  • Abstract Number: 842 • 2013 ACR/ARHP Annual Meeting

    A Cytokine/Chemokine Multiplex Assay That Is Sensitive and Specific For Fibromyalgia Compared To Controls, Systemic Lupus Erythematosus, and Rheumatoid Arthritis

    Daniel J. Wallace1, Igor Gavin2, Oleksiy Karpenko2 and Bruce S. Gillis3, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2University of Illinois College of Medicine at Chicago, Chicago, IL, 3Department of Pathology, University of Illinois College of Medicine at Chicago, Chicago, IL

    Background/Purpose:   Fibromyalgia (FM) is a chronic pain and fatigue syndrome that affects about 6 million adults in the United States.  The clinical diagnosis of…
  • Abstract Number: 844 • 2013 ACR/ARHP Annual Meeting

    Level and Determinants Of Health Related Quality Of Life In Childhood-Onset Systemic Lupus Erythematosus

    Jordan T. Jones1, Shannen L. Nelson2, Janet Wootton3, Brianna Liberio4, Alexandria J. Greenler5, Jennifer L. Huggins1, Laura E. Schanberg6 and Hermine Brunner1, 1Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 4University of Cincinnati College of Medicine, Cincinnati, OH, 5Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Pediatrics, Duke University Medical Center, Durham, NC

    Background/Purpose: Childhood-onset lupus (cSLE) is a chronic autoimmune disease and its effect on health-related quality of life (HRQoL) has not been systematically established, nor does…
  • Abstract Number: 845 • 2013 ACR/ARHP Annual Meeting

    Improving Pneumococcal Vaccination Rate In The Pediatric Rheumatology Clinic

    Julia G. Harris1,2, Kristyn I. Maletta3, Bixiang Ren3 and Judyann C. Olson1,2, 1Medical College of Wisconsin, Milwaukee, WI, 2Children's Hospital of Wisconsin, Milwaukee, WI, 3National Outcomes Center, Children's Hospital of Wisconsin, Milwaukee, WI

    Background/Purpose:  This quality improvement project was conducted to increase pneumococcal vaccination rates in eligible Pediatric Rheumatology Clinic patients.  Streptococcus pneumoniae is a leading cause of…
  • Abstract Number: 846 • 2013 ACR/ARHP Annual Meeting

    Applying Choosing Wisely: Identifying Inefficiencies Of Antinuclear Antibody Subserology Testing In a Safety Net Health System

    Lisa A. Davis1, Barbara L. Goldstein2, Vivian Tran1, Angela Keniston3, Jinoos Yazdany4, Joel M. Hirsh1, Amy Storfa5 and Joann Zell2, 1Medicine, Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO, 2Medicine, National Jewish Health, Denver, CO, 3Department of Medicine, Denver Health and Hospital Authority, Denver, CO, 4Medicine, University of California, San Francisco, San Francisco, CA, 5Medicine, Denver Health and Hospital Authority, Denver, CO

    Applying Choosing Wisely®:  Identifying Inefficiencies of ANA (antinuclear antibody) Subserology Testing in a Safety Net Health System Background/Purpose:   In 2013, the American College of…
  • Abstract Number: 847 • 2013 ACR/ARHP Annual Meeting

    Do Rheumatologists (and Other Specialists) Practice What We Preach?  A Study Of Serology Ordering Patterns With Attention To Subserologies When The Antinuclear Antibody By Enzyme Linked Immunosorbent Assay Is Negative; And The Clinical Significance Of These Positive Subserology Results

    David Bulbin1, Alicia Meadows1, Alfred E. Denio2, H. Lester Kirchner3, Sandi Kelsey4 and Harold Harrison4, 1Dept of General Internal Medicine, Geisinger Medical Center, Danville, PA, 2Dept of Rheumatology, Geisinger Health System, Danville, PA, 3Geisinger Center for Health Research, Geisinger Health System, Danville, PA, 4Dept of Pathology, Geisinger Medical Center, Danville, PA

    Background/Purpose: The American College of Rheumatology (ACR) was asked by the American Board of Internal Medicine to contribute to the “Choosing Wisely” campaign.  The first…
  • Abstract Number: 808 • 2013 ACR/ARHP Annual Meeting

    A Genome Wide Association Study Of Rheumatoid Arthritis Without Antibodies Against Citrullinated Peptides

    Lara Bossini-Castillo1, Carolien de Kovel2, Henrik Kallberg3, Marieke J.H. Coenen4, Paul P. Tak5, Marcel D. Posthumus6, Cisca Wijmenga7, Thomas W.J. Huizinga8, Annette H.M. van der Helm-van Mil9, Luis Rodriguez-Rodriguez10, Isidoro Gonzalez-Alvaro11, Miguel Angel Gonzalez-Gay12, Irene E. van der Horst-Bruinsma13, B.a.C Dijkmans14, G. J. Wolbink15, Roel A. Ophoff2, Piet L.C.M. van Riel16, Lars Klareskog3, J.B.a. Crusius17, Elisabeth Brouwer18, Javier Martin19, Niek de Vries5, René E.M. Toes9, Leonid Padyukov20 and Bobby P.C. Koeleman21, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 2Department of Medical Genetics, UMCU Utrecht, Utrecht, Netherlands, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 6Department of Rheumatology, University of Groningen, University Medical Center, Groningen, Netherlands, 7Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 10Hospital Clínico San Carlos, Department of Rheumatology, Madrid, Spain, 11Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander, Santander, Spain, 13Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 14Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 15Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 16Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 17Pathology, VU University Medical Center, Amsterdam, Netherlands, 18Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 19Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 20Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 21Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease that is associated with a progressive loss of the joints induced by a chronic inflammation of…
  • Abstract Number: 809 • 2013 ACR/ARHP Annual Meeting

    IgM Rheumatoid Factor As a Potentiator Of Anti-Citrullinated Protein Antibody Mediated Inflammation In Rheumatoid Arthritis

    Jeremy Sokolove1, Danye Cheng2, Dannette S. Johnson3, Ted R. Mikuls4 and William H. Robinson5, 1VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 2VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 3Rheumatology, Jackson VA and University of Mississippi Medical Center, Jackson, MS, 4Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose:   The co-occurrence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) is well described in rheumatoid arthritis (RA), and has been associated with…
  • Abstract Number: 810 • 2013 ACR/ARHP Annual Meeting

    Inducible Bronchus Associated Lymphoid Tissue In The Lung Is Associated With Seropositivity For Rheumatoid Arthritis-Related Autoantibodies In Subjects With and Without Clinically Diagnosed Rheumatoid Arthritis

    M. Kristen Demoruelle1, Adam W. Bagley2, Mark C. Parish1, David E. Heinz3, V. Michael Holers4, Carlyne D. Cool5 and Kevin D. Deane1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Internal Medicine, University of Colorado School of Medicine, Aurora, CO, 3Pathology, University of Colorado School of Medicine, Aurora, CO, 4Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, 5University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Data suggest the lung may be a site of RA-related autoantibody (Ab) generation including findings of airways inflammation prior to onset of articular RA…
  • Abstract Number: 811 • 2013 ACR/ARHP Annual Meeting

    Influence Of Smoking On Citrullinated Proteins and Porphyromonas Gingivalis In The Lung: A Priming Site For Autoimmunity In RA

    Elena B. Lugli1, Patrick Venables2, Raquel Correia3, Karin Lundberg4, Ken Bracke5 and Guy Brusselle5, 1University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, 2Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 3Kennedy Institute of Rheumatology, Univerity of Oxford, Oxford, United Kingdom, 4Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5Gent University, Gent, Belgium

    Background/Purpose: Anti-citrullinated peptide/protein antibodies (ACPA) may be detected in RA serum more than 10 years before onset of disease, suggesting that the autoimmune response begins…
  • Abstract Number: 812 • 2013 ACR/ARHP Annual Meeting

    Alveolar Bone Loss Is Associated With Disease Activity and ACPA Expression In Rheumatoid Arthritis

    Ted R. Mikuls1, Jeffrey Payne2, Fang Yu3, Geoffrey M. Thiele4, Shawneen Gonzalez2, Jeffrey Markt5, Jeremy Sokolove6, William H. Robinson7, Richard J. Reynolds8, Grant W. Cannon9, David McGowan10, Gail S. Kerr11, Robert Redman12, Andreas M. Reimold13, Garth Griffiths14, Mark Beatty2, Marian Schmid2, Paul Johnson2, Debra Bergman15, Bartlett C. Hamilton III16, Alan R. Erickson1 and James R. O'Dell17, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 3University of Nebraska Medical Center, Omaha, NE, 4Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, 5Otol-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, 6Stanford University, Palo Alto, CA, 7Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 8Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 9Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 10Dentistry, George E. Wahlen VA Medical Center, Salt Lake City, UT, 11Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 12Dentistry, Washington DC VA, Georgetown and Howard University, Washington, DC, 13Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 14Dentistry, Dallas VA and University of Texas Southwestern, Dallas, TX, 15Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 16University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, 17Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Periodontitis (PD) has been implicated in rheumatoid arthritis (RA) pathogenesis including the expression of anti-citrullinated protein antibody (ACPA).  ACPA, in turn, have been shown…
  • Abstract Number: 813 • 2013 ACR/ARHP Annual Meeting

    Citrulline Specific CD4+ T Cells Exhibit a Th1 Memory Phenotype In Rheumatoid Arthritis Subjects and Their Ex Vivo Frequency Is Influenced By Both Disease Duration and Biologic Therapy

    Eddie James1, Mary Rieck2, Jennifer Pieper3, John Gebe4, Betty Yue4, Megan Tatum5, Charlotta Sandin6, Lars Klareskog7, Vivianne Malmström8 and Jane Buckner9, 1Benaroya Research Institute, Seattle, WA, 2Translational Research Program, Benaroya Research Institute, Seattle, WA, 3Department of Medicine, Karolinska Institutet, Rheumatology Unit, Stockholm, Sweden, 4Diabetes Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, 5Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 9Translational Research Program, Benaroya Research Institute, Seattle, WA 98101, USA,, Seattle, WA

    Background/Purpose: Rheumatoid arthritis is thought to be a T cell mediated disease, based on its strong association with HLA class II alleles, clinical responsiveness to…
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