Abstracts Archive - Page 2376 of 2425 - ACR Meeting Abstracts

Abstract Number: 675 • 2012 ACR/ARHP Annual Meeting
Differential Impairment of Serum Cholesterol Efflux Capacity in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Pier Luigi Meroni¹, Nicoletta Ronda², Elda Favari³, Orietta Borghi⁴, Francesca Zimetti⁵, Mariapia Adorni⁶, Francesca Ingegnoli⁷, Maria Gerosa⁸, Claudia Grossi⁹ and Franco Bernini⁶, ¹Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, ²Department of Pharmacy, University of Parma, Parma, Italy, ³Department of Pharmacological and Biological Sciences,, University of Parma, Parma, Italy, ⁴Department of clinical and comunity sciences, University of Milan, Milan, Italy, ⁵Department of Pharmacological and Biological Sciences, University of Parma, Parma, Italy, ⁶Department of Pharmacological and Biological Sciences, 39-02-58318176, Parma, Italy, ⁷Dept. of clinical and community science, Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, ⁸Department of Clinical Sciences and Community Health, University of Milan, Italy, Division of Rheumatology, Istituto Ortopedico Gaetano Pini,, Milan, Italy, ⁹Lab of immunology, IRCCS Istituto Auxologico Italiano, Milano, Italy
Background/Purpose: Accelerated atherosclerosis associated with autoimmune diseases is partly due to immune system dysregulation aggravating cardiovascular damage, but little is known on lipid metabolism derangement…
Abstract Number: 676 • 2012 ACR/ARHP Annual Meeting
A Novel Biomarker: Nucleotide-Binding Oligomerization Domain 27 in Systemic Lupus Erythematosus
Annika Cutinha¹, Yangsheng Yu², Kaihong Su², James R. O'Dell¹, Lynell W. Klassen³, Amy C. Cannella⁴, Ted R. Mikuls⁵, Alan R. Erickson⁶, Gerald F. Moore⁷ and Michelene Hearth-Holmes⁸, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ³Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴Divison of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁸Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease in which a variety of autoantibodies contribute to the diversified disease phenotypes. In our previous…
Abstract Number: 677 • 2012 ACR/ARHP Annual Meeting
Antibodies to Oxidized Low Density Lipoprotein or Anti-Lipoprotein Lipase May Lead to More Atherosclerotic Plaque in a Sub-Set of SLE Patients
Biji T. Kurien¹, James Fesmire², Skyler P. Dillon³, Marianne Reichlin⁴, Morris Reichlin⁵ and Robert H. Scofield⁶, ¹College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, ³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Oklahoma Medical Res Fndn, Oklahoma City, OK, ⁵Arthritis & Imm Laboratory, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁶Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). Oxidized low density lipoproteins (oxLDL) are important in atherosclerosis and have been reported in SLE…
Abstract Number: 678 • 2012 ACR/ARHP Annual Meeting
Estrogen Modulation of ZAS3 Is Mediated Through Estrogen Receptor α: An Underlying Mechanism of Gender-Bias in Systemic Lupus Erythematosus?
Nicholas Young¹, Alexandra Friedman², Lai-Chu Wu² and Wael N. Jarjour³, ¹Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Global population data has indicated that post-pubertal females have decreased rates of infectious diseases when compared to male counterparts and preadolescent or postmenopausal females. …
Abstract Number: 679 • 2012 ACR/ARHP Annual Meeting
ZAP70+ B Cells and Plasmablasts As Markers of Disease Activity and Remission in Systemic LUPUS Erythematosus Nephritis
Elisa Gremese, Barbara Tolusso, Laura Messuti, Marcin Nowik, Silvia Canestri, Luca Petricca, Maria Rita Gigante and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: To analyze differences in B cells subsets distribution in patients with renal systemic lupus erythematosus (SLE). To define possible cellular biomarkers of active nephritis…
Abstract Number: 680 • 2012 ACR/ARHP Annual Meeting
Plasma Level of Galectin-3 Binding Protein Reflects Type I Interferon Activity and Is Highly Increased in Patients with Systemic Lupus Erythematosus
Christoffer T. Nielsen¹, Ole Østergaard², Line V. Iversen³, Christian Lood⁴, Anders A. Bengtsson⁴, Anne Voss⁵, Søren Jacobsen⁶ and Niels H. H. Heegaard³, ¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen S, Denmark, ²Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institute, Copenhagen S, Denmark, ³Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁵Dept of Rheumatology, Odense University Hospital, Odense C, Denmark, ⁶Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Background/Purpose: Ongoing production of type I interferons (IFN) is a key element in the pathogenesis of systemic lupus erythematosus (SLE). Type I IFNs trigger the…
Abstract Number: 681 • 2012 ACR/ARHP Annual Meeting
Interferon Alpha Decreases Endothelial Nitric Oxide Synthase Function and Expression in Human Umbilical Vein Endothelial Cells
Joy Buie¹ and Jim Oates², ¹Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Premenopausal SLE patients have a devastating increase in cardiovascular disease (CVD) and major associated cardiovascular events (MACE) that are not fully explained by Framingham…
Abstract Number: 682 • 2012 ACR/ARHP Annual Meeting
IL-12p70 Levels Play a Role in Damage Accrual in SLE Patients
Eoghan M. McCarthy¹, Ruth Lee², Joan Ni Gabhann³, Siobhan Smith³, Michele Doran⁴, Gaye Cunnane⁵, Donough G. Howard², Paul G. O'Connell¹, Caroline Jefferies³ and Grainne M. Kearns⁶, ¹Rheumatology, Beaumont Hospital, Dublin, Ireland, ²Rheumatology, Beaumont Hospital, Dublin 9, Ireland, ³Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ⁴Rheumatology Dept, St James's Hospital, Dublin, Ireland, ⁵Dept of Rheumatology, St. James's Hospital, Dublin, Ireland, ⁶Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: Whilst the role of cytokines in promoting disease activity in SLE is well established, the relationship between cytokines in those who sustain irreversible damage…
Abstract Number: 683 • 2012 ACR/ARHP Annual Meeting
Prevalence of Inhibitory or Non-Inhibitory Autoantibodies to Angiotensin Converting Enzyme 2 (ACE2) in Patients with Systemic Lupus Erythematosus
Yuko Takahashi¹, Shiori Haga², Yukihito Ishizaka² and Akio Mimori³, ¹Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan, ²Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, ³Department of Intractable Diseases, National Center for Global Health and Medicine, Tokyo, Japan
Background/Purpose: We previously reported that inhibitory autoantibodies to angiotensin converting enzyme 2 (ACE2) predisposed individuals to connective tissue diseases (i.e., scleroderma or systemic lupus erythematosus…
Abstract Number: 684 • 2012 ACR/ARHP Annual Meeting
Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a with Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Paul R. Dominguez-Gutierrez¹, Angela Ceribelli¹, Minoru Satoh², Eric S. Sobel³, Yi Li², Westley H. Reeves⁴ and Edward K.L. Chan¹, ¹Oral Biology, University of Florida, Gainesville, FL, ²Medicine, University of Florida, Gainesville, FL, ³Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, ⁴Rheumatology & Clinical Imm, University of Florida, Gainesville, FL
Background/Purpose: Anaemia is one of the most common haematological manifestations in SLE patients, occurring in about 50% of active cases. STAT1 is a critical signalling…
Abstract Number: 685 • 2012 ACR/ARHP Annual Meeting
Using a Library of Synthetic Autoantigen Mimics to Discover Biomarkers of Systemic Lupus Erythematosus
Akshai Lakhanpal¹, Jiexia Quan², Sayed Zaman¹, Nancy J. Olsen³ and David R. Karp², ¹Rheumatic Diseases Divsion, UT Southwestern Medical Center, Dallas, TX, ²Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ³Medicine, Penn State MS Hershey Medical Center, Hershey, PA
Background/Purpose: The natural history of systemic lupus erythematosus (SLE) is felt to evolve from a state of normal immunity to serologic autoimmunity and then…
Abstract Number: 686 • 2012 ACR/ARHP Annual Meeting
Cell-Type Specific Type I Interferon Signatures in Autologous Stem Cell Transplanted Lupus Patients: Different Molecular Behavior Between CD4+ T Cells and Monocytes
Chieko Kyogoku¹, Joachim R. Grün¹, Tobias Alexander², Robert Biesen³, Falk Hiepe⁴, Thomas Häupl³, Andreas Radbruch¹ and Andreas Grützkau¹, ¹German Rheumatism Research Centre Berlin (DRFZ), an institute of the Leibniz Association, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that affects multiple organs, whose pathology is mainly caused by the augmented interferon (IFN)…
Abstract Number: 687 • 2012 ACR/ARHP Annual Meeting
Gammadelta T Cells and Their Intracellular Cytokine Profile in Peripheral Blood of Patients with Systemic Lupus Erythematosus
Lingyun Sun, Xia Li and Zhimin Lu, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Gammadelta T cells represent a minor population of human peripheral blood T lymphocytes. As very rapid cytokine-producing cells, gammadelta T cells can regulate other…
Abstract Number: 688 • 2012 ACR/ARHP Annual Meeting
Expression of the Mer Receptor Tyrosine Kinase On Peripheral Blood Mononuclear Cells From Systemic Lupus Erythematosus Patients
Brendan A. Hilliard¹, Gaetano Zizzo¹, Margaret K. Linan¹ and Philip L. Cohen², ¹Medicine, Temple University School of Medicine, Philadelphia, PA, ²Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: The Mer tyrosine kinase (Mertk) is necessary for optimal removal of apoptotic cells in animal models. Its ligation by apoptotic cell-bound protein S…
Abstract Number: 689 • 2012 ACR/ARHP Annual Meeting
Activation of the Interferon Pathway Is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients
Kichul Ko¹, Yelena Koldobskaya¹, Elizabeth Rosenzweig² and Timothy B. Niewold¹, ¹Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ²Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: Gene expression studies have been instrumental in defining important aspects of the complex immunological pathogenesis in systemic lupus erythematosus (SLE) which is a heterogeneous…

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