Abstracts Archive - Page 2370 of 2605 - ACR Meeting Abstracts

Abstract Number: 892 • 2013 ACR/ARHP Annual Meeting
The Functional PTPN22 Variant R620W Is Strongly Associated With Giant Cell Artetitis Predisposition
F. David Carmona¹, Sarah L. Mackie², Aurora Serrano³, Ana Marquez⁴, Roser Solans⁵, Jose A. Miranda-Filloy⁶, Jose Hernández-Rodríguez⁷, Maria C. Cid⁸, Santos Castañeda⁹, Inmaculada C. Morado¹⁰, Javier Narvaez¹¹, Ricardo Blanco¹², Bernardo Sopeña¹³, M. Jesus García-Villanueva¹⁴, Jordi Monfort¹⁵, Norberto Ortego-Centeno¹⁶, Ainhoa Unzurrunzaga¹⁷, Begoña Marí-Alfonso¹⁸, Julio Sánchez-Martín¹⁹, Eugenio de Miguel²⁰, Cesar Magro²¹, Enrique Raya²², Niko Braun²³, Joerg Latus²⁴, Øyvind Molberg²⁵, Benedicte A. Lie²⁶, Frank Moosig²⁷, Torsten Witte²⁸, Ann W. Morgan², Miguel A. González-Gay²⁹ and Javier Martin³, ¹Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ⁴Instituto de Parasitología y Biomedicina 'López-Neyra' (IPBLN-CSIC), Granada, Spain, ⁵Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, ⁶Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁷Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁸Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁹Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ¹⁰Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ¹²Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ¹³Thrombosis and Vasculitis Unit-Internal Medicine, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain, ¹⁴Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ¹⁵Reumatologia, Hospital del Mar, Barcelona, Spain, ¹⁶Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ¹⁷Internal Medicine, Hospital de Galdakano, Vizcaya, Spain, ¹⁸Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Spain, ¹⁹Rheumatology,, Hospital Universitario 12 de Octubre, Madrid, Spain, ²⁰Rheumatology, University Hospital La Paz - IdiPaz, Madrid, Spain, ²¹Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ²²Rheumatology, University Hospital San Cecilio, Granada, Spain, ²³Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, ²⁴Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, ²⁵Oslo University Hospital, Oslo, Norway, ²⁶Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway, ²⁷Department of Clinical Immunology and Rheumatology, University of Luebeck, Bad Bramstedt, Germany, ²⁸Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ²⁹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose: The PTPN22/CSK signaling represents one of the common susceptibility pathways in autoimmunity. Considering that the genetic basis of giant cell arteritis (GCA), an autoimmune…
Abstract Number: 893 • 2013 ACR/ARHP Annual Meeting
Association Between Human Leukocyte Antigen-B’s Amino Acid Variation and Disease-Susceptibility To Takayasu’s Arteritis
Hajime Yoshifuji¹, Chikashi Terao², Kosaku Murakami³, Daisuke Kawabata³, Koichiro Ohmura¹, Takao Fujii⁴, Yasushi Kawaguchi⁵, Hisashi Yamanaka⁵ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ³Dept of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: HLA-B52 and HLA-B51 are frequently seen in Asian population and are almost identical except two amino acid residues(the 63rd and 67th), but HLA-B52 is…
Abstract Number: 894 • 2013 ACR/ARHP Annual Meeting
Intermittent Fever, Immune Dysregulation, and Systemic Vasculopathy Due To Loss-Of-Function Mutations In Adenosine Deaminase2
Qing Zhou¹, Dan Yang², Andrey Zavialov³, Amanda Ombrello⁴, Hyesun Kuehn⁵, Jae Jin Chae⁶, Anton Zavialov³, David Chin⁷, Deborah Stone⁸, Camilo Toro⁹, Joshua Milner¹⁰, Chyi-chia Lee¹¹, Edward Cowen¹², Fabio Candotti¹³, Elaine Remmers⁷, Susan Moir¹⁴, Raman Sood¹⁵, Shawn Burgess¹⁶, Massimo Gadina¹⁷, Sergio Rosenzweig¹⁸, Michael Hershfield¹⁹, Daniel L. Kastner²⁰, Manfred Boehm² and Ivona Aksentijevich⁷, ¹Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ³Turku Centre for Biotechnology, University of Turku, Turku, Finland, ⁴National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁵Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, ⁶Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁷Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁸National Human Genome Research Institute, Bethesda, MD, ⁹NIH Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ¹⁰Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ¹¹National Cancer Institute, National Institutes of Health, Bethesda, MD, ¹²Dermatology Consultation Servce, National Cancer Institute, National Institutes of Health, Bethesda, MD, ¹³Disorder of Immunity Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ¹⁴Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ¹⁵Zebrafish Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ¹⁶Developmental Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ¹⁷Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ¹⁸National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ¹⁹Department of Medicine, Duke University Medical Center, Durham, NC, ²⁰Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD
Background/Purpose: We observed a syndrome characterized by intermittent fevers and livedoreticularis, systemic inflammation, hepatosplenomegaly, cytopenias, vasculopathy, and early-onset lacunar strokes in five unrelated patients. We…
Abstract Number: 895 • 2013 ACR/ARHP Annual Meeting
The Relative Risk Of Aortic Aneurysm In Patients With Giant Cell Arteritis Compared With The General Population
Joanna Robson¹, Amit Kiran², Joseph Maskell³, Andrew Hutchings⁴, Nigel K. Arden⁵, Bhaskar Dasgupta⁶, William Hamilton⁷, Akan Emin⁸, David Culliford³ and Raashid A. Luqmani², ¹Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, ³Faculty of Medicine, University of Southampton, Southampton, United Kingdom, ⁴Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁵NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁶Rheumatology, Southend University Hospital, Westcliff-on-sea, United Kingdom, ⁷Primary Care Diagnostics, University of Exeter Medical School, Exeter, United Kingdom, ⁸Clinical Effectiveness Unit, The Royal College of Surgeons of England, London, United Kingdom
Background/Purpose: To evaluate the risk of aortic aneurysm in patients with giant cell arteritis (GCA) when compared with age, gender and location matched controls from…
Abstract Number: 896 • 2013 ACR/ARHP Annual Meeting
Increased Rho Kinase (ROCK) Activity In Temporal Artery Biopsies From Patients With Giant Cell Arteritis (GCA)
Lindsay Lally¹, Navneet Narula², Alessandra B. Pernis³, Wei-Ti Huang⁴, Uzunma Udeh¹ and Robert F. Spiera¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Pathology, Weill Cornell Medical College, New York, NY, ³Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ⁴Biostatistics, Hospital for Special Surgery, New York, NY
Background/Purpose: ROCKs are implicated in the pathogenesis of many vascular diseases. ROCK activation is associated with Th17 differentiation and production of Th17-associated cytokines, IL-17 and…
Abstract Number: 897 • 2013 ACR/ARHP Annual Meeting
Characterization Of Low Back Symptoms In a Community-Based Sample Of Older Adults: The Johnston County Osteoarthritis Project
Adam P. Goode¹, Kelli D. Allen², Timothy S. Carey³ and Joanne M. Jordan⁴, ¹Community and Family Medicine, Duke University, Durham, NC, ²Health Services Research, Duke and Durham VA Medical Center, Durham, NC, ³UNC School of Medicine, Cecil G. Sheps Center for Health Services Research University of North Carolina, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: The majority of research in low back pain has focused on the middle-aged segment of the population. As such, there is a gap in…
Abstract Number: 898 • 2013 ACR/ARHP Annual Meeting
Sex-Specific Employment Participation Restriction Across Occupational Groups Among Working-Age (18-64 years) U.S. Adults With and Without Arthritis
Kristina A. Theis¹ and Louise Murphy², ¹Athritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Division of Population Health, CDC, Atlanta, GA
Background/Purpose: Previous research has shown arthritis-attributable work limitation to be high (~30%) among U.S. adults with arthritis and for employment to be ~20% lower among…
Abstract Number: 899 • 2013 ACR/ARHP Annual Meeting
Foot Pain, But Not Foot Structure Or Foot Function, Are Associated With Self-Reported Physical Limitations: The Framingham Foot Study
Alyssa B. Dufour¹, Patricia P. Katz², Virginia A. Casey³, Marian T. Hannan⁴ and Hylton B. Menz⁵, ¹Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Institute for Aging Research, Hebrew SeniorLife, Boston, MA, ⁴Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Lower Extremity and Gait Studies Program, La Trobe University, Bundoora, Victoria 3086, Australia
Background/Purpose: The purpose of this cross-sectional study was to examine the relation between self reported physical limitations and foot pain, foot structure and foot function…
Abstract Number: 900 • 2013 ACR/ARHP Annual Meeting
Foot Symptoms Increase Odds Of Falling: The Johnston County Osteoarthritis Project
Yvonne M. Golightly¹, Marian T. Hannan², Alyssa B. Dufour³, Amanda E. Nelson⁴, Adam Dore⁵ and Joanne M. Jordan⁶, ¹Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ²Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA, ⁴University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ⁵Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁶Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Foot symptoms (symptoms=pain, aching, and stiffness) are common in older adults and are associated with poorer physical function, but their contribution to risk…
Abstract Number: 901 • 2013 ACR/ARHP Annual Meeting
Smokers and Overweight Persons Are At Increased Risk Of New Onset Of Severe Foot Pain and Persistent Severe Foot Pain In a Population Study
Alyssa B. Dufour¹, Hylton B. Menz², Arunima Awale³, Thomas J. Hagedorn³, Virginia A. Casey³, Patricia P. Katz⁴ and Marian T. Hannan⁵, ¹Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA, ²Lower Extremity and Gait Studies Program, La Trobe University, Bundoora, Victoria 3086, Australia, ³Institute for Aging Research, Hebrew SeniorLife, Boston, MA, ⁴Medicine, University of California, San Francisco, San Francisco, CA, ⁵Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Few studies have evaluated risk factors for patterns of foot pain in the general population, let alone over time. An understanding of the possible…
Abstract Number: 902 • 2013 ACR/ARHP Annual Meeting
The Effect Of Obesity On Physical Function: The Osteoarthritis Initiative Study
Jingbo Niu¹, Daniel K. White², David T. Felson³, Michael C. Nevitt⁴ and Yuqing Zhang³, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁴Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: Previous studies assessing relationship between obesity and physical function used linear regression model that assumes effects of obesity on physical function were the same…
Abstract Number: 903 • 2013 ACR/ARHP Annual Meeting
A Qualitative Study Of The Educational Needs Of Children With Scleroderma and Their Parents
Cindy F. Mendelson¹, Ana-Alicia Huerta², Jane Kastning³, Bernadette Vargas³ and Janet L. Poole⁴, ¹College of Nursing, University of New Mexico, Albuquerque, NM, ²Univeristy of New Mexico, Albuquerque, NM, ³Occupational Therapy, University of New Mexico, Albuquerque, NM, ⁴Occupational Therapy Program, University of New Mexico, Albuquerque, NM
Background/Purpose: Scleroderma is a rare disease, especially in childhood. Skin changes can be physically disfiguring which can lead to lowered self-esteem, especially during the adolescent…
Abstract Number: 904 • 2013 ACR/ARHP Annual Meeting
Worse Mental Health In Employed Adult Patients With Juvenile Idiopathic Arthritis (JIA): More Than Just A Job
Nadia E. Aikawa¹, Jms Gordo², R Krieger³, LE Paula⁴ and Claudia Goldenstein-Schainberg¹, ¹Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²Reumatologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil, ³Reumatologia, Universidade de Sao Paulo, Sao Paulo, Brazil, ⁴Reumatologia, Faculdade de Medicina, Universidade de São Paulo, Sao PAulo, Brazil
Background/Purpose: Work status and unemployment are significant future concerns among individuals with JIA, because roughly 20% patients enter adulthood with clinically active disease and disabled.…
Abstract Number: 905 • 2013 ACR/ARHP Annual Meeting
Lupus and Reproductive Health Considerations: A Pilot Training For Reproductive Health Care Providers Serving Teens and Young Adults
Shawn Rose¹, Dariana M. Pichardo², Monica C. Richey³, Josephine Isgro⁴ and Roberta Horton⁵, ¹Cardiovascular and Pulmonary Branch, NIAMS, NHLBI, Bethesda, MD, ²Department of Social Work Programs, Hospital For Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Pediatric Rheumatology, Morgan Stanley Children's Hospital of New-York Presbyterian, Columbia University Medical Center, New York, NY, ⁵Department of Social Work Programs, Hospital for Special Surgery, New York, NY
Background/Purpose: Health disparities (our target communities continue to experience some of the highest rates of sexually transmitted disease and teen pregnancy in the country) related…
Abstract Number: 906 • 2013 ACR/ARHP Annual Meeting
Longitudinal Patterns Of Depression In Lupus
Patricia P. Katz, Chris Tonner, Laura Trupin and Jinoos Yazdany, Medicine, University of California, San Francisco, San Francisco, CA
Background/Purpose: Depression is commonly reported in systemic lupus erythematosus (SLE), yet information is lacking about long-term patterns of depression. We examined a longitudinal SLE cohort…

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