Abstract Number: 787 • 2012 ACR/ARHP Annual Meeting
Aberrant Adipogenesis in the Pathogenesis of Scleroderma
Background/Purpose: Skin fibrosis in systemic sclerosis (SSc) is associated with loss of subcutaneous adipose tissue (SCAT) and reduction in adiponectin. The mechanism underlying SCAT atrophy…Abstract Number: 788 • 2012 ACR/ARHP Annual Meeting
Tenofovir, a Potent Anti-Viral Agent, Is an Ecto-5’Nucleotidase (CD73) Inhibitor That Prevents Dermal Fibrosis in a Murine Model of Scleroderma
Background/Purpose: Acyclic nucleoside phosphonates are a key class of antivirals commonly used in the treatment of both DNA and retroviral infections. Adefovir and tenofovir are…Abstract Number: 789 • 2012 ACR/ARHP Annual Meeting
Foot Disorders Associated with Over-Pronated and Over-Supinated Foot Types: The Johnston County Osteoarthritis Project
Background/Purpose: Based on clinical observations, musculoskeletal foot disorders, such as hallux valgus or plantar fasciitis, appear to occur more frequently in a pronated foot…Abstract Number: 790 • 2012 ACR/ARHP Annual Meeting
Biomechanical Function Agrees with Clinical Implications of Foot Disorders in a Population-Based Study
Background/Purpose: Foot disorders are thought to be associated with foot structure and function. However, no population-based studies have objectively evaluated this question. Insights into the…Abstract Number: 791 • 2012 ACR/ARHP Annual Meeting
Leg Muscle Mass Is Not Affected by Foot Pain, Structure or Function: The Framingham Foot Study
Background/Purpose: While foot pain has been linked to poor outcomes, little is known about how the foot might affect physical functioning or, specifically, leg muscle…Abstract Number: 792 • 2012 ACR/ARHP Annual Meeting
Associations of Foot Structure and Function to Low Back and Lower Extremity Pain
Background/Purpose: Common risk factors of low back/lower extremity (LB/LE) joint pain are age, gender and body mass index (BMI), with women, older adults and overweight/obese…Abstract Number: 753 • 2012 ACR/ARHP Annual Meeting
Progress Report On Development of Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies
Background/Purpose: In patients with idiopathic inflammatory myopathies (IIM) persisting muscle impairment after treatment underscores the need for improved management. Inadequate classification criteria for IIM are…Abstract Number: 754 • 2012 ACR/ARHP Annual Meeting
The Functional Index-3 in Adult Dermatomyositis and Polymyositis: Validity and Reliability of an Outcome Measure for Muscle Endurance
Background/Purpose: Although muscle fatigue is a major source of functional impairment in dermatomyositis (DM) and polymyositis (PM), few valid and reliable methods for efficient evaluation…Abstract Number: 755 • 2012 ACR/ARHP Annual Meeting
Sifalimumab, an Anti-IFN-Alpha Monoclonal Antibody Shows Target Suppression of a Type I IFN Signature in Blood and Muscle of Dermatomyositis and Polymyositis Patients
Background/Purpose: To assess the pharmacodynamic effects of sifalimumab, an investigational anti-IFN-alpha monoclonal antibody, in the blood and muscle of adult dermatomyositis and polymyositis patients by…Abstract Number: 756 • 2012 ACR/ARHP Annual Meeting
Effect of B Cell Depletion Therapy with Rituximab On Myositis Associated Autoantibody Levels in Idiopathic Inflammatory Myopathy
Background/Purpose: Myositis associated autoantibodies (MAA) in idiopathic inflammatory myopathy (IIM) demonstrate unique phenotypic features. In some autoimmune disorders, autoantibody levels correlate with disease activity and…Abstract Number: 757 • 2012 ACR/ARHP Annual Meeting
Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
Background/Purpose: Idiopathic inflammatory myopathies are a heterogeneous group of different diseases, classified into four main categories: dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and sporadic inclusion body…Abstract Number: 758 • 2012 ACR/ARHP Annual Meeting
Cutaneous Ulceration in Dermatomyositis: Association with MDA-5 and Interstitial Lung Disease
Background/Purpose: Dermatomyositis (DM) is a multisystem autoimmune disease that affects the muscles and skin and can be associated with malignancy or interstitial lung disease (ILD). …Abstract Number: 759 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Canakinumab in Patients with Active Systemic Juvenile Idiopathic Arthritis and Fever: Results From Two Pivotal Phase 3 Trials
Background/Purpose : Systemic juvenile idiopathic arthritis (sJIA) is an interleukin-1β (IL-1β)-mediated autoinflammatory disease. Canakinumab is a selective, fully human, anti-IL-1β monoclonal antibody. Two pivotal phase…Abstract Number: 760 • 2012 ACR/ARHP Annual Meeting
Catch-up Growth During Tocilizumab Therapy for Systemic Juvenile Idiopathic Arthritis: 2-Year Data From a Phase 3 Clinical Trial
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA), characterized by chronic arthritis associated with prominent systemic and laboratory features, also has a significant impact on the growing…Abstract Number: 761 • 2012 ACR/ARHP Annual Meeting
Analysis of Biomarkers in Systemic Juvenile Idiopathic Arthritis Patients On Canakinumab Therapy
Background/Purpose: Systemic Juvenile Idiopathic Arthritis (SJIA) is a severe disabling subtype of Juvenile Idiopathic Arthritis characterized by arthritis plus systemic symptoms, such as high fever,…
ACR Meeting Abstracts