Abstracts Archive - Page 2370 of 2607 - ACR Meeting Abstracts

Abstract Number: 908 • 2013 ACR/ARHP Annual Meeting
Appearance Dissatisfaction, Social Discomfort, and Helplessness In Patients With Systemic Sclerosis
Shadi Gholizadeh¹, Sarah D. Mills², Rina M. Sobel-Fox¹, Philip J. Clements³, Suzanne Kafaja⁴, Vanessa L. Malcarne^2,5, Dinesh Khanna⁶ and Daniel Furst⁴, ¹Psychology, SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, ²SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, ³University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁴David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁵Department of Psychology, San Diego State University, Psychology, San Diego, CA, ⁶Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a progressive, autoimmune disease with no known cure. It is related to a wide spectrum of adverse health outcomes including…
Abstract Number: 909 • 2013 ACR/ARHP Annual Meeting
Diagnostic Autoantibody Signatures Of Rheumatoid Arthritis Patients Identified With a Bead-Based Assay Approach
Angelika Lueking¹, Petra Budde¹, Stefan Vordenbäumen², Carmen Theek¹, Heike Goehler¹, Martin Gamer¹, Peter Schulz-Knappe¹ and Matthias Schneider³, ¹Protagen AG, Dortmund, Germany, ²Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, ³Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease typically characterized by chronic inflammation, accumulation of self-reactive B-cells and production of autoantibodies of which anti–cyclic citrullinated…
Abstract Number: 910 • 2013 ACR/ARHP Annual Meeting
Anti-Carbamylated Protein Antibodies (Anti-CarP) Precede The Onset Of Rheumatoid Arthritis
Jing Shi¹, Lotte A. van de Stadt², E.W.Nivine Levarht¹, Tom W. J. Huizinga¹, Dörte Hamann³, Dirkjan van Schaardenburg⁴, René E.M. Toes¹ and Leendert A. Trouw¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Sanquin Diagnostic Services, Amsterdam, Netherlands, ⁴Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and IgM-Rheumatoid Factor (IgM-RF) are auto-antibodies that can be detected many years before the clinical diagnosis of Rheumatoid Arthritis (RA)…
Abstract Number: 911 • 2013 ACR/ARHP Annual Meeting
Neutralization Of Anti-Citrullinated Protein Antibodies – a Way To Go?
Catia Cerqueira¹, Elena Ossipova², Monika Hansson³, Linda Mathsson⁴, Lars Klareskog³, Johan Rönnelid⁴ and Per Johan Jakobsson⁵, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁵Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: In a previous study, we have identified endogeneously citrullinated sites in fibrinogen from RA synovial tissue (Hermansson M. et al. Proteomics Clin Appl, 2010).…
Abstract Number: 912 • 2013 ACR/ARHP Annual Meeting
B-Cell Responses To De Novo Identified Citrullinated Fibrinogen Peptides Are Associated With PTPN22 Risk Allele
Vijay Joshua¹, Loes Schobers², Lena Israelsson³, Johan Rönnelid⁴, Monika Hansson⁵, Anca I Catrina⁶, Ger JM Pruijn² and Vivianne Malmström⁷, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Biomolecular Chemistry, Radboud University, Nijmegen, Netherlands, ³Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁷Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Antibodies against citrullinated proteins are common in patients with rheumatoid arthritis (RA) and appear prior to the onset of the disease [1]. Many of…
Abstract Number: 913 • 2013 ACR/ARHP Annual Meeting
High Throughput Epitope Mapping Of Autoantibodies In BXD2 Mice Reveals The Generation Of Autoantibodies Against Citrullinated Antigens At The Predicted Major Immunogenic Sites
Jennie Hamilton¹, Qi Wu², PingAr Yang², Hui-Chen Hsu³ and John D. Mountz⁴, ¹University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Increased polyreactive B cells have been identified in patients with systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). Such autoantibodies (autoAbs) were also identified…
Abstract Number: 914 • 2013 ACR/ARHP Annual Meeting
Accentuated Expression Of RANKL In Switched Memory B Cells From Patients With Rheumatoid Arthritis
Yuri Hirosaki, Hiroaki Niiro, Shun-ichiro Ota, Naoko Ueki, Hirofumi Tsuzuki, Siamak Jabbarzadeh-Tabrizi, Kumiko Noda, Naoyasu Ueda, Naoyasu Ueda, Atsushi Tanaka, Masahiro Ayano, Sho Ueda, Satomi Hisamoto, Daisuke Oryoji, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto, Takahiko Horiuchi and Koichi Akashi, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: Clinical efficacy of B-cell depletion therapy underscores a pathogenic role of B cells in autoimmune diseases such as rheumatoid arthritis (RA). In addition to…
Abstract Number: 915 • 2013 ACR/ARHP Annual Meeting
IL-6R Inhibition Reduces Activation Of Different Peripheral Memory B Cell Subsets In RA
Zafar Mahmood¹, Khalid Muhammad¹, Marc Schmalzing², Petra Roll³, Kathrina Eckert¹, Thomas Dörner⁴ and Hans-Peter Tony⁵, ¹Rheumatology and Clinical Immunology, University of Würzburg, Würzburg, Germany, ²Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany, ³Rheumatology and Clinical immunology, University of Würzburg, Würzburg, Germany, ⁴CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ⁵Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany
Background/Purpose: Enhanced B cell activity has been proposed as part of the pathogenesis of rheumatoid arthritis also based on the clinical experiences obtained by B…
Abstract Number: 916 • 2013 ACR/ARHP Annual Meeting
Role Of CD20+ B Cells As Antigen-Presenting Cells In Arthritis
Estefania Armas-Gonzalez¹, Ana Diaz-Martin¹, María Jesús Dominguez-Luis¹, Maria Teresa Arce-Franco¹, Ada Herrera-Garcia¹, Vanesa Hernandez¹, Alicia Usategui², Jose L. Pablos³, Sagrario Bustabad¹ and Federico Diaz-Gonzalez⁴, ¹Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, ²Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain, ³Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ⁴University of La Laguna, Hospital Universitario de Canarias, La Laguna, Spain
Background/Purpose: B cells participate in the pathogenesis of rheumatoid arthritis (RA) through a mechanism still not fully understood. In RA, B cells are believed to…
Abstract Number: 917 • 2013 ACR/ARHP Annual Meeting
B-Regulatory-, CD19⁺CD20⁺CD24^highCD38^high -Cells Are Functionally Impaired In Patients With Rheumatoid Arthritis and Healthy First Degree Relatives Compared With Controls
Mikael Brink¹, Kristina Lejon², Lisbeth Ärlestig³ and Solbritt Rantapää Dahlqvist⁴, ¹Rheumatology, Umeå University, Umea, Sweden, ²Clinical Microbiology, Division of Immunology, Umeå Universitet, Umeå, Sweden, ³Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ⁴Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a complex disease with both genetic- and environmental risk factors. By studying first degree relatives (FDR) of RA patients which…
Abstract Number: 918 • 2013 ACR/ARHP Annual Meeting
Regulatory B Cells Suppress Skin Inflammation in a Murine Model of Psoriasis
Koichi Yanaba¹ and Shinichi Sato², ¹Dermatology, The University of Tokyo, Tokyo, Japan, ²Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Psoriasis is a cutaneous disorder characterized by widespread erythematous plaques with adherent scales. Recent studies have revealed that both T helper (Th) 17 and…
Abstract Number: 919 • 2013 ACR/ARHP Annual Meeting
B Cell Derived IFN-γ Contributes To The Negative Regulation Of T-Regulatory Cell Differentiation In Arthritis
Susan Olalekan¹, Yanxia Cao² and Alison Finnegan², ¹Immunology, Rush University Medical Center, Chicago, IL, ²Dept of Medicine, Rush University Medical Center, Chicago, IL
Background/Purpose: Depletion of B cells using a monoclonal antibody against CD20 expressed on mature B cells has proven efficacious in patients with rheumatoid arthritis (RA).…
Abstract Number: 920 • 2013 ACR/ARHP Annual Meeting
Fms-Like Tyrosine Kinase 3 Signaling Is Essential For Differentiation Of Antigen Specific Plasma Cells During Experimental Arthritis
Mattias Svensson¹, Kersti Månsson¹, Karin Andersson¹, Mats Bemark², Mikael Brisslert¹ and Maria Bokarewa¹, ¹Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ²Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Signaling through the tyrosine kinase receptor Flt3 plays an important role in early B-cell development. Mice lacking either Flt3 or its ligand (Flt3L) have…
Abstract Number: 921 • 2013 ACR/ARHP Annual Meeting
Blocking The Complement Receptor 2 (CR2) Ligand-Receptor Interaction With a Novel Mouse Anti-Mouse CR2 Monoclonal Antibody Decreases Antigen-Specific Humoral Immune Responses and The Evolution Of Collagen-Induced Arthritis
Rosa Rodriguez¹, Liudmila Kulik¹, Joshua Thurman², Jonathan Hannan¹, Steve Tomlinson³ and V. Michael Holers¹, ¹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ²Renal Division, University of Colorado School of Medicine, Aurora, CO, ³Microbiology and Immunology, Medical University of South Carolina, Charleston, NC
Background/Purpose: The CR2/CD19 complex on B cells serves as a co-receptor for membrane IgM and amplifies B cell responses through physical associations of the bound…
Abstract Number: 922 • 2013 ACR/ARHP Annual Meeting
Role Of B Cells and/Or Autoantibodies In Pulmonary Manifestations Of Inflammatory Arthritis
Lisa K. Peterson¹, Jeremy Sokolove², Paul Jedlicka³, Lauren J. Lahey⁴, William H. Robinson⁵ and Leonard L. Dragone⁶, ¹Pediatrics, National Jewish Health, Denver, CO, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Pathology, University of Colorado Denver, Aurora, CO, ⁴Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁵VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Dept of Pediatrics, National Jewish Health, Denver, CO
Background/Purpose: RA is a systemic condition affecting approximately 1% of the general population leading to progressive arthritis and extra-articular manifestations (ExRA), including interstitial lung disease…

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