Abstract Number: 792 • 2012 ACR/ARHP Annual Meeting
Associations of Foot Structure and Function to Low Back and Lower Extremity Pain
Background/Purpose: Common risk factors of low back/lower extremity (LB/LE) joint pain are age, gender and body mass index (BMI), with women, older adults and overweight/obese…Abstract Number: 753 • 2012 ACR/ARHP Annual Meeting
Progress Report On Development of Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies
Background/Purpose: In patients with idiopathic inflammatory myopathies (IIM) persisting muscle impairment after treatment underscores the need for improved management. Inadequate classification criteria for IIM are…Abstract Number: 754 • 2012 ACR/ARHP Annual Meeting
The Functional Index-3 in Adult Dermatomyositis and Polymyositis: Validity and Reliability of an Outcome Measure for Muscle Endurance
Background/Purpose: Although muscle fatigue is a major source of functional impairment in dermatomyositis (DM) and polymyositis (PM), few valid and reliable methods for efficient evaluation…Abstract Number: 755 • 2012 ACR/ARHP Annual Meeting
Sifalimumab, an Anti-IFN-Alpha Monoclonal Antibody Shows Target Suppression of a Type I IFN Signature in Blood and Muscle of Dermatomyositis and Polymyositis Patients
Background/Purpose: To assess the pharmacodynamic effects of sifalimumab, an investigational anti-IFN-alpha monoclonal antibody, in the blood and muscle of adult dermatomyositis and polymyositis patients by…Abstract Number: 756 • 2012 ACR/ARHP Annual Meeting
Effect of B Cell Depletion Therapy with Rituximab On Myositis Associated Autoantibody Levels in Idiopathic Inflammatory Myopathy
Background/Purpose: Myositis associated autoantibodies (MAA) in idiopathic inflammatory myopathy (IIM) demonstrate unique phenotypic features. In some autoimmune disorders, autoantibody levels correlate with disease activity and…Abstract Number: 757 • 2012 ACR/ARHP Annual Meeting
Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
Background/Purpose: Idiopathic inflammatory myopathies are a heterogeneous group of different diseases, classified into four main categories: dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and sporadic inclusion body…Abstract Number: 758 • 2012 ACR/ARHP Annual Meeting
Cutaneous Ulceration in Dermatomyositis: Association with MDA-5 and Interstitial Lung Disease
Background/Purpose: Dermatomyositis (DM) is a multisystem autoimmune disease that affects the muscles and skin and can be associated with malignancy or interstitial lung disease (ILD). …Abstract Number: 759 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Canakinumab in Patients with Active Systemic Juvenile Idiopathic Arthritis and Fever: Results From Two Pivotal Phase 3 Trials
Background/Purpose : Systemic juvenile idiopathic arthritis (sJIA) is an interleukin-1β (IL-1β)-mediated autoinflammatory disease. Canakinumab is a selective, fully human, anti-IL-1β monoclonal antibody. Two pivotal phase…Abstract Number: 760 • 2012 ACR/ARHP Annual Meeting
Catch-up Growth During Tocilizumab Therapy for Systemic Juvenile Idiopathic Arthritis: 2-Year Data From a Phase 3 Clinical Trial
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA), characterized by chronic arthritis associated with prominent systemic and laboratory features, also has a significant impact on the growing…Abstract Number: 761 • 2012 ACR/ARHP Annual Meeting
Analysis of Biomarkers in Systemic Juvenile Idiopathic Arthritis Patients On Canakinumab Therapy
Background/Purpose: Systemic Juvenile Idiopathic Arthritis (SJIA) is a severe disabling subtype of Juvenile Idiopathic Arthritis characterized by arthritis plus systemic symptoms, such as high fever,…Abstract Number: 762 • 2012 ACR/ARHP Annual Meeting
Potentially Fatal Pulmonary Complications in Systemic Juvenile Idiopathic Arthritis
Background/Purpose: Systemic Juvenile Idiopathic Arthritis (sJIA) is characterized by fevers, rash and arthritis, for which IL1 and IL6 inhibitors appear to be effective. Pulmonary artery…Abstract Number: 763 • 2012 ACR/ARHP Annual Meeting
Incidence of Selected Opportunistic Infections Among Children with Juvenile Idiopathic Arthritis
Background/Purpose: There may be an increased risk of opportunistic infections among children with juvenile idiopathic arthritis (JIA), especially with exposure to immunosuppressant medications. No controlled…Abstract Number: 764 • 2012 ACR/ARHP Annual Meeting
The Impact of Adalimumab On Growth in Patients with Juvenile Idiopathic Arthritis
Background/Purpose: Children with juvenile idiopathic arthritis (JIA) often exhibit growth impairments. Treatment with adalimumab (ADA) has been shown to be safe and effective in JIA…Abstract Number: 765 • 2012 ACR/ARHP Annual Meeting
A Prediction Rule for the Development of Rheumatoid Arthritis: A Prospective Cohort Study of Seropositive Arthralgia Patients
Background/Purpose: Patients presenting with arthralgia and a positive test for anti-cyclic citrullinated peptide antibodies (aCCP) and/or IgM rheumatoid factor (IgM-RF) (seropositive) are at risk for…Abstract Number: 766 • 2012 ACR/ARHP Annual Meeting
Anemia May Provide Clinically Relevant Information Beyond Conventional Disease Activity Assessment to Predict Radiographic Damage Progression in Rheumatoid Arthritis
Anemia may provide clinically relevant information beyond conventional disease activity assessment to predict radiographic damage progression in Rheumatoid ArthritisBurkhard Möller, Frauke Förger, Peter M. Villiger,…