Abstract Number: 777 • 2012 ACR/ARHP Annual Meeting
Effect of Certolizumab Pegol On Signs and Symptoms of Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis: 24 Week Results of a Double Blind Randomized Placebo-Controlled Phase 3 Axial Spondyloarthritis Study
Background/Purpose: Axial spondyloarthritis (axSpA ) includes both ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA), as defined by the ASAS criteria.1 RAPID-axSpA (NCT01087762) is the first…Abstract Number: 778 • 2012 ACR/ARHP Annual Meeting
Spinal MRI Has Little Incremental Diagnostic Value Compared with MRI of the Sacroiliac Joints Alone in Early Spondyloarthritis
Background/Purpose: The definition of a positive MRI as major criterion in the Assessment of SpondyloArthritis classification criteria for axial spondyloarthritis (SpA) is based on MRI…Abstract Number: 779 • 2012 ACR/ARHP Annual Meeting
Changes in Active Inflammatory Lesions Assessed by Magnetic Resonance Imaging: Results of the Infliximab As First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial
Background/Purpose: Few studies have evaluated changes in active inflammation of spine and sacroiliac (SI) joints by MRI during long-term treatment for axial SpA, and no…Abstract Number: 780 • 2012 ACR/ARHP Annual Meeting
The Relationship of Inflammation, Fatty Degeneration and the Effect of Long-Term TNF-Blocker Treatment On the Development of New Bone Formation in Patients with Ankylosing Spondylitis
Background/Purpose: Clinical trial results suggest that new bone formation is neither inhibited nor augmented by anti-TNF agents in ankylosing spondylitis (AS). Recently, a potential role…Abstract Number: 781 • 2012 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Is Associated with an Increased Risk of Osteoporotic Fractures: A Population-Based Cohort Study
TITLE: "Ankylosing Spondylitis is associated with an increased risk of osteoporotic fractures: a population-based cohort study."Background/Purpose: Patients with Ankylosing Spondylitis (AS) have reduced bone mass,…Abstract Number: 782 • 2012 ACR/ARHP Annual Meeting
Anti-TNF Therapy Slows Radiographic Progression of Ankylosing Spondylitis
Background/Purpose: The influence of anti-TNF therapy on radiographic progression in ankylosing spondylitis (AS) is not well established. We studied this effect on radiographic progression in…Abstract Number: 783 • 2012 ACR/ARHP Annual Meeting
The Wnt Inhibitors DKK1 and SFRP1 Are Downregulated by Promoter Hypermethylation in Systemic Sclerosis
Background/Purpose: Tissue fibrosis caused by pathological activation of fibroblasts is a major hallmark of systemic sclerosis (SSc). Epigenetic gene silencing of anti-fibrotic genes such as…Abstract Number: 784 • 2012 ACR/ARHP Annual Meeting
Neutralization of Plasminogen Activator Inhibitor-1 Resolves Skin Fibrosis and Vascular Injury in a Murine Model of Human Scleroderma
Background/Purpose: Scleroderma is a systemic autoimmune disease in which thrombosis and fibrosis contribute to skin pathology. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of…Abstract Number: 785 • 2012 ACR/ARHP Annual Meeting
Resident Lung Fibroblast Gene Expression Signatures Predict Susceptibility or Resistance to Experimental Lung Fibrosis
Background/Purpose: In scleroderma (SSc), lung fibrosis is linked to epithelial damage and dysregulated repair mechanisms. Resident lung fibroblasts may affect multiple cell types including…Abstract Number: 786 • 2012 ACR/ARHP Annual Meeting
Crosstalk Between Integrins and TGFβ in the Pathogenesis and Treatment of Multiple Presentations of Scleroderma
Background/Purpose: Scleroderma, defined as pathologic fibrosis of the skin, has many clinical presentations. In the most commonly recognized form, systemic sclerosis (SSc), previously healthy individuals…Abstract Number: 787 • 2012 ACR/ARHP Annual Meeting
Aberrant Adipogenesis in the Pathogenesis of Scleroderma
Background/Purpose: Skin fibrosis in systemic sclerosis (SSc) is associated with loss of subcutaneous adipose tissue (SCAT) and reduction in adiponectin. The mechanism underlying SCAT atrophy…Abstract Number: 788 • 2012 ACR/ARHP Annual Meeting
Tenofovir, a Potent Anti-Viral Agent, Is an Ecto-5’Nucleotidase (CD73) Inhibitor That Prevents Dermal Fibrosis in a Murine Model of Scleroderma
Background/Purpose: Acyclic nucleoside phosphonates are a key class of antivirals commonly used in the treatment of both DNA and retroviral infections. Adefovir and tenofovir are…Abstract Number: 789 • 2012 ACR/ARHP Annual Meeting
Foot Disorders Associated with Over-Pronated and Over-Supinated Foot Types: The Johnston County Osteoarthritis Project
Background/Purpose: Based on clinical observations, musculoskeletal foot disorders, such as hallux valgus or plantar fasciitis, appear to occur more frequently in a pronated foot…Abstract Number: 790 • 2012 ACR/ARHP Annual Meeting
Biomechanical Function Agrees with Clinical Implications of Foot Disorders in a Population-Based Study
Background/Purpose: Foot disorders are thought to be associated with foot structure and function. However, no population-based studies have objectively evaluated this question. Insights into the…Abstract Number: 791 • 2012 ACR/ARHP Annual Meeting
Leg Muscle Mass Is Not Affected by Foot Pain, Structure or Function: The Framingham Foot Study
Background/Purpose: While foot pain has been linked to poor outcomes, little is known about how the foot might affect physical functioning or, specifically, leg muscle…