Abstracts Archive - Page 2364 of 2425 - ACR Meeting Abstracts

Abstract Number: 857 • 2012 ACR/ARHP Annual Meeting
Impairment of the Inhibitory PD-1-PD-L1 Axis in Giant Cell Arteritis (GCA)
Mazen Nasrallah¹, Augusto Vaglio², Shalini Mohan¹, Bjorn Hartmann³, Joyce Liao⁴, Kenneth J. Warrington⁵, Jorg J. Goronzy³ and Cornelia M. Weyand⁶, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Unit of Nephrology, University Hospital of Parma, Parma, Italy, ³Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Giant cell arteritis (GCA) is an autoimmune syndrome characterized by granuloma formation in the media of medium and large arteries. In a healthy immune…
Abstract Number: 858 • 2012 ACR/ARHP Annual Meeting
Dense Genotyping, Imputation, and Regression Analysis Identifies Multiple Independent Genetic Susceptibility Loci within the HLA Region in Behcet’s Disease
Travis Hughes¹, Adam Adler², Patrick S. Coit¹, Vuslat Yilmaz³, Kenan Aksu⁴, Nursen Duzgun⁵, Gokhan Keser⁴, Ayse Cefle⁶, Ayten Yazici⁶, Andac Ergen⁷, Erkan Alpsoy⁸, Carlo Salvarani⁹, Bruno Casali¹⁰, Ina Koetter¹¹, Javier Gutierrez-Achury¹², Cisca Wijmenga¹², Haner Direskeneli¹³, Guher Saruhan-Direskeneli¹⁴ and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey, ⁴Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, ⁵Ankara University, Ankara, Turkey, ⁶Department of Rheumatology, Kocaeli University, Kocaeli, Turkey, ⁷Okmeydaný Research and Education Hospital, Istanbul, Turkey, ⁸Department of Dermatology, Akdeniz University, Antalya, Turkey, ⁹Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ¹⁰Molecular Biology Laboratory, Arcispedale S. Maria Nuova,, Reggio Emilia, Italy, ¹¹Robert Bosch Krankenhaus, Stuttgart, Germany, ¹²Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, ¹³Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ¹⁴Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: The genetic association between HLA-B51 and Behcet’s disease is well established. However, localizing this genetic effect and exploring additional susceptibility loci within the HLA…
Abstract Number: 859 • 2012 ACR/ARHP Annual Meeting
Endothelin-1 (ET-1) Induces Extracellular Matrix Protein Production by Human Temporal Artery Derived Myointimal Cells. A Mechanism Potentially Leading to Intimal Hyperplasia and Vascular Occlusion in Giant-Cell Arteritis
Ester Planas-Rigol¹, Marc Corbera-Bellalta², Marco A. Alba³, Itziar Tabera-Bahillo³, Sergio Prieto-Gonzalez³, Georgina espigol-Frigole³, Jose Hernandez-Rodriguez⁴, Ester Lozano⁵ and Maria C. Cid⁶, ¹Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Hospital Clinic University Barcelona, Hospital Clinic University Barcelona, Barcelona, Spain, ³Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clinic University Barcelona, Barcelona, Spain, ⁴Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁵Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clinic University Barcelona, ⁶Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Background/Purpose: Endothelin-1 (ET-1) is the main isoform of the Endothelin family. It is also the most powerful vasoconstrictor identified. ET-1 is constitutively produced in blood…
Abstract Number: 860 • 2012 ACR/ARHP Annual Meeting
Interleukin-21, B Cell Activating Factor and Unmethylated CpG Oligodeoxynucleotides Synergize in Promoting Anti-Proteinase 3 Autoantibody Production in Vitro
Nikola Lepse¹, Judith Land², Abraham Rutgers², Cees G.M. Kallenberg², Coen A. Stegeman³, Peter Heeringa¹ and Wayel H. Abdulahad², ¹Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Nephrology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are characterized by the presence of circulating autoantibodies that are often directed against proteinase 3 (PR3). Although the…
Abstract Number: 861 • 2012 ACR/ARHP Annual Meeting
A Family Based Pedometer Walking Program in an Adolescent Population with Juvenile Idiopathic Arthritis
Sara M. Stern¹, Jill R. Blitz², Amber Richards² and Katherine AB Marzan³, ¹Pediatric Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ²Rehab Services, Children's Hospital Los Angeles, Los Angeles, CA, ³Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA
Background/Purpose: Walking programs are effective in adult arthritis but have not been studied in adolescents with arthritis. The study’s objective was to evaluate the impact…
Abstract Number: 862 • 2012 ACR/ARHP Annual Meeting
What Is the Impact of a Transition Program On Adolescents with Juvenile Idiopathic Arthritis and Their Parents ?
Deborah Hilderson¹, Rene Westhovens², Rik Joos³, Carine H. Wouters⁴ and Philip Moons⁵, ¹Department of Paediatrics; Centre for Health Services and Nursing Research, University Hospital Leuven, KU Leuven, Leuven, Belgium, ²Rheumatology Department of development and regeneration, University Hospital KU Leuven, Leuven, Belgium, ³PRINTO, Genoa, Italy, ⁴Pediatric Rheumatology, University Hospital KU Leuven, Leuven, Belgium, ⁵Centre for Health Services and Nursing Research, KU Leuven, Leuven, Belgium
Background/Purpose: To date, there is no structured or systematic approach in Belgium for transferring adolescents with juvenile idiopathic arthritis from pediatric rheumatology to an adult…
Abstract Number: 863 • 2012 ACR/ARHP Annual Meeting
Employment of a Needs Assessment Survey to Shape a Novel Web-Based Pediatric Rheumatology Curriculum for Primary Care Providers
Amy L. Woodward and Z. Leah Harris, Pediatrics, Vanderbilt University School of Medicine, Nashville, TN
Background/Purpose: Pediatric rheumatology faces many challenges due to the shortage of board certified physicians in the field and the imbalance in their geographic distribution. This…
Abstract Number: 864 • 2012 ACR/ARHP Annual Meeting
Will I Waste Your Time? Delays in Help-Seeking for RA Flares
Caroline A. Flurey¹, Marianne Morris², Jon Pollock¹, Rodney A. Hughes³, Pamela Richards⁴ and Sarah Hewlett⁵, ¹Faculty of Health and Life Sciences, University of the West of England, Bristol, United Kingdom, ²University of the West of England, Bristol, United Kingdom, ³Rheumatology, St. Peters Hospital, Chertsey Surrey, United Kingdom, ⁴Academic Rheumatology Unit, University of Bristol, Bristol, United Kingdom, ⁵Academic Rheumatology, University of the West of England, Bristol, United Kingdom
Background/Purpose: Anecdotal evidence suggests that patients vary in how long they wait before seeking medical help for an RA flare. The aim of this research…
Abstract Number: 865 • 2012 ACR/ARHP Annual Meeting
A Methodology for Estimating Disease State Transitions: Repeated Measures Markov Models with Covariate Dependence
George W. Reed¹, Andrew S. Koenig², Katherine C. Saunders³, David H. Collier⁴, Joel M. Kremer⁵ and Sameer Kotak⁶, ¹University of Massachusetts Medical School, Worcester, MA, ²Specialty Care, Pfizer Inc, Collegeville, PA, ³Corrona, LLC., Southborough, MA, ⁴Amgen Inc., Thousand Oaks, CA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶Specialty Care, Pfizer Inc., New York, NY
Background/Purpose: Many RA patients have variable disease activity over time due to disease flare, reduction in efficacy of current medications and other disease mediating…
Abstract Number: 866 • 2012 ACR/ARHP Annual Meeting
Pain Is Associated with Telomere Shortening in Women with Fibromyalgia
Afton L. Hassett¹, Daniel J. Clauw², Richard E. Harris¹, Steven E. Harte¹, Anson E. Kairys³, Steven Buyske⁴ and David A. Williams⁵, ¹Anesthesiology, University of Michigan, Ann Arbor, MI, ²Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ³Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁴Statistics, Rutgers University, Piscataway, NJ, ⁵Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI
Background/Purpose: Telomere length is considered a marker of cellular aging and has been linked to an increased risk for morbidity and mortality. Psychosocial factors associated…
Abstract Number: 867 • 2012 ACR/ARHP Annual Meeting
Events That Trigger the Onset of the Fibromyalgia Syndrome (FMS)
Robert S. Katz¹, Sharon M. Ferbert², Alexandra Small³ and Susan Shott¹, ¹Rush University Medical Center, Chicago, IL, ²Advocates for Funding Fibromyalgia Treatment, Education and Research(AFFTER), Libertyville, IL, ³University of Illinois Medical School, Chicago, IL
Background/Purpose: Triggering events – those that are followed by the onset or rapid increase in FMS symptoms – have a significant impact in some cases. …
Abstract Number: 868 • 2012 ACR/ARHP Annual Meeting
Illness Perceptions Among Patients with Different Forms of Vasculitis
Peter C. Grayson¹, Naomi Amudala², Carol McAlear³, Renée Leduc⁴, Denise Shereff⁵, Rachel Richesson⁶, Liana Fraenkel⁷ and Peter A. Merkel⁸, ¹Section of Rheumatology & the Clinical Epidemiology Unit, Boston University School of Medicine, Vasculitis Center, Boston, MA, ²Rheumatology & Vasculitis, Boston University Medical Center, Boston, MA, ³Vasculitis Clinical Research Consortium, University of Pennsylvania, Philadelphia, PA, ⁴Pediatrics Epidemiology Center, University of South Florida, Tampa, FL, ⁵Division of Bioinformatics and Biostatistics, University of South Florida, Tampa, FL, ⁶Epidemiology & Biostatistics, University of South Florida, Tampa, FL, ⁷Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ⁸University of Pennsylvania, Philadelphia, PA
Background/Purpose: Patient-held beliefs about their illness are central for understanding patient reactions to specific diseases. This study aimed to compare illness perceptions, defined as the…
Abstract Number: 869 • 2012 ACR/ARHP Annual Meeting
Concepts Which Determine Health in a Positive Way Are Important to People with Rheumatoid Arthritis and Are Covered by Some Patient-Reported Outcome Instruments
Mona Dür¹, Michaela Coenen², Josef S. Smolen³ and Tanja A. Stamm⁴, ¹Internal Medicine III Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medical lnformatics, Biometry and Epidemiology, Research Unit for Biopsychosocial Health, Ludwig-Maximilians-University, Munich, Germany, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁴Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease that has a major impact on functioning, health and well-being. Concepts which determine health in a positive…
Abstract Number: 870 • 2012 ACR/ARHP Annual Meeting
To Love and to Hold: Men Describe Parenting in the Presence of Inflammatory Arthritis
Catherine L. Backman¹ and Alana Longson², ¹Occupational Science & Occupational Therapy, The University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Vancouver, BC, Canada
Background/Purpose: Inflammatory arthritis (IA) may limit participation in life roles such as parenting. Surprisingly little research has investigated the impact of IA on parenting tasks…
Abstract Number: 871 • 2012 ACR/ARHP Annual Meeting
Depression Predicts Mortality in RA
Christina Bode¹, Chris Tonner², Laura Trupin³ and Patricia P. Katz⁴, ¹Faculty of Behavioral Sciences, University of Twente, Enschede, Netherlands, ²Medicine, UCSF, San Francisco, CA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Medicine, University of California San Francisco, San Francisco, CA
Background/Purpose: Depression rates are elevated among individuals with rheumatoid arthritis (RA). Studies in cardiovascular disease and among elderly populations have found that depression is…

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