Abstract Number: 882 • 2012 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects of Phosphodiesterase 4 Inhibition Are Mediated by Mitogen-Activated Protein Kinase Phosphatase-1
Background/Purpose: MAP kinase phosphatase-1 (MKP-1) is a nuclear tyrosine/threonine phosphatase that limits p38 MAP kinase activity. MKP-1 KO mice display excessive inflammatory response, and exhibit…Abstract Number: 883 • 2012 ACR/ARHP Annual Meeting
Role of Phospholipase D1 (PLD1) in the Expression of Proinflammatory Genes in Rheumatoid Arthritis Synovial Fibroblasts (RASF)
Background/Purpose: Interleukin-17 (IL-17) and Tumor Necrosis Factor alpha (TNFa), when co-applied to RASF, induce synergistic expression of proinflammatory genes such as IL-6 and IL-8. Work…Abstract Number: 884 • 2012 ACR/ARHP Annual Meeting
Receptor Activator of Nuclear Factor ÊB Ligand-Mediated Osteoclastogenesis Is Augmented by Interleukin-1â Via up-Regulation of Endoplasmic Reticulum Stress Signals
Background/Purpose: Interleukin-1β (IL-1β) and thapsigargin (TG)-augmented endoplasmic reticulum (ER) stress modulate the receptor activator of nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis. However, the mechanism by…Abstract Number: 885 • 2012 ACR/ARHP Annual Meeting
Interferon α and Self-Organized Criticality Theory
Background/Purpose: One of the biggest obstacle we face in elucidating the pathogenesis of autoimmunity today is the mechanism how autoreactive lymphocyte clones could survive or…Abstract Number: 886 • 2012 ACR/ARHP Annual Meeting
Association Between Neutrophil Gene Signature and Disease Characteristics in Systemic Lupus Erythematosus Patients
Background/Purpose: Neutrophils and neutrophil death (“netosis”) are now understood to play a role in the pathogenesis of SLE. A neutrophil gene signature exists in SLE,…Abstract Number: 888 • 2012 ACR/ARHP Annual Meeting
Plasma Cells Express the Novel Cytokine Interleukin-36α in Psoriatic and Rheumatoid Arthritis Synovium
Background/Purpose: IL-36α is a recent described IL-1 cytokine family member with proinflammatory and clear pathogenic properties in psoriasis. Aim of this study was to determine…Abstract Number: 889 • 2012 ACR/ARHP Annual Meeting
Modeling Environmental and Genetic Determinants to Identify the Association of Risk Genes in Anti-Ro60-Mediated Injury: Relaxin Receptor I and Tumor Necrosis Factor
Background/Purpose: Fetuses exposed to maternal anti-Ro60 antibodies can develop cardiac conduction abnormalities and life threatening cardiomyopathy; manifestations of neonatal lupus (NL). Recent data support an injury…Abstract Number: 890 • 2012 ACR/ARHP Annual Meeting
The Role of Adipocytokines in Osteophyte Formation in Osteoarthritis
Background/Purpose: Obesity is an established risk factor in osteoarthritis (OA), but there is not much known about the interaction between bone formation and the so-called…Abstract Number: 891 • 2012 ACR/ARHP Annual Meeting
Fatty Acids Promote Secretion of Proinflammatory and Prodestructive Factors by Synovial Fibroblasts
Background/Purpose: Due to their role in inflammatory metabolic diseases, we hypothesized that free fatty acids (FFA) are also involved in primary inflammatory joint diseases including…Abstract Number: 892 • 2012 ACR/ARHP Annual Meeting
The Epigenetically Repressed Long Noncoding RNA Hotair Influences the Expression of Matrix Metalloproteases in Synovial Fibroblasts
Background/Purpose: Long noncoding RNAs (lncRNA, >200nt) have recently emerged as regulators of gene expression functioning as signals, decoys, guides or scaffolds for transcription factors and/or…Abstract Number: 893 • 2012 ACR/ARHP Annual Meeting
Nuclear Factor-κB Activation by Type II Collagen Peptide in Osteoarthritic Chondrocytes: Its Inhibition by Hyaluronan Via CD44
Background/Purpose: Some proteolytic products of cartilage matrix may contribute to cartilage destruction through their catabolic activities. Recently, we have found that a 24-mer synthetic peptide…Abstract Number: 853 • 2012 ACR/ARHP Annual Meeting
Systemic Sclerosis Classification Criteria: Developing Methods for Multi-Criteria Decision Analysis
Background/Purpose: Classification criteria for systemic sclerosis (SSc) are being developed. Twenty-three candidate criteria have been identified, but need to be reduced. The objectives of this…Abstract Number: 854 • 2012 ACR/ARHP Annual Meeting
Anti-EIF2B: A Novel Interstitial Lung Disease Associated Autoantibody in Patients with Systemic Sclerosis
Background/Purpose: Autoantibodies occur in 75-95% of Systemic Sclerosis (SSc) patients. Studies have shown that the presence of particular SSc-specific autoantibodies (anti-centromere, anti-topoisomerase-1, anti-RNA polymerase III,…Abstract Number: 855 • 2012 ACR/ARHP Annual Meeting
Identification of a Burkholderia-Like Strain From Temporal Arteries of Subjects with Giant Cell Arteritis
Background/Purpose: Giant cell arteritis (GCA) is a granulomatous vasculitis of large- and medium-sized arteries. An infectious organism has been hypothesized to cause GCA. We used…Abstract Number: 856 • 2012 ACR/ARHP Annual Meeting
Am80, a Retinoic Acid Receptor Agonist, Ameliorates Murine Vasculitisthrough the Suppression of Neutrophil Migration and Activation
Background/Purpose: Vasculitis is characterized by leukocyte infiltration in the vessel walls with destructive damage to mural structures. Retinoids are compounds that bind to retinoic acid…
ACR Meeting Abstracts