Abstract Number: 908 • 2012 ACR/ARHP Annual Meeting
Race, Gender and Total Knee Replacement Consideration: The Role of Social Support
Background/Purpose: There is marked variation in patient preference (i.e. willingness) regarding total knee replacement (TKR), an effective treatment option for end-stage osteoarthritis (OA). Studies have…Abstract Number: 909 • 2012 ACR/ARHP Annual Meeting
Determinants of Patient Preferences for Total Knee Replacement: A Comparison of Whites and African-Americans
Background/Purpose: TKR is a cost-effective treatment option for end-stage knee osteoarthritis (OA). Although it is one of the fastest growing elective surgeries, there are marked…Abstract Number: 910 • 2012 ACR/ARHP Annual Meeting
The Cost-Effectiveness of Total Joint Arthroplasty: A Systematic Review of Published Literature
Background/Purpose: Utilization of total hip arthroplasty (THA) and total knee arthroplasty (TKA) has nearly doubled in the last decade. These procedures are increasingly performed in…Abstract Number: 911 • 2012 ACR/ARHP Annual Meeting
Race- and Sex-Specific Estimates of 10-, 20-, 30-Year, and Lifetime Risk of Diagnosed Symptomatic Knee Osteoarthritis and the Need for TKR in the US
Background/Purpose: A growing body of evidence suggests that females are more likely to be diagnosed with knee osteoarthritis (OA) and that obesity increases the risk…Abstract Number: 912 • 2012 ACR/ARHP Annual Meeting
Clinical Features Associated with Progression of Knee Radiographic Osteoarthritis: Data From the Osteoarthritis Initiative
Background/Purpose: A better understanding of the factors associated with structural progression of knee osteoarthritis (OA) may help identify individuals not only at risk for more…Abstract Number: 913 • 2012 ACR/ARHP Annual Meeting
Consultation Prevalence of Osteoarthritis in Southern Sweden
Background/Purpose: To estimate the prevalence of subjects with osteoarthritis (OA) having led to doctor consultation. Methods: The Skåne Health Care Register (SHCR) is a legislative,…Abstract Number: 873 • 2012 ACR/ARHP Annual Meeting
Imbalance Between Histone Acetyl Transferase and Histone Deacteylase Activities and Modulation of HDAC Activity and Tnfa Production by HDAC Inhibitors in Patients with Ankylosing Spondylitis or Rheumatoid Arthritis
Background/Purpose: TNFa is a major cytokine involved in conditions such as ankylosing spondylitis (AS) and rheumatoid arthritis (RA). Epigenetic regulation corresponds to different processes including…Abstract Number: 874 • 2012 ACR/ARHP Annual Meeting
TNFα Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Synovial Fibroblasts
Background/Purpose: The non resolving character of synovial inflammation in rheumatoid arthritis (RA) is a conundrum. To identify the contribution of fibroblast-like synoviocytes (FLS) to the…Abstract Number: 875 • 2012 ACR/ARHP Annual Meeting
Discovery of Pharmacologic MIF Antagonists by Structure-Based Molecular Design
Background/Purpose: Cytokine inhibition is becoming a mainstay for the therapy of autoimmunity but current antibody-based approaches remain limited by high cost, parenteral administration, and anti-idiotype…Abstract Number: 876 • 2012 ACR/ARHP Annual Meeting
Xanthine Oxidase-Derived ROS Direct Context-Dependent Action of NFAT5 Toward Inflammatory Response in Macrophages
Background/Purpose: NFAT5, a well known osmo-protective factor, can be activated by isotonic stimuli, such as Toll-like receptor (TLR) triggering. Here, we identified a novel signal…Abstract Number: 877 • 2012 ACR/ARHP Annual Meeting
Aberrant Expression of BAFF Receptor (BR3) in Peripheral Monocytes of Patients with Primary Sjögren’s Syndrome Impacts Abnormal Activation of BAFF Signaling Through IKK-Alphaand IKK-Beta
Background/Purpose: B cell activating factor belonging to the TNF superfamily (BAFF) regulates proliferation, differentiation and survival of B cells and plays a pivotal role in…Abstract Number: 878 • 2012 ACR/ARHP Annual Meeting
Differential Regulation of Cytokines by Extracellular-Signal Regulated Kinase and c-Jun N-Terminal Kinase in Map Kinase Kinase-3 and -6 Deficiency
Background/Purpose: p38 inhibitors have limited efficacy in rheumatoid arthritis (RA), possibly because p38 blockade suppresses IL-10 production and increases JNK and ERK phosphorylation in…Abstract Number: 879 • 2012 ACR/ARHP Annual Meeting
Fucosyltransferase 1 (fut1) Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Modifies Cytokine Production
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Angiogenesis and cytokine production are involved in the pathogenesis of…Abstract Number: 880 • 2012 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 8 Regulates BAFF Production in Murine Macrophages and Is a Nexus for Cross Talk Between IFN-γ and TGF-β
Background/Purpose: Lupus is a systemic autoimmune disease that can lead to severe end-organ damage characterized by unabated inflammation and aberrant tissue repair. Macrophage dysregulation plays…Abstract Number: 881 • 2012 ACR/ARHP Annual Meeting
Microrna-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocyte
Background/Purpose: Rheumatoid arthritis (RA) is characterized by synovial tissue inflammation leading to joint destruction. Monocytes/macrophages are major effector cells in RA synovitis, principally by releasing…
ACR Meeting Abstracts