Abstract Number: 1142 • 2013 ACR/ARHP Annual Meeting
Distinct Pathways Of Ly6Chi Monocyte Development Identified By a Novel Dual-Reporter Murine Myeloid Progenitor Cell Line
Background/Purpose: Monocytes are essential to innate immunity but also propagate the inflammatory response in autoimmune arthritis and crystal arthropathies. Development of inflammatory monocytes (Ly6Chi CCR2+)…Abstract Number: 1143 • 2013 ACR/ARHP Annual Meeting
Increased Frequency Of Pratroling Monocytes In Experimental Arthritis and Rheumatoid Arthritis Patients In Response To IL6-R Blockade
Background/Purpose: Monocytes represent a heterogeneous circulating population of immune cells that play important roles in the inflammatory response. Two main functional subsets of human monocytes…Abstract Number: 1144 • 2013 ACR/ARHP Annual Meeting
Wnt Signaling Pathway Regulates Multi-Unconventional Differentiation and Function Of Human Dendritic Cells
Background/Purpose: Dendritic cells (DCs) play a central role in regulating immune responses and govern T cell priming and polarization, mediating immunity and tolerance. Recent progress…Abstract Number: 1145 • 2013 ACR/ARHP Annual Meeting
Regulation Of Plasmacytoid Dendritic Cells By Prostaglandin E2
Background/Purpose: Plasmacytoid dendritic cells (pDCs) constitute a rare blood cell subset exquisitely attuned for production of large quantities of interferon-alpha (IFN-α), and these cells have…Abstract Number: 1147 • 2013 ACR/ARHP Annual Meeting
Human Dendritic Cells Produce Thymic Stromal Lymphopoietin In Response To Pattern Recognition Receptor Ligation and This Secretion Is Augmented By Endoplasmic Reticulum Stress
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is a cytokine that has an important role in inducing Th2 cell differentiation and has also been implicated as a…Abstract Number: 1148 • 2013 ACR/ARHP Annual Meeting
Autologous Tolerogenic Dendritic Cells In Rheumatoid and Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease which results from a breakdown of immune tolerance. Current therapies include traditional DMARDs, anti-TNF, B cell depleting…Abstract Number: 1149 • 2013 ACR/ARHP Annual Meeting
Phenotypic and Molecular Profile Of Innate Lymphoid Cells In Chronic Synovial Inflammation
Background/Purpose: Innate lymphoid cells (ILCs) represent a novel family of effector and regulatory cells in innate immunity and tissue remodelling. The family comprises several phenotypically…Abstract Number: 1150 • 2013 ACR/ARHP Annual Meeting
Differential Regulation Of IL-10 and Dusp1 Production By Kinases In The p38 MAPK Pathway
Background/Purpose: MAPK kinases MKK3 and MKK6 regulate p38 function in inflammatory diseases like rheumatoid arthritis (RA). Targeting MKK3 or MKK6 might be superior to traditional…Abstract Number: 1151 • 2013 ACR/ARHP Annual Meeting
Snapin Is Required For Functional Autophagy and Is Critical For Monocyte To Macrophage Differentiation
Background/Purpose: Our recent data indicate that Snapin, a SNAP associated protein, is significantly increased in macrophages (MΦs) in rheumatoid arthritis (RA) synovial tissue and its…Abstract Number: 1152 • 2013 ACR/ARHP Annual Meeting
Ligation Of TLR5 Promotes Myeloid Cell Infiltration and Differentiation Into Mature Osteoclasts In RA Patients and Experimental Arthritis
Background/Purpose: The aim of this study was to examine the importance of TLR5 ligation in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis. Methods:…Abstract Number: 1128 • 2013 ACR/ARHP Annual Meeting
Validation Of a Rapid, Quantitative Method Of Magnetic Resonance Imaging-Detected Osteoarthritis-Related Bone Marrow Lesions In The Patellofemoral Joint
Background/Purpose : We recently developed an efficient semi-automated measure of tibial and femoral BML volume and validated it against the Whole-Organ Magnetic Resonance Imaging Score…Abstract Number: 1112 • 2013 ACR/ARHP Annual Meeting
Examining Phenotypes Of Patients With Psoriasis In The Prepare Study For Similarities Between Diagnosed Psoriatic Arthritis and Those With Signs Of Subclinical Psoriatic Arthritis Detected By Imaging
Background/Purpose: Progression of psoriatic arthritis (PsA) has traditionally been evaluated using clinical assessments. However, a strong relationship between clinical and radiological outcomes has been shown,…Abstract Number: 1113 • 2013 ACR/ARHP Annual Meeting
Scintigraphic Detection Of TNFα With a Radiolabeled Anti-TNFα In Patients With Active Peripheral Spondyloarthritis and Rheumatoid Arthritis
Background/Purpose: Spondyloarthritis (SpA) and rheumatoid arthritis (RA) are the most common chronic inflammatory joint diseases, with a combined prevalence close to 2%. The pathogenetic role…Abstract Number: 1114 • 2013 ACR/ARHP Annual Meeting
Entheses Ultrasound In Patients With Ankyosing Spondylitis: A Controlled Study With Healthy Subjects
Background/Purpose: Inflammation of the entheses (enthesitis) is a characteristic finding of ankylosing spondylitis (AS). Despite the growing interest in rheumatology for musculoskeletal ultrasound (US), there…Abstract Number: 1115 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Structural and Inflammatory Sacroiliitis, Assessed Using Computed Tomography and MR Imaging, In Inflammatory Bowel Disease: A Retrospective Study In 78 Patients
Background/Purpose: The primary objective was to assess the prevalence of structural and inflammatory sacroiliitis on computed tomography (CT) and MRI in inflammatory bowel disease (IBD).…
ACR Meeting Abstracts