Abstract Number: 984 • 2012 ACR/ARHP Annual Meeting
Association of Elevated C5a Levels, but Not the Presence of Anti-Cfh IgG Autoantibodies, with the Deletion of CFHR3 and CFHR1 in SLE
Background/Purpose: We previously reported association of the deletion of complement regulator factor H related CFHR3 and CFHR1 genes (CFHR3-1Δ), rather than CFH exonic SNPs, with…Abstract Number: 985 • 2012 ACR/ARHP Annual Meeting
Inverse Relation Between the tumor Necrosis Factor Promoter Methylation and Trascript Leveles in Leukocytes From Patients with Rheumatoid Arthritis
Background/Purpose: The importance of the epigenetic signature in RA is unclear but levels of methylation of CpG motifs in the TNF promoter are known to…Abstract Number: 986 • 2012 ACR/ARHP Annual Meeting
Genome Wide Association Studies of Knee Osteoarthritis in 2 Large North American Cohorts: A Meta-Analysis with 2667 Cases
Background/Purpose: A strong genetic contribution to knee osteoarthritis (OA) is widely recognized although few loci have been robustly associated with knee OA susceptibility. To identify…Abstract Number: 987 • 2012 ACR/ARHP Annual Meeting
Autoimmune Susceptibility Genes Are Regulators of Gene Expression Response to ER Stress
Background/Purpose: Endoplasmic recticulum (ER) stress is caused by excessive demands on the protein-processing capacity of the ER; inefficiencies in response to ER stress lead to…Abstract Number: 988 • 2012 ACR/ARHP Annual Meeting
Zone-Specific Protein Profiles in Human Cartilage Unraveled by a Quantitative Proteomic Approach
Background/Purpose: Articular cartilage consists of a single type of cells called chondrocytes, which comprise 2-5% of total tissue mass and an extracellular matrix (ECM) mainly…Abstract Number: 989 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Analysis Reveals a Recessive Association of ERAP1 Variants with Behçet’s Disease and Epistasis Between ERAP1 and HLA-B*51
Background/Purpose: We recently performed a genome-wide association study in 1215 patients with Behçet’s disease (BD) and 1278 controls from Turkey and found disease-associated variants within…Abstract Number: 990 • 2012 ACR/ARHP Annual Meeting
Proteomic Shotgun Analysis of Mesenchymal Stem Cells Reveals an Alterated Regulation of Proteosomal Proteins in Osteoarthritis Patients
Background/Purpose: To describe proteins with a potential role in OA pathogenesis, in this study we have followed a proteomic approach based on a shotgun…Abstract Number: 991 • 2012 ACR/ARHP Annual Meeting
MTHFR Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Associations with Intima Media Thickness Scores
Background/Purpose: Previous studies identified polymorphisms in the gene coding for the Methylenetetrahydrofolatereductase (MTHFR) enzyme as genetic contributors for cardiovascular disease in the general population. The…Abstract Number: 992 • 2012 ACR/ARHP Annual Meeting
Functional Genomics of the Human ITGAM Locus
Background/Purpose: ITGAM encodes CD11b, the αM subunit of the Mac-1 -αMβ2 integrin. Mac-1 has many functions on leukocytes including its role as an adhesion molecule…Abstract Number: 993 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide DNA Methylation Analysis Reveals Different Methylation Patterns in the OA Disease
Background/Purpose: DNA methylation is a basic mechanism involved in epigenetic regulation that affects gene transcription by the addition of a methyl group to the cytosine…Abstract Number: 994 • 2012 ACR/ARHP Annual Meeting
The Genome-Wide Expression of Human Osteoarthritic Cartilage Shows A Differential Pattern Between Two Subgroups of OA Patients
Background/Purpose: Many genes, many of them still unknown, are involved in the etiology and development of OA. Today, different tools are available to try to…Abstract Number: 954 • 2012 ACR/ARHP Annual Meeting
Diagnosis of Secondary Fibromyalgia in an Established Rheumatoid Arthritis Cohort
Background/Purpose: The prevalence of fibromyalgia (FM) is 7-10 times higher among rheumatoid arthritis (RA) patients than the general population. However, the diagnosis of FM in…Abstract Number: 955 • 2012 ACR/ARHP Annual Meeting
Post – Surgical Outcome Is Correlated with Pre – Surgical Symptoms of Fibromyalgia in Patients Undergoing Spinal Surgery
Background/Purpose: Chronic pain is a major symptom for which patients undergo spinal surgery. At the same time, chronic pain is considered an entity in and…Abstract Number: 956 • 2012 ACR/ARHP Annual Meeting
Learning Disability in Fibromyalgia Patients: FMS Patients Report More Language and Spatial Difficulties
Background/Purpose: Fibromyalgia patients are reported to have central sensitization and abnormal central processing of sensory input. Fibromyalgia patients also have more neurocognitive complaints and abnormalities on…Abstract Number: 957 • 2012 ACR/ARHP Annual Meeting
Key Psychological Processes Associated with the Fibromyalgia Phenotype Exist On a Continuous Spectrum with Asymptomatic People
Background/Purpose: The core features of the fibromyalgia phenotype, the widespread pain and widespread tenderness, represent one extreme of a continuous spectrum with asymptomatic people at…