Abstracts Archive - Page 2355 of 2607 - ACR Meeting Abstracts

Abstract Number: 1169 • 2013 ACR/ARHP Annual Meeting
A Novel Pro-Inflammatory Signaling Pathway Regulated By Follistatin-Like Protein 1
Yury Chaly¹, Anthony Marinov², Yu Fu², Brian Campfield², John Kellum³, Bruce Hostager⁴, Daniel Bushnell⁵, Yudong Wang², Jerry Vockley² and Raphael Hirsch⁶, ¹Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ²Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴University of Iowa Carver College of Medicine, Iowa City, IA, ⁵Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁶Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein produced mainly by cells of the mesenchymal lineage. The function of FSTL1 is still unclear, but…
Abstract Number: 1170 • 2013 ACR/ARHP Annual Meeting
Expression and Function Of Human Mfg-E8 In The Clearance Of Apoptotic Cells and Suppression Of Inflammation
Lucrezia Colonna¹, Jie An², Xizhang Sun³, Nalini Agrawal⁴, Alice Wiedeman⁵ and Keith B. Elkon³, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴Rheumatology, University of Washington, Seattle, WA, ⁵Immunology, University of Washington, Seattle, WA
Background/Purpose: Effective clearance of apoptotic cells (AC) is necessary for the maintenance of tolerance to self. MFG-E8 is one of ~20 different opsonins reported to…
Abstract Number: 1171 • 2013 ACR/ARHP Annual Meeting
Treatment Of Psoriasis Patients With IMO-3100 Shows Improvement In Gene Expression Patterns Of Meta-Analysis Derived-3 Transcriptome and IL-17 Pathway
Mayte Suarez-Farinas¹, Jennifer Belasco¹, Tim Sullivan², Robert Arbeit² and James G. Krueger¹, ¹Krueger Laboratory, The Rockefeller University, New York, NY, ²Idera Pharmaceuticals, Inc., Cambridge, MA

Background/Purpose: IMO‑3100, an antagonist of TLRs 7 and 9, has shown significant improvement in Psoriasis Area and Severity Index (PASI) scores in a randomized, double‑blind,…
Abstract Number: 1172 • 2013 ACR/ARHP Annual Meeting
Molecular Characterisation Of The Killer Cell Immunoglobulin-Like Receptor 3DL2 Binding To Aberrant HLA-B27 Heavy Chains In Spondyloarthritis
H. Hatano¹, J. Shaw¹, K McHugh², P. Bowness¹ and S. Kollnberger¹, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: KIR3DL2 is a Killer cell Immunoglobulin-like Receptor which binds to HLA class I including HLA-B27 (B27) β2m-free heavy chains (FHC) and HLA-A3/A11. KIR3DL2 is…
Abstract Number: 1173 • 2013 ACR/ARHP Annual Meeting
A Clinically Significant Interaction Between Furosemide and Allopurinol: Potential Implications for Clinical Practice
Lisa K. Stamp¹, Claudia Knake² and Andrew Bahn², ¹Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ²Physiology, University of Otago, Dunedin, New Zealand
Background/Purpose: The xanthine oxidase (XO) inhibitor allopurinol is the most commonly used urate lowering therapy in gout. Allopurinol is metabolized to oxypurinol, which is responsible…
Abstract Number: 1133 • 2013 ACR/ARHP Annual Meeting
Sensitivity To Change Of a New Method Of Computer Measurement Of Hip Joint Space Width: Performance Of Location-Specific Measures Obtained At a 48 Month Interval
Charles Ratzlaff¹ and Jeffrey W. Duryea², ¹Harvard Medical School / Brigham and Women's Hospital, Boston, MA, ²Radiology, Brigham and Women's Hospital, Boston, MA
Background/Purpose : Responsive measures of radiographic joint space width (JSW) in hip osteoarthritis (OA) are a major requirement for the evaluation of treatment interventions. The…
Abstract Number: 1134 • 2013 ACR/ARHP Annual Meeting
More Evidence For Breaking The ‘law Of valgus’: Imaging Evidence For Higher Prevalence and Volume Of Bone Marrow Lesions In The Medial Patellofemoral Joint
Charles Ratzlaff¹ and Jeffrey W. Duryea², ¹Harvard Medical School / Brigham and Women's Hospital, Boston, MA, ²Radiology, Brigham and Women's Hospital, Boston, MA
Background/Purpose : We recently developed an efficient semi-automated measure of tibial and femoral BML volume and validated it against the Whole-Organ Magnetic Resonance Imaging Score…
Abstract Number: 1135 • 2013 ACR/ARHP Annual Meeting
Synovial Fluid Vascular Endothelial Growth Factor Could Predict Progression Of Osteoarthritis According To Radiological and Ultrasonographic Findings
Sang-Heon Lee, Hae-Rim Kim and Ho-Youn Kim, Division of Rheumatology, Konkuk University Medical Center, Seoul, South Korea
Background/Purpose: Vascular endothelial growth factor (VEGF) may have important contribution in the pathogenesis of knee osteoarthritis. MMP-13 is expressed by chondrocytes and synovial cells, and…
Abstract Number: 1141 • 2013 ACR/ARHP Annual Meeting
Response To H. Pylori Treatment and Autoantibody In Chronic Thrombocytopenia
Mitsuyo Kinjo and Kensuke Nakanishi, Internal Medicine, Okinawa Chubu Hospital, Uruma City Okinawa, Japan
Background/Purpose: Helicobacter pylori (H. pylori) infection has been linked to pathogenesis of autoimmune disease including chronic idiopathic thrombocytopenic purpura (ITP). Prior studies showed platelet counts…
Abstract Number: 1132 • 2013 ACR/ARHP Annual Meeting
Sensitivity To Change Of Radiographic Fixed-Location and Magnetic Resonance Imaging-Based Cartilage Thickness Measures In The Lateral Compartment Of Knees With Radiographic Osteoarthritis – Data From The Osteoarthritis Initiative
Wolfgang Wirth¹, Jeffrey W. Duryea², Michael C. Nevitt³, Robert J. Buck⁴, David Hunter⁵ and Felix Eckstein¹, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Radiology, Brigham and Women's Hospital, Boston, MA, ³Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁴StatAnswers Consulting, Minneapolis, MN, ⁵Royal North Shore Hospital, St. Leonards, Australia
Background/Purpose: Radiographic joint space width (JSW) is frequently employed to indirectly assess structural progression in the medial femorotibial compartment, but it is unclear whether assessment…
Abstract Number: 1136 • 2013 ACR/ARHP Annual Meeting
MR T1ρ and T2 Of Meniscus After Acute Anterior Cruciate Ligament Injuries
Elijah Abramson¹, Michael Hoppe², Toran MacLeod¹, Lorenzo Nardo¹, Julien Rivoire², Richard Souza¹, Thomas M Link³, C. Benjamin Ma⁴ and Xiaojuan Li³, ¹University of California, San Francisco, San Francisco, CA, ²Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ³Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁴Department of Orthopedic Surgery, UCSF, San Francisco, CA
Background/Purpose: Acute anterior cruciate ligament (ACL) injuries are high-risk factors for post-traumatic osteoarthritis. Cartilage changes in such cases have been widely studied; however, there are…
Abstract Number: 1137 • 2013 ACR/ARHP Annual Meeting
Evaluating Indeterminate Quantiferon-TB Gold In-Tube Results in Patients With Chronic Inflammatory Diseases On Immunosuppressive Therapy
Cassandra Calabrese¹, Robert A. Overman^2,3, Stacie Dusetzina⁴ and Rula Hajj-Ali⁵, ¹Cleveland Clinic, Cleveland, OH, ²Eshelman School of Pharmacy - Division of Pharmaceutical Policy and Outcomes, University of North Carolina, Chapel Hill, NC, ³Rheumatology, Cleveland Clinic, Cleveland, OH, ⁴Epidemiology, School of Medicine and Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Raleigh-Durham, NC, ⁵Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: The Quantiferon test (QFT) is used to for screen for tuberculosis in patients with autoinflammatory conditions (IC) prior to the use of immunosuppressant medications. …
Abstract Number: 1138 • 2013 ACR/ARHP Annual Meeting
Tuberculin Skin Test and Booster Phenomenon In a Rheumatoid Arthritis Population. Differences Between Early and Established Disease
Lorena Perez-Barbosa¹, David Vega-Morales², Janett Carmen Luzmilla Riega-Torres¹, Octavio Ilizaliturri-Guerra¹ and Mario Alberto Garza-Elizondo¹, ¹Early Arthritis Clinic, Rheumatology Service, Hospital Universitario, Monterrey, Mexico, ²Rheumatology, Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose: Tuberculosis (TB) remains a major global health problem. Chronic inflammation in Rheumatoid Arthritis (RA) and the use of immunosuppressive drugs, increase the risk of…
Abstract Number: 1139 • 2013 ACR/ARHP Annual Meeting
Pyogenic Arthritis: Clinical and Epidemiological Features Of 101 Cases At a University Hospital
Anne Riveros-Frutos¹, Lourdes Mateo¹, Melania Martínez-Morillo², Beatriz Tejera³, Samantha Rodriguez-Muguruza¹, Juana Sanint¹, Susana Holgado¹, Jerónima Cañellas¹, Xavier Tena¹, Alejandro Olivé¹ and Montserrat Gímenez⁴, ¹Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ²Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ³Rheumatology, University Hospital of Canary Islands, Santa Cruz de Tenerife, Spain, ⁴Microbiology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain
Background/Purpose: To describe the clinical characteristics, treatment and outcome of patients diagnosed with pyogenic septic arthritis. Methods: Design: retrospective (1984-2012). Location: University hospital. Referial area:…
Abstract Number: 1140 • 2013 ACR/ARHP Annual Meeting
Study Of The Antibody Titer By Influenza Vaccination In Rheumatoid Arthritis Patients Treated With Biologics In JAPAN
Hisato Ishikawa¹, Daihei Kida², Yosuke Hattori³, Atsushi Kaneko³ and Tomotaro Sato⁴, ¹Nagoya Medical Center, nagano, Japan, ²Department of Rheumatology and Orthopedic Surgery, Nagoya Medical Center, Nagoya, Japan, ³Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Nagoya, Japan, ⁴Orthopaedic Surgery and Rheumatology, Nagoya Medical Center, National Hospital Organization, Nagoya, Japan
Background/Purpose: Vaccination for influenza virus is recommended for patients with rheumatoid arthritis (RA) with underlying such as disease elderly people over the age of 65,…

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