Abstracts Archive - Page 2354 of 2607 - ACR Meeting Abstracts

Abstract Number: 1167 • 2013 ACR/ARHP Annual Meeting
A Possible Mechanism Of NLRP3 Inflammasome Hypersensitivity In Cryopyrin-Associated Periodic Syndrome
Sayaka Ito, Chie Tagami, Yukichi Hara and Tetsuo Kubota, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: NLRP3 in monocytes and other cell types plays a role in innate immunity as one of the intracellular pathogen recognition receptors, and its mutation…
Abstract Number: 1153 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Synovial Fibroblasts Lack Tolerization Of Inflammatory Cytokines and Matrix Degrading Enzymes After Repeated LPS Stimulation
Kerstin Klein¹, Renate E. Gay², Christoph Kolling³, Adrian Ciurea⁴, Beat A. Michel⁵, Lih-Ling Lin⁶, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ³Schultess Clinic, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA
Background/Purpose: In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to adaptation of signaling pathways and epigenetic modifications resulting in a tolerant state of…
Abstract Number: 1154 • 2013 ACR/ARHP Annual Meeting
Poly(I:C)-Induced Cell Death Of Synovial Fibroblasts via an Unknown dsRNA Receptor
Jörg Hamann¹, Paul P. Tak² and Olga N. Karpus³, ¹Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³1Departments of Experimental Immunology and Internal Medicine, Academic Medical Center, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplasia of the synovial tissue due to local proliferation of stromal and recruitment of inflammatory immune cells. Accumulation…
Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting
Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis
Katalin Mikecz¹, Julia Kurko¹, Timea Ocsko¹, Andras Vida¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Joel A. Block², Robert S. Katz³, Anjali Nair², Carla R. Scanzello⁴ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush Medical College, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
Abstract Number: 1157 • 2013 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Prevents Neutrophil Extracellular Trap Formation, Modulates Innate Immune Responses, and Reduces Vascular Damage In Mice
Jason S. Knight¹, Wei Luo², Alexander A. O'Dell¹, Wenpu Zhao³, Venkataraman Subramanian⁴, Chiao Guo², Robert C. Grenn³, Paul Ryan Thompson⁴, Daniel T. Eitzman² and Mariana J. Kaplan⁵, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Cardiology, Ann Arbor, MI, ³University of Michigan Rheumatology, Ann Arbor, MI, ⁴The Scripps Research Institute, Jupiter, FL, ⁵Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular trap (NET) formation promotes vascular damage, while stimulating interferon alpha (IFN-α) production in diseased arteries. Patients with rheumatoid arthritis and systemic…
Abstract Number: 1158 • 2013 ACR/ARHP Annual Meeting
Decreased NK-Cell Numbers and Upregulation Of Markers Of Systemic Inflammation In Autoantibody –Positive Arthralgia Patients and Early Rheumatoid Arthritis Patients But Not In Autoantibody-Negative Rheumatoid Arthritis Patients
Paulina Chalan¹, Johan Bijzet², Kornelis S.M. van der Geest¹, Bart-Jan Kroesen³, Annemieke M.H. Boots^4,5 and Elisabeth Brouwer¹, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Groningen Research initiative on healthy Ageing and Immune Longevity (GRAIL), Groningen, Netherlands
Background/Purpose: Identification of seropositive individuals at risk for arthritis development would open opportunities for early clinical intervention. In a recent study on seropositive arthalgia patients…
Abstract Number: 1159 • 2013 ACR/ARHP Annual Meeting
Exercise Suppresses Systemic Inflammation Via Inhibition Of NF-κB Activation In Monocytes
Alisa Blazek¹, Derrick Knapik², Lai-Chu Wu³, Nicholas A. Young³, Wael N. Jarjour⁴ and Sudha Agarwal⁵, ¹Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH, ²College of Medicine, The Ohio State University, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Inflammation is integral to joint damage and bone erosion in rheumatoid arthritis. We reported previously that physiologic levels of exercise are anti-inflammatory and suppress local…
Abstract Number: 1160 • 2013 ACR/ARHP Annual Meeting
Oxidative Stress As a Disease Marker and Therapeutic Target In Patients With Tumor Necrosis Factor Receptor Associated Periodic Fever Syndrome
Cornelia Cudrici¹, Ariel Bourla¹, Martin Pelletier², Leah Billingham¹, Amanda K. Ombrello³, Michael Murphy⁴, Daniel L. Kastner⁵ and Richard M. Siegel⁶, ¹NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ²Niams, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ³National Human Genome Research Institute,National Institute of Health, Bethesda, MD, ⁴Medical research council mitochondria biology unit Cambridge ,UK, Cambridge, United Kingdom, ⁵Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, ⁶National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Background/Purpose: TRAPS (Tumor necrosis factors receptor associated periodic fever syndrome) is an autosomal dominant autoinflammatory disease associated with missense mutations in TNFRSF1A (tumor necrosis factor…
Abstract Number: 1161 • 2013 ACR/ARHP Annual Meeting
Microrna-155 As a Proinflammatory Regulator via SHIP-1 Down-Regulation In Acute Gouty Arthritis
Hye Mi Jin¹, Young-Nan Cho¹, Seung-Jung Kee², Dong-Jin Park³, Yong-Wook Park³, Shin-Seok Lee⁴ and Tae-Jong Kim¹, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ³Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ⁴Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: Gout is characterised by episodes of intense joint inflammation in response to intra-articular monosodium urate monohydrate (MSU) crystals. miR-155 is crucial for the proinflammatory…
Abstract Number: 1162 • 2013 ACR/ARHP Annual Meeting
The Role Of Microrna 155 In Innate Immunity and Arthritis
Antonia Puchner¹, Victoria Saferding², Eliana Goncalves-Alves³, Josef S. Smolen⁴, Kurt Redlich⁵ and Stephan Blueml⁶, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Vienna, Austria, ⁵Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: MicroRNA 155 (miR155) has been demonstrated to be essential for the development of collagen induced arthritis by controlling the generation of autoreactive T and…
Abstract Number: 1163 • 2013 ACR/ARHP Annual Meeting
The Receptor For Advanced Glycation End Products (RAGE) As a Modulator Of Inflammatory Responses and Its Contribution To Gender-Specific Effects During Arthritis
Timo Wirth¹, Christoph Kessel¹, Philipp Becker², Toni Weinhage³, Nadine Nippe⁴ and Dirk Foell⁵, ¹Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ²University of Muenster, Muenster, Germany, ³Pediatric Rheumatology and Immunology, University of Muenster, Münster, Germany, ⁴Department of Dermatology, University of Muenster, Münster, Germany, ⁵Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany
Background/Purpose: The receptor for advanced glycation end products (RAGE) is a multi-ligand receptor expressed on various cells which interacts with a diverse class of ligands,…
Abstract Number: 1164 • 2013 ACR/ARHP Annual Meeting
Both Endosomal and Surface Toll-Like Receptors Can Act As Biomarkers In Lupus
Maria Perez-Ferro¹, Cristina Serrano², Fredeswinda I. Romero¹, María J Martínez-Becerra², Jorge E Rojas³, María Sanchez-Blazquez², Raquel Largo⁴, Juan A Martínez-López⁵, Gabriel Herrero-Beaumont⁴ and Olga Sanchez-Pernaute¹, ¹Section for Autoimmune Diseases, Rheumatology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ²Immunology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ³Nephrology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ⁴Bone and Joint Research Unit, IIS, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ⁵Rheumatology, Section for Autoimmune Diseases, Jiménez Díaz Foundation University Hospital, Madrid, Spain
Background/Purpose: Toll-like receptors (TLR) are a major class of pathogen detectors in the cell that can trigger the innate defense and lead to activation of…
Abstract Number: 1165 • 2013 ACR/ARHP Annual Meeting
Systems Approach To The Study Of the Microbiome and Inflammatory Pathways In Oral Ulcer Tissue From Patients With Active Behςet’s Syndrome (BS)
Cailin Sibley¹, Gulen Hatemi², Yusuf Yazici³, Yin Liu⁴, Steve Brooks⁵, Hasan Yazici⁶ and Raphaela Goldbach-Mansky⁷, ¹Office of the Clinical Director, NIH / NIAMS, Bethesda, MD, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ⁵NIAMS/NIH, Bethesda, MD, ⁶Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ⁷Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: Behcet's syndrome (BS) exhibits features of both innate and acquired immunity. Oral ulceration is the cardinal lesion which usually precedes other manifestations. Despite the…
Abstract Number: 1166 • 2013 ACR/ARHP Annual Meeting
Anti-Inflammatory Property Of HDL In NOD1 Ligand Induced Kawasaki Arteritis In Mice
Hajime Kono¹, Tamiko Yanagida², Kurumi Asako¹, Toshihiro Nanki¹, Hirotoshi Kikuchi¹, Akiko Okamoto¹, Akiko Onda³ and Maki Takayama¹, ¹Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ²Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Background/Purpose: Atherosclerosis is a chronic metabolic disease of inflammatory processes. Immune cells including monocytes are recruited to the subintimal lesion of the vascular wall and…
Abstract Number: 1168 • 2013 ACR/ARHP Annual Meeting
Innate Immune Cell Production Of Interleukin-12 Drives CpG-Induced Macrophage Activation Syndrome
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatrics/Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Hemophagocytic syndromes are caused by an uncontrolled systemic inflammatory response resulting in cytopenias, multisystem organ failure, and rapid death, often despite aggressive therapy. Macrophage…

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