Abstracts Archive - Page 2354 of 2425 - ACR Meeting Abstracts

Abstract Number: 1029 • 2012 ACR/ARHP Annual Meeting
Frequency of Mediopatellar Plica in Persons with Chronic Knee Pain and Its Cross-Sectional Association with Patellofemoral Cartilage Damage and Bone Marrow Lesions: Data From the Joints On Glucosamine Study
Li Xu¹, Daichi Hayashi¹, Ali Guermazi², C. Kent Kwoh³, Michael J. Hannon⁴, Mohamed Jarraya¹, Carolyn E. Moore⁵, John M. Jakicic⁶, Stephanie M. Green⁷ and Frank Roemer⁸, ¹Department of Radiology, Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Department of Nutrition and Food Science, Texas Women's University, Houston, TX, ⁶University of Pittsburgh, PA, ⁷Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁸Klinikum Augsburg, Augsburg, Germany
Background/Purpose: Osteoarthritis (OA) commonly occurs in the patellofemoral joint (PFJ) and knee pain in subjects with knee OA often emanates from the PFJ rather than…
Abstract Number: 1030 • 2012 ACR/ARHP Annual Meeting
Frequency and Fluctuation of Susceptibility Artifacts in the Tibio-Femoral Joint Space in Painful Knees On 3T MRI and Association with Meniscal Tears, Radiographic Joint Space Narrowing and Calcifications
Daichi Hayashi¹, Mohamed Jarraya¹, Ali Guermazi², C. Kent Kwoh³, Michael J. Hannon⁴, Carolyn E. Moore⁵, John M. Jakicic⁶, Stephanie M. Green⁷ and Frank Roemer⁸, ¹Department of Radiology, Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³Rheum & Clinical Immunology, Univ of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Department of Nutrition and Food Science, Texas Women's University, Houston, TX, ⁶University of Pittsburgh, PA, ⁷Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁸Klinikum Augsburg, Augsburg, Germany
Background/Purpose: Linear or punctate hypointensities are commonly seen on gradient echo (GRE) sequences in the tibiofemoral joint (TFJ) space of osteoarthritic joints. These magnetic susceptibility…
Abstract Number: 1031 • 2012 ACR/ARHP Annual Meeting
High Degree of Symmetricity of MRI-Detected Articular Tissue Damage in Subjects with Knee Pain: A within-Person Analysis From the JOG Study
Frank Roemer¹, C. Kent Kwoh², Michael J. Hannon³, Robert M. Boudreau⁴, Stephanie M. Green⁵, John M. Jakicic⁶, Carolyn E. Moore⁷ and Ali Guermazi⁸, ¹Klinikum Augsburg, Augsburg, Germany, ²School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁵Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶University of Pittsburgh, PA, ⁷Department of Nutrition and Food Science, Texas Women's University, Houston, TX, ⁸Boston University, Boston, MA
Background/Purpose: Several risk factors for osteoarthritis (OA) have been described to be associated with an increased risk for incident radiographic OA, on a local (joint)…
Abstract Number: 1032 • 2012 ACR/ARHP Annual Meeting
Medial Meniscal Root Tears and the Association with Meniscal Extrusion, Prevalent Cartilage Damage and Longitudinal Cartilage Loss: The MOST Study
Mohamed Jarraya¹, David T. Felson², Daichi Hayashi¹, Frank Roemer³, Yuqing Zhang⁴, Jingbo Niu⁵, Michel Crema⁶, Martin Englund⁷, John A. Lynch⁸, Michael C. Nevitt⁹, James Torner¹⁰, C.E. Lewis¹¹ and Ali Guermazi⁶, ¹Department of Radiology, Boston University, Boston, MA, ²Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, ³Radiology, Klinikum Augsburg, Augsburg, Germany, ⁴Clinical Epidemiology Unit, Boston University, Boston, MA, ⁵Boston University, Boston, MA, ⁶Radiology, Boston University, Boston, MA, ⁷Department of Orthopedics, Lund University, Lund, Sweden, ⁸Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁹Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ¹⁰Epidemiology, University of Iowa, Iowa City, IA, ¹¹University of Alabama at Birmingham, Birmingham City, AL
Background/Purpose: The meniscal root is a ligamentous structure that anchors the posterior horn of the meniscus to the tibial plateau. The association of isolated meniscal…
Abstract Number: 1033 • 2012 ACR/ARHP Annual Meeting
Reliability and Responsiveness of Two Methods for Assessment of Magnetic Resonance Imaging Abnormalities in Hip Osteoarthritis in a Placebo-Controlled Trial of Intra-Articular Steroid Injection
Walter P. Maksymowych¹, Jolanda Cibere², Ulrich Weber³, Jacob Jaremko⁴, Damien Loeuille⁵, Veronika Zubler⁶, Frank Roemer⁷, Eric C. Sayre⁸ and Robert GW Lambert⁴, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Div of Rheumatology, Arthritis Research Ctr of CA, Vancouver, BC, Canada, ³Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Rheumatology, CHU Brabois, Vandoeuvre les Nancy, France, ⁶Radiology, Balgrist University Hospital, Zurich, Switzerland, ⁷Klinikum Augsburg, Augsburg, Germany, ⁸Arthritis Research Centre of Canada, Vancouver, BC, Canada
Background/Purpose: Inflammation in osteoarthritis (OA) is the basis for the use of steroid injection therapy which has demonstrated efficacy for symptoms of hip OA in…
Abstract Number: 1034 • 2012 ACR/ARHP Annual Meeting
Changing Osteoarthritis Treatment Assessment Paradigms: Subchondral Bone Is a More Responsive Measure of Progression Than the Current Radiographic Standard
Michael A. Bowes¹, Christopher B. Wolstenholme¹, Devan Hopkinson¹, Graham R. Vincent¹ and Philip G. Conaghan², ¹Imorphics Ltd, Manchester, United Kingdom, ²University of Leeds, Leeds, United Kingdom
Background/Purpose: Radiographic joint space width (JSW) assessment, a surrogate for cartilage assessment, is the standard for structure modification trials of osteoarthritis (OA). However the subchondral…
Abstract Number: 995 • 2012 ACR/ARHP Annual Meeting
Genetic Effects of HLA-DRB1, IL4R, and FcγRIIb On Long-Term Treatment Responses in Patients with Early Rheumatoid Arthritis: 78-Week Results of a Phase 4 Study
Alla Skapenko¹, Josef S. Smolen², Arthur Kavanaugh³, Vipin Arora⁴, Hartmut Kupper⁵ and Hendrik Schulze-Koops⁶, ¹Division of Rheumatology and Clinical Immunology, Med. Poliklinik,, University of Munich, Munich, Germany, ²Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ³UCSD School of Medicine, La Jolla, CA, ⁴Health Outcomes Research, Abbott, Abbott Park, IL, ⁵Immunology Development, Abbott GmbH and Co. KG, Ludwigshafen, Germany, ⁶University of Munich, Munich, Germany
Background/Purpose: Previous analyses suggested that the HLA-DRB1 shared epitope (SE), and the IL4R V50I and the FcγRIIb I232T single nucleotide polymorphisms (SNPs) affected response to…
Abstract Number: 996 • 2012 ACR/ARHP Annual Meeting
Genetic Predictors of Methotrexate Efficacy and Toxicity in Early Rheumatoid Arthritis: Results From the Treatment of Early Aggressive Rheumatoid Arthritis Trial
Stella Aslibekyan¹, Elizabeth Brown², Richard J. Reynolds³, David T. Redden⁴, Sarah L. Morgan⁵, Joseph Baggott¹, Jin Sha¹, Larry W. Moreland⁶, James R. O'Dell⁷, Jeffrey R. Curtis⁸, S. Louis Bridges Jr.⁹ and Donna K. Arnett¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Univ of Alabama at Birmingham, Birmingham, AL, Birmingham, AL, ³Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁸Rheumatology & Immunology, Univ of Alabama-Birmingham, Birmingham, AL, ⁹Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Methotrexate (MTX) has emerged as first-line therapy for early moderate to severe rheumatoid arthritis (RA), but individual variation in treatment efficacy and toxicity remains…
Abstract Number: 997 • 2012 ACR/ARHP Annual Meeting
Evidence of Novel Genetic Predictors of Methotrexate Efficacy in Rheumatoid Arthritis
Stella Aslibekyan¹, Maria I. Danila², Jin Sha¹, David T. Redden³, Richard J. Reynolds⁴, Elizabeth Brown⁵, Laura B. Hughes⁶, Molly S. Bray¹, Sarah L. Morgan⁷, Larry W. Moreland⁸, James R. O'Dell⁹, Jeffrey R. Curtis¹⁰, Robert P. Kimberly¹¹, Lindsey A. Criswell¹², Robert M. Plenge¹³, S. Louis Bridges Jr.¹⁴ and Donna K. Arnett¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Med/Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ³Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Univ of Alabama at Birmingham, Birmingham, AL, Birmingham, AL, ⁶Med Div of Clin Imm & Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama Birmingham, Birmingham, AL, ⁸Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁹Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ¹⁰Rheumatology & Immunology, Univ of Alabama-Birmingham, Birmingham, AL, ¹¹Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹²Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ¹³Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹⁴Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Methotrexate (MTX), a disease-modifying anti-rheumatic drug used as first-line therapy in rheumatoid arthritis (RA), is characterized by considerable heterogeneity in individual treatment response. We…
Abstract Number: 998 • 2012 ACR/ARHP Annual Meeting
Association Study of Genetic Risk Variants for Psoriasis in a Large Cohort of Psoriatic Arthritis, Psoriasis and Controls of the Spanish Population and Association with Relevant Clinical Subphenotypes
J. D. Cañete¹, Jose Luis Fernandez-Sueiro², Raimon Sanmarti³, Jesus Rodriguez⁴, Jordi Gratacós⁵, Rubén Queiro⁶, Juan Carlos Torre-Alonso⁷, Jose Perez Venegas⁸, Santiago Muñoz-Fernandez⁹, Carlos Gonzalez¹⁰, Carlos Montilla¹¹, Daniel Roig¹², Alba Erra¹³, Isabel Acosta¹⁴, Antonio Fernández-Nebro¹⁵, Pedro Zarco¹⁶, Arnald Alonso¹⁷, María América López-Lasanta¹⁷, Antonio Julià¹⁷, Raül Tortosa¹⁷ and Sara Marsal¹⁸, ¹Unitat d'Artritis, Servei de Reumatologia, Hospital Clínic de Barcelona,, Barcelona, Spain, ²Rheumatology Service, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, ³Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, ⁴Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ⁵Rheumatology Service, Hospital Parc Taulí, Sabadell (Barcelona), ⁶Rheumatology Service, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁷Rheumatology Service, Hospital Monte Naranco, Oviedo, Spain, ⁸Rheumatology Service, Hospital del SAS de Jerez de la Frontera, Jerez De La Frontera, Spain, ⁹Rheumatology Service, Hospital Infanta Sofía, Madrid, Spain, ¹⁰Rheumatology Service, Hospital Gregorio Marañon, Madrid, Spain, ¹¹Unit Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain, ¹²Rheumatology Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat- Barcelona, Spain, ¹³Rheumatology Service, Hospital San Rafael, Barcelona, Spain, ¹⁴Rheumatology Service, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ¹⁵Rheumatology Service, Hospital Regional Universitario Carlos Haya, Málaga, Spain, ¹⁶Rheumatology Service, Fundación Hospital Alcorcon, Alcorcon, Madrid, Spain, ¹⁷Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ¹⁸Rheumatology, University Hospital Vall d'Hebron, Barcelona, Spain
Background/Purpose: Psoriatic Arthritis (PsA) is a complex disease with a substantial genetic risk component (first-degree relative risk ~ 55). Recently, Genomewide Association Studies (GWAS) have…
Abstract Number: 999 • 2012 ACR/ARHP Annual Meeting
Identification of New Epistatic Interactions with the HLA Region in the Genetic Etiology of Psoriasis and Psoriatic Arthritis
Sara Marsal¹, Juan D. Cañete², Jose Luis Fernandez-Sueiro³, Raimon Sanmarti², Jesus Rodriguez Moreno⁴, Jordi Gratacós⁵, Rubén Queiro⁶, Carlos Montilla⁷, Juan Carlos Torre-Alonso⁸, Jose Perez Venegas⁹, Santiago Muñoz-Fernández¹⁰, Carlos M. Gonzalez¹¹, Daniel Roig¹², Alba Erra¹³, Isabel Acosta¹, Antonio Fernández-Nebro¹⁴, Pedro Zarco¹⁵, Arnald Alonso¹⁶, María América López-Lasanta¹⁶, Raül Tortosa¹⁶ and Antonio Julià¹⁶, ¹Rheumatology Service, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ²Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, ³Rheumatology Service, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, ⁴Rheumatology Service, Hospital Universitario de Bellvitge., Barcelona, Spain, ⁵Rheumatology Service, Hospital Universitari Parc Taulí, Sabadell (Barcelona), Spain, ⁶Rheumatology Service, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁷Rheumatology Service, Hospital Universitario de Salamanca, Salamanca, Spain, ⁸H. Monte Naranco, Oviedo, Spain, ⁹Rheumatology Service, Hospital del SAS de Jerez de la Frontera, Jerez De La Frontera, Spain, ¹⁰Unit Rheumatology, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes (Madrid), Spain, ¹¹Rheumatology, Hospital Gregorio Maranon, Madrid, Spain, ¹²Rheumatology Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat- Barcelona, Spain, ¹³Rheumatology Service, Hospital San Rafael, Barcelona, Spain, ¹⁴Rheumatology Service, Hospital Regional Universitario Carlos Haya, Málaga, Spain, ¹⁵Rheumatology Service, Fundación Hospital Alcorcon, Alcorcon, Madrid, Spain, ¹⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
Background/Purpose: Psoriatic Arthritis (PsA) is a complex disease and is present in ~11% in patients with Psoriasis (Ps). Recently, Genomewide Association Studies (GWAS) have expanded…
Abstract Number: 1000 • 2012 ACR/ARHP Annual Meeting
Epistatic Interaction Between BANK1 and BLK in Rheumatoid Arthritis: Results From a Large Trans-Ethnic Meta-Analysis
Emmanuelle Genin¹, Baptiste Coustet², Yannick Allanore³, Maria Teruel⁴, Arnaud L. Constantin⁵, Shigeto Tohma⁶, O. Vittecoq⁷, Hiroshi Furukawa⁸, Alejandro Balsa⁹, Thierry Schaeverbeke¹⁰, Miguel Angel González-Gay¹¹, Gilles Chiocchia¹², Naoyuki Tsuchiya¹³, Javier Martin¹⁴ and Philippe Dieude¹⁵, ¹INSERM UMR-S946, Paris, France, ²Rheumatology, Université Paris Descartes, Hopital Cochin, Paris, France, ³Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁵Rheumatology, Purpan University Hospital, Toulouse Cedex 9, France, ⁶Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁷University Hospital, Rouen, France, ⁸Department of Rheumatology, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan, ⁹Rheumatology, La Paz Hospital. IdiPaz, Madrid, Spain, ¹⁰Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, ¹¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ¹²Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ¹³Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ¹⁴Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (CSIC), Granada, Spain, ¹⁵Rheumatology, APHP, Hopital Bichat, Paris, France
Background/Purpose: BANK1 and BLK belong to pleiotropic genes and recently a genetic and physical interaction between BANK1 and BLK has been detected in systemic lupus…
Abstract Number: 1001 • 2012 ACR/ARHP Annual Meeting
CNstream2: Improved SNP and CNV Genotyping Reveals New Loci Associated with Rheumatic Diseases
Arnald Alonso, Antonio Julià, Raül Tortosa and Sara Marsal, Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
Background/Purpose: In Genome-Wide Association Studies (GWAS), the performance of the genotyping algorithm is crucial to identify new SNPs associated to disease risk. Recently, new methods…
Abstract Number: 1002 • 2012 ACR/ARHP Annual Meeting
Microrna Expression Profiles in Peripheral Blood Mononuclear Cells of Early Onset Psoriatic Arthritis
G. Ciancio¹, Manuela Ferracin², Barbara Zagatti², Elena Saccenti², Valentina Bagnari¹, Ilaria Farina³, Matteo Colina⁴, Marco Seri⁵, Francesco Trotta¹, Massimo Negrini² and Marcello Govoni¹, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit-Azienda Ospedaliera-Universitaria Sant'Anna, Ferrara, Italy, ²Department of Experimental and Diagnostic Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy, ³A.O.U. S.Anna di Cona, Ferrara, Italy, ⁴Department of Internal Medicine, Section of Internal Medicine A.Ospedale Maggiore, Bologna, Italy, ⁵Department of Gynecology, Obstetrics and Pediatric, St. Orsola-Malpighi, Medical Genetics Unit, Bologna, Italy
Background/Purpose: Micro-RNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression. It is known that an altered miRNA expression plays an important role in…
Abstract Number: 1003 • 2012 ACR/ARHP Annual Meeting
Role of Particular Class I MHC Haplotypes in Determining Different Traits within the Psoriatic Arthritis Phenotypes
Muhammad Haroon¹, Jon T. Giles², Robert Winchester³ and Oliver M. FitzGerald¹, ¹Department of Rheumatology, Dublin Academic Medical Center, St. Vincent's University Hospital, Dublin, Ireland, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ³Dept of Medicine & Pathology, Columbia University, New York, NY
Background/Purpose: A rigorously ascertained psoriatic arthritis (PsA) cohort demonstrated considerable genetic heterogeneity and provided preliminary evidence that MHC genes determine quantitative traits within the PsA…

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