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  • Abstract Number: 1054 • 2012 ACR/ARHP Annual Meeting

    Diffusion Tensor and Dynamic Contrast Enhanced Perfusion Imaging Metrics Discriminate Chronic Tubercular Synovitis From Chronic Inflammatory Synovitis of the Knee

    Vikas Agarwal1, Rakesh K. Gupta2, Rishi Awasthi2, Deepak Tripathi3, Prativa Sahoo4, Vinita Agrawal5, Kusum Sharma6, Rungmei Marak7, Ram Kishore Singh Rathore4 and CM Pandey8, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 3Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 4Mathematics and statistics, Indian Institute of Technology, Kanpur, India, 5Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 6Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 7MIcrobiology, Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 8Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India

    Background/Purpose: The study was performed to quantify dynamic contrast enhanced (DCE) and diffusion tensor imaging (DTI) metrics in synovium of patients with tubercular synovitis (TS)…
  • Abstract Number: 1015 • 2012 ACR/ARHP Annual Meeting

    Analysis of Integrated Radiographic Data for Two Long-Term, Open-Label Extension Studies of Adalimumab

    Désirée van der Heijde1, Robert Landewé2, Edward Keystone3, Ferdinand C. Breedveld4, Shufang Liu5 and Neelufar Mozaffarian6, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Int Med/Rheumatology, Academic Medical Center, Amsterdam, Netherlands, 3University of Toronto, Professor of Medicine, Toronto, ON, Canada, 4Dept of Rheumatology C1R, Leiden University Medical Center, Leiden, Netherlands, 5Immunology Development, Abbott, Abbott Park, IL, 6Abbott, Abbott Park, IL

    Background/Purpose: The assessment of radiographic data from long-term studies in patients (pts) with rheumatoid arthritis (RA) poses a significant challenge, given the potential involvement of…
  • Abstract Number: 1016 • 2012 ACR/ARHP Annual Meeting

    The Effect of Evaluation Variability At the Unit of Measurement On the Reliability of Omeract Ramris and Van Der Heijde-Modified Sharp Score

    Ruben Tavares1, Naveen Parasu2, Karen Finlay3, Erik Jurriaans3, Hao Wu1, Karen A. Beattie4, Maggie Larche5, Lawrence E. Hart6, William G. Bensen7, Raja S. Bobba5, Alfred A. Cividino4, Colin E. Webber8, Jean-Eric Tarride9 and Jonathan D. Adachi10, 1McMaster University, Hamilton, ON, Canada, 2Radiology, Hamilton Health Sciences, Hamilton, ON, 3Radiology, Hamilton Health Sciences, Hamilton, ON, Canada, 4Medicine, McMaster University, Hamilton, ON, Canada, 5Rheumatology, McMaster University, Hamilton, ON, Canada, 6Medicine (Rheumatology), St. Joseph's Health Care, Hamilton, ON, Canada, 7Department of Medicine, Division of Rheumatology, St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, 8Department of Nuclear Medicine, Hamilton Health Sciences, Hamilton, ON, Canada, 9Clinical Epidemiology and Biostatistics (CE&B) and Economics, Programs for Assessment of Technology in Health (PATH) Research Institute, Hamilton, ON, Canada, 10St Joseph's Healthcare Hamilton, Hamilton, ON, Canada

    Background/Purpose: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) and van der Heijde-modified Sharp score (vdHSS) are recognized semi-quantitative measures…
  • Abstract Number: 1017 • 2012 ACR/ARHP Annual Meeting

    Bye Bye Biopsy: Diffusion Tensor and Dynamic Contrast Enhance Magnetic Resonance Imaging Parameters Reflect Molecular Events of Inflammation in the Synovium

    Vikas Agarwal1, Rishi Awasthi2, Deepak Tripathi3, Vinita Agrawal4, Ram Kishore Singh Rathore5, Kusum Sharma6, CM Pandey7 and Rakesh K. Gupta8, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India,, Lucknow, India, 3Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 4Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 5Mathematics and statistics, Indian Institute of Technology, Kanpur, India, 6Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 7Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 8Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India

    Background/Purpose: Chronic synovial inflammation is characterized by accumulation of inflammatory cells and increased vascularity.  Synovial histology remains the most definitive way to delineate the severity…
  • Abstract Number: 1018 • 2012 ACR/ARHP Annual Meeting

    Reliability of the Early Erosions in Rheumatoid Arthritis Software When Quantifying Bone Loss

    Melissa XP. Koh1, Joshua WJ. Barbosa1, Ruben Tavares2, Stephen Tytus2, Patrick Emond3, Chris Gordon2, George Ioannidis4, Karen A. Beattie5, William G. Bensen6, Raja S. Bobba7, Alfred A. Cividino5, Lawrence E. Hart8, Maggie Larche7, Arthur N. Lau9 and Jonathan D. Adachi10, 1Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3Medical Physics, McMaster University, Hamilton, ON, Canada, 4St Josephs Hospital, McMaster University, Hamilton, ON, Canada, 5Medicine, McMaster University, Hamilton, ON, Canada, 6Department of Medicine, Division of Rheumatology, St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, 7Rheumatology, McMaster University, Hamilton, ON, Canada, 8Medicine (Rheumatology), St. Joseph's Health Care, Hamilton, ON, Canada, 9Rheumatology and Clinical Epidemiology, Division of Rheumatology, McMaster University, Hamilton, ON, Canada, 10St. Joseph's Health Care and McMaster University, Hamilton, ON, Canada

    Background/Purpose: Instruments designed to determine the clinical relevance of bone erosions captured by magnetic resonance imaging (MRI) in rheumatoid arthritis (RA) patients have been set-back…
  • Abstract Number: 1019 • 2012 ACR/ARHP Annual Meeting

    Visualization of Cartilage in High-Resolution Magnetic Resonance Imaging Is a New Imaging Biomarker for the Quantification of Joint Damage in Rheumatoid Arthritis

    Barbara Herz1, Stephanie Finzel1, Andreas Albrecht1, Juergen Rech2, Matthias Englbrecht1, Goetz Welsch3 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 3Department of Traumatic Surgery, Department of Traumatic Surgery, University Clinic of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Recent achievements in Magnetic Resonance Imaging (MRI) have been the gradient-echo-based T1-delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) focussing on the detection of proteoglycan content…
  • Abstract Number: 1020 • 2012 ACR/ARHP Annual Meeting

    Location of Erosions At the Metatarsophalangeal Joints in Patients with Rheumatoid Arthritis

    Heidi J. Siddle1, Richard J. Hodgson2, Andrew J. Grainger3, Anthony C. Redmond4, Richard J. Wakefield4 and Philip S. Helliwell5, 1Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 3NIHR-Leeds Musculoskeletal Biomedical Research Unit and The Leeds Teaching Hospitals Trusts, Leeds, United Kingdom, 4Division of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 5PsAID taskforce, EULAR, Zurich, Switzerland

    Background/Purpose: The forefoot is described as the most common site of symptoms in the foot and ankle of patients with rheumatoid arthritis (RA).  Pressure under…
  • Abstract Number: 1021 • 2012 ACR/ARHP Annual Meeting

    Magnetic Resonance Imaging in Follow-up of Clinical Remission in Juvenile Idiopathic Arthritis

    Mira van Veenendaal1, Robert Hemke2, Marjolein I. Bos3, Mario Maas4, Marion A. J. Van Rossum3 and Taco W. Kuijpers5, 1Departments of Pediatric Rheumatology, Emma Children's Hospital / Academic Medical Center (AMC), Amsterdam, Netherlands, 2Departments of Radiology, Academic Medical Center (AMC), Amsterdam, Netherlands, 3Department of Pediatric Rheumatology and Immunology, Emma Children's Hospital / Academic Medical Center (AMC), Amsterdam, Netherlands, 4Radiology, Academic Medical Center, Amsterdam, Netherlands, 5Pediatric Rheumatology and Immunology, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands

    Background/Purpose: Despite clinical remission, a substantial proportion of Juvenile Idiopathic Arthritis (JIA) patients will flare after a period of inactive disease. MRI has proven to…
  • Abstract Number: 1022 • 2012 ACR/ARHP Annual Meeting

    Imaging of Ankle Joints by MRI in Murine Models of Inflammatory Arthritis

    Shawn M. Rose1, Harris R. Perlman2, Emily Alex Waters3 and Thomas Meade3, 1Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Chemistry of Life Processes Institute, Northwestern University, Evanston, IL

    Background/Purpose: One of the fundamental shortcomings in the field of experimental rheumatology is the inability to non-invasively monitor the development of inflammatory arthritis longitudinally.  Magnetic…
  • Abstract Number: 1023 • 2012 ACR/ARHP Annual Meeting

    Scoring Radiographic Progression in Axial Spa: Should We Use the Modified Stoke in Ankylosing Spondylitis Spine Score or the Radiographic Ankylosing Spondylitis Spinal Score?

    Sofia Ramiro1, A.M. Van Tubergen2, Carmen Stolwijk3, Robert Landewé4 and Désirée van der Heijde5, 1Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, 2Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 3Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 4Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam and Atrium Medical Center, Heerlen, Netherlands, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Radiographic damage is one of the core outcomes in axial SpA and it is usually assessed with the modified Stoke Ankylosing Spondylitis (AS) Spine…
  • Abstract Number: 1024 • 2012 ACR/ARHP Annual Meeting

    What Constitutes the Characteristic Fat Lesion On MRI of the Sacroiliac Joints in Early Spondyloarthritis?

    Ulrich Weber1, Susanne Juhl Pedersen2, Veronika Zubler3, Kaspar Rufibach4, Stanley Chan5, Robert GW Lambert6, Mikkel Ostergaard7 and Walter P. Maksymowych8, 1Rheumatology, Balgrist University Hospital, Zurich, Switzerland, 2Department of Rheumatology, Copenhagen University Hospital Glostrup, Copenhagen, Denmark, 3Radiology, Balgrist University Hospital, Zurich, Switzerland, 4Institute for Social and Preventive Medicine, Division of Biostatistics, University of Zurich, Zurich, Switzerland, 5Division of Ophthalmology, University of Alberta, Edmonton, AB, Canada, 6Radiology, University of Alberta, Edmonton, AB, Canada, 7Dept of Rheumatology RM, Copenhagen University Hospital, Glostrup, Denmark, 8Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: It is well known that fat infiltration (FI) of bone marrow may be observed on T1-weighted MRI in the sacroiliac joints (SIJ) of healthy…
  • Abstract Number: 1025 • 2012 ACR/ARHP Annual Meeting

    Spinal Inflammation in the Absence of SI Joint Inflammation On MRI in Patients with Active Non-Radiographic Axial Spondyloarthritis

    Désirée van der Heijde1, Joachim Sieper2, Walter P. Maksymowych3, Matthew A. Brown4, Suchitrita S. Rathmann5 and Aileen L. Pangan5, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, 3Department of Medicine, University of Alberta, Edmonton, AB, Canada, 4University of Queensland Diamantina Insititute, Brisbane, Australia, 5Abbott Laboratories, Abbott Park, IL

    Background/Purpose: The imaging arm of the ASAS axial spondyloarthritis (SpA) criteria requires the presence of sacroiliitis on MRI or radiographs. In patients (pts) with non-radiographic…
  • Abstract Number: 1026 • 2012 ACR/ARHP Annual Meeting

    Psoriatic Arthritis and Spondyloarthritis: Inflammation Assessed by “Head to Toe” Wholebody Magnetic Resonance Imaging – A Comparison with Clinical Joint Examination

    René Panduro Poggenborg1, Susanne Juhl Pedersen2, Iris Eshed3, Inge Juul Sørensen4, Ole Rintek Madsen5, J.M. Møller6 and Mikkel Østergaard7, 1Department of Rheumatology, Copenhagen University Hospital in Glostrup, Copenhagen, Denmark, 2Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 3Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel, 4Department of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, 5Department of Rheumatology, Copenhagen University Hospital in Gentofte, Copenhagen, Denmark, 6Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, 7Copenhagen University Hospital Glostrup, Glostrup, Denmark

    Background/Purpose: Psoriatic arthritis (PsA) and spondyloarthritis (SpA) is associated with a varied pattern of axial and peripheral inflammation. Wholebody magnetic resonance imaging (WBMRI) is a…
  • Abstract Number: 1027 • 2012 ACR/ARHP Annual Meeting

    Frequency of MRI-Detected Hip Osteoarthritis Features in Persons with Chronic Hip Pain and the Diagnostic Performance of Radiography Using MRI As the Reference

    Li Xu1, Daichi Hayashi1, Ali Guermazi2, David J. Hunter3, Anton Winterstein4, Ling Li5, Klaus Bohndorf4 and Frank Roemer6, 1Department of Radiology, Boston University School of Medicine, Boston, MA, 2Boston University, Boston, MA, 3Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 4Department of Radiology, Klinikum Augsburg, Augsburg, Germany, 5Division of Research, New England Baptist Hospital, Boston, MA, 6Klinikum Augsburg, Augsburg, Germany

    Background/Purpose: Conventional radiography has been the standard imaging tool to diagnose and grade the severity of hip OA. However, radiography cannot visualize the bone marrow,…
  • Abstract Number: 1028 • 2012 ACR/ARHP Annual Meeting

    Semi-Quantitative Assessment of Bone Marrow Edema and Synovitis-Effusion in Osteoarthritis with the Knee Inflammation MRI Scoring System:  A Target Lesion Based Methodology

    Walter P. Maksymowych1, Ulrich Weber2, Marcus Pianta3 and Robert GW Lambert3, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, Balgrist University Hospital, Zurich, Switzerland, 3Radiology, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Current MRI scoring methods for assessment of bone marrow lesions (BML) in the knee of patients with osteoarthritis rely on a complex subdivision of…
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