Abstracts Archive - Page 2351 of 2425 - ACR Meeting Abstracts

Abstract Number: 1064 • 2012 ACR/ARHP Annual Meeting
CD1c-Expressing Myeloid Dendritic Cells From Joints of Rheumatoid Arthritis Patients Produce Increased Levels of T Cell-Attracting Chemokines and Strongly Activate Autologous T Cells
F.M. Moret¹, C.E. Hack², F.P.J.G. Lafeber¹, T.R.D.J. Radstake¹ and J.A.G. van Roon¹, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been implicated to play a crucial role in the regulation of tolerance…
Abstract Number: 1065 • 2012 ACR/ARHP Annual Meeting
Hypoxia-Inducible Factor-1α: Trigger of Toll-Like Receptor Signalling-Engaged Inflammation in Rheumatoid Arthritis
Fanlei Hu¹, Rong Mu¹, Jiaxin Zhu¹, Wenwei Shao², Lianjie Shi¹, Philip L. Cohen³, Xiaoyan Qiu² and Zhanguo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Immunology, School of Basic Medical Science, Peking University, Beijing, China, ³Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Hyperplasia of synovial fibroblasts, infiltration with lymphocytes, and tissue hypoxia are the major characteristics of rheumatoid arthritis (RA). Data has confirmed the central role…
Abstract Number: 1066 • 2012 ACR/ARHP Annual Meeting
Extrathymic Autoimmune Regulator (AIRE) Expression in Rheumatoid Arthritis
A.R. Noort¹, K.P.M. van Zoest², M.C. Lebre³, P. P. Tak⁴ and S.W. Tas³, ¹Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology & Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁴Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: The Autoimmune Regulator (AIRE) is a transcription factor that is involved in the negative selection of self-reactive thymocytes in the thymus and therefore is…
Abstract Number: 1067 • 2012 ACR/ARHP Annual Meeting
Spontaneous Aggregation of the Anti-Viral Mavs Protein in Certain Systemic Lupus Erythematosus Patients May Explain Excessive Type I Interferon Production
Philip L. Cohen¹ and Wen-Hai Shao², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine, Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Patients with systemic lupus (SLE) often have increased type I interferon levels (IFN-I) and activation of IFN-inducible genes (IFN signature). The mitochondrial adaptor protein…
Abstract Number: 1068 • 2012 ACR/ARHP Annual Meeting
A Selective Inhibitor of Endosomal Toll-Like Receptors, IMO-8400, Suppresses Activation of Multiple Cytokines, Th17 Response and Inflammasome Activation
Weiven Jiang, Fugang Zhu, Dong Yu, Ekambar R. Kandimalla, Nicola La Monica and Sudhir Agrawal, Discovery, Idera Pharmaceuticals, Cambridge, MA
Background/Purpose: In autoimmune diseases, activation of Th1 and Th17 pathways has been associated with disease maintenance and progression. Engagement of endosomal Toll-like receptors (TLRs) 7,…
Abstract Number: 1069 • 2012 ACR/ARHP Annual Meeting
The Effects of TNF Stimulation On Control of Apoptosis in Neutrophils
Direkrit Chiewchengchol¹, Connie Lam¹, Kate Roberts¹, Helen Wright¹, Huw Thomas¹, Robert Moots² and Steven Edwards¹, ¹Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, ²University Hospital Aintree, Liverpool, United Kingdom
Background/Purpose: TNF is a key regulator of immune function and plays a pivotal role in inflammatory conditions such as rheumatoid arthritis. Human neutrophils express and…
Abstract Number: 1070 • 2012 ACR/ARHP Annual Meeting
CD11c+ Dendritic Cells Play an Important Proinflammatory Role in Inflammatory Arthritis
Antonia Puchner¹, Stephan Blüml², Harald Leiss², Victoria Saferding³ and Kurt Redlich⁴, ¹Dpt of Rheumatology, Medical University Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) play an important role in bridging innate and adaptive immune responses by serving as antigen presenting cells. Therefore DCs are implicated…
Abstract Number: 1072 • 2012 ACR/ARHP Annual Meeting
Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function
Stefan Uderhardt¹, Tobias Rothe¹, Elisabeth Zinser², Olga Oskolkova³, Martin Herrmann⁴, Alexander Steinkasserer⁵, Valery Bochkov³, Georg Schett⁶ and Gerhard Kronke¹, ¹Internal Medicine 3, University of Erlangen, Erlangen, Germany, ²University of Erlangen, Erlangen, Germany, ³Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria, Vienna, Austria, ⁴Instiute for Immunology, PhD, Erlangen, Germany, ⁵Department of Immune Modulation at the Department of Dermatology, University Hospital Erlangen, Erlangen, Germany, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: During inflammation and tissue damage, pathogens as well as dying cells are ingested by different phagocytes such as macrophages and dendritic cells. The uptake…
Abstract Number: 1073 • 2012 ACR/ARHP Annual Meeting
Increased Oxidative Burst in Neutrophils but Not Monocytes in Systemic Lupus Erythematosus
Sandro F. Perazzio¹, Reinaldo Salomao², Neusa P. Silva³ and Luis Eduardo C. Andrade⁴, ¹Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Infectology, Federal University of Sao Paulo, Sao Paulo, Brazil, ³Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁴Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil
Background/Purpose: The role of innate immunity in the pathogenesis of Systemic Lupus Erythematosus (SLE) has acquired increasing importance lately. Chronic Granulomatosus Disease (CGD), a hereditary…
Abstract Number: 1074 • 2012 ACR/ARHP Annual Meeting
TLR2 Deletion Promotes Arthritis and Joint Destruction Through Reduction of IL-10
Qi Quan Huang¹, Renee E. Koessler¹, Robert Birkett², Harris R. Perlman³, Lianping Xing⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: TLR2 signaling pathway has been suggested as a potential therapeutic target in RA. However, studies with mice deficient in TLR2 (TLR2-/-) and IL-1Ra suggest…
Abstract Number: 1075 • 2012 ACR/ARHP Annual Meeting
Effects of siRNA Depletion of Interferon Regulatory Factor 5 On Pro-Inflammatory Cytokine Production and IgG Secretion by Primary Human Immune Cells in Response to TLR7/8 Stimulation
Dinesh Srinivasan¹, Sandip Panicker², Gang Lu³, Yajuan Gu³, Rothschild Soto², Seng-Lai Tan³ and Julie Demartino¹, ¹Inflammation Discovery, Hoffmann-La Roche, Nutley, NJ, ²Inflammation, Hoffmann La Roche, Nutley, NJ, ³Inflammation, Hoffmann-La Roche, Nutley, NJ
Background/Purpose: Interferon regulatory factor 5 (IRF5) has been identified as a genetic risk factor for multiple human autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid…
Abstract Number: 1035 • 2012 ACR/ARHP Annual Meeting
Characterisation of New Bone Formation in Gout: A Quantitative Site-by-Site Analysis Using Plain Radiography and Computed Tomography
Nicola Dalbeth¹, Aaron Milligan², Barnaby Clark², Fiona M. McQueen³ and Anthony Doyle⁴, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ³Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand
Background/Purpose: Radiographic descriptions of gout have noted the tendency to hypertrophic bone changes. The aim of this study was to characterise the features of…
Abstract Number: 1036 • 2012 ACR/ARHP Annual Meeting
The Prevalence of Chondrocalcinosis of the Acromioclavicular Joint On Chest Radiographs and correlation with Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Konstantinos M. Parperis¹, Guillermo F. Carrera², Keith E. Baynes², Alan P. Mautz², Melissa S. DuBois², Ross M. Cerniglia² and Lawrence M. Ryan³, ¹Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ²Radiology, Medical College of Wisconsin, Milwaukee, WI, ³Department of Rheumatology, Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: Digital imaging combined with picture archiving and communication system (PACS) access allows detailed image retrieval and magnification. Calcium pyrophosphate dihydrate (CPPD) crystals preferentially deposit…
Abstract Number: 1037 • 2012 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging (MRI) Assessment of Inflammatory Myopathy: Quantitative Fat-Corrected Muscle T2 and Conventional T2 Measurement Versus Standard MRI and Clinical Metrics
Lawrence Yao¹, Adrienne L. Yip², Sepehr Mesdaghinia², Ashkan Shademan², Joseph A. Shrader³, Anna V. Jansen⁴, Frederick W. Miller⁴ and Lisa G. Rider⁴, ¹Diagnostic Radiology, NIH Clinical Center, Bethesda, MD, ²NIEHS, NIH, Bethesda, MD, ³Rehabilitation Medicine, Clinical Center, NIH, Bethesda, MD, ⁴Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD
Background/Purpose: Active muscle disease in patients with idiopathic inflammatory myopathies (IIM) is characterized by prolonged muscle T2 relaxation on MRI. We examined the utility of…
Abstract Number: 1038 • 2012 ACR/ARHP Annual Meeting
Assessment of Aortic Stiffness by Cardiac Magnetic Resonance Imaging in Systemic Autoimmune Rheumatic Diseases
Galia Karp¹, Arik Wolak², Nina Baram³, Victor Novack⁴, Philip Rosen³, Yael Perl⁵, Talia Wolak⁶, Ilan Shelef³ and Mahmoud Abu-Shakra⁷, ¹Medicine and Rheumatology, Department of Medicine, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel, ²Cardiology and and MRI Unit, Dept. of Cardiology, Cardiac MRI unit, Soroka University Medical Center, and Ben Gurion University, Beer-Sheva, Israel, ³Radiology division, Soroka University Medical Center and Ben Gurion University, Radiology division, Soroka University Medical Center and Ben Gurion University, ⁴Department of Medicine and Clinical Research center, Department of Medicine, Clinical Research center, Soroka University Medical Center and Ben Gurion University, ⁵Department of Medicine and Clinical Research center, Clinical Research center, Soroka University Medical Center and Ben Gurion University, ⁶Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, ⁷Medicine and Rheumatology, Department of Medicine and Rheumatology, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel
Background/Purpose: Systemic Lupus Erythematosus (SLE) and rheumatoid arthritis (RA) are known to cause premature arterial aging and early atherosclerosis hence leading to increased stiffness of…

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