Abstract Number: 1069 • 2012 ACR/ARHP Annual Meeting
The Effects of TNF Stimulation On Control of Apoptosis in Neutrophils
Background/Purpose: TNF is a key regulator of immune function and plays a pivotal role in inflammatory conditions such as rheumatoid arthritis. Human neutrophils express and…Abstract Number: 1070 • 2012 ACR/ARHP Annual Meeting
CD11c+ Dendritic Cells Play an Important Proinflammatory Role in Inflammatory Arthritis
Background/Purpose: Dendritic cells (DCs) play an important role in bridging innate and adaptive immune responses by serving as antigen presenting cells. Therefore DCs are implicated…Abstract Number: 1072 • 2012 ACR/ARHP Annual Meeting
Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function
Background/Purpose: During inflammation and tissue damage, pathogens as well as dying cells are ingested by different phagocytes such as macrophages and dendritic cells. The uptake…Abstract Number: 1073 • 2012 ACR/ARHP Annual Meeting
Increased Oxidative Burst in Neutrophils but Not Monocytes in Systemic Lupus Erythematosus
Background/Purpose: The role of innate immunity in the pathogenesis of Systemic Lupus Erythematosus (SLE) has acquired increasing importance lately. Chronic Granulomatosus Disease (CGD), a hereditary…Abstract Number: 1074 • 2012 ACR/ARHP Annual Meeting
TLR2 Deletion Promotes Arthritis and Joint Destruction Through Reduction of IL-10
Background/Purpose: TLR2 signaling pathway has been suggested as a potential therapeutic target in RA. However, studies with mice deficient in TLR2 (TLR2-/-) and IL-1Ra suggest…Abstract Number: 1075 • 2012 ACR/ARHP Annual Meeting
Effects of siRNA Depletion of Interferon Regulatory Factor 5 On Pro-Inflammatory Cytokine Production and IgG Secretion by Primary Human Immune Cells in Response to TLR7/8 Stimulation
Background/Purpose: Interferon regulatory factor 5 (IRF5) has been identified as a genetic risk factor for multiple human autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid…Abstract Number: 1035 • 2012 ACR/ARHP Annual Meeting
Characterisation of New Bone Formation in Gout: A Quantitative Site-by-Site Analysis Using Plain Radiography and Computed Tomography
Background/Purpose: Radiographic descriptions of gout have noted the tendency to hypertrophic bone changes. The aim of this study was to characterise the features of…Abstract Number: 1036 • 2012 ACR/ARHP Annual Meeting
The Prevalence of Chondrocalcinosis of the Acromioclavicular Joint On Chest Radiographs and correlation with Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Background/Purpose: Digital imaging combined with picture archiving and communication system (PACS) access allows detailed image retrieval and magnification. Calcium pyrophosphate dihydrate (CPPD) crystals preferentially deposit…Abstract Number: 1037 • 2012 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging (MRI) Assessment of Inflammatory Myopathy: Quantitative Fat-Corrected Muscle T2 and Conventional T2 Measurement Versus Standard MRI and Clinical Metrics
Background/Purpose: Active muscle disease in patients with idiopathic inflammatory myopathies (IIM) is characterized by prolonged muscle T2 relaxation on MRI. We examined the utility of…Abstract Number: 1038 • 2012 ACR/ARHP Annual Meeting
Assessment of Aortic Stiffness by Cardiac Magnetic Resonance Imaging in Systemic Autoimmune Rheumatic Diseases
Background/Purpose: Systemic Lupus Erythematosus (SLE) and rheumatoid arthritis (RA) are known to cause premature arterial aging and early atherosclerosis hence leading to increased stiffness of…Abstract Number: 1039 • 2012 ACR/ARHP Annual Meeting
Cardiac Involvement in Systemic Sclerosis: The Added Value of Magnetic Resonance Imaging
Background/Purpose: Cardiac involvement in systemic sclerosis (SSc) affects the prognosis of the disease. Myocardial fibrosis is the pathological hallmark of this complication and has been…Abstract Number: 1040 • 2012 ACR/ARHP Annual Meeting
Combined High-Resolution Single Photon Emission Computed Tomography and Magnetic Resonance Imaging for Therapy Monitoring in Rheumatoid Arthritis
Background/Purpose: To evaluate whether combined multi-pinhole single photon emission computed tomography (MPH-SPECT) with technetium-99m-labelled disphosphonates (Tc99m-DPD) and magnetic resonance imaging (MRI) detect changes in inflammation…Abstract Number: 1041 • 2012 ACR/ARHP Annual Meeting
Whole-Body Magnetic Resonance Imaging – A New Diagnostic Tool in the Assessment of Activity in Juvenile Dermatomyositis Patients?
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare autoimmune disorder, but remains the most commonly chronic inflammatory myopathy among children. A redefinition of the diagnostic criteria…Abstract Number: 1042 • 2012 ACR/ARHP Annual Meeting
Psoriatic Arthritis Patients Assessed by Dynamic Contrast-Enhanced MRI in High Disease Versus Minimal Disease Activity State – a Cross-Sectional Study Correlating Conventional MRI and Clinical Composite Measures
Background/Purpose: Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has been validated in rheumatoid arthritis for measuring inflammation, but has rarely been studied in psoriatic arthritis…Abstract Number: 1043 • 2012 ACR/ARHP Annual Meeting
Assessment of Rheumatoid Arthritis Disease Activity by Power Doppler Ultrasonography: Association with Routine Clinical Indices and Its Usefulness in Detecting Remission
Background/Purpose: Power Doppler ultrasonography (PDUS) is sensitive for detecting synovitis in patients with rheumatoid arthritis (RA). We aimed to clarify the association of PDUS findings…