Abstracts Archive - Page 2350 of 2425 - ACR Meeting Abstracts

Abstract Number: 1090 • 2012 ACR/ARHP Annual Meeting
A Comparison of Patient-Reported and Measured Range of Motion in a Cohort of Total Knee Replacement Patients
Jamie E. Collins¹, Benjamin N. Rome¹, Vladislav Lerner¹, Jeffrey N. Katz² and Elena Losina¹, ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Range of motion (ROM) is an important component of the assessment of total knee replacement (TKR) outcome. Traditionally, ROM is measured by a clinician…
Abstract Number: 1091 • 2012 ACR/ARHP Annual Meeting
Trends in Patient Physical Activity Before and After Primary Total Hip Arthroplasty
Anne Lübbeke¹, Dorith Zimmermann², Constantinos Roussos¹, Alexis Bonvin¹, Robin Peter¹ and Pierre Hoffmeyer¹, ¹Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland, ²Geneva University Hospitals, Geneva, Switzerland
Background/Purpose: Total hip arthroplasties (THA) are performed to reduce pain and enhance patients’ function and physical activity (PA) level. PA is also recognized as the…
Abstract Number: 1092 • 2012 ACR/ARHP Annual Meeting
Effect of FULL Contact FOOT Orthosis On Plantar Fasciitis
Hilda A. Oliveira¹, Anamaria Jones², Emilia Moreira³, Fabio Jennings³ and Jamil Natour⁴, ¹Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Unifesp-EPM, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ⁴Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
EFFECT OF FULL CONTACT FOOT ORTHOSIS ON PLANTAR FASCIITIS Background/Purpose: Plantar fasciitis (PF) is an inflammation of the foot plantar fascia, characterized by stiffness in…
Abstract Number: 1093 • 2012 ACR/ARHP Annual Meeting
Obesity Is Not a Risk Factor for Poor Pain and Function Two Years After Total Knee Replacement
Lisa A. Mandl¹, Mark P. Figgie², Alejandro Gonzalez Della Valle³, Michael Alexiades³ and Susan M. Goodman¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Orthopedics, Hospital for Special Surgery, New York, NY, ³Orthopaedics, Hospital for Special Surgery, New York, NY
Background/Purpose: Almost 90% of referring physicians think obesity increases the likelihood of poor outcomes after total knee replacement (TKR). However, current data are conflicting. The…
Abstract Number: 1094 • 2012 ACR/ARHP Annual Meeting
The Relationship Between Lumbar Spine Individual Radiographic Features and Low Back Symptoms with and without Associated Leg Symptoms: The Johnston County Osteoarthritis Project
Adam P. Goode¹, Janet K. Freburger², Timothy S. Carey³, Chad E. Cook⁴, Jordan Renner⁵, Sean D. Rundell⁶ and Joanne M. Jordan⁷, ¹Community and Family Medicine, Duke University, Durham, NC, ²Sheps Center for HSR & IOA, University of NC CB 7590, Chapel Hill, NC, ³UNC School of Medicine, Cecil G. Sheps Center for Health Services Research University of North Carolina, Chapel Hill, NC, ⁴Physical Therapy, Walsh University, OH, ⁵UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁶Department of Radiology, University of Washington, Seatle, WA, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known of the relationships between low back symptoms (LBS) and associated leg symptoms and lumbar spine individual radiographic features (IRF). We examined…
Abstract Number: 1095 • 2012 ACR/ARHP Annual Meeting
Metal Concentrations in Patients with Failed Metal-On-Metal Hip Prostheses Determine the Inflammatory Phenotype in Peri-Implant Tissue
Erja-Leena Paukkeri¹, Riku Korhonen¹, Antti Eskelinen², Marko Pesu³, Kaija Vasama⁴, Teemu Moilanen² and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland, ³Immunoregulation, Institute of Biomedical Technology, University of Tampere, Tampere, Finland, ⁴Fimlab Laboratories, Tampere, Finland
Background/Purpose: Hip arthroplasty is the standard treatment of a painful hip destruction in rheumatoid arthritis and osteoarthritis. The use of metal-on-metal (MoM) bearing surfaces in…
Abstract Number: 1055 • 2012 ACR/ARHP Annual Meeting
Sec61 Is Indispensable for Antigen Cross-Presentation and the Development of Lupus Nephritis: A Novel ‘Self-Organized Criticality Theory’ Explaining the Cause of Systemic Lupus Erythematosus (SLE)
Ken Tsumiyama and Shunichi Shiozawa, Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 1056 • 2012 ACR/ARHP Annual Meeting
Fc Receptor Gamma-Dependent Autoimmune Endocarditis in K/BxN Mice
Patricia M. Hobday¹, Jennifer L. Auger², J. Sjef Verbeek³, Jeffrey V. Ravetch⁴ and Bryce A. Binstadt², ¹Department of Pediatrics, Division of Pediatric Rheumatology, University of Minnesota, Minneapolis, MN, ²Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, ³Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands, ⁴The Rockefeller University, New York, NY
Background/Purpose: Arthritis and endocarditis co-exist in several human rheumatic diseases, including systemic lupus erythematosus, rheumatic fever, and rheumatoid arthritis. K/BxN TCR transgenic mice, well known…
Abstract Number: 1057 • 2012 ACR/ARHP Annual Meeting
A Specific Inhibitor of Spleen Tyrosine Kinase, PRT062607, Is a Potent Modulator of Innate Immune Cell Function
Lynn A. Kamen¹, Gillian Stephens¹, Anjali Pandey² and Uma Sinha¹, ¹Biology, Portola Pharmaceuticals, South San Francisco, CA, ²Chemistry, Portola Pharmaceuticals, South San Francisco, CA
Background/Purpose: Tumor Necrosis Factor-α (TNF-α) is an essential component of the inflammatory stimuli leading to rheumatoid arthritis (RA). Therapeutics targeting TNF-α are the standard of…
Abstract Number: 1058 • 2012 ACR/ARHP Annual Meeting
Fulminant Toll-Like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis Occur Independently of Interferon Gamma
Scott W. Canna¹, Julia Wrobel², Portia A. Kreiger³, Michele E. Paessler⁴ and Edward M. Behrens⁵, ¹Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Pathology, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, ⁴Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, ⁵Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Macrophage Activation Syndrome (MAS) is a potentially lethal cytokine storm syndrome that complicates various rheumatic diseases. We have previously shown that Toll-like Receptor (TLR9)…
Abstract Number: 1059 • 2012 ACR/ARHP Annual Meeting
Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis
Nirmal K. Banda¹, Gaurav Mehta², Viviana P. Ferreira³, Claudio Cortes³, Michael K. Pangburn⁴, William P. Arend² and V. Michael Holers², ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Department of Medical Microbiology and Immunology, University of Toledo Health Science Campus, Toledo, OH, ⁴Department of Biochemistry, University of Texas Health Sciences Center, Tyler, TX
Background/Purpose: The complement system, a major component of innate immunity, likely plays an important role in the pathogenesis of rheumatoid arthritis (RA). Factor H (fH)…
Abstract Number: 1060 • 2012 ACR/ARHP Annual Meeting
Protein Kinase C Inhibitor Generates Human Tolerogenic Dendritic Cells That Induce Tr1 and Foxp3⁺ Regulatory T Cells
Takuya Matsumoto, Hitoshi Hasegawa, Jun Ishizaki, Koichiro Suemori, Sachiko Onishi and Masaki Yasukawa, Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Japan
Background/Purpose: Tolerogenic dendritic cells (tDCs) play a critical role in immune tolerance and are involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis.…
Abstract Number: 1061 • 2012 ACR/ARHP Annual Meeting
Generation of Myeloid-Derived Suppressor Cells in Vitro From Murine Bone Marrow Precursors
Julia Kurko¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Colt Egelston², Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that expand under pathological conditions (such as cancer and autoimmune diseases) in response to local growth…
Abstract Number: 1062 • 2012 ACR/ARHP Annual Meeting
Identification of Highly Potent and Selective Interleukin-1 Receptor-Associated Kinase 4 Inhibitors for the Treatment of Rheumatic Diseases
Divya Chaudhary¹, Shaughnessy Robinson², Craig E. Masse¹, Matthew D. Wessel², Shawn Watts², Jeremy Greenwood², Mee Shelley², Mark Brewer², Geraldine Harriman¹, Leah L. Frye², Ronald T. Wester¹, Rosana Kapeller¹ and Donna Romero¹, ¹25 First Street Suite 404, Nimbus Discovery, Inc., Cambridge, MA, ²Schrödinger, Inc., New York, NY
Background/Purpose: Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key mediator of the innate immune response orchestrated by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), IL-33…
Abstract Number: 1063 • 2012 ACR/ARHP Annual Meeting
Dysfunction of Natural Killer and Natural Killer T Cells in Patients with Adult Onset Still’s Disease
Young-Nan Cho¹, Sung-Ji Lee¹, Tae-Jong Kim², Hye-Mi Jin¹, Dong-Jin Park², Seung-Jung Kee³ and Yong-Wook Park¹, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ³Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose: Adult onset Still’s disease (AOSD) is an uncommon systemic inflammatory disorder of unknown etiology. Natural killer (NK) cell dysfunction is frequently observed in some…

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