Abstracts Archive - Page 2346 of 2425 - ACR Meeting Abstracts

Abstract Number: 1150 • 2012 ACR/ARHP Annual Meeting
Adverse Events in Juvenile Idiopathic Arthritis: Results From the Enhanced Drug Safety Surveillance (EDSS) Pilot Project
Sarah Ringold¹, Audrey F. Hendrickson², Carol A. Wallace³ and Rachel E. Sobel⁴, ¹Pediatrics, Seattle Children's Hospital/Univ of Washington, Seattle, WA, ²Rheumatology, Seattle Children's Research Institute, Seattle, WA, ³Pediatrics, Seattle Childrens Hospital, Seattle, WA, ⁴Epidemiology, Worldwide Safety Strategy, Pfizer, Inc., New York, NY
Background/Purpose: There are few data available regarding the rates of serious and important medical events (SAEs and IMEs) for most of the medications used to…
Abstract Number: 1151 • 2012 ACR/ARHP Annual Meeting
Low-Dose Methotrexate and the Selective Accumulation of Intracellular Aminoimidazolecarboxamide Ribotide
Ryan S. Funk¹, Leon van Haandel¹, Mara L Becker² and J.S. Leeder¹, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Current evidence suggests that the anti-folate methotrexate (MTX) mediates its anti-inflammatory effects through inhibition of the purine synthesis pathway causing the accumulation of…
Abstract Number: 1152 • 2012 ACR/ARHP Annual Meeting
Improvement in Health-Related Quality of Life for Children with Juvenile Ideopathic Arthritis After Start of Treatment with Etanercept
Jens Klotsche¹, Kirsten Minden² and Gerd Horneff³, ¹Programme Area Epidemiology, German Rheumatism Research Center, a Leibniz institute, Berlin, Germany, ²Programme Area Epidemiology, German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany, ³Department of Pediatrics, Centre of Pediatric Rheumatology, Sankt Augustin, Germany
Background/Purpose: The concept of Health-related quality of life (HrQoL) has been widely accepted as a burden of disease measure in recent years. The improvement in…
Abstract Number: 1153 • 2012 ACR/ARHP Annual Meeting
Perceived Health-Related Quality of Life and Its Determining Factors in Children with Recent-Onset JIA
Jens Klotsche¹, Ina Liedmann¹, Martina Niewerth², Gerd Horneff³, Johannes Peter Haas⁴ and Kirsten Minden⁵, ¹Programme Area Epidemiology, German Rheumatism Research Center, a Leibniz institute, Berlin, Germany, ²Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ³Department of Pediatrics, Centre of Pediatric Rheumatology, Sankt Augustin, Germany, ⁴German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ⁵Programme Area Epidemiology, German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease and a major cause of chronic disability in children aged below 16 years.…
Abstract Number: 1154 • 2012 ACR/ARHP Annual Meeting
Impact of FokI VDR and TNFalpha–308 Polymorphism On Disease Severity and Long Term Outcome in JIA Patients On Anti-TNF Treatment
Jelena Vojinovic¹, Jelena Basic², Gordana Susic³, Dragana Lazarevic⁴ and Nemanja Damjanov⁵, ¹Dept Pediatric Rheumatology, Clinical Center, School of Medicine University of Nis, Nis, Serbia, ²Institute of Biochemistry, School of Medicine University of Nis, Dr, Nis, Serbia, ³Istituto Giannina Gaslini, Genoa, Italy, ⁴Dept Pediatric Rheumatology, Clinical Center, School of Medicine University of Nis, Dr, Nis, Serbia, ⁵Institute for Rheumatology, University of Belgrade, Prof, Belgrade, Serbia
Background/Purpose: Genetic contribution of SNP (single nucleotide polymorphism) of TNFα–308 promoter and FoxI for VDR (vitamin D receptor) polymorphism on disease severity and outcome in…
Abstract Number: 1155 • 2012 ACR/ARHP Annual Meeting
A New Measure of Visual Function for Children with Juvenile Idiopathic Arthritis-Associated Uveitis
Sheila T. Angeles-Han¹, Steven Yeh², Courtney McCracken¹, Larry B. Vogler³, Kelly A. Rouster-Stevens⁴, Christine W. Kennedy⁵, Kirsten Jenkins⁶, Matthew Kent³, Scott Lambert⁷, Carolyn Drews-Botsch⁸ and Sampath Prahalad⁹, ¹Emory University School of Medicine, Atlanta, GA, ²Ophthalmology, Emory University School of Medicine, Atlanta, GA, ³Dept of Pediatrics, Emory Univ School of Medicine, Atlanta, GA, ⁴Pediatric Rheumatology, Emory Univ School of Medicine, Atlanta, GA, ⁵Rheumatology Immunology, Emory Children's Center, Atlanta, GA, ⁶Children's Healthcare of Atlanta, Atlanta, GA, ⁷Ophthalmology, Emory Univ School of Medicine, Atlanta, GA, ⁸Epidemiology, Emory University School of Public Health, Atlanta, GA, ⁹Pediatrics, Emory Children's Center, Atlanta, GA
Background/Purpose: Studies on outcomes of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) focus on the clinical ocular exam and physical disability secondary to arthritis. This…
Abstract Number: 1116 • 2012 ACR/ARHP Annual Meeting
Diagnostic Value of Internal Rotation Measurement in Patients with Cam- and Pincer-Type Deformities of the Hip
Stephan Reichenbach¹, Michael Leunig², Stefan Werlen³, Andreas Limacher¹, Christian W. Pfirrmann⁴, Reinhold Ganz⁵ and Peter Jüni¹, ¹University of Bern, Bern, Switzerland, ²Schulthess Clinic, Zurich, Switzerland, ³Hospital Sonnenhof, Bern, Switzerland, ⁴Balgrist University Hospital, Zurich, Switzerland, ⁵Department of Orthopedic Surgery, University of Bern, Bern, Switzerland
Background/Purpose: It has been proposed that femoroacetabular impingement (FAI) causes early osteoarthritis (OA) in non-dysplastic hips. FAI occurs predominantly in two different types, ”cam” or…
Abstract Number: 1117 • 2012 ACR/ARHP Annual Meeting
Association Between Hip Bone Marrow Lesions (BMLs) and Bone Mineral Density: A Cross-Sectional and Longitudinal Population-Based Study
Harbeer Ahedi¹, Dawn Dore¹, Leigh Blizzard², Flavia Cicuttini³ and Graeme Jones⁴, ¹Musculoskeletal Unit, Menzies Research institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ³Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia, ⁴Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia
Background/Purpose: Bone marrow lesions (BMLs) have been identified one of the key pathologic features in knee osteoarthritis (OA) 1. However, there is limited data on…
Abstract Number: 1118 • 2012 ACR/ARHP Annual Meeting
Association Between Hip and Knee Cartilage Measured Using Radiographs and Magnetic Resonance Imaging: The Tasmanian Older Adult Cohort Study
Hussain Ijaz Khan¹, Dawn Dore², Guangju Zhai³, Changhai Ding⁴, Jean Pierre Pelletier⁵, Johanne Martel-Pelletier⁶, Flavia Cicuttini⁷ and Graeme Jones⁸, ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ³Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Musculoskeletal and Epidemilogy, Menzies research institute & Monash University, Hobart, Australia, ⁵Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁶Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁷Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia, ⁸Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia
Background/Purpose: Cartilage loss is the key pathological feature of osteoarthritis (OA) and can be assessed indirectly using radiography or directly through magnetic resonance imaging…
Abstract Number: 1119 • 2012 ACR/ARHP Annual Meeting
Prediction of MRI-Detected Cartilage Loss Over 30 Months Using Simplified Radiographic and Clinical Stratification: The MOST Study
Frank Roemer¹, David T. Felson², Jingbo Niu³, Yuqing Zhang², Michael C. Nevitt⁴, Michel Crema⁵, Cora E. Lewis⁶, James Torner⁷ and Ali Guermazi⁵, ¹Klinikum Augsburg, Augsburg, Germany, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁵Boston University, Boston, MA, ⁶Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ⁷Epidemiology, University of Iowa, Iowa City, Iowa City, IA
Background/Purpose: MRI-detected cartilage loss is the main structural outcome measure in large studies of knee OA. Definition of subjects at high risk for cartilage loss…
Abstract Number: 1120 • 2012 ACR/ARHP Annual Meeting
Cartilage Volume Loss Occurs in Most Older Adults and the Rate of Loss Increases with Age
Andreea M. Harsanyi¹, Dawn Dore², Changhai Ding³, Jean-Pierre Pelletier⁴, Johanne Martel-Pelletier⁴, Flavia Cicutinni⁵ and Graeme Jones³, ¹Menzies Research Institute Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Research institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ³Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ⁴Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁵Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia
Background/Purpose: Radiographic data suggests knee osteoarthritis is a relatively static disease even over the long term. It is uncertain how much this is influenced by…
Abstract Number: 1121 • 2012 ACR/ARHP Annual Meeting
Degenerative Medial Meniscal Pathology May Initiate in the Posterior Horn: Data From the Osteoarthritis Initiative
Robert J. Ward¹, Jeffrey B. Driban², Eric E. Wong¹, Jonathan W. Pack¹, Kunal K. Kothari³, Grace H. Lo⁴ and Timothy E. McAlindon⁵, ¹Radiology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Radiology, Tufts University School of Medicine, Boston, MA, ⁴Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, ⁵Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Meniscal pathology is highly prevalent in knee Osteoarthritis (OA). However, details regarding the distribution of pathology within the meniscus has yet to be described…
Abstract Number: 1122 • 2012 ACR/ARHP Annual Meeting
Identifying Radiographic Phenotypes of Early Knee Osteoarthritis Using Separate Quantitative Features Might Improve Patient Selection for More Targeted Treatment
Margot B. Kinds¹, Anne C. A. Marijnissen¹, Max A. Viergever², P.J. Emans³, J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and P.M.J. Welsing⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ³Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Rheumatology & Clinical Immunology, F02.127, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by pain and functional disability. The expression of OA varies significantly between individuals and over time,…
Abstract Number: 1123 • 2012 ACR/ARHP Annual Meeting
Comparison of Anatomic Knee Alignment On Physical Examination and Radiographs
Iman Hemmati¹, Eric C. Sayre², Ali Guermazi³, Savvakis Nicolaou⁴, Anona Thorne⁵, Joel Singer⁶ and Jolanda Cibere⁷, ¹Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Vancouver, BC, Canada, ³Radiology, Boston University, Boston, MA, ⁴Department of Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵School of Population and Public Health, University of British Columbia, Canadian Institutes of Health Research HIV Trials Network, Vancouver, BC, Canada, ⁶School of Population and Public Health, University of British Columbia, University of British Columbia, Vancouver, BC, Canada, ⁷Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: Severity of knee malalignment is a risk factor for osteoarthritis (OA) progression. Currently the hip-knee-angle (mechanical axis), assessed on a full-limb radiograph, is the…
Abstract Number: 1124 • 2012 ACR/ARHP Annual Meeting
Total Knee Replacement As an Osteoarthritis Study Outcome: Predictors Derived From Long-Term Observation Following a Randomized Clinical Trial
Jean-Pierre Raynauld¹, Johanne Martel-Pelletier¹, Marc Dorais², Boulos Haraoui¹, Denis Choquette¹, François Abram³, André Beaulieu⁴, Louis Bessette⁵, Frédéric Morin⁶, Lukas M. Wildi¹ and Jean Pierre Pelletier⁷, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada, ³Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ⁴Faculty of Medicine, Laval University, Quebec, QC, Canada, ⁵Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, ⁶Centre de Recherche Musculo-squelettique, Trois-Rivières, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada
Background/Purpose: Using data from a 4-year follow-up of knee OA patients who formerly received treatment with chondroitin sulfate (CS) within a 6-month clinical trial, we…

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