Abstracts Archive - Page 2346 of 2607 - ACR Meeting Abstracts

Abstract Number: 1279 • 2013 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Is Effective In Arthritis Regardless Of Obesity In Mouse Model
Miho Suzuki, Hiroto Yoshida and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Compared with non-obese patients, obese patients with rheumatoid arthritis (RA) reportedly experience worsening of symptoms [Arthritis Care Res (Hoboken). 2013; 65: 78-87] and do…
Abstract Number: 1293 • 2013 ACR/ARHP Annual Meeting
Serum Matrix Metalloproteinase 13 As a Translational Marker For Efficacy Of Anti-Arthritic Treatments In Rat Collagen Induced Arthritis and Mouse Model Of Lipopolysaccharide-Induced Bone Resorption
Ines Glojnaric, Snjezana Cuzic, Boska Hrvacic, Vanesa Ivetic Tkalcevic, Miroslava Dominis Kramaric and Vesna Erakovic Haber, Fidelta Ltd., Zagreb, Croatia
Background/Purpose: Matrix metalloproteinase 13 (MMP-13) is expressed by chondrocytes and synovial cells in human osteoarthritis and rheumatoid arthritis (RA) (Takaishi et al., 2008). Serum MMP-13…
Abstract Number: 1276 • 2013 ACR/ARHP Annual Meeting
Immunologic Monitoring and Infectious Complications In Pediatric Rheumatology Patients Treated With Rituximab
Alysha Taxter¹, Kathleen E. Sullivan² and Jon Burnham³, ¹Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Rituximab is an anti-CD20 monoclonal antibody increasingly used in immunologic and malignant conditions to deplete B cells. Suppression of humoral immunity after rituximab exposure may…
Abstract Number: 1277 • 2013 ACR/ARHP Annual Meeting
A Pilot Study Of Young Adults With Juvenile Dermatomyositis With Decreased Nailfold Capillary End Row Loops: Brachial Artery Reactivity and Oxidized Lipids
Lauren M. Pachman^1,2, Maureen A. McMahon³, Tamar Polonsky⁴, Gabrielle A. Morgan¹, Maria Amoruso⁵ and Chiang-Ching Huang⁶, ¹Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ²Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Cardiology, University of Chicago Medicine, Chicago, IL, ⁵Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, ⁶Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI
Background/Purpose: Our center previously reported increased carotid intima media thickness, and lower high-density lipoprotein (HDL) levels in young or middle-age adults with a history of…
Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…
Abstract Number: 1280 • 2013 ACR/ARHP Annual Meeting
The Role of Sphingosine-1-Phosphate Receptor 3 Signaling in Murine Collagen-Induced Arthiritis
Hidetake Nagahara¹, Masataka Kohno¹, Ken Murakami¹, Aihiro Yamamoto¹, Takahiro Seno¹, Wataru Fujii¹, Kazuki Fujioka¹, Yuji Kukida¹, Ryo Oda², Hiroyoshi Fujiwara² and Yutaka Kawahito¹, ¹Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, kyoto, Japan
Background/Purpose: Sphingolipids represent a major class of lipids that are ubiquitously expressed in eukaryotic cell membranes. Through the interaction with a family of five G-protein-coupled…
Abstract Number: 1281 • 2013 ACR/ARHP Annual Meeting
Inadequate Glucocorticoid Secretion in Experimental Arthritis in Rats Is Closely Linked to Impaired Mitochondria and Reduced Lipid Breakdown in the Adrenal Cortex
Christine Wolff¹, Katharina Krinner¹, Josef Schröder² and Rainer H. Straub³, ¹Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, Department of Internal Medicine I, University Hospital, Regensburg, Germany, ²Department of Phatology, University Hospital, Regensburg, Germany, ³Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: In rheumatoid arthritis a functional deterioration of the HPA-axis in form of inadequately low secretion of glucocorticoids in relation to severity of inflammation can…
Abstract Number: 1282 • 2013 ACR/ARHP Annual Meeting
Effect of RC-3095, An Antagonist of Gastrin-Releasin Peptide Receptor, Regulating Synovial Fibroblasts in Experimental Arthritis
Patricia Oliveira¹, Lidiane Filippin², Mirian Farinon², Vanessa Clarimundo², Gilberto Schwartsmann² and Ricardo M. Xavier³, ¹Rheumatology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil, ²Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ³Rheumatology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Background/Purpose: The gastrin-releasing peptide (GRP) is the mammalian homologue of the bombesin (BN), and its receptor signaling is involved in several functions, including inflammatory response.…
Abstract Number: 1283 • 2013 ACR/ARHP Annual Meeting
Power Doppler Ultrasound Phenotyping of Expanding Versus Collapsed Popliteal Lymph Nodes in Murine Inflammatory Arthritis
Echoe M. Bouta¹, Yawen Ju², Homaira Rahimi³, Ronald Wood⁴, Lianping Xing⁵ and Edward M. Schwarz⁶, ¹University of Rochester, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY, ³Pediatrics, University of Rochester, Rochester, NY, ⁴Department of Urology, University of Rochester Medical Center, Rochester, NY, ⁵Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁶Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis is a chronic inflammatory disease manifested by episodic flares in affected joints that are challenging to predict and treat. Longitudinal contrast…
Abstract Number: 1284 • 2013 ACR/ARHP Annual Meeting
Nuclear Receptor 4A2 Is Differentially Expressed In Animal Models Of RA During Inflammation and Resolution
Jordan Everett¹, Fiona E. McCann², Andrew C. Palfreeman², Anita T. Shaw³, Ellen M. Gravallese⁴ and Kimberlee S. Mix¹, ¹Biological Sciences, Loyola University New Orleans, New Orleans, LA, ²NDORMS, The Kennedy Institute of Rheumatology, University of Oxford, London, United Kingdom, ³Division of Rheumatology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ⁴Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Nuclear receptor 4A2 (NR4A2 / nuclear receptor related 1 / Nurr1) is a constitutively active transcription factor with diverse roles in normal physiology and…
Abstract Number: 1285 • 2013 ACR/ARHP Annual Meeting
Choline Kinase: A Novel Target For Rheumatoid Arthritis
Monica Guma¹, Elsa Sanchez-Lopez², Alessia Lodi³, Stefano Tiziani⁴, Juan Carlos Lacal⁵, Michael Karin⁶ and Gary S. Firestein⁷, ¹Rheumatology, UCSD School of Medicine, La Jolla, CA, ²Pharmacology, UCSD School of Medicine, La Jolla, CA, ³nutritional Sciences, University of Texas at Austin, Austin, TX, ⁴Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁵Oncology, University Hospital Fundacion Jimenez Diaz, Madrid, Spain, ⁶Departments of Pharmacology, UCSD School of Medicine, La Jolla, CA, ⁷Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Choline kinase (ChoKa) is an essential enzyme for phosphatidylcholine biosynthesis and is required for cell proliferation. The enzyme has also been implicated in cancer…
Abstract Number: 1286 • 2013 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects Of Tyrosine-Hydroxylase(TH)-Positive Catecholamine Producing Cells In Chronic Arthritis
Zsuzsa Jenei-Lanzl¹, Silvia Capellino², Frieder Kees³ and Rainer H. Straub⁴, ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²2Department of Pediatrics, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Baltimore, MD, ³Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany, ⁴Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: In previous studies we have shown that inflammatory processes in experimental arthritis are strongly affected by the sympathetic nervous system (SNS): In the early…
Abstract Number: 1287 • 2013 ACR/ARHP Annual Meeting
Pre-Clinical Proof-Of-Concept Of ALX-0761, a Nanobody^® Neutralizing Both IL-17A and F In a Cynomolgus Monkey Collagen Induced Arthritis Model
Katrien Vanheusden¹, Laurent Detalle¹, Alex Hemeryck¹, Alain Vicari², Roland Grenningloh³, Sofie Poelmans¹, Heidi Wouters⁴ and Thomas Stöhr¹, ¹Pharmacology, Ablynx NV, Gent, Belgium, ²Calypso Biotech, Geneva, Switzerland, ³Pharmacology, Merck-Serono, Darmstadt, Germany, ⁴Clinical Development, Ablynx nv, Zwijnaarde, Belgium
Background/Purpose: Interleukin (IL)-17 and Th17 cells are implicated in many auto-immune diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis. Although IL-17(A) is the…
Abstract Number: 1288 • 2013 ACR/ARHP Annual Meeting
Development Of Antibodies Specific For Carbamylated Protein Precedes Disease Onset In Mice With Collagen-Induced Arthritis
Leendert A. Trouw¹, Bisheng Liu¹, Jing Shi¹, Diahann T.S.L. Jansen¹, Martin Hegen², Tom W.J. Huizinga¹, Jeroen N. Stoop¹ and René E. M. Toes¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Pfizer, Cambridge, MA
Background/Purpose: Antibodies against citrullinated proteins are a characteristic of rheumatoid arthritis (RA). Recently, we demonstrated that autoantibodies recognizing homocitrulline containing proteins are present in sera…
Abstract Number: 1289 • 2013 ACR/ARHP Annual Meeting
IL-6 Is Required For Th1- and Th17- Mediated Arthritis
Alison Finnegan¹, Yanxia Cao¹ and Susan Olalekan², ¹Dept of Medicine, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: We have reported that the route of immunization in proteoglycan-induced arthritis (PGIA) determines the T helper phenotype responsible for arthritis. Intraperitoneal (i.p.) immunization induces…

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