ACR Meeting Abstracts

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  • Abstract Number: 1160 • 2012 ACR/ARHP Annual Meeting

    Assessment of Subclinical Synovitis by Power Doppler Ultrasonography in Patients with Juvenile Idiopathic Arthritis

    Maria Teresa Terreri1, Vanessa M. Bugni2, Claudio A. Len2, Sônia de A.V. Mitraud3, Rita NV. Furtado4 and Jamil Natour5, 1Pediatrics, Universidade Federal de São Paulo / UNIFESP, Sao Paulo, Brazil, 2Pediatrics, Universidade Federal de São Paulo / UNIFESP, São Paulo, Brazil, 3Radiology and Diagnostic Imaging, Escola Paulista de Medicina/ Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, Brazil, 4Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 5Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood, leading to physical disability and poor quality of life. Advances in…
  • Abstract Number: 1161 • 2012 ACR/ARHP Annual Meeting

    Current Evidence of Anti-TNFα Treatment Efficacy in Childhood Chronic Uveitis: A Systematic Review and Meta-Analysis Approach Comparing the Different Drugs

    Gabriele Simonini1, Kate Druce2, Rolando Cimaz1, Gary J. Macfarlane2 and Gareth T. Jones2, 1Pediatric Rheumatology, Anna Meyer Children's Hospital-University of Florence, Firenze, Italy, 2Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom

    Background/Purpose: To summarize evidence regarding the effectiveness of anti-TNFα treatments in childhood autoimmune chronic uveitis (ACU), non responder and/or failure to previous DMARD course.Methods: A…
  • Abstract Number: 1162 • 2012 ACR/ARHP Annual Meeting

    Patients with Juvenile Idiopathic Arthritis From a Low Socio-Economic Background Perceive Their Disease Activity and Physical Limitations Higher Than Patients from a High Socio-Economic Background

    Suzanne Verstappen1, Joanna Cobb2, H. E. Foster3, Eileen Baildam4, Lucy R. Wedderburn5, Janet Gardner-Medwin6, Alice Chieng7, Joyce Davidson6, Wendy Thomson8 and Kimme L. Hyrich9, 1Arthritis Research UK Epidemiology Unit,, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 2Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, 3Paediatric Rheumatology, Newcastle Hospitals NHS Foundation Trust and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, 4Paediatric Rheumatology, Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, 5Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, 6Royal Hospital for Sick Children, Glasgow, United Kingdom, 7Manchester Children's Hospital, Manchester, United Kingdom, 8Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, Manchester, United Kingdom, 9Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom

    Background/Purpose:   It has been suggested that socio-economic status (SES) may be associated with delayed to access to rheumatology care and with worse disease severity…
  • Abstract Number: 1163 • 2012 ACR/ARHP Annual Meeting

    Risk Factors for Radiologic Progression in Polyarticular Juvenile Idiopathic Arthritis Patients Treated with Biologic Agents

    Tomohiro Kubota1, Tsuyoshi Yamatou2, Yukiko Nonaka2, Harumi Akaike2, Tomokazu Nagakura3, Yuichi Yamasaki1, Tomoko Takezaki2, Yasuhito Nerome2, Hiroyuki Imanaka2 and Syuji Takei4, 1Dept of Pediatrics, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, 2Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan, 3Department of Pediatrics, House of Meguminoseibo, Usuki, Japan, 4School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

    Background/Purpose: Progression of joint damage is sometimes observed in JIA patients during the biologic therapy.  However, it is difficult to evaluate the radiographic progression by…
  • Abstract Number: 1164 • 2012 ACR/ARHP Annual Meeting

    Orofacial Anomalies in Children with Confirmed Juvenile Idiopathic Arthritis

    Bernd Koos1, Franka Stahl de Castrillon2, Robert Ciesielski1 and Nikolay Tzaribachev3, 1Clinic of Orthodontics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany, 2Department of Orthodontics, University of Rostock, Germany, Department of Orthodontics, University of Rostock, Germany, Rostock, Germany, 3Pediatric Rheumatology, Center for Rheumatic Diseases, Bad Bramstedt, Germany

    Background/Purpose: In children with juvenile idiopathic arthritis (JIA) temporomandibular joints (TMJ) are affected in up to 96% of the patients, where TMJ arthritis is frequently…
  • Abstract Number: 1165 • 2012 ACR/ARHP Annual Meeting

    Factors Associated with Achievement of Inactive Disease in Children with Juvenile Idiopathic Arthritis Treated with Etanercept

    Nicoletta Solari1, Elena Palmisani1, Alessandro Consolaro1, Sara Dalprà1, Benedetta Schiappapietra1, Giulia Bracciolini1, Silvia Rosina1, Giorgia Negro1, Alberto Martini2 and Angelo Ravelli3, 1Pediatria II, Istituto Giannina Gaslini, Genova, Italy, 2Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, 3Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose: The advent of new therapies for juvenile idiopathic arthritis (JIA), particularly the introduction of biologic medications, has increased considerably the potential for treatment benefit,…
  • Abstract Number: 1166 • 2012 ACR/ARHP Annual Meeting

    Clinical and Therapeutic Features of 312 Patients with Macrophage Activation Syndrome Enrolled in a Multinational Survey

    Sergio Davì1, Francesca Minoia1, Erkan Demirkaya2, Chiara Suffia3, Mario Abinun4, Amita Aggarwal5, Nuray Aktay Ayaz6, Maria Alessio7, Jordi Anton8, Maria Apaz6, Tadej Avcin9, Patrizia Barone10, Blanca E. Bica11, Isabel Bolt12, Luciana Breda13, Vyacheslav Chasnyk14, Rolando Cimaz6, Fabrizia Corona6, Ruben Cuttica15, Gianfranco D'Angelo16, AnnaCarin Horne17, Nicola Ruperto18, Alberto Martini19, Randy Q. Cron20 and Angelo Ravelli6, 1Pediatria II, Istituto Giannina Gaslini, Genova, Italy, 2International Investigator Consortium for MAS Diagnostic Criteria, Ankara, Turkey, 3Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini, Genova, Italy, 4International Investigator Consortium for MAS Diagnostic Criteria, Newcastle upon Tyne, United Kingdom, 5Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 6Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy, 7Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy, 8Rheumatology, Hospital Sant Joan de Deu, Barcelona, Spain, 9International Investigator Consortium for MAS Diagnostic Criteria, Ljubljana, Slovenia, 10Azienda Policlinico Università di Catania, Catania, Italy, 11International Investigator Consortium for MAS Diagnostic Criteria, Rio de Janeiro, Brazil, 12Kinderspital Zuerich, Universitaetskinderklinik, Zurich, Switzerland, 13International Investigator Consortium for MAS Diagnostic Criteria, Chieti, Italy, 14Hospital Pediatry, State Pediatric Medical University, Saint-Petersburg, Russia, 15International Investigator Consortium for MAS Diagnostic Criteria, Buenos Aires, Argentina, 16International Investigator Consortium for MAS Diagnostic Criteria, Ancona, Italy, 17Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, 18Istituto Gaslini, Genova, Italy, 19Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, 20Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: A multinational collaborative effort aimed to develop a new set of criteria for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA) has…
  • Abstract Number: 1167 • 2012 ACR/ARHP Annual Meeting

    Golimumab in 25 Young Adults Affected by Juvenile Idiopathic ARTHRITIS NON Responders to OTHER Biological Agents: Preliminary DATA

    Irene Pontikaki1, Orazio De Lucia2, Maurizio Gattinara3, Alessandra Salmaso1, Pier Luigi Meroni4 and Valeria Gerloni1, 1Pediatric Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, 2Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, 3Pediatric Rheumatology, Istituto Ortopedico Gaetano Pini, Milano, Italy, 4Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy

    Background/Purpose: Biological agents licensed in JIA have demonstrated a favourable benefit-to-risk profile. Nevertheless, intolerance, loss and lack of efficacy or adverse events have led to…
  • Abstract Number: 1168 • 2012 ACR/ARHP Annual Meeting

    Cost-Effectiveness Analysis of Early Biologic Treatment in Polyarticular Juvenile Idiopathic Arthritis

    Nadia Luca1, Heather Burnett2, Wendy Ungar2, Timothy Beukelman3, Brian M. Feldman4, Gwen Schwartz5 and Ahmed Bayoumi6, 1Pediatric Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, 2Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 3Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 4Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 5Health Economics Unit, St. Michael's Hospital, Toronto, ON, Canada, 6General Internal Medicine, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada

    Background/Purpose: The optimal timing of high cost biologic therapies in the treatment of polyarticular juvenile idiopathic arthritis (JIA) is uncertain. We evaluated the economic and…
  • Abstract Number: 1169 • 2012 ACR/ARHP Annual Meeting

    Obstetrical Complications in Women with Juvenile Idiopathic Arthritis

    Evelyne Vinet1, Sasha Bernatsky2, Mohammed Kaouache2, Christian A. Pineau3, Ann E. Clarke4, Elizabeth Hazel5, Ciaran M. Duffy6, Anick Bérard7 and Debbie Ehrmann Feldman8, 1McGill University Health Center, Montreal, QC, Canada, 2Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada, 3Rheumatology, McGill University Health Centre, Montreal, QC, Canada, 4Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, 5Rhematology, McGill University Health Centre, Montreal, QC, Canada, 6Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, 7Université de Montréal, Montréal, QC, Canada, 8Rehabilitation, Université de Montréal, Montreal, QC, Canada

    Background/Purpose: Juvenile idiopathic arthritis (JIA) most often affects women before childbearing age. Patients with JIA and their parents often ask about the potential impact of…
  • Abstract Number: 1170 • 2012 ACR/ARHP Annual Meeting

    Folate Usage in Methotrexate -Treated Juvenile Idiopathic Arthritis Patients Is Inconsistent and Highly Variable

    Gil Amarilyo1, Ornella J. Rullo2, Deborah K. McCurdy3, Jennifer M.P. Woo1 and Daniel Furst4, 1Pediatrics/Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, 2Pediatric Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, 3Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, 4David Geffen School of Medicine, Div of Rheumatology, University of California at Los Angeles, Los Angeles, CA

    Background/Purpose: Low-dose weekly methotrexate (MTX) is the first-choice second-line drug in the treatment of juvenile idiopathic arthritis (JIA). Folate (as either Folic acid (FA) or…
  • Abstract Number: 1171 • 2012 ACR/ARHP Annual Meeting

    Validation of BASDAI and BASFI in Children with Spondyloarthritis

    Alisa C. Rachlis1, Bertha Wong2, Kristi J. Whitney-Mahoney3, Michelle Batthish2, Michelle Anderson4, JoAnne Marcuz4, Margaret Reaume4, Ashley DeLaurier5, Ronald Laxer4, Brian M. Feldman5 and Shirley M. Tse2, 1Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, 2Pediatric Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 3Rehab Services, The Hospital for Sick Children, Toronto, ON, Canada, 4Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 5Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Juvenile-onset Spondyloarthritis (JSpAs), referred to as Enthesitis-Related Arthritis (ERA) subtype under the International League of Associations for Rheumatology (ILAR) classification is characterized by arthritis…
  • Abstract Number: 1172 • 2012 ACR/ARHP Annual Meeting

    Delineating the Role of Multiple Corticosteroid Joint Injections in the Management of Juvenile Idiopathic Arthritis in the Biologic Era

    Charalampia Papadopoulou1, Maria I. Gonzalez1, Juan C. Nieto1, Mikhail Kostik2, Marek Bohm1, Stefano Lanni1, Valentina Muratore3, Alessandro Consolaro1, Alberto Martini4 and Angelo Ravelli5, 1Pediatria II, Istituto Giannina Gaslini, Genova, Italy, 2Hospital Pediatrics, State Pediatric Medical University, Saint-Petersburg, Russia, 3Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 4Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, 5University of Genova, Genova, Italy

    Background/Purpose: Intra-articular corticosteroid injection (IACI) therapy in juvenile idiopathic arthritis (JIA) is generally considered for the treatment of children with arthritis in a small number…
  • Abstract Number: 1173 • 2012 ACR/ARHP Annual Meeting

    Targeting Remission in Juvenile Idiopathic Arthritis in Routine Clinical Care: Experience in 175 Newly-Diagnosed Patients

    Alessandro Consolaro1, Giorgia Negro1, Nicoletta Solari1, Cristina Ferrari1, Sergio Davì1, Silvia Pederzoli1, Giulia Bracciolini1, Maria C. Gallo1, Alberto Martini2 and Angelo Ravelli3, 1Pediatria II, Istituto Giannina Gaslini, Genova, Italy, 2Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, 3Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose: The recent advances in the management of juvenile idiopathic arthritis (JIA) have increased considerably the potential to achieve disease remission or, at least, low…
  • Abstract Number: 1174 • 2012 ACR/ARHP Annual Meeting

    Severe Adverse Events Associated with Use of Biologic Therapy in Juvenile Idiopathic Arthritis: A Single-Center Study

    Ricardo A. G. Russo1 and Marìa M. Katsicas2, 1Immunology & Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina, 2Immunology & Rheumatology., Hospital de Pediatrìa Garrahan, Buenos Aires, Argentina

    Background/Purpose: biologic agents have revolutionized the treatment of Juvenile Idiopathic Arthritis (JIA) and other conditions due to their high efficacy and safety. However, with the…
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