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  • Abstract Number: 1351 • 2013 ACR/ARHP Annual Meeting

    A Comparison Of The Clinical Effectiveness Of Treatment Strategies For Active RA Patients : Using a Prospective Biologic Registry (BIOPSY) and an RA Specific Cohort (KORONA)

    Yoon-Kyoung Sung1,2, Soo-Kyung Cho1,2, Chan-Bum Choi3,4, Soyoung Won5, So-Young Bang6, Hoon-Suk Cha7, Jung-Yoon Choe8, Won Tae Chung9, Seung-Jae Hong10, Jae-Bum Jun4, Hyoun Ah Kim11, Jinseok Kim12, Seong-Kyu Kim8, Tae-Hwan Kim4, Hye-Soon Lee13, Jaejoon Lee7, Jisoo Lee14, Shin-Seok Lee15, Sung Won Lee16, Yeon-Ah Lee10, Seong-Su Nah17, Chang-Hee Suh18, Dae-Hyun Yoo4, Bo Young Yoon19 and Sang-Cheol Bae1,2, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Department of Rheumatology, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 3Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 4Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 5Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 6Hanyang University Guri Hospital, Guri, South Korea, 7Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 8Catholic University of Daegu School of Medicine, Daegu, South Korea, 9Division of Rheumatology, Department of Internal Medicine, Dong-A University Hospital, Busan, South Korea, 10Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, 11Ajou University Hospital, Suwon, South Korea, 12Division of Rheumatology, Internal Medicine, Jeju National University Hospital, Jeju, Korea, South Korea, 13Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, 14Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea, 15Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 16Rheumatology, Dong-A University Hospital, Busan, South Korea, 17Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South Korea, 18Department of Rheumatology, Ajou University Hospital, Suwon, South Korea, 19Inje University Ilsan Paik Hospital, Goyang, South Korea

    Background/Purpose: The results from RCTs may not be generalizable to clinical practice because of their inclusion and exclusion criteria. Instead, observational cohorts and registries might…
  • Abstract Number: 1352 • 2013 ACR/ARHP Annual Meeting

    What Factors Lead To Achieve and Sustain Remission In Rheumatoid Arthritis Patients With Moderate To High Disease Activity?

    Soo-Kyung Cho1,2, Yoon-Kyoung Sung1,2, Jeeseon Shim3, Chan-Bum Choi4,5, Jung-Yoon Choe6, Won Tae Chung7, Seung-Jae Hong8, Jae-Bum Jun5, Tae-Hwan Kim9, Tae-Jong Kim10, Eun-Mi Koh11, Jisoo Lee12, Shin-Seok Lee10, Sung Won Lee13, Dae-Hyun Yoo5 and Sang-Cheol Bae1,2, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Department of Rheumatology, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 3Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 4Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 5Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 6Catholic University of Daegu School of Medicine, Daegu, South Korea, 7Division of Rheumatology, Department of Internal Medicine, Dong-A University Hospital, Busan, South Korea, 8Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, 9Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 10Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 11Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 12Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea, 13Rheumatology, Dong-A University Hospital, Busan, South Korea

    Background/Purpose: Clinical remission has now become the treatment goal in rheumatoid arthritis (RA), but it is not common in clinical practice. This study aimed to…
  • Abstract Number: 1353 • 2013 ACR/ARHP Annual Meeting

    Remission After Twelve Month Of Treatment In The Prague Early Rheumatoid Arhritis Cohort

    Herman F. Mann1, Olga Ruzickova2, Olga Sleglova1, Marketa Fojtikova3, Dana Tegzova4, Sarka Forejtova2 and Ladislav Senolt5, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 4Institute of Rheumatology, Prague, Czech Republic, 5Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Institute of Rheumatology, Prague, Czech Republic

    Background/Purpose: Recent data have demonstrated that early treatment  with disease modifying anti-rheumatic drugs (DMARDs)  improves outcome in patients with Rheumatoid arthritis (RA). Early arthritis clinic…
  • Abstract Number: 1354 • 2013 ACR/ARHP Annual Meeting

    Successful Self-Administration Of Methotrexate In Rheumatoid Arthritis Patients Using a Prefilled Autoinjector Pen

    Jaime Pachon1, Alan Kivitz2, Kay-Uwe Heuer3 and Uwe Pichlmeier3, 1Arthritis and Rheumatic Care Center, Miami Research Associates, South Miami, FL, 2Altoona Center for Clinical Research, Duncansville, PA, 3medac GmbH, Wedel, Germany

    Background/Purpose:  Methotrexate (MTX) is the most commonly used and recommended DMARD for the treatment of RA. SC administered MTX is well absorbed and appears to…
  • Abstract Number: 1356 • 2013 ACR/ARHP Annual Meeting

    Disease Activity Of Rheumatoid Arthritis Is Influenced By Seasonal Change, As Analyzed Based On a Nationwide Japanese Cohort Database

    Tetsuji Sawada1, Hiroaki Mori2, Kota Shimada3, Haeru Hayashi1, Koichiro Tahara1, Jinju Nishino4 and Shigeto Tohma5, 1Rheumatology, Tokyo Medical University, Tokyo, Japan, 2Rheumatology, Tokyo Meidical University, Tokyo, Japan, 3Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, 4Nishino Clinic, Orthopedics and Rheumatology, Tokyo, Japan, 5Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan

    Background/Purpose: Previous studies have suggested that environmental factors, such as weather, humidity and seasonal change, may affect rheumatoid arthritis (RA). In the present study, we…
  • Abstract Number: 1330 • 2013 ACR/ARHP Annual Meeting

    Prednisone Use Associated With Worse Outcomes In Rheumatoid Arthritis Pregnancies

    Prateek Chaudhary1 and M. E. B. Clowse2, 1Division of Rheumatology, Duke University Medical Center, Durham, NC, 2Rheumatology, Duke University Medical Center, Durham, NC

    Background/Purpose: Prior reports suggest that disease activity in rheumatoid arthritis (RA) improves in the setting of pregnancy.  However, prior studies report half of patients having…
  • Abstract Number: 1316 • 2013 ACR/ARHP Annual Meeting

    MMP3 As a Predictor Identifying a Subgroup Of Rheumatoid Patients Who Are Successfully Treated With Methotrexate (MTX) Alone But Still Subject To Radiographic Progression

    Shunichi Shiozawa1, Yasushi Tanaka2, Ryosuke Yoshihara2, Miki Murata2, Takashi Yamane3, Chihiro Tanaka2, Noriaki Yo3 and Kazuko Shiozawa2, 1Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 2The Rheumatic Diseases Center, Kohnan Kakogawa Hospital, Kakogawa, Japan, 3Kohnan Kakogawa Hospital, Kakogawa, Japan

    Background/Purpose: To discover the prognostic factor identifying a subgroup with clinical relevant radiographic progression (CRRP) and rapid radiographic progressoion (RRP) among rheumatoid patients successfully treated…
  • Abstract Number: 1317 • 2013 ACR/ARHP Annual Meeting

    Methotrexate Optimization (ie introduction during the first 3 months and with dose escalation at 6 months at least at 20mg/w or 0.3mg/kg/w) Is Associated With Better Clinical Outcomes In Daily Practice: Results From The Espoir Cohort

    Cécile Gaujoux-Viala1, Simon Paternotte2, Bernard Combe3, Maxime Dougados4 and Bruno Fautrel5, 1EA 2415, Montpellier I University, Nîmes University Hospital, Rheumatology Department, Nîmes, France, 2Rheumatology Department, Paris- Descartes University, Cochin hospital, Paris, France, 3Rheumatology, Lapeyronie Hospital, Montpellier I university, Montpellier, France, 4Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, 5Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France

    Background/Purpose: Methotrexate (MTX) is recommended as the first DMARD in rheumatoid arthritis (RA) at a weekly dose of 20-25mg in combination with folic acid supplementation.…
  • Abstract Number: 1318 • 2013 ACR/ARHP Annual Meeting

    Prevalence and Impact Of Soft Tissue Manifestations In Early Inflammatory Arthritis: Results From The Canadian Early Arthritis Cohort

    Mihaela Popescu1, Edith Villeneuve2, Boulos Haraoui3, Gilles Boire4, Carol A. Hitchon5, Edward C. Keystone6, Janet E. Pope7, J. Carter Thorne8, Diane Tin9 and Vivian P. Bykerk6, 1Internal Medecine, University of Montreal, Montreal, QC, Canada, 2Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, 3Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 5Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 6Medicine, Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, 7St Joseph Health Care, London, ON, Canada, 8Southlake Regional Health Centre, Newmarket, ON, Canada, 9The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada

    Background/Purpose: It is increasingly recognized that soft tissue inflammation in patients with inflammatory arthritis is frequent and might be of clinical importance. However, when therapeutic adjustments are made,…
  • Abstract Number: 1319 • 2013 ACR/ARHP Annual Meeting

    Diagnostic Value Of Anti-Citrullinated Proteins Antibodies In Rheumatoid Arthritis

    Claudia L. Giraldo1, Rafael Chaparro del Moral2, Mercedes Ciancio3,4, Oscar L. Rillo5, Emilia Saint Martin6, Emilce Schneeberger7, Gustavo Citera7, Federico Zazzetti8, Amalia Schiel9 and Juan C. Barreira10, 1Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 2Rheumatology Section, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 3Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, 4Biochemestry, Buenos Aires, Argentina, 5Rheumatology, Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, 6Rheumatology, Instituto de Rehabilitacion Psicofisica, Buenos Aires, Argentina, 7Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 8Rheumatology, Buenos Aires Hospital Britanico, Buenos Aires, Argentina, 9Central Laboratory, British Hospital, Buenos Aires, Argentina, 10Rheumatology, Buenos Aires British Hospital, Buenos Aires, Argentina

    Background/Purpose: Citrulline and vimentin are some of the proteins used as antigens for anti-citrullinated proteins antibodies (ACPAs) detection for the diagnosis of rheumatoid arthritis (RA).…
  • Abstract Number: 1320 • 2013 ACR/ARHP Annual Meeting

    Categorization Of Rheumatoid Arthritis Subjects By Rheumatoid Factor and Anti-Cyclic Citrullinated Autoantibody Status Identifies Rheumatoid Arthritis Subjects With Different Characteristics

    Swati Modi1, Mariely Nieves-Plaza2, Donald M. Jones3, Erich R Wilkerson4, Christine L. Amity5, Kelly A. Reckley6, Ilinca D. Metes7, Jason Lyons8, Heather Eng9, Stephen R. Wisniewski9 and Marc C. Levesque10, 1Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 4Medicine, University of Pittsburgh, Pittsburgh, PA, 5Rheumatology & Clinical Immun, Univ of Pittsburgh, Pittsburgh, PA, 6Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 7Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, 8School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 9Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, 10Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA

    Background/Purpose:  Rheumatoid factor (RF) and anti-citrullinated cyclic peptide (CCP) antibodies have been used to diagnose rheumatoid arthritis (RA) patients, although there is substantial heterogeneity among…
  • Abstract Number: 1321 • 2013 ACR/ARHP Annual Meeting

    Vasoactive Intestinal Peptide Serum Levels As a Marker Of Prognosis In Rheumatoid Arthritis

    Rosario Garcia-Vicuña1, Ana M. Ortiz2, Iria Valino-Seoane3, Amalia Lamana1, Javier Leceta3, Yasmina Juarranz3, Isidoro González-Alvaro2, Rosa P Gomariz3 and Carmen Martinez-Mora4, 1Rheumatology, Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, 2Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 3Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, 4Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain

    Background/Purpose: The current shift to earlier treatment of Rheumatoid Arthritis (RA) has a major unmet need in the availability of biomarkers to identify patients requiring more…
  • Abstract Number: 1322 • 2013 ACR/ARHP Annual Meeting

    Osteoprotegerin and TNF-Related Apoptosis Inducing Ligand Are Respectively Predictive Factors Of Remission and Erosion In Early Rheumatoid Arthritis Patients Included In The French Cohort Espoir

    Rachel Audo1, Laura Papon1, Claire I. Daien1,2, Cédric Lukas3, Bernard Combe2, Olivier Vittecoq4, Michael Hahne1 and Jacques Morel5, 1IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 2Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, 3Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, 4Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, 5Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France

    Background/Purpose: TNF-Related Apoptosis Inducing Ligand (TRAIL) is a member of the TNF familly. Its soluble receptor Osteoprotegerin (OPG) also inhibits Receptor activator of nuclear factor…
  • Abstract Number: 1323 • 2013 ACR/ARHP Annual Meeting

    Plasma Leucine-Rich Alpha-2 Glycoprotein Is a Useful Disease Activity Biomarker In Rheumatoid Arthritis

    Jung-Soo Song1, You-Jung Ha2, Eun-Jin Kang3, Kwang-Hoon Lee4, Sang-Won Lee5, Yong-Beom Park6, Soo-Kon Lee6 and Sang Tae Choi1, 1Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 3Rheumatology, Busan Medical Center, Busan, South Korea, 4Dongguk University Ilsan Hospital, Goyang, South Korea, 5Department of Internal Medicine, Yonsei University College of Medicine, Seoul, NV, South Korea, 6Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

    Background/Purpose: Leucine-rich a2-glycoprotein (LRG) is a plasma protein which contains leucine-rich repeats (LRRs). Though physiological functions of LRG have not been clarified yet, it has…
  • Abstract Number: 1324 • 2013 ACR/ARHP Annual Meeting

    Evaluation Of The Usefulness Of Interferon-Gamma Release Assays and Tuberculin Skin Test For Detection Of Latent Mycobacterium Tuberculosis Infection In Korean Rheumatic Patients With Biologic Agents

    Jae-Hoon Kim1, Soyoung Won2, Chan-Bum Choi3, Yoon-Kyoung Sung4, Gwan Gyu Song1 and Sang-Cheol Bae5, 1Div of Rheum, Dept of Int Med, Korea Univ College of Med, Seoul, South Korea, 2Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 3Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 4Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 5Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea

    Background/Purpose: The screening for and treatment of latent tuberculosis infection (LTBI) before starting biologic agents is crucial to prevent reactivation and resultant serious infection. Several…
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