Abstract Number: 1210 • 2012 ACR/ARHP Annual Meeting
Effect of HLA-DRB1*0901 Suggest Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility
Background/Purpose: Although HLA-DRB1 shared epitope (SE) alleles and DRB1*0901 have repeatedly been shown to be associated with RA susceptibility, the effect of each allele on…Abstract Number: 1211 • 2012 ACR/ARHP Annual Meeting
ANTI-Cyclic Citrullinated Protein Antibodies Induce Inflammation and Oxidative Stress in WHITE Blood CELLS of Rheumatoid Arthritis Patients
Background/Purpose: Anti-cyclic citrulinated protein antibodies (anti-CCP) are the most specific autoantibody markers in rheumatoid arthritis (RA) patients. However no previous studies have evaluated their role…Abstract Number: 1212 • 2012 ACR/ARHP Annual Meeting
Elevated Fecal Secretory Immunoglobulin A, Anti-Cyclic Citrullinated Peptide Antibodies, and Cytokine Levels in Rheumatoid Arthritis Patients
Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disease with genetic and environmental contributions. There has been increasing interest in the microbiome and its potential…Abstract Number: 1213 • 2012 ACR/ARHP Annual Meeting
The Serum Cytokine Profile of Interstitial Lung Disease in Rheumatoid Arthritis
Background/Purpose: Interstitial lung disease (ILD) is associated with significant morbidity and mortality in rheumatoid arthritis (RA). There are currently no proven biomarkers for ILD in…Abstract Number: 1214 • 2012 ACR/ARHP Annual Meeting
The Impact of Periodontal Disease On Early Inflammatory Arthritis Persists Even After All Teeth Are Lost
Background/Purpose: Data suggests that individuals with periodontal disease (PD) may be more likely to develop rheumatoid arthritis (RA) and have worse disease activity. PD is…Abstract Number: 1215 • 2012 ACR/ARHP Annual Meeting
Rates of Orthopaedic Interventions for Rheumatoid Arthritis Have Changed Over the Last 25 Years. A Report From Two UK Inception Cohorts Reflecting Treatment Changes From Sequential DMARD Monotherapy to Anti-TNF Agents (1986-2011)
Background/Purpose: Orthopaedic surgery is considered an important, although uncommonly reported, outcome measure in rheumatoid arthritis (RA) and a surrogate marker for joint destruction. The expectation…Abstract Number: 1176 • 2012 ACR/ARHP Annual Meeting
Galactosylation, and Not Sialylation, of Immunoglobulin G Is Associated with Improvement of Rheumatoid Arthritis During Pregnancy
Background/Purpose: Rheumatoid arthritis (RA) is known to improve during pregnancy and to flare after delivery [1]. Changes in the glycosylation of immunoglobulin G’s fragment crystallizable…Abstract Number: 1177 • 2012 ACR/ARHP Annual Meeting
Talin Is Cleaved and Expressed As a Short Form in Patients with Rheumatoid Arthritis
Methods: Western Blot analysis showed that the N-terminal 32kDa and the C-terminal 15kDa of calpain1 fragment of talin (32kDa and 15kDa short-talin, respectively) was expressed…Abstract Number: 1178 • 2012 ACR/ARHP Annual Meeting
IL-6 and IL-21 in Rheumatoid Arthritis
Background/Purpose: Interleukin-6 (IL-6) levels are known to be increased in patients with rheumatoid arthritis (RA). Tocilizumab, a monoclonal antibody to the IL-6 receptor (IL-6R), reduces…Abstract Number: 1179 • 2012 ACR/ARHP Annual Meeting
Vitamin D Receptor Polymorphisms Are Associated with Clinical Outcomes and IgM Responses to Common Pathogens but Not Baseline Disease Activity in Early Inflammatory Arthritis
Background/Purpose: Vitamin D (VitD) exerts immunoregulatory activities of potential importance to rheumatoid arthritis and acts by binding to nuclear vitamin D receptors (VDRs) and regulating…Abstract Number: 1180 • 2012 ACR/ARHP Annual Meeting
The Sex-Determining Region Y Box 6 Locus: Shared Genetic Susceptibility Between Rheumatoid Arthritis and Psychotic Disorder
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease and schizophrenia (SZ) is a common psychotic disorder. There is an established negative association between RA…Abstract Number: 1181 • 2012 ACR/ARHP Annual Meeting
The Role of á-Defensin-1 and Its Signal Transduction Mechanisms in the Production of IL-6, IL-8 and MMPs in Rheumatoid Fibroblast-Like Synoviocytes
Background/Purpose: Fibroblast-like synoviocytes (FLS) play an essential role in the pathophysiology of rheumatoid arthritis (RA). Also, neutrophils are the most abundant cell type of synovial…Abstract Number: 1182 • 2012 ACR/ARHP Annual Meeting
Familial Aggregation and Heritability of Rheumatoid Arthritis in Taiwan: A Nationwide Population Study
Background/Purpose: The present study was to estimate the familial relative risk (RR) of rheumatoid arthritis (RA) in individuals with affected first-degree relatives compared to individuals with…Abstract Number: 1183 • 2012 ACR/ARHP Annual Meeting
Podoplanin-Mediated Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Platelets Modulates IL-8 Expression
Background/Purpose: Synovial fibroblasts (SF) are the most abundant resident stromal cells in the synovium. In rheumatoid arthritis (RA), SF expand and undergo phenotypic changes that…Abstract Number: 1184 • 2012 ACR/ARHP Annual Meeting
Negative Association Between Testosterone Levels and Risk of Future Rheumatoid Factor Negative Rheumatoid Arthritis in Men
Background/Purpose: Rheumatoid arthritis (RA) is a heterogeneous disease with female predominance. Sex hormones have been suggested to play a part in the pathogenesis. We have previously…
ACR Meeting Abstracts