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  • Abstract Number: 1245 • 2012 ACR/ARHP Annual Meeting

    Age-Specific Association Between Disease-Related Measures and Incident Cardiovascular Events and All-Cause Mortality in Early Rheumatoid Arthritis

    Sofia Ajeganova1, Maria LE Andersson2, Johan Frostegård3 and Ingiäld Hafström1, 1Karolinska Institutet, Unit of Rheumatology, Department of Medicine Huddinge, Stockholm, Sweden, 2R&D Center, Spenshult Hospital, Oskarström, Sweden, 3Karolinska Institutet, Section of Immunology and chronic disease, Institute of Environmental Medicine, Stockholm, Sweden

    Background/Purpose: Increased risk of cardiovascular disease (CVD) and premature mortality in rheumatoid arthritis (RA) has been established, but the impact of inflammatory and disease related…
  • Abstract Number: 1246 • 2012 ACR/ARHP Annual Meeting

    Cardiovascular Risk Assessment in Rheumatoid Arthritis (RA) Patients Treated by Biologic Response Modifiers

    Majed M. Khraishi1, Rana Aslanov2 and Katie Doyle1, 1Nexus Clinical Research, Memorial University of Newfoundland, St Johns, NF, Canada, 2Clinical Epidemiology Department, Faculty of Medicine, Memorial University of Newfoundland, St.John's, NF, Canada

    Background/Purpose: We aimed to assess the 10-year CV event risk in patients with RA at the baseline and 1 year after the initiation of treatment…
  • Abstract Number: 1247 • 2012 ACR/ARHP Annual Meeting

    Delay in Diagnosis of Rheumatoid Arthritis Increases the Cardiovascular Risk

    Chan-Bum Choi1, Yoon-Kyoung Sung2, Soo-Kyung Cho2, Dae-Hyun Yoo3, Shin-Seok Lee4, Jisoo Lee5, Jinseok Kim6, Hye-Soon Lee7, Tae-Hwan Kim3, Bo Young Yoon8, Wan-Hee Yoo9, Jung-Yoon Choe10, Sang-Heon Lee11, Seung-Cheol Shim12, Won-Tae Chung13, Seung-Jae Hong14, Choong Ki Lee15, Eunmi Koh16, Jae-Bum Jun3, So-Young Bang7, Seong-Kyu Kim17, Hoon-Suk Cha16, Jeeseon Shim18, Sang-Cheol Bae19 and Korean Observational Study Network for Arthritis (KORONA)20, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 2Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 3Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 4Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 5Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea, 6Internal Medicine, Jeju National University Hospital, Jeju, South Korea, 7Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, 8Inje University Ilsan Paik Hospital, Goyang, South Korea, 9Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 10Internal Medicine, Catholic university of Daegu School of mediine, Arthritis and autoimmunty research center, Daegu, 11Division of Rheumatology, Department of Internal Medicine,, Konkuk University School of Medicine, Seoul, South Korea, 12Rheumatology, Eulji University Hospital, Daejeon, South Korea, 13Rheumatology, Dong-A University Hospital, Busan, South Korea, 14Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, 15Internal medicine, school of medicine, Yeungnam University, Daegu, South Korea, 16Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 17Catholic University of Daegu School of Medicine, Daegu, South Korea, 18Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 19Hanyang University Hospital for Rheumatic Disease, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 20Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul

    Background/Purpose: Patients with rheumatoid arthritis (RA) are known to be at increased risk for cardiovascular diseases. Inflammation as well as traditional risk factors contributes to…
  • Abstract Number: 1248 • 2012 ACR/ARHP Annual Meeting

    Accelerated Aging Influences Cardiovascular Disease Risk in Rheumatoid Arthritis

    Cynthia S. Crowson1, Terry M. Therneau1, John M. Davis III2, Veronique L. Roger3, Eric L. Matteson2 and Sherine E. Gabriel4, 1Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Health Sciences Research and Cardiology, Mayo Clinic, Rochester, MN, 4Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: People with rheumatoid arthritis (RA) suffer an excess burden of cardiovascular disease (CVD), yet standard risk assessments designed for the general population do not…
  • Abstract Number: 1249 • 2012 ACR/ARHP Annual Meeting

    The Impact of Statin Use On Lipid Levels in Statin-Naive Patients with Rheumatoid Arthritis (RA) Vs. Non-RA Subjects: Results From a Population-Based Study

    Elena Myasoedova1, Cynthia S. Crowson2, Abigail B. Green2, Eric L. Matteson3 and Sherine E. Gabriel4, 1Internal Medicine and Rheumatology, Mayo Clinic, Rochester, MN, 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 3Rheumatology, Mayo Clinic, Rochester, MN, 4Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: Dyslipidemia in patients with rheumatoid arthritis (RA) is well recognized. The impact of lipid-lowering medications on lipid levels in patients with RA vs non-RA…
  • Abstract Number: 1250 • 2012 ACR/ARHP Annual Meeting

    Heightened Aortic Wall Inflammation in Patients with Rheumatoid Arthritis Versus Patients with Established Coronary Artery Disease without Autoimmune Disease

    Jeffrey D. Greenberg1, Zahi Fayad2, Victoria Furer3, Michael Farkouh2, Michael J. Colin4, Pamela B. Rosenthal5, Jonathan Samuels5, Svetlana Krasnokutsky Samuels4, Soumya M. Reddy6, Peter M. Izmirly5, Cheongeun Oh7, Manish Jain5 and Venkatesh Mani2, 1New York Hospital for Joint Disease, New York, NY, 2Mount Sinai School of Medicine, New York, NY, 3Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 4NYU School of Medicine, New York, NY, 5Rheumatology, NYU School of Medicine, New York, NY, 6Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 7Biostatistics, NYU School of Medicine, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) has been associated with premature atherosclerosis and increased prevalence of cardiovascular disease. 18-fluoro-deoxyglucose positron emission tomography (18-FDG-PET) is a promising imaging…
  • Abstract Number: 1251 • 2012 ACR/ARHP Annual Meeting

    Vulnerability Features Are Common in Coronary Plaques of Asymptomatic Patients with Rheumatoid Arthritis Compared to Controls: Associations with Lipid and Oxidative Stress Biomarkers

    George A. Karpouzas1, Jennifer Malpeso2, Tae-Young Choi2, Silvia Munoz1 and Matthew Budoff2, 1Rheumatology, Harbor-UCLA, Torrance, CA, 2Cardiology, Harbor-UCLA Medical Center, Torrance, CA

    Background/Purpose: Computed tomography angiography (CTA) reliably evaluates coronary plaque presence, severity, burden, and composition. CT characteristics of culprit lesions in acute coronary syndromes (ACS) include…
  • Abstract Number: 1252 • 2012 ACR/ARHP Annual Meeting

    Association of Paraoxonase 1 Gene Polymorphisms and Enzyme Activity with Carotid Plaque in Rheumatoid Arthritis

    Christina Charles-Schoeman1, Yuen Yin Lee1, Veena K. Ranganath1, John FitzGerald1, Mihaela B. Taylor2, Maureen A. McMahon1, David Elashoff3 and Srinivasa T. Reddy4, 1University of California, Los Angeles, CA, 2University of California, Los Angeles, Los Angeles, CA, 3Medicine- Statistic Core, UCLA Department of Medicine Statistics Core, Los Angeles, CA, 4Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme, which promotes the anti-oxidant and anti-inflammatory properties of HDL.  PON1 polymorphisms and enzyme…
  • Abstract Number: 1253 • 2012 ACR/ARHP Annual Meeting

    Identifying Vulnerable Plaque in Rheumatoid Arthritis:  A Pilot Study Using Novel Microbubble-Contrast Enhanced Carotid Ultrasonography

    Kimberly P. Liang1, Douglas P. Landsittel2, Suresh R. Mulukutla3, Steven E. Reis4, Marc C. Levesque1, Flordeliza S. Villanueva3, Hunter C. Champion5 and Larry W. Moreland1, 1Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, 3Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, 4Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, 5Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD). Markers of systemic inflammation, as seen in RA, are associated…
  • Abstract Number: 1254 • 2012 ACR/ARHP Annual Meeting

    In Treatment-Naive Early RA the Left Ventricular Function Is Correlated to CRP, Doctors Global and Anti-CCP Status

    BB Løgstrup1, LD Kristensen1, A. Hedemann-Andersen2 and Torkell Ellingsen3, 1Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, 2Department of Radiology, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, 3Department of Internal Medicine, Diagnostic Centre Regional Hospital Silkeborg, 8600 Silkeborg, Denmark

    Background/Purpose: The role of inflammation and anti-CCP status in the pathogenesis of cardiovascular disease in RA remains unclear. Previous studies have suggested that both disease…
  • Abstract Number: 1255 • 2012 ACR/ARHP Annual Meeting

    Vascular Calcification On Hand and Feet X-Rays, VFA Imaging of the Spine, and Cardiovascular Disease in Rheumatoid Arthritis

    Ausaf Mohammad1, Collette English2, Derek Lohan2, Diane Bergin2, Sarah Mooney2, John Newell3, Martin O'Donnell4, Robert J. Coughlan1 and John J. Carey1, 1Rheumatology, Galway University Hospitals, Galway, Ireland, 2Radiology, Galway University Hospitals, Galway, Ireland, 3Clinical Research Facility, National University of Ireland, Galway, Ireland, 4Clinical Research Facility, Galway University Hospitals, Galway, Ireland

    Vascular Calcification on Hand and Feet X-rays, VFA imaging of the spine, and Cardiovascular Disease in Rheumatoid ArthritisBackground/Purpose: Patients with rheumatoid arthritis (RA) are at…
  • Abstract Number: 1216 • 2012 ACR/ARHP Annual Meeting

    Flare Self Management Strategies Used by Patients with Rheumatoid Arthritis

    Susan J. Bartlett1, Clifton O. Bingham III2, Juan Xiong3, Ernest Choy4, Gilles Boire5, Carol A. Hitchon6, Janet E. Pope7, J. Carter Thorne8, Diane Tin9, Boulos Haraoui10, Edward Keystone11, Vivian P. Bykerk12, OMERACT Flare Working Group13 and CATCH14, 1Clinical Epidemiology, McGill University, Montreal, QC, Canada, 2Department of Medicine, Johns Hopkins University, Baltimore, MD, 3Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 4Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, 5Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 6University of Manitoba, Winnipeg, MB, Canada, 7Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, 8Southlake Regional Health Centre, Newmarket, ON, Canada, 9The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 10Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 11Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, 12Rheumatology, Hospital for Special Surgery, New York, NY, 13Ottawa, Canada, 14Dr. Vivian P. Bykerk, Toronto, ON, Canada

    Background/Purpose: Though disease flares are common, very little is known about strategies RA patients use for self management (SM) of flares. We asked patients to…
  • Abstract Number: 1217 • 2012 ACR/ARHP Annual Meeting

    Decreased Survival in Rheumatoid Arthritis Complicated with Bronchiectasis: A Family-Based Cohort Study

    Xavier Puéchal1, Emmanuelle Génin2, Thierry Bienvenu3 and Daniel J. Dusser4, 1National Referral Center for Rare Systemic Auto-immune Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 2Biostatistics, INSERM UMR-S946, Université Paris Diderot, Paris, France, 3Biochemistry and Molecular Biology, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 4Respiratory Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Background/Purpose: In cystic fibrosis, mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to diffuse bronchiectasis (DB) and decreased survival. DB is also…
  • Abstract Number: 1218 • 2012 ACR/ARHP Annual Meeting

    Genetic Markers of Functional Stress Response in Patients with Rheumatoid Arthritis

    Olga Malysheva and Christoph G. Baerwald, Rheumatology, University Hospital, Leipzig, Germany

    Background/Purpose: Stress is recognized as an important risk factor in the pathogenesis of rheumatoid arthritis (RA). However, it is still incompletely understood how the stress…
  • Abstract Number: 1219 • 2012 ACR/ARHP Annual Meeting

    Periodontal Disease Is Associated with Rheumatoid Arthritis but Its Severity Is Not Correlated with Rheumatoid Arthritis Disease Activity

    In Ah Choi1, Jin-Hee Kim2, Kyung Hwa Kim2, Hye Won Kim3, Myeong Jae Yoon1, Bon Seung Ku4, Hyejin Oh3, Joo Youn Lee5, Eun Young Lee1, Eun Bong Lee6, Yong-Moo Lee2 and Young Wook Song7, 1Department of Internal Medicine, School of Medicine, Seoul National University, Seoul, South Korea, 2Department of Periodontology, School of Dentistry, Seoul National University, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Central Hospital, Ulsan, South Korea, 5Department of molecular medicine and biophamaceutical sciences,Seoul National University, Seoul, South Korea, 6Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 7Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea

    Background/Purpose: The prevalence of periodontal disease is known to be increased in patients with rheumatoid arthritis (RA) compared to the general population. We investigated whether…
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