Abstracts Archive - Page 2338 of 2607 - ACR Meeting Abstracts

Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting
Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis
Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
Abstract Number: 1398 • 2013 ACR/ARHP Annual Meeting
Comparison Of Atherogenicity Of Plasma From Patients With Rheumatoid Arthritis and Psoriatic Arthritis
Beenish Hafiz¹, Iryna Voloshyna², Michael J. Littlefield², Steven E. Carsons³, Elise Belilos¹, Kristina Belostocki¹, Lois A. Bonetti⁴, Gary C. Rosenblum¹ and Allison B. Reiss², ¹Rheumatology, Winthrop University Hospital, Mineola, NY, ²Medicine, Winthrop University Hospital, Mineola, NY, ³Div of Rheumatology, Winthrop University Hospital, Mineola, NY, ⁴Rheum & Immun, Winthrop University Hospital, Mineola, NY
Background/Purpose: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are immune mediated inflammatory disorders linked to increased risk of cardiovascular disease (CVD), mostly due to accelerated…
Abstract Number: 1399 • 2013 ACR/ARHP Annual Meeting
Citrullinated Proteoglycan (Aggrecan) Present In Human Cartilage Is Recognized By Serum Antibodies From Rheumatoid Arthritis Patients
Timea Ocsko¹, Beata Tryniszewska¹, Andras Vida¹, Janos Gal², Gyorgyi Soos², Zoltan Szekanecz³, Tibor A. Rauch¹, Joshua Jacobs¹, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Background/Purpose: Citrullination is a post-translational protein modification, where arginine (Arg) is converted to citrulline (Cit) by peptidyl arginine deiminases (PADI). The presence of anti-citrullinated protein…
Abstract Number: 1400 • 2013 ACR/ARHP Annual Meeting
Dipeptidyl Peptidase IV (DPP-IV, CD26) Levels In Patients With Rheumatoid Arthritis Treated With Biologic Therapies and Correlation With The Activity Of The Disease
José M. Pego-Reigosa¹, Oscar Cordero², Tania López-González², Coral Mouriño-Rodríguez³, Bruno Aspe⁴, Juan Viñuela-Roldán⁵, Rubén Varela-Calviño⁶, Cristina Calviño⁶, Marina Rodríguez-López⁴, Íñigo Hernández-Rodríguez⁴ and Víctor del Campo-Pérez⁷, ¹Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Spain, ²Biochemistry and Molecular Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain, ³Rheumatology, Meixoeiro Hospital, Vigo, Spain, ⁴Rheumatology, University Hospital Complex of Vigo, Vigo, Spain, ⁵Immunology, University Hospital Complex of Santiago, Santiago de Compostela, Spain, ⁶Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, Spain, ⁷Preventive Medicine and Epidemiology, University Hospital Complex of Vigo, Vigo, Spain
Background/Purpose: Dipeptidyl peptidase IV (DPP-IV, CD26), a protease cleaving N-terminal X-Pro dipeptides from selected proteins including chemokines is expressed both as a soluble form and…
Abstract Number: 1401 • 2013 ACR/ARHP Annual Meeting
Reduced Oral Glucose Tolerance Is Associated With a Lower Risk Of Rheumatoid Arthritis
Carl Turesson¹, Ulf Bergström², Mitra Pikwer², Jan-Åke Nilsson² and Lennart Jacobsson¹, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
Background/Purpose: Studies have demonstrated a negative association between high body mass index (BMI) and development of rheumatoid arthritis (RA) in men, and a neutral or…
Abstract Number: 1402 • 2013 ACR/ARHP Annual Meeting
Regulatory B10 Cells Are Decreased In Patients With Rheumatoid Arthritis and Inversely Correlated With Disease Activity
Claire I. Daien^1,2, Sarah Gailhac³, Thibault Mura⁴, Bernard Combe⁵, Michael Hahne¹ and Jacques Morel⁶, ¹IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ²Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ³Igmm UMR3555, CNRS, Montpellier, France, ⁴CIC, Hopital Gui De Chauliac, Montpellier, France, ⁵Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁶Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France
Background/Purpose: Regulatory IL-10 producing B cells (B10) have been shown to prevent and cure collagen-induced arthritis in mice. In human, very little is known about…
Abstract Number: 1403 • 2013 ACR/ARHP Annual Meeting
Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Is Expressed In a TNF-Dependent Manner In RA Synovial Tissues
Borbala Aradi¹, Masaru Kato¹, Mária Filková², Stephanie Kasper³, Kerstin Klein¹, Michael Bader¹, Michael Scharl³, Beat A Michel⁴, Renate E Gay¹, Edit I Buzas⁵, Steffen Gay¹ and Astrid Jüngel¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ³Division of Gastroenterology and Hepatology, University Hospital Zürich and Zürich Center for Integrative Human Physiology, Zurich, Switzerland, ⁴Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, ⁵Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Background/Purpose: Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2) is a protein phosphatase that has been associated with the development of autoimmune diseases in GWA studies.…
Abstract Number: 1404 • 2013 ACR/ARHP Annual Meeting
Effects Of Smoking On Joint Physiology In Men and Mice
Caroline Ospelt¹, Giovanni Camici², Anna Engler³, Christoph Kolling⁴, Renate E. Gay⁵, Beat A. Michel⁶ and Steffen Gay¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Institute of Physiology, University of Zurich, Zurich, Switzerland, ³Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Schultess Clinic, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁶Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Smoking is a major risk factor for the development of anti-citrullinated protein antibodies positive rheumatoid arthritis (RA) in individuals who carry shared epitope alleles.…
Abstract Number: 1405 • 2013 ACR/ARHP Annual Meeting
Expression Of High Mobility Group Protein B1 and Its Receptors In Heart Of Patients With Coronary Artery Disease With and Without Inflammatory Rheumatic Disease: A Biopsy Study
Mei Zong¹, Ivana Hollan², Huiyuan Xiao³, Cecilia Grundtman⁴, Eva Lindroos⁵, Helena E. Harris⁶, Knut MIkkelsen⁷, Stein E. Rynning⁷, Sven M. Almdahl⁸ and Ingrid E. Lundberg⁹, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ³University of Oxford, Oxford, United Kingdom, ⁴Innsbruck Medical University, Innsbruck, Austria, ⁵Department of Medicine, Rheumatology Unit, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden., Stockholm, Sweden, ⁶Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁷Feiring Heart Clinic, Feiring, Norway, ⁸Cardiothoracic surgery, University Hospital of North Norway, Tromsø, Norway, ⁹Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Patients with inflammatory rheumatic diseases (IRD) have increased risk of morbidity and mortality in coronary artery disease (CAD) compared to the general population. High…
Abstract Number: 1406 • 2013 ACR/ARHP Annual Meeting
The Scaffold Protein p62 Is Involved In NF-κB Signaling, Caspase-3 Dependent and -Independent Cell Death and Autophagy In Rheumatoid Arthritis Synovial Fibroblasts
Masaru Kato¹, Caroline Ospelt¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴, Steffen Gay⁵ and Kerstin Klein¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Schulthess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Sequestosome 1 (p62/ SQSTM1) is a multifunctional ubiquitin-binding protein implicated in selective autophagy, cell signaling pathways and regulation of cell death. Recently, we described…
Abstract Number: 1407 • 2013 ACR/ARHP Annual Meeting
High Serum Cholesterol Predicts Rheumatoid Arthritis In Women
Carl Turesson¹, Ulf Bergström², Mitra Pikwer², Jan-Åke Nilsson² and Lennart Jacobsson², ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
Background/Purpose: Patients with active rheumatoid arthritis (RA) tend to have low cholesterol levels due to effects of inflammation on lipid metabolism. However, several prospective studies…
Abstract Number: 1408 • 2013 ACR/ARHP Annual Meeting
High Body Mass Index Is Associated With a Reduced Long Term Risk Of Rheumatoid Arthritis In Men
Carl Turesson¹, Ulf Bergström², Mitra Pikwer², Jan-Åke Nilsson² and Lennart Jacobsson², ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
Background/Purpose: There are diverging results on the relation between body mass index (BMI) and risk of rheumatoid arthritis (RA). From a previous nested case-control study,…
Abstract Number: 1409 • 2013 ACR/ARHP Annual Meeting
Long-Term Impact of Delaying Combination Therapy With Adalimumab Plus Methotrexate By 2 Years in Patients With Early Rheumatoid Arthritis: Final 10-Year Results of the Premier Trial
Edward C. Keystone¹, Ferdinand C. Breedveld², Désiréé van der Heijde², Robert Landewe³, Stefan Florentinus⁴, Udayasankar Arulmani⁵, Shufang Liu⁵, Hartmut Kupper⁶ and Arthur Kavanaugh⁷, ¹University of Toronto, Toronto, ON, Canada, ²Leiden University Medical Center, Leiden, Netherlands, ³Academic Medical Center, Amsterdam, Netherlands, ⁴AbbVie, Rungis, France, ⁵AbbVie Inc., North Chicago, IL, ⁶AbbVie Deutschland GmBH & Co. KG, Ludwigshafen, Germany, ⁷University of California San Diego, San Diego, CA
Background/Purpose: The PREMIER trial demonstrated the superiority of initial adalimumab (ADA)+MTX vs the individual monotherapies in MTX-naïve patients (pts) with early, aggressive rheumatoid arthritis (RA).…
Abstract Number: 1410 • 2013 ACR/ARHP Annual Meeting
Tocilizumab Improves Left Ventricular Mass and Cardiac Output in Patients With Rheumatoid Arthritis. A Cohort Study
Kensuke Kume¹, Kanzo Amano¹, Susumu Yamada¹, Toshikatsu Kanazawa², Hiroshi Komori³, Hiroyuki Ohta⁴, Kuniki Amano⁵ and Noriko Kuwaba⁶, ¹Rheumatology, Hiroshima Clinic, Hiroshima, Japan, ²rheumatology, hiroshima clinic, hiroshima, Japan, ³internal medicine, hiroshima clinic, hiroshima, Japan, ⁴Medical Research, hiroshima clinic, Hiroshima, Japan, ⁵Rheumatology, Sky Clinic, Hiroshima, Japan, ⁶Medical Research, Sanki Clinical Link, Hiroshima, Japan
Background/Purpose: Rheumatologists need to develop primary prevention strategies for cardiovascular disease (CVD) in rheumatoid arthritis (RA) patients. We reported tocilizumab (TCZ) improved arterial stiffness as…
Abstract Number: 1411 • 2013 ACR/ARHP Annual Meeting
The Peroxisome Proliferator Activated Receptor-gamma pioglitazone Decreases Cardiovascular Risk and Disease Activity In Patients With Rheumatoid arthritis
Wendy Marder¹, Shokoufeh Khalatbari², James D. Myles³, Rita Hench⁴, Susan Lustig⁴, Srilakshmi Yalavarthi⁵, Aishwarya Parameswaran⁴, Robert Brook² and Mariana J. Kaplan⁶, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Medicine, University of Michigan at Ann Arbor, Ann Arbor, MI, ³Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Michigan Rheumatology, Ann Arbor, MI, ⁶Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Rheumatoid arthritis (RA) is associated with heightened mortality due to atherosclerotic cardiovascular disease (CVD). Inflammatory pathways in RA negatively affect vascular physiology and promote…

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