ACR Meeting Abstracts

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  • Abstract Number: 1295 • 2012 ACR/ARHP Annual Meeting

    Effectiveness and Tolerability of Subcutaneous Tocilizumab in Rheumatoid Arthritis Patients Switched From Intravenous Tocilizumab: Results From the Extension Period of the Musashi Study

    Atsushi Ogata1 and the MUSASHI study group2, 1Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, 2Japan

    Background/Purpose: In the MUSASHI study (i.e., Double-blind, parallel-group, Phase III non-inferiority study comparing subcutaneous tocilizumab [SC-TCZ] monotherapy versus intravenous tocilizumab [IV-TCZ] monotherapy), the effectiveness and…
  • Abstract Number: 1256 • 2012 ACR/ARHP Annual Meeting

    High Inflammation May Condition the Antiatherogenic Function of Small, Dense HDL in Patients with Active Rheumatoid Arthritis

    Carla Saucedo1, Leonardo gomez Rosso2, Tomas Meroño2, Fernando Brites2, Anatol Kontush3, Luis J. Catoggio4, Enrique Soriano4, Laurent Camont5, Marie Lhomme5, Veronica Malah6, Patricia Sorroche7, Sandrine Chantepie5, Paul Robillard8 and John Chapman5, 1Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2University of Buenos Aires, Laboratory of Lipids and Lipoproteins, School of Pharmacy and Biochemistry, Buenos Aires, Argentina, 3Université Pierre et Marie Curie-Paris, Paris, France, 4Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Université Pierre et Marie Curie, Paris, France, 6Rheumatology section, Hospital de Clínicas “José de San Martín”, Buenos Aires, Argentina, 7Central Laboratory , Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 8Université Pierre et Marie Curie, Paris, Argentina

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased mortality, mainly due to cardiovascular disease.  High grade inflammation might drive to premature atherosclerosis. High-density lipoprotein (HDL)…
  • Abstract Number: 1257 • 2012 ACR/ARHP Annual Meeting

    Subclinical Atherosclerosis in Hispanic Patients with Rheumatoid Arthritis. Correlation with the Presence of Anti-Oxidized LDL Antibodies and Serum Levels of CD40L

    Yurilis Fuentes-Silva1, Soham Al Snih2, Natali Serra-Bonett1, Juan De Sanctis3 and Martin A. Rodriguez4, 1Rheumatology, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, 2Division of Rehabilitation Sciences, Division of Geriatrics. Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, 3Immunology, Instituto de Inmunología, Caracas, Venezuela, 4Centro Nacional de Enfermedades Reumáticas, Hospital Universitario de Caracas, Caracas, Venezuela

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease, associated with an excess of cardiovascular morbidity and mortality due to accelerated atherosclerosis. The appearance of…
  • Abstract Number: 1258 • 2012 ACR/ARHP Annual Meeting

    Association Between Low Vitamin D Levels and Indicators of Osteoporosis and Atherosclerosis

    Barry J. Sheane1, Ruth Dunne2, Ken Scott3, Mary Hall4, Michelle O'Connor2, Martin Healy5, John Feely4, J.B. Walsh6 and Gaye Cunnane7, 1Dept. of Rheumatology, St. James's Hospital, Dublin, Ireland, 2Diagnostic Imaging Department, St James's Hospital, Dublin, Ireland, 3Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin 8, Ireland, 4Department of Pharmacology and Therapeutics, St James's Hospital, Dublin, Ireland, 5Central Pathology Laboratory, St James's Hospital, Dublin, Ireland, 6Medicine for the Elderly, St James's Hospital, Dublin, Ireland, 7Dept of Rheumatology, St James's Hospital, Dublin, Ireland

    Background/Purpose: Osteoporosis and cardiovascular disease are complications of chronic rheumatoid arthritis (RA). It is not known if these processes share pathogenetic mechanisms. Low levels of…
  • Abstract Number: 1259 • 2012 ACR/ARHP Annual Meeting

    Association Between Subclinical Atherosclerosis and Bone Mineral Density in Rheumatoid Arthritis

    Barry J. Sheane1, Ruth Dunne2, Ken Scott3, Mary Hall4, Michelle O'Connor2, Martin Healy5, John Feely4, J.B. Walsh6 and Gaye Cunnane7, 1Rheumatology, St. James Hospital, Dublin, Ireland, 2Diagnostic Imaging Department, St James's Hospital, Dublin 8, Ireland, 3Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin 8, Ireland, 4Department of Pharmacology and Therapeutics, St James's Hospital, Dublin 8, Ireland, 5Central Pathology Laboratory, Dublin 8, Ireland, 6Medicine for the Elderly, Dublin 8, Ireland, 7Dept of Rheumatology, St James's Hospital, Dublin, Ireland

    Background/Purpose: Rheumatoid arthritis (RA) is associated with a higher risk of osteoporosis (OP) and cardiovascular disease (CVD). This cross-sectional study was undertaken to identify links…
  • Abstract Number: 1260 • 2012 ACR/ARHP Annual Meeting

    Hydroxychloroquine Reduces the Risk of Coronary Artery Disease in Patients with Rheumatoid Arthritis

    Li Chun1, Mu Rong1, Su Yin1, Li Xiaofeng2, Wang Yongfu3, Wang Guochun4, Zhu Ping5, Liu Xiangyuan6, Chen Haiying7, Cui Liufu8, Zhang Zhuoli9, Li Zhenbin10, Li Junfang11, Zhang Fengxiao12, Han Shuling13, Lin Jinying14, Liu Xiaomin15, Hu Shaoxian16, Yang Xiuyan17, Huang Cibo Sr.18, Li Xingfu19, Wang Yi20 and Li Zhanguo1, 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Taiyuan, China, 3Department of Rheumatology and Immunology, Baotou, China, 4Department of Rheumatology and Immunology, Beijing, China, 5Department of Rheumatology and Immunology,Xijing Hospital, Xian, China, 6Department of Rheumatology and Immunology,Peking University Third Hospital, Beijing, China, 7Department of Rheumatology and Immunology,The Third Hospital of, Shijiazhuang, China, 8Department of Rheumatology and Immunology,Kailuan hospital of North China Coal Hospital, Tangshan, China, 9Department of Rheumatology and Immunology,Peking University First Hospital, Beijing, China, 10Department of Rheumatology and Immunology,Peace Hospital, Shijiazhuang, China, 11Department of Rheumatology and Immunology, Hebei Handan Central Hospital, Handan, China, 12Department of Rheumatology and Immunology,Hebei People's Hospital, China, 13Department of Rheumatology and Immunology, Peking University Shougang Hospital, Beijing, China, 14Department of Rheumatology and Immunology,The people's hospital of guangxi zhuang autonomous region, Nanning, China, 15Department of Rheumatology and Immunology,Beijing shunyi hospital of China Medical University, Beijing, China, 16Department of Rheumatology and Immunology,Tongji Medical College Huazhong University of Science & Technology, Wuhan, China, 17Department of Rheumatology and Immunology,First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 18Rheumatology and Immunology Department, Beijing Hospital, Ministry of Health, Beijing, China, 19.Department of Rheumatology and Immunology,Qilu Hospital of Shandong University, Jinan, China, 20Department of Rheumatology and Immunology,Second hospital of Lanzhou University, Lanzhou, China

    Background/Purpose: Disease modifying anti-rheumatic drugs (DMARDs) can alter cardiovascular risk in RA by inflammation or by influencing cardiovascular risk factors indirectly. However, previous studies predominantly…
  • Abstract Number: 1261 • 2012 ACR/ARHP Annual Meeting

    Epicardial Adipose Tissue Is Associated with Cardiometabolic Risk and the Metabolic Syndrome in Patients with Rheumatoid Arthritis

    Michelle J. Ormseth1, Aliza Lipson2, Nikolaos Alexopoulos3, Gregory R. Hartlage3, Annette M. Oeser4, Aihua Bian4, Tebeb Gebretsadik5, Ayumi Shintani4, Paolo Raggi6 and C. Michael Stein7, 1Rheumatology, Vanderbilt Medical Center, Nashville, TN, 2Rheumatology, Emory University, Atlanta, GA, 3Emory University, Atlanta, GA, 4Vanderbilt Medical Center, Nashville, TN, 5Biostatistics, Vanderbilt University, Nashville, TN, 6University of Alberta, Edmonton, AB, Canada, 7School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis and this may be related to their increased prevalence of visceral adiposity, insulin resistance, and…
  • Abstract Number: 1262 • 2012 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patients with Higher Disease Severity and Subclinical Carotid Plaque Experience More Cardiovascular Events Despite a Favorable Conventional Cadiovascular Risk Profiles

    Yeon-Ah Lee1, Somi Kim1, Sang-Hoon Lee2, Ran Song2, Hyung In Yang2 and Seung-Jae Hong1, 1Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, 2Rheumatology, Hospital at GANGDONG, Kyung Hee University, Seoul, South Korea

    Background/Purpose: It has been shown that patients with rheumatoid arthritis (RA) experience cardiovascular (CV) events more often than expected. Increased risks of CV diseases in…
  • Abstract Number: 1263 • 2012 ACR/ARHP Annual Meeting

    Carotid Arterial Wall Inflammation Is Associated with a Specific Profile of Inflammatory Biomarkers and Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Patients

    Caroline Grönwall1, Gregg J. Silverman1, Zahi Fayad2, Venkatesh Mani2, Victoria Furer3, Michael Farkouh2, Manish Jain1, Cheongeun Oh4, John Todd5, Mukundan Attur6, Steven B. Abramson7 and Jeffrey D. Greenberg8, 1Rheumatology, NYU School of Medicine, New York, NY, 2Mount Sinai Hospital, New York, NY, 3Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 4Biostatistics, NYU School of Medicine, New York, NY, 5Singulex, Alameda, California, Alameda, CA, 6Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, 7Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, 8New York Hospital for Joint Disease, New York, NY

    Background/Purpose: Patients with RA are at increased risk of cardiovascular (CV) comorbidity and premature mortality. While generally attributed to accelerated atherosclerosis, the pathogenesis remains poorly understood.…
  • Abstract Number: 1264 • 2012 ACR/ARHP Annual Meeting

    Vascular Age in Rheumatoid Arthritis Patients

    Jl Rosales-Alexander1, César Magro Checa1, Juan Salvatierra1, Silvia Montes García1, Jesús Cantero Hinojosa2 and Enrique Raya Álvarez1, 1Rheumatology, University Hospital San Cecilio, Granada, Spain, 2Internal Medicine, University Hospital San Cecilio, Granada, Spain

    Background/Purpose: The European League Against Rheumatism (EULAR) recommends cardiovascular risk (CV) assessment using the systematic coronary risk evaluation (SCORE) chart in rheumatoid arthritis (RA) patients.…
  • Abstract Number: 1265 • 2012 ACR/ARHP Annual Meeting

    Lipoprotein Subclass Particles and Small Vessel Elasticity As a Potential Marker for Early Atherosclerosis in Rheumatoid Arthritis:  a Prospective, Controlled Study

    Marty T. Mertens1 and Elie Gertner2, 1Rheumatology, University of Minnesota, Minneapolis, MN, 2Section of Rheumatology, Regions Hospital and University of Minnesota Medical School, St. Paul, MN

    Background/Purpose: Rheumatoid arthritis (RA) has increased rates of cardiovascular (CV) events.  However, standard CV risk factors, such as routine lipid profiles, are not different in…
  • Abstract Number: 1266 • 2012 ACR/ARHP Annual Meeting

    Evaluation of Metabolic Syndrome in 97 Patients with Rheumatoid Arthritis

    Fernanda G. G Chaer1, Juliana Lucena2, Rogerio Castro Reis3, Fabiola Brasil2, Murilo Melo4, Amanda Callegari5 and Branca Souza5, 1Reumatologia, Santa Casa de Sao Paulo, São Paulo, Brazil, 2Reumatologia, Irmandade da Santa Casa de Misericordia de Sao Paulo, São Paulo, Brazil, 3Reumatologia, Santa Casa de Sao Paulo, São Paulo, Brazil, 4Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, Brazil, 5Reumatologia, Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, Brazil

    Background/Purpose: Rheumatoid arthritis (RA) is an independent risk factor for cardiovascular disease (CVD), which is the leading cause of death in this group. Thus, the…
  • Abstract Number: 1267 • 2012 ACR/ARHP Annual Meeting

    Inflammatory Burden Predicts Progression of Carotid Plaque in Rheumatoid Arthritis: A 24-Month Longitudinal Analysis

    Churl Hyun Im1, Na Ri Kim1, Jong Wan Kang1, Young Ji Kim1, Kyung Hye Kim1, Eon Jeong Nam1 and Young Mo Kang2, 1Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 2Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea

    Background/Purpose: Carotid atherosclerosis, which is associated with the increased risk of cardiovascular (CV) disease, is increased in rheumatoid arthritis (RA) patients. In our previous study,…
  • Abstract Number: 1268 • 2012 ACR/ARHP Annual Meeting

    Lipid Alterations and Measurement of Arterial Stiffness in Rheumatoid Arthritis

    Marina Scolnik1, Carla Saucedo2, David A. Navarta3, Leandro Ferreyra Garrott2, Erika Catay4, Maria L. Acosta Felquer5, Eliana Lancioni6, Cristian Quiroz3, Federica Varela Guidetti5, Zaida Bedran2, Mirtha Sabelli4, Javier Rosa4, Maria Victoria Garcia4, Patricia M. Imamura5, Patricia Sorroche7, Jose Alfie8, Margarita Morales9, Gabriel Waisman9, Luis J. Catoggio1 and Enrique Soriano1, 1Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Internal Medicine, Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 6Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 7Central Laboratory , Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 8Internal Medicine, Hypertension Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 9Hypertension Section, Internal Medicine Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease. Increased arterial stiffness, an independent risk factor for premature coronary artery disease, has been reported in…
  • Abstract Number: 1269 • 2012 ACR/ARHP Annual Meeting

    Serum Cytokines Associated with Carotid Atherosclerosis in Rheumatoid Arthritis

    Inmaculada del Rincon1, Roy W. Haas2, Daniel H. O'Leary3, Joseph F. Polak3, Daniel F. Battafarano4 and Agustin Escalante5, 1Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, 3Radiology, Tufts University-Boston Campus, Boston, MA, 4Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, 5Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX

    Background/Purpose: The mechanism for the increased cardiovascular morbidity and mortality in rheumatoid arthritis (RA) is incompletely understood. In a previous analysis, we found that both…
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