Abstract Number: 1486 • 2012 ACR/ARHP Annual Meeting
Poor Outcome in Patients with Systemic Sclerosis and Myocardial Involvement: A Combined Approach Based On Clinical and Laboratory Findings, EKG-Holter and Cardiac Magnetic Resonance
Background/Purpose: Cardiac involvement is a relevant prognostic determinant in Systemic Sclerosis (SSc), but the diagnosis is often delayed due to the lack of a specific…Abstract Number: 1487 • 2012 ACR/ARHP Annual Meeting
Incidence of Fibromyalgia Syndrome in Systemic Sclerosis and Rheumatoid Arthritis. Comparative Results According to Clinical Diagnosis, Screening Test with Fibromyalgia Rapid Screening Tool, Diagnosis with ACR1990 and ACR 2010 Criteria
Background/Purpose: Fibromyalgia (FMS) is a chronic widespread pain condition that may be associated with inflammatory chronic disorders like rheumatoid arthritis (RA) and systemic sclerosis (SSc).…Abstract Number: 1488 • 2012 ACR/ARHP Annual Meeting
Prevalence and Risk Factors of Low Bone Mineral Density in Chinese Patients with Systemic Sclerosis: A Case-Control Study
Background/Purpose: To study the prevalence and risk factors of low bone mineral density (BMD) in patients with systemic sclerosis (SSc). Methods: Consecutive patients who fulfilled…Abstract Number: 1489 • 2012 ACR/ARHP Annual Meeting
Peripheral Neuropathy: A Complication of Systemic Sclerosis
Background/Purpose: We performed bedside testing for peripheral neuropathy in our Systemic Sclerosis (SSc) population to determine whether foot care guidelines should be developed for SSc. …Abstract Number: 1490 • 2012 ACR/ARHP Annual Meeting
Dysregulation of Angiogenic Homeostasis in Systemic Sclerosis
Background/Purpose: systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue hypoxia and excessive fibrosis of skin and internal organs. The present study was…Abstract Number: 1491 • 2012 ACR/ARHP Annual Meeting
Systemic Sclerosis – Effects of Agonistic Autoantibodies Directed Against the Angiotensin Receptor Type 1 and the Endothelin Receptor Type A On Effector Cells
Background/Purpose: Autoimmunity, vasculopathy and fibrosis are features of systemic sclerosis (SSc). The functional link between these three pathophysiological components is still missing. Research suggests an…Abstract Number: 1492 • 2012 ACR/ARHP Annual Meeting
IL-13 Receptors and Signaling in the Dermal Fibroblasts From Patients with Systemic Sclerosis
Background/Purpose: Interleukin (IL)-13 is a pleiotropic cytokine involved in T helper type 2 cell immune response and in the development of fibrotic conditions such as…Abstract Number: 1493 • 2012 ACR/ARHP Annual Meeting
Transforming Growth Factor-β and Endothelin-1 Induce Endothelial-to-Mesenchymal Transition in Cultured Human Endothelial Cells
Background/Purpose: The endothelial/microvascular injury and the myofibroblast activation are crucial events that seem to contribute to the development of fibrosis in connective tissue diseases such…Abstract Number: 1494 • 2012 ACR/ARHP Annual Meeting
CD40 Signaling Results in Microvascular Endothelial Dysfunction: A Possible Clue to the Pathogenesis of Scleroderma Vasculopathy
Background/Purpose: Increased expression of CD40 in SSc- Microvascular Endothelial Cells (MVEC) was noted on a gene expression array and increased concentrations of soluble CD40 ligand (sCD40L)…Abstract Number: 1495 • 2012 ACR/ARHP Annual Meeting
Platelet Aggregability, Eicosanoid Biosynthesis and Oxidative Stress in Primary Raynaud’s Phenomenon and Systemic Sclerosis
Background/Purpose: Increased platelet activation, endothelial dysfunction and oxidative stress are all thought to contribute to the pathogenesis of Raynaud’s phenomenon (RP), particularly in the context…Abstract Number: 1496 • 2012 ACR/ARHP Annual Meeting
Downregulated Expression of Metallothionein Genes in Response to the Gadolinium Contrast Agent Omniscan in Normal Human Differentiated Macrophages and Dermal Fibroblasts
Background/Purpose: Metallothioneins bind heavy metals with high affinity and can serve as storage proteins for labile Zn2+ which in turn can regulate immune system activity…Abstract Number: 1456 • 2012 ACR/ARHP Annual Meeting
A Tolerogenic Peptide Down-Regulates the Expression of Interferon-a in Murine and Human Systemic Lupus Erythematosus
Background/Purpose: The tolerogenic peptide, designated hCDR1, was shown to ameliorate manifestations of systemic lupus erythematosus (SLE) via down-regulation of pro-inflammatory cytokines, up-regulation of immunosuppressive cytokines…Abstract Number: 1457 • 2012 ACR/ARHP Annual Meeting
A Novel Small Molecular Anti-Rheumatic Drug, T-614, Ameliorates Lupus-Like Disease in MRL/Lpr Mice by Suppressing B Cell Functions
Background/Purpose: T-614 is a small molecular drug that has multiple immunomodulatory effects and has been used for treating rheumatoid arthritis. Previous work has revealed this…Abstract Number: 1458 • 2012 ACR/ARHP Annual Meeting
Left Ventricular Diastolic Dysfunction May Play a Role in Pathophysiology and Poor Prognosis of Pulmonary Arterial Hypertension Associated with Systemic Sclerosis
Background/Purpose: Cardio-pulmonary involvements of systemic sclerosis (SSc), including cardiomyopathy, interstitial lung disease, and pulmonary arterial hypertension (PAH) are leading causes of SSc-related deaths. Several potent…Abstract Number: 1459 • 2012 ACR/ARHP Annual Meeting
Limited Utility of Pulmonary Function Tests and B-Type Natriuretic Peptide As Screening Tools for Pre-Capillary Pulmonary Hypertension in Patients with Systemic Sclerosis
Background/Purpose: A series of recent studies indicate that early detection of pulmonary hypertension (PH) improves a survival in patients with systemic sclerosis (SSc). Thus, annual…
ACR Meeting Abstracts