Abstracts Archive - Page 2322 of 2425 - ACR Meeting Abstracts

Abstract Number: 1511 • 2012 ACR/ARHP Annual Meeting
Low Circulating Endothelial Progenitor Cell Levels and High VEGF Serum Levels Are Associated with the Late Nailfold Capillaroscopic Pattern in Systemic Sclerosis
Jerome Avouac¹, Maeva Vallucci², Vanessa Smith³, Barbara Ruiz², Alberto Sulli⁴, Carmen Pizzorni⁵, Gilles Chiocchia⁶, Maurizio Cutolo⁷ and Yannick Allanore⁸, ¹Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ²Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁶Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁷Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁸Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
Background/Purpose: To assess whether nailfold videocapillaroscopy (NVC) changes are associated with peripheral blood or serum levels of angiogenic biomarkers in systemic sclerosis (SSc). Methods: Endothelial…
Abstract Number: 1512 • 2012 ACR/ARHP Annual Meeting
Bleomycin Delivery by Osmotic Pump: A Superior Model for Human ILD
Rebecca Lee¹, Michael Bonner², Charles Reese², Elena Tourkina³, Zoltan Hajdu², Jing Zhang², Richard Visconti² and Stanley Hoffman², ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of SC, Charleston, SC
Background/Purpose: Interstitial lung disease (ILD) represents a group of chronic, progressive, irreversible diseases associated with pulmonary fibrosis, including systemic sclerosis and idiopathic pulmonary fibrosis. In…
Abstract Number: 1513 • 2012 ACR/ARHP Annual Meeting
TSLP Receptor Deficiency Reduces IL-13 Expression and Prevents Fibrosis in Experimental Scleroderma
Alicia Usategui¹, Vanessa Miranda¹, Gabriel Criado², Manuel J. Del Rey¹, Elena Izquierdo¹, Warren J. Leonard³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. Although SSc shares pathogenetic features with other…
Abstract Number: 1514 • 2012 ACR/ARHP Annual Meeting
Differences in the Activation Levels and Expression Patterns of the Molecular Targets of Tyrosine Kinase Inhibitors May Account for the Heterogeneous Treatment Responses
Britta Maurer¹, Alfiya Akhmetshina², Renate E. Gay³, Beat A. Michel³, Steffen Gay⁴, Joerg H. W. Distler² and Oliver Distler³, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland
Background/Purpose: In SSc, treatment responses to tyrosine kinase inhibitors (TKI) are less distinct compared to animal models. Therefore, we assessed whether the heterogeneous therapeutic effects…
Abstract Number: 1515 • 2012 ACR/ARHP Annual Meeting
Pharmacological Blockade of Adenosine A2A Receptors (A_2AR) Prevents Radiation-Induced Dermal Injury
Miguel Perez Aso¹, Yee C. Low², Obinna Ezeamuzie², Jamie Levine² and Bruce N. Cronstein³, ¹NYU School of Medicine, New York, NY, ²Department of Plastic Surgery, New York Univ Medical Center, New York, NY, ³Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Ionizing radiation is a commonly used therapeutic modality and following irradiation dermal changes, including fibrosis and atrophy, may lead to such problems as contractures.…
Abstract Number: 1516 • 2012 ACR/ARHP Annual Meeting
TSLP Upregulation in Human SSc Skin and Induction of Overlapping Profibrotic Genes and Intracellular Signaling with IL-13 and TGFb
Romy Christmann¹, Allison Mathes², Giuseppina Stifano², Alsya J. Affandi³, Andreea Bujor³, Cristina Padilla³ and Robert Lafyatis³, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, Boston University, Boston, MA
Background/Purpose: to investigate the expression of Thymic Stromal Lymphopoietin (TSLP) in diffuse cutaneous systemic sclerosis (dcSSc) patients and explore its effects in vivo and in vitro…
Abstract Number: 1477 • 2012 ACR/ARHP Annual Meeting
Skin Autofluorescence As a Measure of Oxidative Stress in Systemic Sclerosis Is Not Affected by Skin Thickness, Erythema or Melanin
Andrea Murray¹, T. Moore¹, J. Manning², Christopher E.M Griffiths³ and Ariane Herrick⁴, ¹School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom, ²Department of Clinical Rheumatology, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ³Dermatology Centre, University of Manchester, Manchester, United Kingdom, ⁴Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom
Background/Purpose: Skin autofluorescence (AF) has been suggested as a non-invasive measure of oxidative stress in patients with diabetes and other diseases. We have previously shown…
Abstract Number: 1478 • 2012 ACR/ARHP Annual Meeting
Gender-Associated Differences in Disease Characteristics and Outcome in Systemic Sclerosis
Svetlana I. Nihtyanova¹, Voon H. Ong² and Christopher P. Denton³, ¹Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom
Background/Purpose: Although significant female gender predominance is seen in majority of large systemic sclerosis (SSc) cohorts, multiple studies have suggested that male gender generally associates…
Abstract Number: 1479 • 2012 ACR/ARHP Annual Meeting
Early Versus Late Onset Systemic Sclerosis: Analysis of 1037 Patients From Rescle Registry
Marco A. Alba¹, Juan Carlos Mejia², Gerard Espinosa³, María-Victoria Egurbide⁴, Carles Tolosa⁵, Luis Trapiella⁶, Carmen Pilar Simeon⁷, Vicent Fonollosa⁸ and And RESCLE investigators⁹, ¹Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Department of Systemic Autoimmune Diseases, Hospital Clinic University Barcelona, Barcelona, Spain, ³Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Barcelona, Spain, ⁴Autoimmune Disease Research Unit, Service of Internal Medicine,, Hospital de Cruces, UPV/EHU, Barakaldo, Spain, Barakaldo, Spain, ⁵Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Barcelona, Spain, ⁶Department of Internal Medicine,, Hospital Universitario Central de Asturias, Asturias, Spain, ⁷Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, ⁸Department of Internal Medicine, Hospital Vall dxHebron, Barcelona, Spain, ⁹RESCLE, Barcelona, Spain
Background/Purpose: Systemic sclerosis (SSc) is characterized by extensive fibrosis, vascular dysfunction and the presence of several auto-antibodies. As in other autoimmune diseases, age at disease…
Abstract Number: 1480 • 2012 ACR/ARHP Annual Meeting
The 15% Rule in Scleroderma: A Systematic Review of the Frequency of Organ Complications in Systemic Sclerosis
Chayawee Muangchan¹, Murray Baron², Janet E. Pope³ and Canadian Scleroderma Research Group⁴, ¹Division of Rheumatology, Department of Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand, ²Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁴Division of Rheumatology, SMBD Jewish General Hospital, Montreal, QC, Canada
Background/Purpose : The prevalence of each organ complication in scleroderma (SSc) varies by definition used. However, it is important to be aware of several complications…
Abstract Number: 1481 • 2012 ACR/ARHP Annual Meeting
A Double-Blind Placebo-Controlled Crossover Trial of the Alpha-_2C Adrenoceptor Antagonist Orm-12741 for Prevention of Cold-Induced Vasospasm in Patients with Systemic Sclerosis
Ariane Herrick¹, Andrea Murray², Angela Ruck³, Juha Rouru⁴, Tonia Moore², John Whiteside³, Pasi Hakulinen⁴, Fredrick M. Wigley⁵ and Amir Snapir⁴, ¹Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, ²School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom, ³Orion Pharma UK, Research & Development, Nottingham, United Kingdom, ⁴Orion Corporation Orion Pharma, Turku, Finland, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The alpha-2C adrenoceptor is thought to play a key role in mediating cold-induced vasospasm in the digits. A previous study suggested that in patients…
Abstract Number: 1482 • 2012 ACR/ARHP Annual Meeting
Laser Speckle Contrast Imaging May Help in the Differential Diagnosis of Raynaud’s Phenomenon
Alessandra Della Rossa¹, Massimiliano Cazzato¹, Walter Bencivelli¹, Anna d'Ascanio², Marta Mosca¹ and Stefano Bombardieri³, ¹Internal Medicine, Rheumatology Unit, Pisa, Italy, ²Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Department of Internal Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy
Background/Purpose: to investigate blood flow and microvascular reactivity by laser speckle perfusion imager (Perimed, Jarfalla) in consecutive patients affected by Raynaud’s phenomenon at baseline and…
Abstract Number: 1483 • 2012 ACR/ARHP Annual Meeting
Predictors of Digital Ulcers in Systemic Sclerosis: Correlation Between Clinical and Hemodynamic Features, Capillaroscopy, Endothelium Dysfunction and Angiogenesis Biomarkers
Ivone Silva¹, Isabel Almeida¹, António Marinho² and Carlos Vasconcelos³, ¹Raynaud Clinics, Porto, Portugal, ²Unidade de Imunologia Clínica, Porto, Portugal, ³Imunologia Clinica - M Interna, Hospital Geral Santo Antonio, Porto, Portugal
Background/Purpose: Digital Ulcers (DU) are a major disabling complication of Systemic Sclerosis (SSc) interfering with personal and professional life of our patients. The aim of…
Abstract Number: 1484 • 2012 ACR/ARHP Annual Meeting
Investigating Determinants of Subjective and Objective Assessments of Peripheral Vascular Function in Primary Raynaud’s Phenomenon and Systemic Sclerosis
John D. Pauling¹, Jacqueline A. Shipley¹, Nigel Harris² and Neil McHugh², ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
Background/Purpose: The Raynaud’s condition score (RCS) diary is recommended for use in clinical trials of Raynaud’s phenomenon (RP) and systemic sclerosis (SSc). We report the…
Abstract Number: 1485 • 2012 ACR/ARHP Annual Meeting
Patients with Very Early Diagnosis of Systemic Sclerosis (VEDOSS) Present Esophageal and Anorectal Involvement: Data From a Single Centre
Gemma Lepri¹, Silvia Bellando-Randone², Serena Guiducci³, Iacopo Giani⁴, Cosimo Bruni⁵, Giulia Carnesecchi², Jelena Blagojevic², Alessandra Radicati², Filippo Pucciani⁶ and Marco Matucci Cerinic², ¹Department of Internal Medicine, Section of Rheumatology, Transition Clinic, University of Florence, Florence, Italy, ²Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy, ³Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ⁴General Surgery, ASL 8, Arezzo, Italy, Arezzo, Italy, ⁵Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁶General and Urgency Surgery, University of Florence, Florence, Italy, Florence, Italy
Background/Purpose: Systemic Sclerosis (SSc) affects gastrointestinal tract in more than 80% of patients. Esophageal involvement is the most common manifestation with a prevalence ranging between…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].