Abstract Number: 1683 • 2013 ACR/ARHP Annual Meeting
High Prevalence Of Metabolic Syndrome In Takayasu Arteritis: An Increased Cardiovascular Risk and Lower Adiponectin Serum Levels
Background/Purpose: The prevalence of Metabolic Syndrome (MetS) tends to be high among rheumatic patients, and cardiovascular disease is the leading cause of death in these…Abstract Number: 1684 • 2013 ACR/ARHP Annual Meeting
Early Combination Immunosuppression and Serial Non-Invasive Imaging Improves Outcome In Takayasu Arteritis
Background/Purpose: Takayasu arteritis (TA) affects the aorta and its branches, pre-disposing to stenoses and aneurysmal dilatation. While morbidity remains high, evidence for efficacy of immunosuppressive…Abstract Number: 1659 • 2013 ACR/ARHP Annual Meeting
Systematic Review Of Amyloid Beta-Related Angiitis: A Treatable Cause Of Vasculitis Affecting Central Nervous System
Background/Purpose: Amyloid β-related angiitis (ABRA) is a rare type of Central Nervous System Vasculitis (CNSV), which complicates Cerebral Amyloid Angiopathy (CAA). Data about clinical features,…Abstract Number: 1643 • 2013 ACR/ARHP Annual Meeting
Ex Vivo Suppression Of RA Effector T Cells (Teff) By Mapc Media Is Synergistic With Treg
Background/Purpose: Use of mesenchymal/multipotent stem cells (MSCs/MAPCs) is an emerging immune modulatory therapeutic strategy promising for a number of human diseases. Multipotent adult progenitor cells…Abstract Number: 1645 • 2013 ACR/ARHP Annual Meeting
Circulating CD4+CD161+ T Lymphocytes Are Increased In Seropositive Arthralgia Patients But Decreased In Patients With Newly Diagnosed Rheumatoid Arthritis
Background/Purpose: Improved understanding of the immune events discriminating between seropositive arthralgia and clinical synovitis is of key importance in rheumatology research. Ample evidence suggests a…Abstract Number: 1646 • 2013 ACR/ARHP Annual Meeting
Alterations In Circulating T Follicular Helper Cells and T Regulatory Cells In Autoimmune Rheumatic Diseases Treated With B Cell Depletion Therapy: Rituximab
Background/Purpose: Granulomatosis with polyangiitis (GPA) and systemic lupus erythematosus (SLE) are autoimmune rheumatic diseases which develop due to failure of immune self-tolerance. T follicular helper…Abstract Number: 1647 • 2013 ACR/ARHP Annual Meeting
An Altered Frequency Of Circulating Follicullar T Helper Cell Counterparts and Their Subsets Is Associated With Increased Circulating Plasmablasts In Seropositive RA Patients
Background/Purpose: Follicular T helper (Tfh) cells, a CD4 T helper subset localized in lymphoid organs, help B cell differentiation and function. Circulating CD4 T cells…Abstract Number: 1648 • 2013 ACR/ARHP Annual Meeting
PD-1+CD45RBlo122lo Autoantibody-Inducing CD4 T Cells (aiCD4 T cells) As a Key In The Pathogenesis Of Systemic Lupus Erythematosus (SLE)
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…Abstract Number: 1649 • 2013 ACR/ARHP Annual Meeting
Assessment Of Cytomegalovirus-Specific T Cell Responses Upon Initiation Of Immunosuppression In Patients Suffering From Rheumatic Diseases As Novel Approach For Functional Immune Monitoring
Background/Purpose: The management of immunosuppressive therapies is challenging, as physicians are confronted with difficulties to keep the balance between immunosuppression on one hand and raised…Abstract Number: 1650 • 2013 ACR/ARHP Annual Meeting
The Route Of T Cell Priming Determines The Requirement For IL-23 In The Development Of Arthritis
Background/Purpose: Rheumatoid arthritis is a very heterogeneous disease and distinct molecular mechanisms may underlie the disease process. IL-23 is an important cytokine for the expansion…Abstract Number: 1652 • 2013 ACR/ARHP Annual Meeting
Autophagy May Contribute To Glucocorticoid Resistance In Patients With Myositis By Maintaining T Lymphocytes Homeostasis In The Muscles
Background/Purpose: Infiltrating T cells is a typical histopathologic feature in muscles of patients with myositis and these cells are also believed to play important roles…Abstract Number: 1653 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Synovial IL-21+CD4+ T Cells Specifically Induce Matrix Metalloproteinase Production By Fibroblast-Like Synoviocytes
Background/Purpose: IL-21 is a cytokine produced by activated CD4+ T cells and T follicular helper cells (TFh) that has been implicated in several autoimmune diseases…Abstract Number: 1654 • 2013 ACR/ARHP Annual Meeting
Characterization Of T Cell Phenotype and Function In a Double Transgenic (Collagen-Specific TCR /HLA-DR1) Humanized Model Of Arthritis
Background/Purpose: T cells orchestrate joint inflammation in rheumatoid arthritis (RA), yet they are difficult to study due to the small numbers of antigen-specific cells. The…Abstract Number: 1655 • 2013 ACR/ARHP Annual Meeting
HLA-B27 and KIR3DL2 Interactions Promote The Differentiation and Survival Of Proinflammatory T Cells In Spondyloarthritis
Background/Purpose: T helper 17 (Th17) cells are a subset of pro-inflammatory CD4+ T cells implicated in a number of inflammatory arthritides including the Spondyloarthritides (SpAs). …Abstract Number: 1656 • 2013 ACR/ARHP Annual Meeting
Interferon Type I and T Helper 17: A Dangerous Liaison In Primary Sjögren’s Syndrome?
Background/Purpose: The T helper 17 (Th17) cell subset, which produces IL-17A, IL-17F, IL-22 and IL-21, has been implicated in the pathogenesis of primary Sjögren’s syndrome…
ACR Meeting Abstracts