Abstract Number: 1521 • 2012 ACR/ARHP Annual Meeting
A Possible Contribution of Decreased Cathepsin V Expression to the Development of Dermal Fibrosis, Proliferative Vasculopathy, and Altered Keratinocyte Phenotype in Systemic Sclerosis
Background/Purpose: Cathepsin V (CTSV) is a proteolytic enzyme potentially modulating angiogenic processes, collagen degradation, and keratinocyte differentiation. Although our latest paper demonstrated that cathepsin B,…Abstract Number: 1522 • 2012 ACR/ARHP Annual Meeting
Differential Response to Endoplasmic Reticulum Stress Between Alveolar Epithelial Cells and Lung Fibroblasts in Systemic Sclerosis
Background/Purpose: Interstitial lung disease is a prevalent and worrisome complication of systemic sclerosis (SSc), which is now the leading cause of death in SSc. There…Abstract Number: 1523 • 2012 ACR/ARHP Annual Meeting
Systemic Vasculitis and Pregnancy: a Multicenter Study On Maternal and Neonatal Outcome of 43 Prospectively Followed Pregnancies
Background/Purpose: Systemic Vasculitis (SV) are rare diseases that may affect females during childbearing age. Quite a few data are available in literature, and mostly from…Abstract Number: 1524 • 2012 ACR/ARHP Annual Meeting
The Use of the International Classification of Function, Disability and Health As a Conceptual Framework for Comparison of the Content of Core Outcome Instruments with the Patient Perspective in Vasculitis
Background/Purpose: The International Classification of Functioning, Disability and Health (ICF) is a general health model endorsed by the World Health Organization. It describes health along…Abstract Number: 1525 • 2012 ACR/ARHP Annual Meeting
Determinants of Poor Quality of Life in ANCA Associated Vasculitis (AAV)
Determinants of Poor Quality of Life in ANCA Associated Vasculitis (AAV) Background/Purpose : Patients with ANCA associated vasculitis (AAV) report significantly reduced quality of life (QOL),…Abstract Number: 1526 • 2012 ACR/ARHP Annual Meeting
Patient Reported Outcomes in ANCA-Associated Vasculitis. A Prospective Comparison Between Birmingham Vasculitis Activity Score and Routine Assessment of Patient Index Data 3
Background/Purpose: ANCA-associated vasculitis (AAV) is a rare group of diseases comprising Granulomatosis with polyangiitis (Wegener’s; GPA), Microscopic Polyangiitis (MPA), and Churg-Strauss Syndrome (CSS). These diseases…Abstract Number: 1527 • 2012 ACR/ARHP Annual Meeting
Patient Global Assessments for Disease Activity Are Predictive of Future Flare in Granulomatosis with Polyangiitis (Wegener’s)
Background/Purpose: In granulomatosis with polyangiitis GPA), disease activity is assessed by physician-based measures. In some other rheumatic diseases, such as rheumatoid arthritis (RA) and ankylosing…Abstract Number: 1528 • 2012 ACR/ARHP Annual Meeting
Assessing Fatigue in Systemic Vasculitis From the Patient’s Perspective
Background/Purpose: Fatigue is considered an important disease burden by patients with vasculitis, yet mechanisms underlying fatigue are poorly understood. Physician-derived measures of vasculitis disease activity…Abstract Number: 1529 • 2012 ACR/ARHP Annual Meeting
Upper Airway Gene Expression Profiling in Granulomatosis with Polyangiitis
Background/Purpose: Nasal disease occurs in the majority of patients with granulomatosis with polyangiitis (Wegener's, GPA) and is often a presenting symptom of the disease. The…Abstract Number: 1530 • 2012 ACR/ARHP Annual Meeting
Plasma Cell Analysis As a Biomarker for Disease Activity in Patients with Granulomatosis with Polyangiitis
Background/Purpose: B cells are thought to play an important role in granulomatosis with polyangiitis (GPA) due to the presence of autoantibodies reacting with specific neutrophil…Abstract Number: 1531 • 2012 ACR/ARHP Annual Meeting
Comparative Proteomic Analysis of Neutrophils Between Microscopic Polyangiitis and Granulomatosis with Polyangiitis
Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which dysfunction of polymorphonuclear cells (PMN) is thought to…Abstract Number: 1532 • 2012 ACR/ARHP Annual Meeting
Serum Angiopoietin-2 Level Reflects the Disease Activity and Renal Function in Antineutrophilic Cytoplasmic Antibody-Associated Vasculitis
Background/Purpose: Angiopoietin-2 (Ang-2) has emerged as a key mediator of endothelial cell activation. Ang-1 and Ang-2 are antagonistic ligands which bind with similar affinity to…Abstract Number: 1533 • 2012 ACR/ARHP Annual Meeting
Increased Circulating FoxP3+ T-Cells in Patients with Granulomatosis with Polyangiitis Are Attributed to an Increase in the Non-Suppressor FoxP3Low CD45RO+ TReg Cell Subpopulation
Background/Purpose: Human FoxP3+T-cells are functionally heterogeneous, and can be classified into three phenotypically distinct subpopulations based on the expression levels of FoxP3 and the memory…Abstract Number: 1534 • 2012 ACR/ARHP Annual Meeting
IgG4 Plasma Cell Infiltration in Granulomatosis with Polyangiitis (formerly Wegener’s) Lung Biopsies
Background/Purpose: Granulomatosis with polyangiitis (GPA) and IgG4-related disease (IgG4-RD) are both immune-mediated conditions that can involve multiple organ systems. In GPA, IgG4-positive plasma cell infiltration…Abstract Number: 1535 • 2012 ACR/ARHP Annual Meeting
Genetic Background of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Japanese Population: Association of STAT4 with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Vasculitis
Background/Purpose: In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), geographic difference in the type of vasculitis is well known. While granulomatosis with polyangiitis (GPA) is the…
ACR Meeting Abstracts