Abstract Number: 1526 • 2012 ACR/ARHP Annual Meeting
Patient Reported Outcomes in ANCA-Associated Vasculitis. A Prospective Comparison Between Birmingham Vasculitis Activity Score and Routine Assessment of Patient Index Data 3
Background/Purpose: ANCA-associated vasculitis (AAV) is a rare group of diseases comprising Granulomatosis with polyangiitis (Wegener’s; GPA), Microscopic Polyangiitis (MPA), and Churg-Strauss Syndrome (CSS). These diseases…Abstract Number: 1527 • 2012 ACR/ARHP Annual Meeting
Patient Global Assessments for Disease Activity Are Predictive of Future Flare in Granulomatosis with Polyangiitis (Wegener’s)
Background/Purpose: In granulomatosis with polyangiitis GPA), disease activity is assessed by physician-based measures. In some other rheumatic diseases, such as rheumatoid arthritis (RA) and ankylosing…Abstract Number: 1528 • 2012 ACR/ARHP Annual Meeting
Assessing Fatigue in Systemic Vasculitis From the Patient’s Perspective
Background/Purpose: Fatigue is considered an important disease burden by patients with vasculitis, yet mechanisms underlying fatigue are poorly understood. Physician-derived measures of vasculitis disease activity…Abstract Number: 1529 • 2012 ACR/ARHP Annual Meeting
Upper Airway Gene Expression Profiling in Granulomatosis with Polyangiitis
Background/Purpose: Nasal disease occurs in the majority of patients with granulomatosis with polyangiitis (Wegener's, GPA) and is often a presenting symptom of the disease. The…Abstract Number: 1530 • 2012 ACR/ARHP Annual Meeting
Plasma Cell Analysis As a Biomarker for Disease Activity in Patients with Granulomatosis with Polyangiitis
Background/Purpose: B cells are thought to play an important role in granulomatosis with polyangiitis (GPA) due to the presence of autoantibodies reacting with specific neutrophil…Abstract Number: 1531 • 2012 ACR/ARHP Annual Meeting
Comparative Proteomic Analysis of Neutrophils Between Microscopic Polyangiitis and Granulomatosis with Polyangiitis
Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which dysfunction of polymorphonuclear cells (PMN) is thought to…Abstract Number: 1532 • 2012 ACR/ARHP Annual Meeting
Serum Angiopoietin-2 Level Reflects the Disease Activity and Renal Function in Antineutrophilic Cytoplasmic Antibody-Associated Vasculitis
Background/Purpose: Angiopoietin-2 (Ang-2) has emerged as a key mediator of endothelial cell activation. Ang-1 and Ang-2 are antagonistic ligands which bind with similar affinity to…Abstract Number: 1533 • 2012 ACR/ARHP Annual Meeting
Increased Circulating FoxP3+ T-Cells in Patients with Granulomatosis with Polyangiitis Are Attributed to an Increase in the Non-Suppressor FoxP3Low CD45RO+ TReg Cell Subpopulation
Background/Purpose: Human FoxP3+T-cells are functionally heterogeneous, and can be classified into three phenotypically distinct subpopulations based on the expression levels of FoxP3 and the memory…Abstract Number: 1534 • 2012 ACR/ARHP Annual Meeting
IgG4 Plasma Cell Infiltration in Granulomatosis with Polyangiitis (formerly Wegener’s) Lung Biopsies
Background/Purpose: Granulomatosis with polyangiitis (GPA) and IgG4-related disease (IgG4-RD) are both immune-mediated conditions that can involve multiple organ systems. In GPA, IgG4-positive plasma cell infiltration…Abstract Number: 1535 • 2012 ACR/ARHP Annual Meeting
Genetic Background of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Japanese Population: Association of STAT4 with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Vasculitis
Background/Purpose: In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), geographic difference in the type of vasculitis is well known. While granulomatosis with polyangiitis (GPA) is the…Abstract Number: 1536 • 2012 ACR/ARHP Annual Meeting
Clinical Features of Patients with Anti-Neutrophil Cytoplasmic Autoantibodies Targeting Native Myeloperoxidase Antigen
Background/Purpose: ANCA is a useful diagnostic marker in systemic vasculitic disorders with small-vessel involvement, but depending on the particular test used the myeloperoxidase (MPO)-ANCA results…Abstract Number: 1497 • 2012 ACR/ARHP Annual Meeting
Activation of Sirt1 Attenuates Bleomycin Induced Scleroderma Through Inhibiting Mammalian Target of Rapamycin Activation
Background/Purpose: Scleroderma is an autoimmune disease, characterized by progressive fibrosis of skin and internal organs. Inflammation is one of the main manifestations of scleroderma, especially…Abstract Number: 1498 • 2012 ACR/ARHP Annual Meeting
Wisp-1 Neutralization Reduces Gvhd-Induced Skin Fibrosis by Altering TSLP-OX40L Axis-Dependent Th2 Responses
Background/Purpose: There is accumulating evidence for a role of Wnt-signaling pathway activation in connective tissue disorders, including dermal and lung fibrosis. In particular, expression of…Abstract Number: 1499 • 2012 ACR/ARHP Annual Meeting
The Soluble Guanylate Cyclase Mediates Its Anti-Fibrotic Effects by Inhibiting TGF-β Signaling
Background/Purpose: We have recently demonstrated that stimulation of the soluble guanylate cyclase (sGC) has potent anti-fibrotic activity in different models of fibrosis. sGC stimulation increases…Abstract Number: 1500 • 2012 ACR/ARHP Annual Meeting
Activation of Pregnane X Receptor Induces Regression of Experimental Dermal Fibrosis
Background/Purpose: Pregnane-X-receptor (PXR) belongs to a superfamily of nuclear receptors that function as ligand-activated transcriptional factors. Although endogenous ligands have not yet been identified, PXR…