Abstracts Archive - Page 2319 of 2425 - ACR Meeting Abstracts

Abstract Number: 1546 • 2012 ACR/ARHP Annual Meeting
Rhinosinusits and Nasal Polyps in the Diagnosis and Follow up of Patients with Eosinophilic Granulomatosis with Polyangitis (ex-Churg Strauss Syndrome)
Chiara Baldini¹, Veronica Seccia², Manuela Latorre³, Paolo Iannicelli², Daniela Martini¹, Francesco Ferro¹, Nicoletta Luciano¹, Antonio Tavoni⁴, Stefano Sellari Franceschini² and Stefano Bombardieri⁵, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Unit of Otorhinolaryngology, Department of Neuroscience, University of Pisa, Pisa, Italy, Pisa, Italy, ³University of Pisa, Pneumology Unit, Pisa, Italy, ⁴University of Pisa, Immunoallergology Unit, Pisa, Italy, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Chronic rhinosinusitis with nasal polyposis (CRSwP) is a common manifestation of granulomatosis with polyangitis (EGPA), and may represent an invalidating feature of the disease,…
Abstract Number: 1547 • 2012 ACR/ARHP Annual Meeting
A 4 Plus 2 Infusion Protocol of Rituximab Provides Long-Term Beneficial Effects in Patients with HCV-Associated Mixed Cryoglobulinemia with Membranoproliferative Nephritis and Severe Polyneuropathy
Dario Roccatello¹, Savino Sciascia², Simone Baldovino³ and Daniela Rossi¹, ¹Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, ²Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, ³Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Torino, Italy
Background/Purpose: Mixed cryoglobulinemia syndrome (MCs) is a systemic vasculitis characterized by multiple organ involvement due to the vascular deposition of immune-complexes, mainly the cryoglobulins. B…
Abstract Number: 1548 • 2012 ACR/ARHP Annual Meeting
Cutaneous Vasculitis as a Paraneoplastic Syndrome
Javier Loricera¹, Vanesa Calvo-Rio², Francisco Ortiz Sanjuan³, Marcos Antonio Gonzalez-Lopez⁴, Hector Fernandez-Llaca⁴, Javier Rueda-Gotor², Carmen Gonzalez-Vela⁵, Cristina Mata-Arnaiz³, Miguel A. Gonzalez-Gay² and Ricardo Blanco², ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ³Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁴Dermatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁵Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose: Cutaneous Leukocytoclastic Vasculitis (CLV) may be associated with malignancies, and sometimes it behaves as a paraneoplastic syndrome. This association has been reported in a…
Abstract Number: 1549 • 2012 ACR/ARHP Annual Meeting
Sibling Relative Risk and Heritability of Kawasaki Disease: A Nationwide Population Study in Taiwan
I-Jun Chou¹, Chang-Fu Kuo², Jing-Long Huang³, Chang-Teng Wu¹, Shao-Hsuan Hsia¹ and Hsiao-Chun Chang⁴, ¹Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ³Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁴Division of Rheumatology, Immunology and Allergy, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Background/Purpose: Kawasaki disease (KD) is an autoimmune disease involving primarily medium-sized vessels and is the leading cause of acquired cardiac disease in children. The pathogenesis…
Abstract Number: 1550 • 2012 ACR/ARHP Annual Meeting
Long-Term Outcomes of Patients with Reversible Cerebral Vasoconstriction Syndromes (RCVS)
Seby John¹, Leonard H. Calabrese², Stewart Tepper³, Mark Stillman³, Ken Uchino¹ and Rula Hajj-Ali³, ¹Neurology, Cleveland Clinic Foundation, Cleveland, OH, ²Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: RCVS is a syndrome characterized by acute onset of severe headaches, with or without neurologic deficit with evidence of reversible cerebral vasoconstriction. Natural history…
Abstract Number: 1551 • 2012 ACR/ARHP Annual Meeting
Primary Angiitis of the Central Nervous System: Description of the First 52 Adult Patients Enrolled in the French COVAC’ Cohort
Hubert de Boysson¹, Mathieu Zuber², Olivier Naggara³, Jean-Philippe Neau⁴, Françoise Gray⁵, Marie-Germaine Bousser⁶, Isabelle Crassard⁶, Emmanuel Touze⁷, Pierre-Olivier Couraud⁸, Philippe Kerschen⁹, Catherine Oppenheim³, Olivier Detante¹⁰, Anthony Faivre¹¹, Nicolas Gaillard¹², Caroline Arquizan¹³, Boris Bienvenu¹⁴, Antoine Neel¹⁵, Loic Guillevin¹⁶, Christian Pagnoux¹⁷ and French Vasculitis Study Group and NeuroVascular Society¹⁸, ¹Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, ²Department of Neurology, Groupe Hospitalier Saint-Joseph, Université Paris Descartes, Paris, France, ³Department of Neuroradiology, Hôpital Sainte-Anne, Paris, France, ⁴Department of Neurology, Centre Hospitalier Universitaire La Milétrie, Poitiers, France, ⁵Department of Pathology, APHP Hôpital Lariboisière, Université Paris Diderot, Paris, France, ⁶Department of Neurology, APHP Hôpital Lariboisière, Université Paris Diderot, Paris, France, ⁷Department of Neurology, Hôpital Sainte-Anne, Université Paris Descartes, Paris, France, ⁸Department of Cellular Biology, Institut Cochin, Paris, France, ⁹Department of Neurology, Centre Hospitalier Universitaire Henri Mondor, Créteil, France, ¹⁰Department of Neurology, Centre Hospitalier Universitaire de Grenoble, Grenoble, France, ¹¹Department of Neurology, Hôpital d'Instruction des Armées Saint-Anne, Toulon, France, ¹²Department of Neurology, Centre Hospitalier de Perpignan, Perpignan, France, ¹³Department of Neurology, Hôpital Gui de Chauliac, Université Montpellier, Montpellier, France, ¹⁴Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, ¹⁵Department of Internal Medicine, Centre Hospitalier Universitaire de Nantes, Nantes, France, ¹⁶Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, ¹⁷Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, ¹⁸Paris, France
Background/Purpose: Primary angiitis of the central nervous system (PACNS) is rare and only 1 pediatric and 1 adult large cohorts including >30 PACNS patients have…
Abstract Number: 1552 • 2012 ACR/ARHP Annual Meeting
Clinical Correlates, Treatment Outcomes and Predictors of Vasculitis Associated with Rheumatoid Arthritis in the ‘Biologic Era’ : A Case-Control Study
Ashima Makol¹, Cynthia S. Crowson², Eric L. Matteson³ and Kenneth J. Warrington¹, ¹Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: 1.To determine the clinical presentation, treatment and outcomes of vasculitis (RV) associated with rheumatoid arthritis (RA) in the era of biologic use. 2. To…
Abstract Number: 1553 • 2012 ACR/ARHP Annual Meeting
The Effect of Knee Replacement On Participation Outcomes: The Multicenter Osteoarthritis Study and Osteoarthritis Initiative
Jessica L. Maxwell¹, Jingbo Niu², Julie J. Keysor³, Tuhina Neogi⁴, Tianzhong Yang⁵, Michael C. Nevitt⁶, Jasvinder A. Singh⁷, Laura Frey-Law⁸ and David T. Felson⁹, ¹Physical Therapy & Athletic Training, Boston Univ Sargent College, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Physical Therapy, Boston University Sargent College, Boston, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ⁶Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁷Department of Medicine, University of Alabama, Tuscaloosa, AL, ⁸University of Iowa, Iowa City, IA, ⁹Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Little research has explored participation outcomes, defined as involvement in life situations, among persons following knee replacement (KR). We recently reported (OARSI 2012) that…
Abstract Number: 1554 • 2012 ACR/ARHP Annual Meeting
Clusters of Fatigue- a Comparison Between Persons with Systemic Lupus Erythematosus and Age and Gender Matched Controls
Susanne Pettersson¹, Karin Eriksson², Carina Boström², Elisabet Svenungsson¹, Iva Gunnarsson¹ and Elisabet MB Welin Henriksson³, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Department of Neurobiology, Care Sciences and Society,, Division of Physiotherapy, Karolinska Institutet Huddinge, Stockholm, Sweden, ³Medicine, Karolinska Institutet Rheum, Stockholm, Sweden
Background/Purpose: The aim (1) of this study was to explore fatigue in patients with SLE with age and gender match controls using cluster analysis and…
Abstract Number: 1555 • 2012 ACR/ARHP Annual Meeting
Minimal Clinically Important Difference for Seven Measures of Fatigue in Patients with Systemic Lupus Erythematosus – Results From a Swedish Setting
Susanne Pettersson¹, Ingrid E. Lundberg² and Elisabet MB Welin Henriksson³, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ³Medicine, Karolinska Institutet Rheum, Stockholm, Sweden
Background/Purpose: The objective of this study was to estimate the minimal clinically important difference (MCID) of seven self-administered measures assessing fatigue in persons with systemic…
Abstract Number: 1556 • 2012 ACR/ARHP Annual Meeting
The Effect of Ginger Therapy On Symptoms of Osteoarthritis: An Open Pilot Study
Tessa Therkleson, Nursing, Edith Cowan University, Perth, Australia
Background/Purpose: Osteoarthritis (OA) is a painful, progressive disease of synovial joints characterised by deterioration of cartilage and bone and inflammation. Osteoarthritis of the knee and…
Abstract Number: 1517 • 2012 ACR/ARHP Annual Meeting
TLR9 Signaling in Fibroblasts Promotes Pro-Fibrotic Responses Via TGF-Beta
Yang Yang¹, Feng Fang², Lei Liu¹, Junjie Shangguan³, Boping Ye¹ and John Varga³, ¹School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Division of Rheumatology, Northwestern University, Chicago, IL
Background/Purpose: Systemic sclerosis (SSc) is associated with progressive fibrosis and transforming growth factor β (TGF-β) is implicated in its pathogenesis. Toll-like receptors (TLR) respond to…
Abstract Number: 1518 • 2012 ACR/ARHP Annual Meeting
Damage-Associated Endogenous TLR4 Ligand Fibronectin-EDA Is Overexpressed in Scleroderma and Drives Persistent Fibrosis Via TLR4 and Inhibition of TLR4 Prevents and Reverses Experimental Dermal Fibrosis: Novel Target for Scleroderma Therapy
Swati Bhattacharyya¹, Zenshiro Tamaki², Wenxia Wang³, Paul Hoover⁴, Adam Booth⁵, Alyssa Dreffs⁶, Monique E. Hinchcliff⁷, Feng Fang⁸, Spiro Getsios⁴, Hang Yin⁹, Eric S. White⁶ and John Varga¹⁰, ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Rheumatology, Northwestern Univ Med School, Chicago, IL, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Ann Arbor, MI, ⁶Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁷Division of Rheumatology, Northwestern Univ Med School, Chicago, IL, ⁸Rheumatology Division, Northwestern University, Chicago, IL, ⁹University of Colorado at Boulder, Boulder, CO, ¹⁰Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Recent studies implicate innate immune signaling and Toll like receptor-4 (TLR4) in fibrogenesis. We hypothesized that injury in scleroderma leads to tissue accumulation of…
Abstract Number: 1519 • 2012 ACR/ARHP Annual Meeting
Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud’s Phenomenon
Satoshi Serada¹, Minoru Fujimoto² and Tetsuji Naka², ¹Laboratory for immune signal, National Institute of Biomedical Innovation, Laboratory for immune signal, Japan, Ibaraki, Japan, ²Laboratory for immune signal, National Institute of Biomedical Innovation, Ibaraki, Japan
Background/Purpose: Raynaud’s phenomenon (RP) is a vasospastic disorder and shows discoloration of the fingers, toes, and occasionally other areas. RP affects 3-9% of the general…
Abstract Number: 1520 • 2012 ACR/ARHP Annual Meeting
Role of 12/15-Lipoxygenase(LOX) in Patients with Systemic Sclerosis
Hirahito Endo, Makoto Kabraki, Koutarou Shikano, Sei Muraoka, Nahoko Tanaka, Tatsuhiro Yamamoto, Kanako Kitahara, Kaichi Kaneko, Yoshie Kusunoki, Natsuko Kusunoki, Kenji Takagi, Tomoko Hasunuma and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Recently 12/15-lipoxygenase (LOX) and it’s metabolites have a prominent anti-fibrotic role during dermal fibrosis in scleroderma experimental model using 12/15-LOX deficient mice were reported…

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