Abstract Number: 1551 • 2012 ACR/ARHP Annual Meeting
Primary Angiitis of the Central Nervous System: Description of the First 52 Adult Patients Enrolled in the French COVAC’ Cohort
Background/Purpose: Primary angiitis of the central nervous system (PACNS) is rare and only 1 pediatric and 1 adult large cohorts including >30 PACNS patients have…Abstract Number: 1552 • 2012 ACR/ARHP Annual Meeting
Clinical Correlates, Treatment Outcomes and Predictors of Vasculitis Associated with Rheumatoid Arthritis in the ‘Biologic Era’ : A Case-Control Study
Background/Purpose: 1.To determine the clinical presentation, treatment and outcomes of vasculitis (RV) associated with rheumatoid arthritis (RA) in the era of biologic use. 2. To…Abstract Number: 1553 • 2012 ACR/ARHP Annual Meeting
The Effect of Knee Replacement On Participation Outcomes: The Multicenter Osteoarthritis Study and Osteoarthritis Initiative
Background/Purpose: Little research has explored participation outcomes, defined as involvement in life situations, among persons following knee replacement (KR). We recently reported (OARSI 2012) that…Abstract Number: 1554 • 2012 ACR/ARHP Annual Meeting
Clusters of Fatigue- a Comparison Between Persons with Systemic Lupus Erythematosus and Age and Gender Matched Controls
Background/Purpose: The aim (1) of this study was to explore fatigue in patients with SLE with age and gender match controls using cluster analysis and…Abstract Number: 1555 • 2012 ACR/ARHP Annual Meeting
Minimal Clinically Important Difference for Seven Measures of Fatigue in Patients with Systemic Lupus Erythematosus – Results From a Swedish Setting
Background/Purpose: The objective of this study was to estimate the minimal clinically important difference (MCID) of seven self-administered measures assessing fatigue in persons with systemic…Abstract Number: 1556 • 2012 ACR/ARHP Annual Meeting
The Effect of Ginger Therapy On Symptoms of Osteoarthritis: An Open Pilot Study
Background/Purpose: Osteoarthritis (OA) is a painful, progressive disease of synovial joints characterised by deterioration of cartilage and bone and inflammation. Osteoarthritis of the knee and…Abstract Number: 1517 • 2012 ACR/ARHP Annual Meeting
TLR9 Signaling in Fibroblasts Promotes Pro-Fibrotic Responses Via TGF-Beta
Background/Purpose: Systemic sclerosis (SSc) is associated with progressive fibrosis and transforming growth factor β (TGF-β) is implicated in its pathogenesis. Toll-like receptors (TLR) respond to…Abstract Number: 1518 • 2012 ACR/ARHP Annual Meeting
Damage-Associated Endogenous TLR4 Ligand Fibronectin-EDA Is Overexpressed in Scleroderma and Drives Persistent Fibrosis Via TLR4 and Inhibition of TLR4 Prevents and Reverses Experimental Dermal Fibrosis: Novel Target for Scleroderma Therapy
Background/Purpose: Recent studies implicate innate immune signaling and Toll like receptor-4 (TLR4) in fibrogenesis. We hypothesized that injury in scleroderma leads to tissue accumulation of…Abstract Number: 1519 • 2012 ACR/ARHP Annual Meeting
Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud’s Phenomenon
Background/Purpose: Raynaud’s phenomenon (RP) is a vasospastic disorder and shows discoloration of the fingers, toes, and occasionally other areas. RP affects 3-9% of the general…Abstract Number: 1520 • 2012 ACR/ARHP Annual Meeting
Role of 12/15-Lipoxygenase(LOX) in Patients with Systemic Sclerosis
Background/Purpose: Recently 12/15-lipoxygenase (LOX) and it’s metabolites have a prominent anti-fibrotic role during dermal fibrosis in scleroderma experimental model using 12/15-LOX deficient mice were reported…Abstract Number: 1521 • 2012 ACR/ARHP Annual Meeting
A Possible Contribution of Decreased Cathepsin V Expression to the Development of Dermal Fibrosis, Proliferative Vasculopathy, and Altered Keratinocyte Phenotype in Systemic Sclerosis
Background/Purpose: Cathepsin V (CTSV) is a proteolytic enzyme potentially modulating angiogenic processes, collagen degradation, and keratinocyte differentiation. Although our latest paper demonstrated that cathepsin B,…Abstract Number: 1522 • 2012 ACR/ARHP Annual Meeting
Differential Response to Endoplasmic Reticulum Stress Between Alveolar Epithelial Cells and Lung Fibroblasts in Systemic Sclerosis
Background/Purpose: Interstitial lung disease is a prevalent and worrisome complication of systemic sclerosis (SSc), which is now the leading cause of death in SSc. There…Abstract Number: 1523 • 2012 ACR/ARHP Annual Meeting
Systemic Vasculitis and Pregnancy: a Multicenter Study On Maternal and Neonatal Outcome of 43 Prospectively Followed Pregnancies
Background/Purpose: Systemic Vasculitis (SV) are rare diseases that may affect females during childbearing age. Quite a few data are available in literature, and mostly from…Abstract Number: 1524 • 2012 ACR/ARHP Annual Meeting
The Use of the International Classification of Function, Disability and Health As a Conceptual Framework for Comparison of the Content of Core Outcome Instruments with the Patient Perspective in Vasculitis
Background/Purpose: The International Classification of Functioning, Disability and Health (ICF) is a general health model endorsed by the World Health Organization. It describes health along…Abstract Number: 1525 • 2012 ACR/ARHP Annual Meeting
Determinants of Poor Quality of Life in ANCA Associated Vasculitis (AAV)
Determinants of Poor Quality of Life in ANCA Associated Vasculitis (AAV) Background/Purpose : Patients with ANCA associated vasculitis (AAV) report significantly reduced quality of life (QOL),…