Abstracts Archive - Page 2318 of 2607 - ACR Meeting Abstracts

Abstract Number: 1746 • 2013 ACR/ARHP Annual Meeting
Pericardial Effusions Are Not a Poor Prognostic Factor In Systemic Sclerosis Patients With Pulmonary Hypertension
Elana J. Bernstein¹, Jessica K. Gordon², Wei-Ti Huang³ and Virginia D. Steen⁴, ¹Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Biostatistics, Hospital for Special Surgery, New York, NY, ⁴Department of Rheumatology, Georgetown University Medical Center, Washington, DC
Background/Purpose: Pulmonary hypertension (PH) (defined as a mean pulmonary arterial pressure ≥ 25 mmHg on right heart catheterization) is a leading cause of death in…
Abstract Number: 1747 • 2013 ACR/ARHP Annual Meeting
Plasma MCP-1 and IL-10 Levels Predict Long-Term Progression Of Interstitial Lung Disease In Patients With Early Systemic Sclerosis
Minghua Wu¹, Claudia Pedroza², Gloria Salazar¹, Xiaodong Zhou¹, John D. Reveille¹, Maureen D. Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: The currently available clinical markers are not reliable predictors of long-term progression of systemic sclerosis (SSc) related interstitial lung disease (ILD). SSc patients have…
Abstract Number: 1714 • 2013 ACR/ARHP Annual Meeting
Grey-Scale and Power Doppler Findings Of Lower Extremity Entheses In Healthy Children
Clara Lin¹ and Diana Milojevic², ¹Pediatric Rheumatology, University of California-San Francisco, San Francisco, CA, ²Dept of Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: The aim of our study is to describe the grey-scale and Power Doppler findings in lower extremity entheses in healthy children ages 5-18 years.…
Abstract Number: 1723 • 2013 ACR/ARHP Annual Meeting
Lesinurad, An Inhibitor Of The Uric Acid Transporter URAT1 and a Potential Therapy For Gout, Requires URAT1 Phenylalanine 365 For High Affinity Inhibition
Philip K. Tan, David Hyndman and Jeffrey N. Miner, Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: Gout is caused by a lack of efficient excretion of uric acid, resulting in hyperuricemia and the formation of crystal deposits of uric acid. …
Abstract Number: 1706 • 2013 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Variation Associated With Ankylosing Spondylitis Susceptibility
Adrian Cortes¹, International Genetics of Ankylosing Spondylitis Consortium (IGAS)², Paul de Bakker³ and Matthew A. Brown⁴, ¹Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ²University of Queensland Diamantina Institute, brisbane, Australia, ³Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ⁴University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis. Thus far, 27 susceptibility loci have been identified in and outside the MHC in…
Abstract Number: 1707 • 2013 ACR/ARHP Annual Meeting
Biological Insights From Genetics Of Rheumatoid Arthritis Contribute To Drug Discovery
Yukinori Okada^1,2,3, Di Wu^2,4,5,6, Chikashi Terao^7,8, Katsunori Ikari⁹, Yuta Kochi¹⁰, Koichiro Ohmura¹¹, Akari Suzuki¹⁰, Hisashi Yamanaka⁹, Joshua C. Denny¹², Jeffrey D. Greenberg¹³, Robert R. Graham¹⁴, Matthew A. Brown¹⁵, Sang-Cheol Bae¹⁶, Jane Worthington¹⁷, Leonid Padyukov¹⁸, Lars Klareskog¹⁹, Peter K. Gregersen²⁰, Peter M. Visscher^21,22, Katherine A. Siminovitch^23,24 and Robert M. Plenge²⁵, ¹Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Broad Institute, Cambridge, MA, ⁴Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁵Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, ⁶Department of Statistics, Harvard University, Cambridge, MA, ⁷Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ⁸Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ¹⁰Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ¹¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ¹²Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, ¹³Rheumatology, NYU Hospital for Joint Diseases, New York, NY, ¹⁴ITGR Human Genetics, Genentech, Inc., South San Francisco, CA, ¹⁵Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ¹⁶Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ¹⁷Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ¹⁸Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ¹⁹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²⁰Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²¹The University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia, ²²Queensland Brain Institute, The University of Queensland, St Lucia, Brisbane, Australia, ²³Mount Sinai Hospital, Toronto, ON, Canada, ²⁴University of Toronto, Toronto, ON, Canada, ²⁵Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological datasets to provide…
Abstract Number: 1708 • 2013 ACR/ARHP Annual Meeting
Can People With Rheumatoid Arthritis Self Monitor Their Disease Activity?
Noura AL Osaimi¹, Erin Carruthers², Charles H Goldsmith^3,4, Paul M Adam⁵ and Diane Lacaille^1,6, ¹Medicine, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Richmond, BC, Canada, ³Biostatistics, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Health Sciences, Simon Fraser University, Burnaby, BC, Canada, ⁵Rheumatology Liaison, Mary Pack Arthritis Centre, Vancouver, BC, Canada, ⁶Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada
Background/Purpose: In rheumatoid arthritis (RA) the target for treatment is clinical remission or minimal disease activity. Active involvement of patients in monitoring their own disease…
Abstract Number: 1709 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patient Cardiovascular Disease Prevention Experiences: Qualitative Analysis and Implications
Christie M. Bartels¹, Sarah Tweddell², Barbara Bowers³, Elizabeth Jacobs⁴ and Tonya Roberts³, ¹Rheumatology/Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²UW School of Medicine and Public Health, Madison, WI, ³UW School of Nursing, Madison, WI, ⁴Internal Medicine, UW School of Medicine and Public Health, Madison, WI
Background/Purpose: Although rheumatoid arthritis (RA) increases cardiovascular disease (CVD) risk, RA patients receive less CVD preventive care than peers. We previously showed gaps in lipid…
Abstract Number: 1711 • 2013 ACR/ARHP Annual Meeting
Folic Acid Prescription Among Older Adult Methotrexate Initiators Is Poor
Gabriela Schmajuk¹, Jinoos Yazdany², Yinghui Miao³, David I. Daikh⁴ and Michael Steinman³, ¹Rheumatology, UCSF / San Francisco VA Medical Center, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Division of Geriatrics, UCSF, San Francisco Veterans Affairs Medical Center, San Francisco, CA, ⁴Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Methotrexate (MTX) is the most commonly used disease modifying agent for rheumatoid arthritis (RA), although liver enzyme (LFT) elevations limit its use in some…
Abstract Number: 1712 • 2013 ACR/ARHP Annual Meeting
Identification Of Factors Associated With Agreement Between Rheumatoid Arthritis Electronic Medication Lists and Prescribed Disease Modifying Treatment Plans
Ilinca D. Metes¹, Heather Eng², June Feng², G.K. Balasubramani³, Stephen R. Wisniewski³ and Marc C. Levesque⁴, ¹Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ³Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁴Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Federal government programs incentivize the use of Electronic Health Records (EHR) including accurate medication lists. The accuracy of a patient’s EHR medication list is…
Abstract Number: 1713 • 2013 ACR/ARHP Annual Meeting
Disparity In Biologic Therapy In Ethnic Minorities With Rheumatoid Arthritis: Can It All Be Due To Lack Of Access To Drug?
Gail S. Kerr¹, Ted R. Mikuls², Christopher J. Swearingen³, Chunqiao Luo⁴ and Yusuf Yazici⁵, ¹Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³Pediatric Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, ⁴Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, ⁵Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Ethnic disparities in the administration of DMARDs exist, but the impact of differing health care systems on access in ethnic minorities treated by rheumatologists,…
Abstract Number: 1715 • 2013 ACR/ARHP Annual Meeting
Detection Of Enthesitis In Children With Enthesitis-Related Arthritis: Dolorimeter Examination Compared To Ultrasonography
Pamela F. Weiss¹, Nancy Chauvin², Andrew J. Klink³, Russell A. Localio⁴, Chris Feudtner⁵, Diego Jaramillo², Robert A. Colbert⁶, David D. Sherry⁷ and Ron Keren³, ¹Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Radiology, Children's Hospital of Philadelphia, PHILADELPHIA, PA, ³Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁵Division of General Pediatrics, Children's Hospital of Philadelphia; University of Pennsylvania Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA, ⁶NIAMS/NIH, Bethesda, MD, ⁷Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: To evaluate the distribution of enthesitis and accuracy of physical examination (PE) for the detection of enthesitis in children, using ultrasound with power Doppler…
Abstract Number: 1716 • 2013 ACR/ARHP Annual Meeting
Childhood-Onset Systemic Lupus Erythematosus With Clinical Neurocognitive Dysfunction Have Lower Nodal Density and Connectivity On Diffusion Tensor Imaging
Jordan T. Jones¹, Mark DiFrancesco², Ahmad I. Zaal¹, Marisa S. Klein-Gitelman³, Darren Gitelman⁴, Jun Ying⁵ and Hermine Brunner¹, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Division of Rheumatology, Children's Memorial Hospital, Chicago, IL, ⁴Neurology, Northwestern University, Chicago, IL, ⁵Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH
Background/Purpose: Neurocognitive dysfunction (NCD) is common in childhood-onset systemic lupus erythematosus (cSLE), and often difficult to detect with current resources. Diffusion tensor imaging (DTI) is…
Abstract Number: 1717 • 2013 ACR/ARHP Annual Meeting
Do Bone Marrow Edema (BME) Lesions In The Sacroiliac Joint (SIJ) Change Into Fatty Lesions Over a 3-Month Period In Patients With Axial Spondyloarthritis (axSpA)?
Manouk de Hooge¹, Rosaline van den Berg², Victoria Navarro-Compán², Monique Reijnierse³, Floris van Gaalen², Karen Fagerli⁴, Robert Landewé⁵, Maikel van Oosterhout⁶, Roberta Ramonda⁷, Tom Huizinga² and Désiréé van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Int Med/Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ⁶Rheumatology, GHZ Hospital, Gouda, Netherlands, ⁷Rheumatology Unit, University of Padova, Padova, Italy
Background/Purpose: BME lesions may change into fatty lesions in the SIJ over time. In one study significant changes of fatty lesions in the SI joints…
Abstract Number: 1718 • 2013 ACR/ARHP Annual Meeting
Reading Of The Sacroiliac Joints On Plain Radiographs: Agreement Between Clinical Practice and Trained Central Reading Of The DESIR-Cohort
Rosaline van den Berg¹, Grégory Lenczner², Antoine Feydy³, Désirée van der Heijde¹, Monique Reijnierse⁴, Alain Saraux⁵ and Pascal Claudepierre⁶, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Henri Mondor Teaching Hospital, AP-HP, Créteil, France, ³Radiology B, Paris Descartes University, Côchin Hospital, APHP, Paris, France, ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France, ⁶Rheumatology, Henri Mondor Teaching Hospital, AP-HP, Créteil, France
Background/Purpose: In daily practice, radiologists/rheumatologist judge sacroiliac (SI) joints on X-rays (X-SI). However, reliable identification of radiographic sacroiliitis is difficult. Consequently, large inter- and intra-observer…

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