Abstracts Archive - Page 2315 of 2425 - ACR Meeting Abstracts

Abstract Number: 1606 • 2012 ACR/ARHP Annual Meeting
Identifying a Link Between Uranium Exposure and Systemic Lupus Erythematosus in a Community Living near a Uranium Plant
Pai-Yue Lu¹, Leah C. Kottyan², Susan M. Pinney³, Judith A. James⁴, Changchun Xie³, Jeanette M. Buckholz³ and John B. Harley⁵, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Environmental Health, University of Cincinnati, Cincinnati, OH, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Effects of environmental exposures on the development of systemic lupus erythematosus (SLE) are potentially important and relatively unexplored in SLE pathogenesis. An excess of…
Abstract Number: 1607 • 2012 ACR/ARHP Annual Meeting
The Association Between Thyroxin Substitution and Rheumatoid Arthritis; Results From the Swedish EIRA Study
Camilla Bengtsson¹, Henrik Källberg¹, Leonid Padyukov² and Saedis Saevarsdottir³, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Hypothyroidism is usually of autoimmune nature, in areas with sufficient iodine, and leads to chronic substitution treatment with thyroxin. The disease shares some risk…
Abstract Number: 1608 • 2012 ACR/ARHP Annual Meeting
Overweight and Obesity Increase Risk of Rheumatoid Arthritis in Women in a Large Prospective Study
Bing Lu¹, Chia-Yen Chen², Linda T. Hiraki³, Karen H. Costenbader¹ and Elizabeth W. Karlson⁴, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Epidemiology, Harvard School of Public Health, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Overweight and Obesity Increase Risk of Rheumatoid Arthritis in Women in a Large Prospective StudyBackground/Purpose: Several case-control studies have suggested that overweight and obesity may…
Abstract Number: 1609 • 2012 ACR/ARHP Annual Meeting
Circulating 25-Hydroxyvitamin D Level and Risk of Developing Rheumatoid Arthritis
Linda T. Hiraki¹, Jing Cui², Susan Malspeis³, Karen H. Costenbader³ and Elizabeth W. Karlson⁴, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Vitamin D has demonstrated immunomodulatory properties with potential etiologic implications for autoimmune diseases including rheumatoid arthritis (RA). However, a causal association between decreased vitamin…
Abstract Number: 1610 • 2012 ACR/ARHP Annual Meeting
The DNA Methylation Signature in Fibroblast-Like Synoviocytes (FLS) Defines Critical Pathogenic Pathways in Rheumatoid Arthritis (RA)
David L. Boyle¹, Robert Shoemaker², David W. Anderson³, Wei Wang⁴ and Gary S. Firestein⁵, ¹Div of Rheum, UCSD School of Medicine, La Jolla, CA, ²NexDx, Inc., San Diego, CA, ³Research and Development, NexDx, Inc., San Diego, CA, ⁴Chemistry, UCSD, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: A DNA methylation signature has been characterized that distinguishes RA FLS from osteoarthritis (OA) and normal (NL) FLS. The presence of epigenetic changes in…
Abstract Number: 1611 • 2012 ACR/ARHP Annual Meeting
Targeted Deep Re-Sequencing Implicates Rare and Low Frequency Coding Variants in IL23R, MEFV, TLR4, and NOD2 in Behçet’s Disease
Yohei Kirino¹, Qing Zhou¹, Yoshiaki Ishigatsubo², Nobuhisa Mizuki³, Ilknur Tugal-Tutkun⁴, Emire Seyahi⁵, Yilmaz Ozyazgan⁶, F. Sevgi Sacli⁷, Burak Erer⁸, Zeliha Emrence⁹, Atilla Cakar¹⁰, Duran Ustek¹⁰, Akira Meguro¹¹, Atsuhisa Ueda², Mitsuhiro Takeno², Michael J. Ombrello¹, Colleen Satorius¹², Baishali Maskeri¹³, Jim Mullikin¹³, Hong-Wei Sun¹⁴, Gustavo Gutierrez-Cruz¹⁵, Yoonhee Kim¹⁶, Ahmet Gül¹⁷, Daniel L. Kastner¹² and Elaine F. Remmers¹², ¹Inflammatory Disease Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ³Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁴Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁵Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁶Ophthalmology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁷Division of Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁸Department of Internal Medicine, Rheumatology Division, Istanbul Faculty of Medicine, Istanbul University,, Istanbul, Turkey, ⁹Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey, ¹⁰Genetics, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, ¹¹Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ¹²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ¹³NIH intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Rockville, MD, ¹⁴Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ¹⁵Genome Analysis Core Facility, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ¹⁶Genometrics section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, ¹⁷Department of Internal Medicine, Division of Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Background/Purpose: Genome-wide association studies (GWAS) have successfully identified common variants that contribute to Behçet’s disease (BD) susceptibility. However, associations due to rare and low-frequency variants…
Abstract Number: 1612 • 2012 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Is Associated with Single Nucleotide Polymorphisms in Loci Implicating Four Aminopeptidases
Philip Robinson¹, Adrian Cortes¹, Paul Leo¹, Australian-Anglo-American Spondylitis Consortium (TASC)², Wellcome Trust Case Control Consortium (WTCCC) .³, International Genetics of Ankylosing Spondylosis Consortium (IGAS)⁴, David Evans⁵ and Matthew A. Brown¹, ¹Human Genetics Group, University of Queensland Diamantina Insititute, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, ³Wellcome Trust Case Control Consortium, Wellcome Trust Case Control Consortium, United Kingdom, ⁴IGAS, Igas, Australia, ⁵School of Social and Community Medicine, Bristol University, Bristol, United Kingdom
Background/Purpose: The aim of the study was to examine regions implicated in autoimmune diseases for association with AS. A previous association with AS has been…
Abstract Number: 1613 • 2012 ACR/ARHP Annual Meeting
The SLE-Associated TLR7 Variant Confers Differential Gene Expression Modulated by Microrna-3148
Yun Deng¹, Jian Zhao¹, Daisuke Sakurai¹, Kenneth M. Kaufman², Jeffrey C. Edberg³, Robert P. Kimberly⁴, Diane L. Kamen⁵, Gary S. Gilkeson⁶, Chaim O. Jacob⁷, Robert H. Scofield⁸, Carl D. Langefeld⁹, Jennifer A. Kelly¹⁰, Marta E. Alarcün-Riquelme on behalf of BIOLUPUS and GENLES networks¹¹, John B. Harley², Timothy J. Vyse¹², Barry I. Freedman¹³, Patrick M. Gaffney¹⁴, Kathy Moser Sivils¹⁰, Judith A. James¹⁵, Timothy B. Niewold¹⁶, Rita M. Cantor¹⁷, Weiling Chen¹, Bevra H. Hahn¹⁸, Elizabeth E. Brown on behalf of PROFILE⁴ and Betty P. Tsao¹⁹, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ²Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ⁶Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁸Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ¹⁰Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Centro de Genómica e Investigación Oncológica (GENYO) Pfizer-Universidad de Granada-Junta de Andalucia, Granada, Spain, ¹²Medical & Molecular Genetics, King's College London, London, United Kingdom, ¹³Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ¹⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ¹⁷Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, ¹⁸Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ¹⁹David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA
Background/Purpose: We established an X-linked TLR7 3’UTR SNP (rs3853839) as a risk locus for SLE in 9,274 Eastern Asians (Pcombined = 6.5×10-10). Risk-allele carriers have…
Abstract Number: 1614 • 2012 ACR/ARHP Annual Meeting
Analysis of the Immunochip in a Large Cohort of Juvenile Idiopathic Arthritis Cases Identifies 17 Loci At Genome-Wide Significance
Anne Hinks¹, Joanna Cobb¹, Miranda C. Marion², Marc Sudman³, John Bowes⁴, Kathryn J. A. Steel⁵, Mehdi Keddache⁶, John F. Bohnsack⁷, Stephen Guthery⁸, Lucy R. Wedderburn⁹, Johannes Peter Haas¹⁰, David N. Glass¹¹, Sampath Prahalad¹², Carl D. Langefeld¹³, Wendy Thomson⁵ and Susan D. Thompson³, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, ³Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁶Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Pediatriacs, University of Utah, Salt Lake City, UT, ⁸Pediatrics, University of Utah, Salt Lake City, UT, ⁹Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, ¹⁰German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ¹¹Divison of Rheumatology, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH, ¹²Pediatrics, Emory Children's Center, Atlanta, GA, ¹³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC
Background/Purpose: Genome-wide (GW) association studies have been hugely successful in the identification of susceptibility loci for autoimmune diseases, interestingly many of the loci are shared…
Abstract Number: 1615 • 2012 ACR/ARHP Annual Meeting
Evidence for Distinct Roles of Environmental and Genetic Factors in the Emergence of Anti Citrullinated-Protein Antibodies Positive Rheumatoid Arthritis-an Epidemiological Investigation in Twins
Aase Haj Hensvold¹, Patrik KE Magnusson², Monika Hansson³, Lena Israelsson⁴, Cecilia Carlens¹, Johan Askling⁵, Vivianne Malmström⁶, Lars Klareskog⁷ and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Medical Epidemiology and Biostatistics, Swedish Twin Registry Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
Background/Purpose: The aim of the current study was to investigate the influence of genetic and environmental factors in developing anti citrullianted-proteins antibodies (ACPA) and ACPA…
Abstract Number: 1616 • 2012 ACR/ARHP Annual Meeting
Comparison of Conventional and Wholebody Magnetic Resonance Imaging for Assessing Inflammation and Structural Damage in Psoriatic Arthritis and Axial Spondyloarthritis
René Panduro Poggenborg¹, Susanne Juhl Pedersen², Iris Eshed³, Inge Juul Sørensen⁴, Ole Rintek Madsen⁵, J.M. Møller⁶ and Mikkel Østergaard⁷, ¹Department of Rheumatology, Copenhagen University Hospital in Glostrup, Copenhagen, Denmark, ²Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ³Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel, ⁴Department of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ⁵Department of Rheumatology, Copenhagen University Hospital in Gentofte, Copenhagen, Denmark, ⁶Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, ⁷Copenhagen University Hospital Glostrup, Glostrup, Denmark
Background/Purpose: Wholebody magnetic resonance imaging (WBMRI) is a new imaging modality where patients are scanned from “head to toe” in one single scan, but with…
Abstract Number: 1577 • 2012 ACR/ARHP Annual Meeting
Barriers to Recruit Unaffected Family Members of Patients with Rheumatoid Arthritis
Axel Finckh¹, A. Debost-Legrand², Martin Soubrier³, I. von Muehlenen⁴, I. Creveaux², JJ Dubost³, MH Papon², H. Ayadi⁵, P. Migliorini⁶, E. Petit-Teixeira⁷, F. Cornélis² and Eprac⁸, ¹Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, ²GenHotel-Auvergne, Clermon-Ferrand, France, ³Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, ⁴Rheumatology, Universitäts-Poliklinik, Felix-Platter Spital, Basel, Switzerland, ⁵Sfax university, Sfax, Tunisia, ⁶Pisa university hospital, Pisa, Italy, ⁷GenHotel-Evry-EA3886, Evry, France, ⁸(European pre-RA consortium), Clermont-Ferrand, France
Background/Purpose: Prospective studies are needed to answer key questions on rheumatoid arthritis (RA) screening in at risk populations : (1) How accurately does risk factor…
Abstract Number: 1578 • 2012 ACR/ARHP Annual Meeting
How Disease Activity Trajectories Affect the Willingness to Change Treatment
Paul Falzer¹ and Liana Fraenkel², ¹Medicine, VA Connecticut Healthcare System, New Haven, CT, ²Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT
Background/Purpose: Disease activity (DA) can change markedly over a short period, for a variety of reasons. The changes influence clinical practice and affect the willingness…
Abstract Number: 1579 • 2012 ACR/ARHP Annual Meeting
Why Do We Need to Pilot Interventions? Essential Refinements Identified During Pilots of a Fatigue Intervention
Emma Dures¹, Nicholas Ambler², Debbie Fletcher³, Denise Pope³, Frances Robinson⁴, Royston Rooke⁴ and Sarah Hewlett⁵, ¹University of the West of England, Bristol, United Kingdom, ²Frenchay Hospital, Bristol, United Kingdom, ³University Hospitals Bristol, United Kingdom, ⁴University of Bristol, Bristol, United Kingdom, ⁵Academic Rheumatology, University of the West of England, Bristol, United Kingdom
Background/Purpose: An RCT showed a 6 week group cognitive-behavioural (CB) intervention for RA fatigue self-management was effective, when delivered by a clinical psychologist.1 Few rheumatology…
Abstract Number: 1580 • 2012 ACR/ARHP Annual Meeting
The Relationship Between Perceived Cognitive Dysfunction and Objective Neuropsychological Performance in Persons with Rheumatoid Arthritis
So Young Shin¹, Patricia P. Katz² and Laura J. Julian², ¹Physiological Nursing, University of California San Francisco, San Francisco, CA, ²Medicine, University of California San Francisco, San Francisco, CA
Background/Purpose: There is an increased appreciation of the burden of cognitive impairment in persons with rheumatoid arthritis (RA). Research shows a gap between perceived cognitive…

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