Abstracts Archive - Page 2314 of 2425 - ACR Meeting Abstracts

Abstract Number: 1631 • 2012 ACR/ARHP Annual Meeting
Osteoarthritis-Associated Basic Calcium Phosphate Crystals Induce IL-1β, IL-18 and S100A8 Production in a Tyrosine Kinase Dependent Manner
Geraldine M. McCarthy¹, Evanna Mills², Kingston Mills² and Aisling Dunne², ¹Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intraarticular basic calcium phosphate (BCP) crystals are present in the majority of osteoarthritic (OA) joints and are associated with severe degeneration. In vitro, BCP…
Abstract Number: 1632 • 2012 ACR/ARHP Annual Meeting
Arhalofenate Is a Novel Dual-Acting Agent with Uricosuric and Anti-Inflammatory Properties
Yun-Jung Choi, Vanina Larroca, Annette Lucman, Vic Vicena, Noe Abarca, Tim Rantz, Brian E. Lavan and Charles A. McWherter, Biology, Metabolex, Inc., Hayward, CA
Background/Purpose: In most patients with gout, elevated serum urate is linked to excess uric acid reabsoprtion in the proximal renal tubule by anion transporters/exchangers, including…
Abstract Number: 1633 • 2012 ACR/ARHP Annual Meeting
Ulodesine (BCX4208) Add-On Therapy to Allopurinol 300mg Lowers Hypoxanthine and Xanthine Plasma Levels in a Dose-Dependent Fashion: Results From a 12-Week Randomized Controlled Trial in Patients with Gout
Shanta Bantia¹, Leigh Harman², Cynthia Parker¹, Damon Papac³, Andreas Maetzel⁴, Brian Taubenheim⁴ and Alan S. Hollister⁴, ¹Discovery Biology, BioCryst Pharmaceuticals, Inc., Durham, NC, ²Bioanalytical Chemistry, BioCryst Pharmaceuticals, Inc., Durham, NC, ³Bioanalytical Sciences, Southern Research Institute, Birmingham, AL, ⁴Development, BioCryst Pharmaceuticals, Inc., Durham, NC
Background/Purpose: Ulodesine (BCX4208) is an oral, once-daily, purine nucleoside phosphorylase (PNP) inhibitor in clinical development as add-on therapy for the chronic management of hyperuricemia in…
Abstract Number: 1634 • 2012 ACR/ARHP Annual Meeting
Delivering Mesenchymal Stem Cells to Arthritic Joints with Nano-Fiber Scaffold Resulted in Inhibition of Arthritis and Joint Damage in Arthritis Models
Xiangmei Zhang¹, Kunihiro Yamaoka¹, Koshiro Sonomoto¹, Masahiro Kondo¹, Shunsuke Fukuyo¹, Makoto Satake², Hiroaki Kaneko², Kazuhisa Nakano¹, Shingo Nakayamada³, Yosuke Okada¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The Third Laboratory, Integrative Technology Research Institute, Teijin Limited, Tokyo, Japan, ³First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Even though treatment of rheumatoid arthritis (RA) has emerged, aiming bone repair is still a challenge. Mesenchymal stem cells (MSCs) possess immunoregulatory function with…
Abstract Number: 1635 • 2012 ACR/ARHP Annual Meeting
Polyarthritis Caused by TIARP (TNFAIP9) Deficiency Critically Dependent On Dysregulated STAT3, NF-κB Signaling and Cell Death in Macrophage
Asuka Inoue¹, Isao Matsumoto¹, Naoto Umeda¹, Yuki Tanaka¹, Satoru Takahashi² and Takayuki Sumida¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan
Background/Purpose: TNFα-induced adipose-related protein (TIARP) is a six-transmembrane protein induced by TNFα and IL-6 in adipose tissue. Recently, we found that TIARP is dominantly expressed…
Abstract Number: 1636 • 2012 ACR/ARHP Annual Meeting
Commensal Gut-Derived Bacteria As Therapy for Systemic Autoimmune Disease
David Luckey¹, Eric Marietta¹, Harvinder S. Luthra², Robin Patel³, Joseph A. Murray⁴, Ashutosh Mangalam¹ and Veena Taneja¹, ¹Immunology, Mayo Clinic, Rochester, MN, ²Medicine/Division of Rheum, Mayo Clinic, Rochester, MN, ³Medicine, Mayo Clinic, Rochester, MN, ⁴Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that leads to destruction of joints. Although etiology of RA is unknown, both genetic and environmental factors…
Abstract Number: 1597 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Tocilizumab in Patients with Polyarticular Juvenile Idiopathic Arthritis: Data From a Phase 3 Trial
Hermine Brunner¹, Nicolino Ruperto², Zbigniew Zuber³, Caroline Keane⁴, Olivier Harari⁵, Andrew Kenwright⁴, Rubén J. Cuttica⁶, Vladimir Keltsev⁷, Ricardo Xavier³, Inmaculada Calvo Penades⁷, Irina Nikishina⁸, Nadina Rubio-Perez⁹, Ekaterina Alekseeva¹⁰, Vyacheslav Chasnyk¹¹, Jose Chavez³, Gerd Horneff¹², Violetta Opoka-Winiarska³, Pierre Quartier¹³, Clovis A. Silva⁷, Earl D. Silverman¹⁴, Alberto Spindler¹⁴, D. J. Lovell¹⁵, Alberto Martini¹⁴ and Fabrizio De Benedetti¹⁶, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Paediatric Rheumatology International Trials Organisation [PRINTO], Genova, Italy, ³PRINTO, Genoa, Italy, ⁴Roche, Welwyn Garden City, United Kingdom, ⁵Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁶Hospital de Niños Pedro de Elizalde - University of Buenos Aires, Buenes Aires, Argentina, ⁷Paediatric Rheumatology International Trials Organisation–IRCCS [PRINTO], Genoa, Italy, ⁸Pediatric Department, Scientific Research Institute of Rheumatology RAMS, Moskow, Moskow, Russia, ⁹Hospital Universitario Dr. José Eleuterio Gonzalez, Monterrey, Mexico, ¹⁰Istituto Giannina Gaslini, Genoa, Italy, ¹¹Hospital Pediatry, State Pediatric Medical University, Saint-Petersburg, Russia, ¹²Department of Pediatrics, Centre of Pediatric Rheumatology, Sankt Augustin, Germany, ¹³Pediatria II, Istituto Giannina Gaslini, Genoa, Italy, ¹⁴Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, ¹⁵Cincinnati Children's Hospital, Cincinnati, OH, ¹⁶PRINTO and PRSCG, Genoa, Italy
Background/Purpose: Elevated IL-6 levels are associated with disease activity in patients (pts) with juvenile idiopathic arthritis (JIA).1 Tocilizumab (TCZ), an IL-6 receptor inhibitor, was evaluated…
Abstract Number: 1598 • 2012 ACR/ARHP Annual Meeting
Clinical and Serologic Predictors of Response in Rituximab-Treated Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM) – the RIM Study
Rohit Aggarwal¹, Ann M. Reed², Dana P. Ascherman³, Richard J. Barohn⁴, Brian M. Feldman⁵, Frederick W. Miller⁶, Lisa G. Rider⁶, Michael Harris-Love⁷, Marc C. Levesque⁸, Chester V. Oddis⁹ and the RIM Study Group¹⁰, ¹Rheumtology, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Medicine/Rheumatology, University of Miami, Miami, FL, ⁴Department of Neurology, University of Kansas Medical Center, Kansas City, USA, Kansas City, MO, ⁵Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁷Geriatrics Service, VA Medical Ctr, Washington, DC, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁹Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁰
Background/Purpose: The Rituximab in Myositis (RIM) Study evaluated 200 refractory myositis patients treated with rituximab, 83% of whom met the definition of improvement (DOI). The…
Abstract Number: 1599 • 2012 ACR/ARHP Annual Meeting
NF-Kb Inducing Kinase (NIK) Is a Key Regulator of Inflammation-Induced Angiogenesis
A.R. Noort¹, K.P.M. van Zoest¹, P. Koolwijk², D.V. Novack³, M.J. Siemerink⁴, P. P. Tak⁵ and S.W. Tas⁶, ¹Division of Clinical Immunology & Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Physiology, Institute for Cardiovascular Research (ICaR-VU) / VU University Medical Center, Amsterdam, Netherlands, ³Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, ⁴Department of Ophthalmology and Department of Cell Biology and Histology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: In rheumatoid arthritis (RA) synovial tissue (ST) angiogenesis can be observed already in the earliest phase of disease, which may be critical in the…
Abstract Number: 1600 • 2012 ACR/ARHP Annual Meeting
Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis
Satoshi Iwata, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Hiroshi Kawasaki, Osamu Hosono, Hirotoshi Tanaka and Chikao Morimoto, Department of Rheumatology and Allergy, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Background/Purpose: It has been reported that the expression levels of β1 integrins and the ligands such as VCAM-1 are elevated in the affected joints of…
Abstract Number: 1601 • 2012 ACR/ARHP Annual Meeting
Role of Focal Adhesion Kinase in Synovial Fibroblast Invasion and Arthritis
Miriam A. Shelef¹, David Bennin² and Anna Huttenlocher³, ¹Medicine, Univ of Wisconsin Schl of Med, Madison, WI, ²Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI, ³Dept of Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI
Background/Purpose: Rheumatoid arthritis is an inflammatory arthritis characterized by joint erosions and destruction. This damage is mediated in part by invasion of synovial fibroblasts into…
Abstract Number: 1602 • 2012 ACR/ARHP Annual Meeting
Tie2 Signalling Induces a Pro-Inflammatory and Pro-Angiogenic Phenotype in Differentiated Macrophages, Independently of Macrophage Polarization Conditions, and Contributes to Production of Cytokines Elevated in Early Rheumatoid Arthritis
Samuel Garcia¹, Sarah Krausz², Carmen A. Ambarus³, Bea Malvar Fernandez², Dominique L. Baeten⁴, Paul P. Tak⁵ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Angiopoietin (Ang) -1 and -2 signalling to the Tie2 tyrosine kinase receptor has an essential role in blood vessel remodeling and angiogenesis. Ang-1, Ang-2…
Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Takeo Isozaki¹, M. Asif Amin², Alisa E. Koch³, Ali Arbab⁴, Stephanie A. Shuman¹, Christine M. Ha¹, G. Kenneth Haines III⁵ and Jeffrey H. Ruth⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²Department of Medicine, University of Michigan, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…
Abstract Number: 1604 • 2012 ACR/ARHP Annual Meeting
Parity and the Risk of Developing Rheumatoid Arthritis: Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Cecilia Orellana¹, Lars Klareskog², Lars Alfredsson¹ and Camilla Bengtsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is more common among women than among men and the gender difference in incidence seems to be most striking before menopause…
Abstract Number: 1605 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Peptide Autoantibodies to Rheumatoid Synovium Epitopes in Women and Risk of Future Rheumatoid Arthritis
Elizabeth V. Arkema¹, Barbara L. Goldstein², William H. Robinson³, Catriona Cramb⁴, Jeremy Sokolove⁵, Jing Cui⁶, Susan Malspeis⁷, Elizabeth W. Karlson⁸ and Karen H. Costenbader⁷, ¹Epidemiology, Harvard School of Public Health, Boston, MA, ²Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁵Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁷Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁸Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Recent studies have shown that anti-citrullinated protein antibodies (ACPA) are detectable years before rheumatoid arthritis (RA) diagnosis, representing a potential early marker of RA…

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