Abstract Number: 1611 • 2012 ACR/ARHP Annual Meeting
Targeted Deep Re-Sequencing Implicates Rare and Low Frequency Coding Variants in IL23R, MEFV, TLR4, and NOD2 in Behçet’s Disease
Background/Purpose: Genome-wide association studies (GWAS) have successfully identified common variants that contribute to Behçet’s disease (BD) susceptibility. However, associations due to rare and low-frequency variants…Abstract Number: 1612 • 2012 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Is Associated with Single Nucleotide Polymorphisms in Loci Implicating Four Aminopeptidases
Background/Purpose: The aim of the study was to examine regions implicated in autoimmune diseases for association with AS. A previous association with AS has been…Abstract Number: 1613 • 2012 ACR/ARHP Annual Meeting
The SLE-Associated TLR7 Variant Confers Differential Gene Expression Modulated by Microrna-3148
Background/Purpose: We established an X-linked TLR7 3’UTR SNP (rs3853839) as a risk locus for SLE in 9,274 Eastern Asians (Pcombined = 6.5×10-10). Risk-allele carriers have…Abstract Number: 1614 • 2012 ACR/ARHP Annual Meeting
Analysis of the Immunochip in a Large Cohort of Juvenile Idiopathic Arthritis Cases Identifies 17 Loci At Genome-Wide Significance
Background/Purpose: Genome-wide (GW) association studies have been hugely successful in the identification of susceptibility loci for autoimmune diseases, interestingly many of the loci are shared…Abstract Number: 1615 • 2012 ACR/ARHP Annual Meeting
Evidence for Distinct Roles of Environmental and Genetic Factors in the Emergence of Anti Citrullinated-Protein Antibodies Positive Rheumatoid Arthritis-an Epidemiological Investigation in Twins
Background/Purpose: The aim of the current study was to investigate the influence of genetic and environmental factors in developing anti citrullianted-proteins antibodies (ACPA) and ACPA…Abstract Number: 1616 • 2012 ACR/ARHP Annual Meeting
Comparison of Conventional and Wholebody Magnetic Resonance Imaging for Assessing Inflammation and Structural Damage in Psoriatic Arthritis and Axial Spondyloarthritis
Background/Purpose: Wholebody magnetic resonance imaging (WBMRI) is a new imaging modality where patients are scanned from “head to toe” in one single scan, but with…Abstract Number: 1577 • 2012 ACR/ARHP Annual Meeting
Barriers to Recruit Unaffected Family Members of Patients with Rheumatoid Arthritis
Background/Purpose: Prospective studies are needed to answer key questions on rheumatoid arthritis (RA) screening in at risk populations : (1) How accurately does risk factor…Abstract Number: 1578 • 2012 ACR/ARHP Annual Meeting
How Disease Activity Trajectories Affect the Willingness to Change Treatment
Background/Purpose: Disease activity (DA) can change markedly over a short period, for a variety of reasons. The changes influence clinical practice and affect the willingness…Abstract Number: 1579 • 2012 ACR/ARHP Annual Meeting
Why Do We Need to Pilot Interventions? Essential Refinements Identified During Pilots of a Fatigue Intervention
Background/Purpose: An RCT showed a 6 week group cognitive-behavioural (CB) intervention for RA fatigue self-management was effective, when delivered by a clinical psychologist.1 Few rheumatology…Abstract Number: 1580 • 2012 ACR/ARHP Annual Meeting
The Relationship Between Perceived Cognitive Dysfunction and Objective Neuropsychological Performance in Persons with Rheumatoid Arthritis
Background/Purpose: There is an increased appreciation of the burden of cognitive impairment in persons with rheumatoid arthritis (RA). Research shows a gap between perceived cognitive…Abstract Number: 1581 • 2012 ACR/ARHP Annual Meeting
The Association Between Symptoms, Pain Coping Strategies, and Physical Activity Among People with Symptomatic Knee and Hip Osteoarthritis
Background/Purpose: Effective use of coping strategies by people with chronic pain conditions is associated with better functioning and adjustment to chronic disease. Although the effects…Abstract Number: 1582 • 2012 ACR/ARHP Annual Meeting
Long Term Costs and Cost-Effectiveness of an Integrated Rehabilitation Programme for Chronic Knee Pain
Background/Purpose: Management of chronic knee pain incurs enormous direct and indirect healthcare costs. Enabling Self-management and Coping with Arthritic knee Pain through Exercise (ESCAPE-knee pain)…Abstract Number: 1583 • 2012 ACR/ARHP Annual Meeting
Therapist and Patient Perspectives On Exercise Adherence: Are We On the Same Page?
Background/Purpose: Exercise is essential to the health and function of children with chronic diseases. Patient adherence to home exercise programs has long been an obstacle…Abstract Number: 1584 • 2012 ACR/ARHP Annual Meeting
Validity of the Nurses Health Study II Physical Activity Questionnaire (NHSPAQ) in Estimating Physical Activity in Adults with Rheumatoid Arthritis (RA)
Background/Purpose: An accurate assessment of physical activity (PA) is critical to manage rheumatoid arthritis (RA). Accelerometry is an objective measure of PA but is not…Abstract Number: 1585 • 2012 ACR/ARHP Annual Meeting
Physical Activity and Timing of Discharge From Physical Therapy Following Total Knee Replacement
Background/Purpose: In 2009 over 620,000 total knee replacement (TKR) surgeries were performed. That number is expected to increase to 3.5 million annually by 2030. Post-operative…