Abstract Number: 1636 • 2012 ACR/ARHP Annual Meeting
Commensal Gut-Derived Bacteria As Therapy for Systemic Autoimmune Disease
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that leads to destruction of joints. Although etiology of RA is unknown, both genetic and environmental factors…Abstract Number: 1597 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Tocilizumab in Patients with Polyarticular Juvenile Idiopathic Arthritis: Data From a Phase 3 Trial
Background/Purpose: Elevated IL-6 levels are associated with disease activity in patients (pts) with juvenile idiopathic arthritis (JIA).1 Tocilizumab (TCZ), an IL-6 receptor inhibitor, was evaluated…Abstract Number: 1598 • 2012 ACR/ARHP Annual Meeting
Clinical and Serologic Predictors of Response in Rituximab-Treated Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM) – the RIM Study
Background/Purpose: The Rituximab in Myositis (RIM) Study evaluated 200 refractory myositis patients treated with rituximab, 83% of whom met the definition of improvement (DOI). The…Abstract Number: 1599 • 2012 ACR/ARHP Annual Meeting
NF-Kb Inducing Kinase (NIK) Is a Key Regulator of Inflammation-Induced Angiogenesis
Background/Purpose: In rheumatoid arthritis (RA) synovial tissue (ST) angiogenesis can be observed already in the earliest phase of disease, which may be critical in the…Abstract Number: 1600 • 2012 ACR/ARHP Annual Meeting
Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis
Background/Purpose: It has been reported that the expression levels of β1 integrins and the ligands such as VCAM-1 are elevated in the affected joints of…Abstract Number: 1601 • 2012 ACR/ARHP Annual Meeting
Role of Focal Adhesion Kinase in Synovial Fibroblast Invasion and Arthritis
Background/Purpose: Rheumatoid arthritis is an inflammatory arthritis characterized by joint erosions and destruction. This damage is mediated in part by invasion of synovial fibroblasts into…Abstract Number: 1602 • 2012 ACR/ARHP Annual Meeting
Tie2 Signalling Induces a Pro-Inflammatory and Pro-Angiogenic Phenotype in Differentiated Macrophages, Independently of Macrophage Polarization Conditions, and Contributes to Production of Cytokines Elevated in Early Rheumatoid Arthritis
Background/Purpose: Angiopoietin (Ang) -1 and -2 signalling to the Tie2 tyrosine kinase receptor has an essential role in blood vessel remodeling and angiogenesis. Ang-1, Ang-2…Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…Abstract Number: 1604 • 2012 ACR/ARHP Annual Meeting
Parity and the Risk of Developing Rheumatoid Arthritis: Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Background/Purpose: Rheumatoid arthritis (RA) is more common among women than among men and the gender difference in incidence seems to be most striking before menopause…Abstract Number: 1605 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Peptide Autoantibodies to Rheumatoid Synovium Epitopes in Women and Risk of Future Rheumatoid Arthritis
Background/Purpose: Recent studies have shown that anti-citrullinated protein antibodies (ACPA) are detectable years before rheumatoid arthritis (RA) diagnosis, representing a potential early marker of RA…Abstract Number: 1606 • 2012 ACR/ARHP Annual Meeting
Identifying a Link Between Uranium Exposure and Systemic Lupus Erythematosus in a Community Living near a Uranium Plant
Background/Purpose: Effects of environmental exposures on the development of systemic lupus erythematosus (SLE) are potentially important and relatively unexplored in SLE pathogenesis. An excess of…Abstract Number: 1607 • 2012 ACR/ARHP Annual Meeting
The Association Between Thyroxin Substitution and Rheumatoid Arthritis; Results From the Swedish EIRA Study
Background/Purpose: Hypothyroidism is usually of autoimmune nature, in areas with sufficient iodine, and leads to chronic substitution treatment with thyroxin. The disease shares some risk…Abstract Number: 1608 • 2012 ACR/ARHP Annual Meeting
Overweight and Obesity Increase Risk of Rheumatoid Arthritis in Women in a Large Prospective Study
Overweight and Obesity Increase Risk of Rheumatoid Arthritis in Women in a Large Prospective StudyBackground/Purpose: Several case-control studies have suggested that overweight and obesity may…Abstract Number: 1609 • 2012 ACR/ARHP Annual Meeting
Circulating 25-Hydroxyvitamin D Level and Risk of Developing Rheumatoid Arthritis
Background/Purpose: Vitamin D has demonstrated immunomodulatory properties with potential etiologic implications for autoimmune diseases including rheumatoid arthritis (RA). However, a causal association between decreased vitamin…Abstract Number: 1610 • 2012 ACR/ARHP Annual Meeting
The DNA Methylation Signature in Fibroblast-Like Synoviocytes (FLS) Defines Critical Pathogenic Pathways in Rheumatoid Arthritis (RA)
Background/Purpose: A DNA methylation signature has been characterized that distinguishes RA FLS from osteoarthritis (OA) and normal (NL) FLS. The presence of epigenetic changes in…