Abstracts Archive - Page 2313 of 2425 - ACR Meeting Abstracts

Abstract Number: 1656 • 2012 ACR/ARHP Annual Meeting
Treatment of Systemic Necrotizing Vasculitides in Patients ≥65 Years Old: Results of the Multicenter Randomized Cortage Trial
Christian Pagnoux¹, Thomas Quemeneur², Jacques Ninet³, Elodie Perrodeau⁴, Elizabeth Diot⁵, Xavier Kyndt⁶, Benoit de Wazières⁷, jean-Luc Reny⁸, Xavier Puéchal⁹, Pierre-Yves Leberruyer¹⁰, Olivier Lidove¹¹, Philippe Vanhille¹², Pascal Godmer¹³, Aimé Albath-Sadiki¹⁴, Boris Bienvenu¹⁵, Pascal Cohen¹⁶, Luc Mouthon¹⁷, Philippe Ravaud⁴, Loic Guillevin¹⁸ and French Vasculitis Study Group (FVSG)¹⁹, ¹Internal Medicine, Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hôpital Cochin, Assistance Publique – Hôpitaux de Paris, Université Paris – Descartes, Paris, France, Paris, France, ²Internal medicine, CHR de Valenciennes, Valenciennes, France, ³Department of Nephrology and Internal Medicine, Hôpital Edouard Herriot, Lyon, France, Lyon, France, ⁴Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ⁵Department of Internal Medicine, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, Tours, France, Tours, France, ⁶Department of Nephrology and Internal Medicine, CH, Valenciennes, Valenciennes, France, ⁷Department of Internal Medicine and Gerontology, Hôpital Universitaire Carémeau, Nîmes, France, Nimes, France, ⁸Service de médecine interne générale Hôpitaux universitaires de Genève, Geneve, Switzerland, ⁹National Referral Center for Rare Systemic Auto-immune Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ¹⁰Hôpital Robert Debré, Centre Hospitalier Universitaire de Reims, Reims, France, Reims, France, ¹¹Médecine interne, Hôpital Croix-Saint-Simon, PARIS, France, ¹²Department of Nephrology and Internal Medicine, Hospital of Valenciennes, Valenciennes, France, Valenciennes, France, ¹³Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France, ¹⁴Urc, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, 27 rue du faubourg Saint Jacques, Paris, 75014, France, Paris, France, ¹⁵Médecine interne, CHU Côte de Nacre, CAEN, France, ¹⁶National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ¹⁷Internal Medicine, Hopital Cochin, Paris, France, ¹⁸Internal Medicine, Cochin University Hospital, Paris, France, ¹⁹Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hôpital Cochin, Assistance Publique – Hôpitaux de Paris, Université Paris – Descartes, Paris, France
Background/Purpose: To optimize the therapeutic strategy for the elderly with systemic necrotizing vasculitides (SNV; polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) or…
Abstract Number: 1617 • 2012 ACR/ARHP Annual Meeting
Whole-Body Magnetic Resonance Imaging of Disease Manifestations in Axial and Peripheral Joints and Entheses in Rheumatoid Arthritis Patients
Mette Bjørndal Axelsen¹, Anne Duer², Iris Eshed³, Jakob M. Møller⁴, Susanne Juhl Pedersen¹ and Mikkel Østergaard⁵, ¹Depart of Rheumatology RM, Glostrup Hospital, Copenhagen, Denmark, ²Department of Radiology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark, ³Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel, ⁴Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, ⁵Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: To investigate the ability of whole-body magnetic resonance imaging (WBMRI) to visualize synovitis, bone marrow edema and erosions in patients with rheumatoid arthritis (RA)…
Abstract Number: 1618 • 2012 ACR/ARHP Annual Meeting
Prevalence of Inflammatory Sacroiliitis Assessed On MR Imaging of Inflammatory Bowel Disease: A Retrospective Study Performed On 186 Patients
Sophie Leclerc-Jacob¹, Guillaume Lux², Anne-Christine Rat¹, Valérie Laurent², Alain Blum², Isabelle Chary-Valckenaere¹, Laurent Peyrin-Biroulet³ and Damien Loeuille¹, ¹Rheumatology, Nancy Teaching Hospital, Nancy, France, ²Radiology, Nancy Teaching Hospital, Nancy, France, ³Gastroenterology and Hepatology, Nancy Teaching Hospital, Nancy, France
Background/Purpose: Articular involvements are by far the most common extra-intestinal manifestations in inflammatory bowel disease (IBD). They include peripheral arthritis and inflammatory axial manifestation. Until…
Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting
Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Xenofon Baraliakos¹, Frank Heldmann², Ravi Suppiah³, Fiona M. McQueen⁴ and Jürgen Braun², ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
Abstract Number: 1620 • 2012 ACR/ARHP Annual Meeting
Early Magnetic Resonance Imaging Measures Independently Predict 1- and 2- Year X-Ray Progression: Results From a Large Clinical Trial
Joshua Baker¹, Mikkel Østergaard², Paul Emery³, Elizabeth C. Hsia⁴, J. D. Lu⁵, Daniel Baker⁴ and Philip G. Conaghan⁶, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ³Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴Janssen Research & Development, LLC., Spring House, PA, ⁵Janssen Research & Development, LLC/U of Penn, Spring House/Phila, PA, ⁶University of Leeds, Leeds, United Kingdom
Early MRI Measures Independently Predict 1- and 2- year X-ray Progression: Results from a Large Clinical TrialBackground/Purpose: Early predictors of progression in structural joint…
Abstract Number: 1621 • 2012 ACR/ARHP Annual Meeting
In Vivo Synovial Oxygen Levels Are Inversely Related to Metabolic Turnover and Disease Activity in Rheumatoid and Psoriatic Arthritis Biologic Responders
Leonard C. Harty¹, John Ryan², Chin Teck Ng³, Monika Biniecka⁴, Aisling Kennedy⁴, Eric J. Heffernan⁵, Ursula Fearon³ and Douglas J. Veale⁶, ¹Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Ziltron, Unit 4, Castletroy Business Park, Plassey, Limerick, Ireland, ³Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁴Dublin Academic Medical Centre, St. Vincent's University Hospital, Translation Rheumatology Research Group, Dublin, Ireland, ⁵Radiology, St. Vincent's University Hospital, Dublin, Ireland, ⁶Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose: Hypoxia, leukocyte infiltration and dysfunctional vascularity play a key role in the pathogenesis of inflammatory arthritis (IA). We examine the relationship of metabolic turnover…
Abstract Number: 1622 • 2012 ACR/ARHP Annual Meeting
Characteristics of Patients with Infectious Cryoglobulinemia Vasculitis in the Absence of HCV Infection: Results From the French Nationwide Cryovas Survey
Benjamin Terrier¹, Isabelle Marie², Adeline Lacraz³, Pauline Belenotti⁴, Fabrice Bonnet⁵, Laurent Chiche Sr.⁴, Bruno Graffin Sr.⁶, Arnaud Hot⁷, Jean-Emmanuel Kahn⁸, Thomas Quemeneur⁹, Olivier Hermine Sr.¹⁰, Jean-Marc Léger¹¹, Patricia Senet¹², Emmanuelle Plaisier¹³, Xavier Mariette¹⁴ and Patrice Cacoub Sr.¹⁵, ¹Internal Medicine, Cochin University Hospital, Paris, France, ²Service de médecine interne, CHU de Rouen, Rouen, France., Rouen, France, ³Nephrology, CHU Bordeaux, Bordeaux, France, ⁴Internal Medicine, CHU Marseille, Marseille, France, ⁵Internal Medicine, Bordeaux University Hospital, Bordeaux, France, ⁶Internal Medicine, Metz hospital, Metz, France, ⁷Internal Medicine, Edouard Herriot University Hospital, Lyon, France, ⁸Internal Medicine, Foch Hospital, Suresnes, France, ⁹Internal medicine, CHR de Valenciennes, Valenciennes, France, ¹⁰Department of Hematology, Hôpital Necker, Paris, France, ¹¹Neurology, Hôpital Pitié-Salpêtrière, Neurology, Paris, France, ¹²Dermatology, Tenon hospital, Paris, France, ¹³Nephrology, Tenon Hospital, Paris, France, ¹⁴Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France, ¹⁵Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: Hepatitis C virus infection (HCV) is the main cause of mixed cryoglobulinemia vasculitis (CryoVas). Recent data are lacking regarding demographical, clinical and biological features…
Abstract Number: 1623 • 2012 ACR/ARHP Annual Meeting
Serum Biomarkers Signature Identifies Patients with Overt B-Cell Non-Hodgkin Lymphoma Associated with Mixed Cryoglobulinemia in Chronic HCV Infection
Benjamin Terrier¹, Wahiba Chaara², Guillaume Geri³, David Saadoun⁴, Michelle Rosenzwajg Sr.⁵, Damien Sene Sr.⁶, Adrien Six², David Klatzmann Sr.⁵ and Patrice Cacoub Sr.⁷, ¹Internal Medicine, Cochin University Hospital, Paris, France, ²Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Paris, France, ³Intensive Care Unit, Cochin Hospital, Paris, France, ⁴Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ⁵Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Paris, France, ⁶Department of Internal Medicine; 5 P3S post-genomic plateform, Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie, Paris, France, ⁷Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: Hepatitis C virus (HCV) is associated with B-cell disorders, including mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). Early diagnosis of B-NHL in HCV-infected…
Abstract Number: 1624 • 2012 ACR/ARHP Annual Meeting
Deletion of HLA-B27 T Cells Underlies the Immunodominant Response to Influenza Infection On Class I MHC Transgenic Mice
Ali Akram¹ and Robert D. Inman², ¹Institute of Medical Science and Department of Immunology, University of Toronto and University Health Network (UHN), Toronto, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: The role of HLA-B27 in modulating host response to infection is undefined, yet has important implications for the mechanism whereby B27 confers susceptibility to…
Abstract Number: 1625 • 2012 ACR/ARHP Annual Meeting
With Chlamydia Infection the Macrophage Serves As Gate-Keeper for Dissemination and Induction of Host Immunity
Eric Gracey¹ and Robert D. Inman², ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: The obligate intracellular pathogen, Chlamydia, is the most common cause of reactive arthritis (ReA). We have demonstrated that susceptibility to experimental Chlamydia-induced ReA is…
Abstract Number: 1626 • 2012 ACR/ARHP Annual Meeting
Frequent Conversion of Tuberculosis Screening Tests During Anti-Tumor Necrosis Factor Therapy in Patients with Rheumatic Diseases
Chrisoula Hatzara¹, Emilia Hadziyannis², Anna Kandili¹, Stamatoula Tsikrika¹, Martha Minopetrou¹, Georgios Georgiopoulos¹ and Dimitrios Vassilopoulos¹, ¹2nd Department of Medicine, Athens University School of Medicine, Athens, Greece, ²2nd Department of Medicine and Laboratory of Clinical Immunology-Rheumatology, Hippokration General Hospital, University of Athens Medical School, Athens, Greece
Background/Purpose: The most recent ACR Recommendations suggest annual screening for latent tuberculosis (TB) with standard tuberculin skin test (TST) or the newer interferon-gamma release assays…
Abstract Number: 1627 • 2012 ACR/ARHP Annual Meeting
New Insights Into the Presentation and the Management of Hepatitis B Reactivation in Patients with Autoimmune Diseases and Inflammatory Arthritis
Nina Droz¹, Laurent Gilardin², Patrice Cacoub Sr.³, Francis Berenbaum⁴, Daniel Wendling⁵, Bertrand Godeau⁶, Anne-Marie Piette⁷, Emmanuelle Dernis⁸, Mikael Ebbo⁹, Bruno Fautrel¹⁰, Arsène Meikinian¹¹, Aude Rigolet¹², Sophie Rivière¹³, Stanislas Pol¹⁴, Loic Guillevin¹⁵, Luc Mouthon¹⁶ and Benjamin Terrier¹⁷, ¹Internal Medicine, Cochin Hospital, Paris, France, ²Internal Medicine, Saint Antoine Hospital, Paris, France, ³Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France, ⁴Rheumatology, AP-HP, St Antoine Hospital, Paris, France, ⁵Service de Rhumatologie, Minjoz University Hospital, Besancon, France, ⁶Internal Medicine, University of Paris, AP-HP, Hôpital Mondor Créteil, Creteil, France, ⁷Internal Medicine, Foch Hospital, Suresnes, France, ⁸Centre Hospitalier, Le Mans, France, ⁹Internal Medicine, Conception Hospital, Marseille, France, ¹⁰Rheumatology / GRC08-EEMOIS, APHP-Pitie Salpetriere Hospital / UPMC, Paris, France, ¹¹Internal Medicine, Jean Verdier Hospital, Bondy, France, ¹²Internal Medicine I & II, Pitie-Salpetriere Hospital, APHP, UPMC Paris VI, Paris, France, ¹³Internal Medicine, Lapeyronie, Montpellier, France, ¹⁴Hepatology, Cochin Hospital, Paris, France, ¹⁵Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ¹⁶Internal Medicine, Hopital Cochin, Paris, France, ¹⁷Internal Medicine, Cochin University Hospital, Paris, France
Background/Purpose: In patients with autoimmune diseases and inflammatory arthritis, immunosuppressive therapy may trigger Hepatitis B virus (HBV) reactivation, leading to significant morbidity and mortality. Objective.…
Abstract Number: 1628 • 2012 ACR/ARHP Annual Meeting
Epistatic Interaction Between Solute Carrier 2A9 Genotype and Sugar-Sweetened Beverage Consumption in the Determination of Gout Risk
Tony R. Merriman¹, Nicola Dalbeth², Peter J. Gow³, Andrew Harrison⁴, John Highton⁵, Peter B. B. Jones⁶, Lisa K. Stamp⁷, Murray Cadzow⁸, Marilyn E. Merriman¹, Ruth Topless¹, Michael A. Black⁸, Amanda Phipps-Green¹ and Caitlin M. Batt⁸, ¹Department of Biochemistry, University of Otago, Dunedin, New Zealand, ²Medicine, University of Auckland, Auckland, New Zealand, ³Rheumatology Dept, Middlemore Hospital, Auckland, New Zealand, ⁴Rheumatology Unit, Hutt Hospital, Lower Hutt, New Zealand, ⁵Dept of Medicine, Univ of Otago Med Sch, Dunedin, New Zealand, ⁶Medicine, Waikato Clinical School, Waikato Hospital, Hamilton, New Zealand, ⁷Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ⁸University of Otago, Dunedin, New Zealand
Background/Purpose: Consumption of drinks sweetened with sugar or high fructose corn syrup increases both serum urate levels and the risk for gout. SLC2A9 encodes a…
Abstract Number: 1629 • 2012 ACR/ARHP Annual Meeting
Microarray Analysis of Acute and Intercritical Gout
Alicia Rodriguez-Pla¹, Lynda Bennett¹, Kathryn H. Dao², Edwardo Delgado³, Typhanie Maurouard¹, M. Virginia Pascual⁴ and John J. Cush⁵, ¹Baylor Healthcare System, Baylor Institute for Immunology Research, Dallas, TX, ²Rheumatology, Baylor Research Institute, Dallas, TX, ³Arthritis Care and Research Center, Dallas, TX, ⁴Baylor Institute for Immunology Research, Dallas, TX, ⁵Baylor Research Institute, Dallas, TX
Background/Purpose: We aimed to identify the immune mechanism underlying gouty inflammation using microarrays analysis and modular gene expression signatures. Methods: Whole blood along with clinical…
Abstract Number: 1630 • 2012 ACR/ARHP Annual Meeting
Genetic Variants of Serum Uric Acid and Gout: An Analysis of > 170,000 Individuals
Hyon Choi¹, Robert M. Plenge², Anna Köttgen³, Veronique Vitart⁴, Murielle Bochud⁵, Christian Gieger⁶, Mark Caulfield⁷, Marina Ciullo⁸, Eva Albrecht⁶, Alexander Teumer⁹, Gary Curhan¹⁰, Jan Krumsiek¹¹, Conall O'Seaghdha¹², Caroline Fox¹³ and The Global Urate Genetics Consortium (GUGC)¹⁴, ¹Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ²Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Renal Division, Freiburg University Hospital, Freiburg, Germany, ⁴Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom, ⁵Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Switzerland, ⁶German Research Center for Environmental Health, Neuherberg, Germany, ⁷William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁸Institute of Genetics and Biophysics, "A. Buzzati-Traverso", Italy, ⁹Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt- University Greifswald, Greifswald, Germany, ¹⁰German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ¹¹Institute of Bioinformatics and Systems Biology, German Research Center for Environmental Health, Neuherberg, Germany, ¹²German Research Center for Environmental Health, NHLBI's Framingham Heart Study and Center for Population Studies,, Neuherberg, ¹³Institute of Genetics and Biophysics, NHLBI's Framingham Heart Study and Center for Population Studies, Framingham, MA, ¹⁴Section of Rheumatology and the Clinical Epidemiology Unit, Boston University of School of Medicine, Boston, MA
Background/Purpose: Gout is a common and excruciatingly painful inflammatory arthritis caused by hyperuricemia. In addition to various lifestyle risk factors, a substantial genetic predisposition to…

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