Abstracts Archive - Page 2312 of 2607 - ACR Meeting Abstracts

Abstract Number: 1816 • 2013 ACR/ARHP Annual Meeting
Exercise Therapy Reduces Pain Sensitivity In Patients With Knee Osteoarthritis: A Randomized Controlled Trial
Marius Henriksen¹, Louise Klokker², Thomas Graven-Nielsen³, Cecilie Bartholdy², Tanja Schjoedt Joergensen⁴, Elisabeth Bandak¹, Bente Danneskiold-Samsøe⁵, Robin Christensen⁶ and Henning Bliddal¹, ¹Department of Rheumatology, The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark, ²The Parker Institute, Copenhagen, Denmark, ³Center for Sensori-Motor Interaction, Aalborg University, Aalborg, Denmark, ⁴The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen F, Denmark, ⁵Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark, ⁶Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark
Background/Purpose: Exercise has beneficial effects on pain in patients with knee osteoarthritis (OA), yet the underlying analgesic mechanisms are ambiguous. A deeper understanding of the…
Abstract Number: 1817 • 2013 ACR/ARHP Annual Meeting
The Clinical Burden Of Generalized Osteoarthritis Represented By Activity Limitations and Health Related Quality Of Life: A Cross-Sectional Study
Nienke Cuperus¹, Thea Vliet Vlieland², Elien Mahler¹, Clarinda Kersten¹, Thomas Hoogeboom³ and Els van den Ende¹, ¹Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Department of Orthopaedics, University Medical Center Leiden, Leiden, Netherlands, ³Department of Epidemiology, CAPHRI school for public health and primary care, CCTR centre for Care Technology Research, Maastricht University, Maastricht, Netherlands
Background/Purpose: A growing body of evidence shows that generalized osteoarthritis (GOA) is fairly common, however research and clinical practice recommendations are mainly focused on a…
Abstract Number: 1818 • 2013 ACR/ARHP Annual Meeting
Automated Telephone-Linked Communication: A Novel Approach To Enhance Long-Term Adherence To Resistance Training Exercise Among People With Knee Osteoarthritis
Kristin Baker¹, Aileen Ledingham¹, Michael P. Lavalley², Julie J. Keysor¹ and David T. Felson³, ¹Physical Therapy, Boston University Sargent College, Boston, MA, ²Biostatistics, Boston University, Boston, MA, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose: Knee Osteoarthritis (OA) is one of the most common chronic musculoskeletal conditions and is a leading cause of disability. Strengthening exercise is well known…
Abstract Number: 1819 • 2013 ACR/ARHP Annual Meeting
Effectiveness Of Pilates Method For The Treatment Of Chronic Mechanical Neck PAIN
Luciana A. Cazotti¹, Anamaria Jones¹, Diego Roger Silva², Luiza H. C. Ribeiro¹ and Jamil Natour³, ¹Unifesp-EPM, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: The neck pain comes from multifactorial origin and affects approximately 70% of individuals at some point in their lives being considered a frequent problem…
Abstract Number: 1820 • 2013 ACR/ARHP Annual Meeting
Assessing 24-Hour Physical (In)Activity and Sleep In People With Early Rheumatoid Arthritis
Christopher Feehan¹, Eric C. Sayre², Erin Carruthers² and Lynne M. Feehan³, ¹Medicine, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Richmond, BC, Canada, ³Physical Therapy, Arthritis Research Centre of Canada and University of British Columbia, Vancouver, BC, Canada
Background/Purpose: For people with inflammatory arthritis, the health benefits of physical activity (PA) and negative impact of sedentary lifestyle are clear. However, it is unclear…
Abstract Number: 1821 • 2013 ACR/ARHP Annual Meeting
Benefits Of Progressive Muscle Strengthening Using a Swiss Ball In Patients With Ankylosing Spondylitis: A Randomized Controlled Trial
Marcelo Souza¹, Fabio Jennings², Hisa Morimoto¹ and Jamil Natour³, ¹Division of Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Ankylosing spondylitis (AS) is a systemic inflammatory disease that affects the physical capacity of patients globally. Exercises are recommended to the management of patients…
Abstract Number: 1822 • 2013 ACR/ARHP Annual Meeting
Oleanolic Acid Acetate Inhibits Osteoclast Differentiation By Downregulating Phospholipase Cγ² –calcium ion oscillation-Nuclear Factor Of Activated T Cell c1 Signaling, and Suppresses Bone Loss In Mice
Chang-Hoon Lee¹, Myeung Su Lee¹, Won Seok Lee², Wan-Hee Yoo³, Ju-Young Kim⁴, Jae-Min Oh⁴ and Yong-Geun Jeong⁵, ¹Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ²Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ⁴Department of Anatomy, School of Medicine, Wonkwang University, Iksan, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Changwon Fatima Hospital, Changwon, South Korea
Background/Purpose: we first isolated oleanolic acid acetate (OAA), a triterpenoid compound, from Vigna angularis(azuki bean) to discover anti-bone resorptive agents. Many studies have identified and…
Abstract Number: 1823 • 2013 ACR/ARHP Annual Meeting
IL-6 Suppresses Osteoblast Differentiation Through The SHP2/MEK2 and SHP2/Akt2 Pathways In Vitro
Shoichi Kaneshiro¹, Kosuke Ebina¹, Kenrin Shi¹, Chikahisa Higuchi², Hideki Yoshikawa¹, Jun Hashimoto³ and Makoto Hirao⁴, ¹Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ²Osaka University Graduate School of Medicine, Suita, Japan, ³Dept of Rheumatology, Osaka-Minami Medical Center, Kawachinagano City, Japan, ⁴Orthopaedic Surgery, Osaka Minami Medical Center, Osaka, Japan
Background/Purpose: Interleukin-6 (IL-6), a potent inflammatory cytokine, plays a key role in the pathogenesis of rheumatoid arthritis (RA), including osteoporosis not only in inflamed joints…
Abstract Number: 1826 • 2013 ACR/ARHP Annual Meeting
Immune Complex Formation By Adalimumab Contributes Significantly To Its Inhibitory Effect On TNF-Enhanced Human Osteoclast Development Even In The Absence Of Fc Receptor Binding
Bohdan P. Harvey and Zehra Kaymakcalan, Biologics, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast development. …
Abstract Number: 1824 • 2013 ACR/ARHP Annual Meeting
ONO-4059 – A Novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase- Suppresses Osteoclastic Bone Resorption and Inflammation
Yuko Ariza¹, Toshio Yoshizawa¹, Yoshiko Ueda¹, Shingo Hotta¹, Tomoko Yasuhiro¹, Masami Narita¹, Yutaka Shichino² and Kazuhito Kawabata¹, ¹Discovery Research Laboratories 3, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ²Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by leukocyte infiltration, synoviocyte hyperplasia and osteoclastogenesis, leading to erosion of the joints and cartilage,…
Abstract Number: 1825 • 2013 ACR/ARHP Annual Meeting
Osteoclast Progenitors, Fibroblast-Like Cells and Draining Lymph Node Cells Induce Catecholaminergic-To-Cholinergic Transition Of Sympathetic Nerve Fibers Under Healthy Conditions But Not In Highly Inflamed Arthritic Tissue
Hubert Stangl¹, Dominique Muschter², Susanne Graessel³ and Rainer H. Straub⁴, ¹Department of Internal Medicine 1, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, ²Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital Regensburg, Regensburg, Germany, ³Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital of Regensburg, Regensburg, Germany, ⁴Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: Sympathetic nerve fibers innervate bone and tissue adjacent to joints. They play an important role in bone and tissue homeostasis. Under certain conditions, sympathetic…
Abstract Number: 1827 • 2013 ACR/ARHP Annual Meeting
The Intraarticular Injection Of An Inhibitor Of Complex V Of Mitochondrial Respiratory Chain Induces a Pathological Response In Rat Knee Joints
Carlos Vaamonde-García¹, Jesus Loureiro¹, Eduardo López-Peláez², Alberto Centeno-Cortés², Romina R. Riveiro-Naveira¹, M. Noa Valcárcel-Ares¹, Francisco J. Blanco³ and Maria J. López-Armada¹, ¹Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, ²Experimental Surgery Unit, CHU A Coruña, A Coruña, Spain, ³Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain
Background/Purpose: A decline of mitochondrial function has been described in OA chondrocytes and RA synoviocytes. Recent ex vivo findings support a connection between mitochondrial dysfunction…
Abstract Number: 1805 • 2013 ACR/ARHP Annual Meeting
Hydroxychloroquine Levels Identify Four Distinct Subsets of Systemic Lupus Erythematosus Patients
Michelle Petri, Hong Fang and William Clarke, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Hydroxychloroquine is used for both its effect on SLE disease activity (cutaneous and arthritis) and for its preventive roles (reduction in flares, renal damage,…
Abstract Number: 1788 • 2013 ACR/ARHP Annual Meeting
The Multi-Biomarker Disease Activity Test (Vectra^® DA) Estimates Risk Of Radiographic Progression For Patients With Rheumatoid Arthritis From The Leiden Early Arthritis Clinic
Wanying Li¹, DJ Haney¹, Guy Cavet¹, Thomas W. Huizinga², Eric H. Sasso¹ and A. H. M. van der Helm-van Mil³, ¹Crescendo Bioscience Inc., South San Francisco, CA, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The multi-biomarker disease activity (MBDA) blood test assesses disease activity in patients with rheumatoid arthritis (RA) using a validated algorithm to provide a score…
Abstract Number: 1789 • 2013 ACR/ARHP Annual Meeting
In Early Rheumatoid Arthritis, The 12 Individual Biomarkers That Comprise The Multiple Biomarker Disease Activity Score Relate Differentially To Clinical Response and Radiographic Progression: Results From a Randomized Trial
Karen Hambardzumyan¹, Saedis Saevarsdottir², Rebecca Bolce³, Kristina Forslind⁴, Sofia Ernestam⁵, Ingemar F. Petersson⁶, Pierre Geborek⁷, David Chernoff³, Douglas J. Haney³, Eric H. Sasso³ and Ronald F van Vollenhoven⁸, ¹ClinTRID, the Karolinska Institute, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³Crescendo Bioscience Inc., South San Francisco, CA, ⁴Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden, ⁵Huddinge Hospital, Karolinska University Hospital, Huddinge, Sweden, ⁶Lund University, Lund, Sweden, ⁷Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁸ClinTRID, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: In early rheumatoid arthritis (eRA), clinical and radiographic predictors would be very useful for optimizing available therapies. Individual biomarkers and their combinations, such as…

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