Abstracts Archive - Page 2306 of 2607 - ACR Meeting Abstracts

Abstract Number: 1927 • 2013 ACR/ARHP Annual Meeting
Assessing Adherence To Choosing Wisely® Recommendations Regarding Antinuclear Antibody and Antinuclear Antibody Subserology Testing In An Urban Community Health System
Adam Carlson¹, Jinoos Yazdany², Kara Lynch³ and Laura Trupin², ¹Medicine, UC San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Laboratory Medicine, San Francisco General Hospital, San Francisco, CA
Background/Purpose: As part of the American Board of Internal Medicine's Choosing Wisely Campaign®, the ACR published recommendations in 2013 advising clinicians against ordering anti-nuclear…
Abstract Number: 1928 • 2013 ACR/ARHP Annual Meeting
Outcomes Of The Fast-Track Pathway In Giant Cell Arteritis: A Sight Saver
Pravin Patil¹, Win Win Maw¹, Katerina Achilleos¹, Christian Dejaco^2,3, Mark Williams⁴, Tochukwu Adizie², Dimitrios Christidis⁵, Frances Borg¹ and Bhaskar Dasgupta², ¹Rheumatology, Southend University Hospital, Westcliff-on-sea, United Kingdom, ²Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ³Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria, ⁴Rheumatology, Southend University Hospital, Westcliff on sea, United Kingdom, ⁵Rheumatology, Southend University Hospital, Westcliffe on sea, United Kingdom
Outcomes of the fast-track pathway in Giant cell arteritis: A sight saverBackground/Purpose: Giant cell arteritis (GCA) is a medical emergency, with permanent visual loss…
Abstract Number: 1888 • 2013 ACR/ARHP Annual Meeting
Transcriptional Regulation Of Peptidylarginine Deiminase Type IV: Implications For Rheumatoid Arthritis
Ali Abbas¹, Kevin Le¹, Virginia Pimmett¹, David A. Bell², Ewa Cairns² and Rodney P. DeKoter¹, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: High titers of anti-citrullinated protein/peptide antibodies (ACPA) have been detected in sera of rheumatoid arthritis (RA) patients, implicating citrullinating enzymes in the pathogenesis of…
Abstract Number: 1889 • 2013 ACR/ARHP Annual Meeting
Genome-Wide Association Study Of Knee Radiographic Osteoarthritis In African-American Populations
Youfang Liu¹, Michelle S. Yau², Laura Yerges-Armstrong², M C. Hochberg³, Braxton D. Mitchell², Rebecca D. Jackson⁴, Jordan B. Renner⁵, David Duggan⁶ and Joanne M. Jordan⁷, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, ³Department of Medicine, University of Maryland, Baltimore, MD, ⁴Ohio State University, Columbus, OH, ⁵University of North Carolina Department of Radiology, Chapel Hill, NC, ⁶Translational Genomics Research Institute, Phoenix, AZ, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Few SNPs and susceptibility genes have been identified in previous genome-wide and candidate gene association studies for knee radiographic osteoarthritis (OA). Nearly all studies…
Abstract Number: 1890 • 2013 ACR/ARHP Annual Meeting
Chemokine Receptor Polymorphisms On Chromosome 3 Are Associated With Anticitrullinated Protein Antibody Specificities In African Americans With Rheumatoid Arthritis
Richard J. Reynolds¹, Maria I. Danila², Jeremy Sokolove³, William H. Robinson⁴, Doyt L. Conn⁵, Beth L. Jonas⁶, Leigh F. Callahan⁷, Larry W. Moreland⁸, Richard D. Brasington⁹, Edwin A. Smith¹⁰, Peter K. Gregersen¹¹ and S. Louis Bridges Jr.¹², ¹Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Med/Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ³VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁵Rheumatology, Emory Univ School of Medicine, Atlanta, GA, ⁶Thurston Arthritis Research Ct, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁹Div of Rheumatology, Washington Univ School of Med, St. Louis, MO, ¹⁰Dept of Med Div of Rheum, Med Univ of South Carolina, Charleston, SC, ¹¹Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹²Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: ACPA antibody specificities to citrullinated autoantigens (e.g., histones, vimentin, fibrinogen) are associated with the preclinical phase of RA and may predict the onset of…
Abstract Number: 1891 • 2013 ACR/ARHP Annual Meeting
Proteomic Profile Of Tears: Can It Help To Diagnose Juvenile Arthritis – Associated Uveitis Prior To The Clinical Signs Of Joints Inflammation
Vyacheslav Chasnyk¹, Sergei Nekhai², Alla Hynes³, Tatiana Ammosova⁴, Yuri Obukhov⁴, Ekaterina Gaidar⁵, Anatolyi Kononov⁵, Margarita Dubko⁶, Elena Serogodskaia⁶ and Tatiana Nikitina⁵, ¹Hospital Pediatry, State Pediatric Medical University, Saint-Petersburg, Russia, ²Department of Medicine, Center for Sickle Cell Disease, Howard University, Washington, DC, ³Eye Care Physicians and Surgeons, Winchester, VA, ⁴Howard University, Washington, DC, ⁵Saint-Petersburg State Pediatric Medical University, St. Petersburg, Russia, ⁶State Pediatric Medical University, Saint-Petersburg, Russia
Background/Purpose: Approximately 6% of all cases of uveitis arise in children (Nguyen, Foster, 1998). One of the common causes of uveitis is Juvenile Idiopathic Arthritis…
Abstract Number: 1892 • 2013 ACR/ARHP Annual Meeting
High-Throughput Immunoglobulin G Fab Glycosylation Profiling Reveals Differential Glycosylation On Fab and Fc
Albert Bondt^1,2, Yoann Rombouts³, Maurice H.J. Selman¹, Radboud JEM Dolhain⁴ and Manfred Wuhrer¹, ¹Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands
Background/Purpose: Rheumatoid arthritis is known to improve during pregnancy, and a flare of disease activity is observed after delivery (1). N-glycosylation of the constant region…
Abstract Number: 1893 • 2013 ACR/ARHP Annual Meeting
Altered DNA Methylation Profiles In Individuals With Osteoarthritis
Kathryn A Bailey¹, Daniel Rojas², Nikhil Umesh¹, Lisa Smeester¹, Tristan De Buysscher³, Jordan B. Renner⁴, Joanne M. Jordan⁵ and Rebecca C. Fry¹, ¹Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²School of Medicine, Curriculum in Toxicology, Univeristy of North Carolina at Chapel Hill, Chapel Hill, NC, ³Center for Bioinformatics, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina Department of Radiology, Chapel Hill, NC, ⁵Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Major risk factors associated with osteoarthritis (OA) development include age, joint stress/injury, obesity, and genetic predisposition. In recent years, the role epigenetic processes that…
Abstract Number: 1894 • 2013 ACR/ARHP Annual Meeting
Association Of Alleles and Amino Acids Of The Major Histocompatibility Complex Class I Chain-Related Gene A With Psoriatic Disease
Remy Pollock¹, Fawnda Pellett², Renise Ayearst³, Fatima Abji¹, Dafna D. Gladman² and Vinod Chandran², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: We previously reported associations between alleles of the major histocompatibility complex class I chain-related gene A (MICA) and psoriatic disease that were independent of…
Abstract Number: 1895 • 2013 ACR/ARHP Annual Meeting
Identification Of Aberrant Pathways In Osteoarthritis Using RNA-Seq
Kathleen M. Fisch¹, Masahiko Saito², Ryuichiro Akagi¹, Stuart Duffy¹, Andrew I. Su¹ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan
Background/Purpose: Osteoarthritis (OA) is a prevalent joint disease that is characterized by the destruction of articular cartilage, although the disease process affects all joint tissues. …
Abstract Number: 1896 • 2013 ACR/ARHP Annual Meeting
Arthritis Associated Sequence Alterations Within a Genetic Susceptibility Region Of Mouse Chromosome 3; A Genomic Region Which Is Syntenic With a Prominent Non-MHC Locus In Rheumatoid Arthritis
Andras Vida¹, Timea Besenyei², Beata Tryniszewska¹, Timea Ocsko¹, Zoltan Szekanecz³, Tibor A. Rauch¹, Katalin Mikecz¹ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Department of Rheumatology, University of Debrecen, Debrecen, Hungary, ³Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that results in inflammatory destruction of synovial joints in affected patients. The involvement of genetic and epigenetic…
Abstract Number: 1897 • 2013 ACR/ARHP Annual Meeting
Algorithms Using Genome-Wide SNP Analysis For Prediction Of Progression Of Joint Space Narrowing Or Erosion In Rheumatoid Arthritis Patients Using Data From Multiple Medical Cohorts
Tsukasa Matsubara¹, Satoru Koyano², Yoshitada Sakai³, Keiko Funahashi², Takako Miura¹, Kosuke Okuda¹, Takeshi Nakamura¹, Akira Sagawa⁴, Takeo Sakurai⁵, Hiroaki Matsuno⁶, Tomomaro Izumihara⁷ and Eisuke Shono⁸, ¹Matsubara Mayflower Hospital, Kato, Japan, ²Research Institute of Joint Diseases, Kobe, Japan, ³Kobe University, Kobe, Japan, ⁴Sagawa Akira Rheumatology Clinic, Sapporo, Japan, ⁵Inoue Hospital, Takasaki, Japan, ⁶Matsuno Clinic for Rheumatic Diseases, Toyama, Japan, ⁷Izumihara Rheumatic and Medical Clinic, Kagoshima, Japan, ⁸Shono Rheumatology Clinic, Fukuoka, Japan
Background/Purpose: Although not yet fully possible, ideally, since patients with rapidly progressing joint space narrowing/erosion exist, predicting progression of joint space narrowing/erosion would be pivotal…
Abstract Number: 1898 • 2013 ACR/ARHP Annual Meeting
Repression Of Wolf-Hischhorn Syndrome Candidate-1 (WHSC1) Contributes To The Osteoarthritis-Inducing Cartilage Loss Of Functions
Francisco Espinoza¹, Yves-Marie Pers², Paul Chuchana³, Jean Marc Brondello⁴ and Christian Jorgensen², ¹INSERM U844, MONTPELLIER, France, ²Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ³INSERM U844, Montpellier, France, ⁴Inserm U844, UM1, Montpellier, France
Background/Purpose: Accumulation of senescent p16INK4A-positive cells within numerous tissues through out life span contributes to the onset of several age-related disease such as intervertebral disc…
Abstract Number: 1899 • 2013 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 5 Gene Variant rs2004640 Is Associated With Carotid Intimal Medial Thickness In Rheumatoid Arthritis Patients
Saskia Vosslamber¹, Alper M. van Sijl², Carina Bos¹, A.E. Voskuyl², Michael T. Nurmohamed² and Cornelis L. Verweij³, ¹Pathology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Pathology and Rheumatology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease which is associated with an increased cardiovascular (CV) risk.. An important process in atherogenesis…
Abstract Number: 1900 • 2013 ACR/ARHP Annual Meeting
Mass Spectrometry-Based Salivary Proteomics For The Discovery Of Novel Diagnostic Biomarkers For Primary Sjögren’s Syndrome and Its Clinical Subsets
Camillo Giacomelli¹, Chiara Baldini¹, Francesca Sernissi¹, Daniela Martini¹, Pasquale Pepe², Nicoletta Luciano¹, Francesco Ferro¹, Chiara Tani¹, Marta Mosca³ and Stefano Bombardieri¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Institute of Clinical Physiology, National Research Council, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Nowadays, the advances of novel proteomic technologies are encouraging research projects for generating reliable diagnostic biomarkers for primary Sjögren’s syndrome (pSS) to be used…

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